Cfl1 (cofilin 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Cfl1 (cofilin 1) Rattus norvegicus
Analyze
Symbol: Cfl1
Name: cofilin 1
RGD ID: 69285
Description: Enables actin filament binding activity; phosphatidylinositol bisphosphate binding activity; and protein phosphatase binding activity. Involved in several processes, including cellular response to cytokine stimulus; negative regulation of cellular component organization; and positive regulation of cellular component organization. Acts upstream of or within cell projection organization and negative regulation of cell size. Located in several cellular components, including cofilin-actin rod; dendritic spine; and lamellipodium. Is active in glutamatergic synapse. Used to study myocardial infarction. Biomarker of several diseases, including epilepsy (multiple); impotence; muscular atrophy; ureteral obstruction; and vitamin B12 deficiency. Orthologous to human CFL1 (cofilin 1); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rab family mediated signaling pathway; Fc gamma receptor mediated signaling pathway; INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cofilin 1 non-muscle; cofilin 1, non-muscle; cofilin, non-muscle isoform; cofilin-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Cfl1-ps4  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81212,227,124 - 212,230,656 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1212,226,121 - 212,231,353 (+)EnsemblGRCr8
mRatBN7.21202,796,012 - 202,801,337 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1202,786,627 - 202,817,587 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1211,150,090 - 211,153,626 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01218,243,191 - 218,246,723 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01210,934,235 - 210,937,767 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01220,869,805 - 220,873,337 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1220,869,805 - 220,873,337 (+)Ensemblrn6Rnor6.0
Rnor_5.01227,799,126 - 227,802,658 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41208,133,876 - 208,137,408 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1200,333,275 - 200,336,807 (+)NCBICelera
RGSC_v3.11208,287,328 - 208,290,861 (+)NCBI
Cytogenetic Map1q43NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
8-(4-chlorophenylthio)-cAMP  (EXP)
acetamide  (EXP)
aconitine  (EXP)
acrolein  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (EXP)
bromobenzene  (EXP)
buspirone  (EXP)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
carvedilol  (EXP)
CGP 52608  (ISO)
chlordecone  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP,ISO)
ciguatoxin CTX1B  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
CU-O LINKAGE  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
dihydroartemisinin  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
diuron  (ISO)
dopamine  (ISO)
doxorubicin  (EXP,ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
fasudil  (EXP,ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (EXP,ISO)
formaldehyde  (EXP)
FR900359  (ISO)
fumonisin B1  (ISO)
furfural  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glyphosate  (EXP)
haloperidol  (ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
imidacloprid  (EXP)
indometacin  (ISO)
ionomycin  (ISO)
isoflurane  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
lithocholic acid  (ISO)
lovastatin  (EXP)
Mesaconitine  (EXP)
methimazole  (EXP)
methylmercury(1+)  (ISO)
miconazole  (ISO)
Monobutylphthalate  (ISO)
myricetin  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
nitrates  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
potassium hydroxide  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
probucol  (ISO)
progesterone  (ISO)
quercetin  (ISO)
quinpirole  (ISO)
resveratrol  (ISO)
rhosin  (ISO)
Sanggenon C  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
streptozocin  (EXP)
sulfadimethoxine  (EXP)
T-2 toxin  (EXP)
temozolomide  (ISO)
tetraphene  (ISO)
thapsigargin  (EXP)
thiabendazole  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
Y-27632  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament depolymerization  (IEA,ISO)
actin filament fragmentation  (IBA,IEA,ISO)
actin filament organization  (ISO,ISS)
actin filament severing  (IBA)
cell motility  (ISO)
cell projection organization  (IDA)
cellular response to epidermal growth factor stimulus  (IEP,IMP)
cellular response to ether  (IEP)
cellular response to hydrogen peroxide  (IDA)
cellular response to insulin-like growth factor stimulus  (IDA)
cellular response to interleukin-1  (IDA)
cellular response to interleukin-6  (IDA)
cellular response to tumor necrosis factor  (IDA)
establishment of cell polarity  (ISO)
establishment of spindle localization  (IEA,ISO,ISS)
hippocampus development  (IEP)
host-mediated activation of viral process  (IEA,ISO)
mitotic cytokinesis  (IBA,ISO)
modification of postsynaptic actin cytoskeleton  (EXP,IDA)
modulation of chemical synaptic transmission  (EXP,IDA)
negative regulation of actin filament bundle assembly  (IMP)
negative regulation of actin filament depolymerization  (IMP)
negative regulation of cell adhesion  (IMP)
negative regulation of cell motility  (IMP)
negative regulation of cell size  (IDA)
negative regulation of dendritic spine maintenance  (IMP,NAS)
negative regulation of lamellipodium assembly  (IMP)
negative regulation of postsynaptic density organization  (IMP)
negative regulation of unidimensional cell growth  (IMP)
neural crest cell migration  (ISO)
neural fold formation  (ISO)
positive regulation of actin filament depolymerization  (IEA,ISO)
positive regulation of barbed-end actin filament capping  (IMP)
positive regulation of cell growth  (IMP)
positive regulation of cell motility  (IMP)
positive regulation of dendritic spine development  (IMP)
positive regulation of embryonic development  (IEA,ISO,ISS)
positive regulation of establishment of cell polarity regulating cell shape  (IMP)
positive regulation of focal adhesion assembly  (IMP)
positive regulation of lamellipodium assembly  (IMP)
positive regulation of protein localization to cell leading edge  (IMP)
positive regulation of proteolysis  (IMP)
positive regulation of synaptic plasticity  (IMP)
protein import into nucleus  (IMP)
protein phosphorylation  (ISO)
regulation of dendritic spine morphogenesis  (IEA,ISO,ISS)
regulation of NMDA receptor activity  (IMP)
response to activity  (IEP)
response to amino acid  (ISO)
response to virus  (IEA,ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Maternal micronutrient deficiency leads to alteration in the kidney proteome in rat pups. Ahmad S, etal., J Proteomics. 2015 Sep 8;127(Pt A):178-84. doi: 10.1016/j.jprot.2015.04.035. Epub 2015 May 14.
2. Identification of cofilin and LIM-domain-containing protein kinase 1 as novel interaction partners of 14-3-3 zeta. Birkenfeld J, etal., Biochem J. 2003 Jan 1;369(Pt 1):45-54.
3. Spatial regulation of RhoC activity defines protrusion formation in migrating cells. Bravo-Cordero JJ, etal., J Cell Sci. 2013 Aug 1;126(Pt 15):3356-69. doi: 10.1242/jcs.123547. Epub 2013 May 23.
4. Activity-dependent dendritic spine shrinkage and growth involve downregulation of cofilin via distinct mechanisms. Calabrese B, etal., PLoS One. 2014 Apr 16;9(4):e94787. doi: 10.1371/journal.pone.0094787. eCollection 2014.
5. NMDA receptor triggered molecular cascade underlies compression-induced rapid dendritic spine plasticity in cortical neurons. Chen LJ, etal., Exp Neurol. 2015 Apr;266:86-98. doi: 10.1016/j.expneurol.2015.02.014. Epub 2015 Feb 20.
6. Arp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cells. Chiu TT, etal., Mol Biol Cell. 2010 Oct 15;21(20):3529-39. doi: 10.1091/mbc.E10-04-0316. Epub 2010 Aug 25.
7. SPIN90 dephosphorylation is required for cofilin-mediated actin depolymerization in NMDA-stimulated hippocampal neurons. Cho IH, etal., Cell Mol Life Sci. 2013 Nov;70(22):4369-83. doi: 10.1007/s00018-013-1391-4. Epub 2013 Jun 14.
8. Restoration of erectile function by suppression of corporal apoptosis, fibrosis and corporal veno-occlusive dysfunction with rho-kinase inhibitors in a rat model of cavernous nerve injury. Cho MC, etal., J Urol. 2015 May;193(5):1716-23. doi: 10.1016/j.juro.2014.10.099. Epub 2014 Oct 27.
9. Expression of actin-interacting protein 1 suppresses impaired chemotaxis of Dictyostelium cells lacking the Na+-H+ exchanger NHE1. Choi CH, etal., Mol Biol Cell. 2010 Sep 15;21(18):3162-70. doi: 10.1091/mbc.E09-12-1058. Epub 2010 Jul 28.
10. Chronophin coordinates cell leading edge dynamics by controlling active cofilin levels. Delorme-Walker V, etal., Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):E5150-9. doi: 10.1073/pnas.1510945112. Epub 2015 Aug 31.
11. Synergistic interaction between the Arp2/3 complex and cofilin drives stimulated lamellipod extension. DesMarais V, etal., J Cell Sci. 2004 Jul 15;117(Pt 16):3499-510.
12. Shank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanism. Duffney LJ, etal., J Neurosci. 2013 Oct 2;33(40):15767-78. doi: 10.1523/JNEUROSCI.1175-13.2013.
13. Cofilin is a pH sensor for actin free barbed end formation: role of phosphoinositide binding. Frantz C, etal., J Cell Biol. 2008 Dec 1;183(5):865-79. doi: 10.1083/jcb.200804161. Epub 2008 Nov 24.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
16. GABA promotes the competitive selection of dendritic spines by controlling local Ca2+ signaling. Hayama T, etal., Nat Neurosci. 2013 Oct;16(10):1409-16. doi: 10.1038/nn.3496. Epub 2013 Aug 25.
17. O-GlcNAcylation of cofilin promotes breast cancer cell invasion. Huang X, etal., J Biol Chem. 2013 Dec 20;288(51):36418-25. doi: 10.1074/jbc.M113.495713. Epub 2013 Nov 8.
18. Decrease of Both Cofilin and LIM Kinase Phosphorylation in the Skeletal Muscles of Immobilization-induced Atrophy Rats. Kim MY, etal., J Phys Ther Sci. 2014 Mar;26(3):355-7. doi: 10.1589/jpts.26.355. Epub 2014 Mar 25.
19. The Rho kinase inhibitor, fasudil, ameliorates diabetes-induced cardiac dysfunction by improving calcium clearance and actin remodeling. Lai D, etal., J Mol Med (Berl). 2016 Aug 30.
20. Cofilin Activation Is Temporally Associated with the Cessation of Growth in the Developing Hippocampus. Lauterborn JC, etal., Cereb Cortex. 2016 Apr 12. pii: bhw088.
21. Membrane ERalpha attenuates myocardial fibrosis via RhoA/ROCK-mediated actin remodeling in ovariectomized female infarcted rats. Lee TM, etal., J Mol Med (Berl). 2014 Jan;92(1):43-51. doi: 10.1007/s00109-013-1103-4. Epub 2013 Nov 29.
22. Cyclosporine A protects podocytes via stabilization of cofilin-1 expression in the unphosphorylated state. Li X, etal., Exp Biol Med (Maywood). 2014 Aug;239(8):922-936. Epub 2014 Apr 15.
23. LIMK-dependent actin polymerization in primary sensory neurons promotes the development of inflammatory heat hyperalgesia in rats. Li Y, etal., Sci Signal. 2014 Jun 24;7(331):ra61. doi: 10.1126/scisignal.2005353.
24. Physical exercise mitigates doxorubicin-induced brain cortex and cerebellum mitochondrial alterations and cellular quality control signaling. Marques-Aleixo I, etal., Mitochondrion. 2016 Jan;26:43-57. doi: 10.1016/j.mito.2015.12.002. Epub 2015 Dec 8.
25. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
26. Distinct triggering and expression mechanisms underlie LTD of AMPA and NMDA synaptic responses. Morishita W, etal., Nat Neurosci. 2005 Aug;8(8):1043-50. doi: 10.1038/nn1506. Epub 2005 Jul 17.
27. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
28. ROCK1 and 2 differentially regulate actomyosin organization to drive cell and synaptic polarity. Newell-Litwa KA, etal., J Cell Biol. 2015 Jul 20;210(2):225-42. doi: 10.1083/jcb.201504046. Epub 2015 Jul 13.
29. Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation. Oser M, etal., J Cell Biol. 2009 Aug 24;186(4):571-87. doi: 10.1083/jcb.200812176.
30. Latrunculin B or ATP depletion induces cofilin-dependent translocation of actin into nuclei of mast cells. Pendleton A, etal., J Biol Chem 2003 Apr 18;278(16):14394-400.
31. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
32. Simvastatin Attenuates Neuropathic Pain by Inhibiting the RhoA/LIMK/Cofilin Pathway. Qiu Y, etal., Neurochem Res. 2016 Sep;41(9):2457-69. doi: 10.1007/s11064-016-1958-1. Epub 2016 May 23.
33. GOA pipeline RGD automated data pipeline
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. Inhibiting geranylgeranylation increases neurite branching and differentially activates cofilin in cell bodies and growth cones. Samuel F, etal., Mol Neurobiol. 2014 Aug;50(1):49-59. doi: 10.1007/s12035-014-8653-5. Epub 2014 Feb 11.
37. Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. Shankar GM, etal., J Neurosci. 2007 Mar 14;27(11):2866-75.
38. Topical administration of a Rock/Net inhibitor promotes retinal ganglion cell survival and axon regeneration after optic nerve injury. Shaw PX, etal., Exp Eye Res. 2016 Jul 18. pii: S0014-4835(16)30181-6. doi: 10.1016/j.exer.2016.07.006.
39. Large-Scale, Ion-Current-Based Proteomic Investigation of the Rat Striatal Proteome in a Model of Short- and Long-Term Cocaine Withdrawal. Shen S, etal., J Proteome Res. 2016 May 6;15(5):1702-16. doi: 10.1021/acs.jproteome.6b00137. Epub 2016 Apr 11.
40. Identification of Bax-interacting proteins in oligodendrocyte progenitors during glutamate excitotoxicity and perinatal hypoxia-ischemia. Simonishvili S, etal., ASN Neuro. 2013 Dec 23;5(5):e00131. doi: 10.1042/AN20130027.
41. Decabrominated diphenyl ether (BDE-209) and/or BDE-47 exposure alters protein expression in purified neural stem/progenitor cells determined by proteomics analysis. Song J, etal., Int J Dev Neurosci. 2014 Apr;33:8-14. doi: 10.1016/j.ijdevneu.2013.10.008. Epub 2013 Nov 14.
42. Involvement of Rho-Kinase/LIM Kinase/Cofilin Signaling Pathway in Corporal Fibrosis after Cavernous Nerve Injury in Male Rats. Song SH, etal., J Sex Med. 2015 Jul;12(7):1522-32. doi: 10.1111/jsm.12903. Epub 2015 Apr 28.
43. Proteomic identification of early changes in the renal cytoskeleton in obstructive uropathy. Stodkilde L, etal., Am J Physiol Renal Physiol. 2014 Jun 15;306(12):F1429-41. doi: 10.1152/ajprenal.00244.2013. Epub 2014 Apr 23.
44. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
45. Non-overlapping activities of ADF and cofilin-1 during the migration of metastatic breast tumor cells. Tahtamouni LH, etal., BMC Cell Biol. 2013 Oct 5;14:45. doi: 10.1186/1471-2121-14-45.
46. Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2. Tavazoie SF, etal., Nat Neurosci. 2005 Dec;8(12):1727-34. Epub 2005 Nov 6.
47. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
48. Cofilin1 controls transcolumnar plasticity in dendritic spines in adult barrel cortex. Tsubota T, etal., PLoS Biol. 2015 Feb 27;13(2):e1002070. doi: 10.1371/journal.pbio.1002070. eCollection 2015 Feb.
49. Myoinositol Attenuates the Cell Loss and Biochemical Changes Induced by Kainic Acid Status Epilepticus. Tsverava L, etal., Biomed Res Int. 2016;2016:2794096. doi: 10.1155/2016/2794096. Epub 2016 Aug 23.
50. Amyloid-beta and proinflammatory cytokines utilize a prion protein-dependent pathway to activate NADPH oxidase and induce cofilin-actin rods in hippocampal neurons. Walsh KP, etal., PLoS One. 2014 Apr 23;9(4):e95995. doi: 10.1371/journal.pone.0095995. eCollection 2014.
51. Proteomic analysis on infantile spasm and prenatal stress. Wang J, etal., Epilepsy Res. 2014 Sep;108(7):1174-83. doi: 10.1016/j.eplepsyres.2014.06.001. Epub 2014 Jun 14.
52. Cofilin1 is involved in hypertension-induced renal damage via the regulation of NF-kappaB in renal tubular epithelial cells. Wang QZ, etal., J Transl Med. 2015 Oct 8;13:323. doi: 10.1186/s12967-015-0685-8.
53. Ezrin is down-regulated in diabetic kidney glomeruli and regulates actin reorganization and glucose uptake via GLUT1 in cultured podocytes. Wasik AA, etal., Am J Pathol. 2014 Jun;184(6):1727-39. doi: 10.1016/j.ajpath.2014.03.002. Epub 2014 Apr 13.
54. CFL1 and Arp3 are biomarkers for metastasis and poor prognosis of squamous cell/adenosquamous carcinomas and adenocarcinomas of gallbladder. Yang ZL, etal., Cancer Invest. 2013 Feb;31(2):132-9. doi: 10.3109/07357907.2012.756113. Epub 2013 Jan 15.
Additional References at PubMed
PMID:9078368   PMID:9877327   PMID:11139403   PMID:11809832   PMID:11812157   PMID:14627549   PMID:15004221   PMID:15337778   PMID:15489334   PMID:15532723   PMID:15548599   PMID:15606898  
PMID:15649475   PMID:16548883   PMID:16803871   PMID:16854843   PMID:17018287   PMID:17110338   PMID:17113383   PMID:17993279   PMID:19190083   PMID:19199708   PMID:19542631   PMID:19654210  
PMID:19946888   PMID:20442266   PMID:20458337   PMID:20610540   PMID:20696146   PMID:20971191   PMID:21187345   PMID:21423176   PMID:21474314   PMID:21715328   PMID:21834987   PMID:22117609  
PMID:22317922   PMID:22496574   PMID:22855535   PMID:22871113   PMID:22981401   PMID:23106098   PMID:23376485   PMID:23533145   PMID:23537649   PMID:23580065   PMID:23793062   PMID:23921380  
PMID:23979707   PMID:24006456   PMID:24052308   PMID:24096734   PMID:24464040   PMID:24625528   PMID:25107909   PMID:25556234   PMID:28791377   PMID:29162887   PMID:29476059   PMID:29932353  
PMID:31400829   PMID:31686426   PMID:32015554   PMID:32357304   PMID:35352799  


Genomics

Comparative Map Data
Cfl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81212,227,124 - 212,230,656 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1212,226,121 - 212,231,353 (+)EnsemblGRCr8
mRatBN7.21202,796,012 - 202,801,337 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1202,786,627 - 202,817,587 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1211,150,090 - 211,153,626 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01218,243,191 - 218,246,723 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01210,934,235 - 210,937,767 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01220,869,805 - 220,873,337 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1220,869,805 - 220,873,337 (+)Ensemblrn6Rnor6.0
Rnor_5.01227,799,126 - 227,802,658 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41208,133,876 - 208,137,408 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1200,333,275 - 200,336,807 (+)NCBICelera
RGSC_v3.11208,287,328 - 208,290,861 (+)NCBI
Cytogenetic Map1q43NCBI
CFL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381165,854,673 - 65,858,180 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1165,823,022 - 65,862,026 (-)Ensemblhg38GRCh38
GRCh371165,622,144 - 65,625,651 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361165,378,858 - 65,382,380 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341165,378,862 - 65,382,380NCBI
Celera1162,946,188 - 62,949,710 (-)NCBICelera
Cytogenetic Map11q13.1NCBI
HuRef1161,948,799 - 61,952,321 (-)NCBIHuRef
CHM1_11165,506,695 - 65,510,217 (-)NCBICHM1_1
T2T-CHM13v2.01165,849,144 - 65,852,651 (-)NCBIT2T-CHM13v2.0
Cfl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39195,540,483 - 5,544,059 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl195,540,483 - 5,545,229 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38195,490,455 - 5,494,031 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl195,490,455 - 5,495,201 (+)Ensemblmm10GRCm38
MGSCv37195,490,455 - 5,494,031 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36195,490,525 - 5,495,201 (+)NCBIMGSCv36mm8
Celera195,362,154 - 5,365,730 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map194.34NCBI
Cfl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542219,479,181 - 19,482,571 (+)Ensembl
ChiLan1.0NW_00495542219,479,181 - 19,482,571 (+)NCBIChiLan1.0ChiLan1.0
CFL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2967,083,366 - 67,089,768 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11168,126,152 - 68,131,657 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01161,215,092 - 61,218,628 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11164,544,275 - 64,548,372 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1164,544,275 - 64,550,806 (-)EnsemblpanPan2panpan1.1
CFL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11851,404,649 - 51,408,240 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1851,401,659 - 51,408,212 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1850,013,157 - 50,016,753 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01852,442,507 - 52,446,103 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1852,439,523 - 52,446,096 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11851,542,563 - 51,546,159 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01851,116,937 - 51,120,532 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01851,906,246 - 51,909,842 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cfl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049477,236,442 - 7,239,965 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365993,677,804 - 3,682,307 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365993,678,724 - 3,682,314 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CFL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl26,469,254 - 6,475,035 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.126,471,558 - 6,475,019 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.225,575,587 - 5,579,048 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CFL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.118,408,560 - 8,410,564 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038105,687,711 - 105,692,145 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cfl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476720,574,966 - 20,579,796 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476720,574,884 - 20,578,413 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Cfl1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v122,180,333 - 2,183,938 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cfl1
30 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:71
Count of miRNA genes:54
Interacting mature miRNAs:67
Transcripts:ENSRNOT00000015962
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1207243873252243873Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1207243873252243873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1209203273254203273Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1207243873252243873Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1203300512229359342Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1191190115223964326Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1208798288253798288Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1197807365233480676Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1202851915223964440Rat
6480783Insul19Insulin level QTL 194.33blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1203300512213659238Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1207099883252099883Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat

Markers in Region
Cfl1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21054,675,300 - 54,676,175 (+)MAPPERmRatBN7.2
Rnor_6.01056,562,267 - 56,563,141NCBIRnor6.0
Rnor_5.01056,307,386 - 56,308,260UniSTSRnor5.0
RGSC_v3.41056,795,989 - 56,796,862UniSTSRGSC3.4
Celera1053,829,226 - 53,830,099UniSTS
Cytogenetic Map1q43UniSTS
Cfl1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21202,800,003 - 202,800,736 (+)MAPPERmRatBN7.2
mRatBN7.28108,490,519 - 108,490,693 (+)MAPPERmRatBN7.2
Rnor_6.08116,573,307 - 116,573,480NCBIRnor6.0
Rnor_6.01220,872,010 - 220,872,742NCBIRnor6.0
Rnor_5.08115,927,896 - 115,928,069UniSTSRnor5.0
Rnor_5.01227,801,331 - 227,802,063UniSTSRnor5.0
RGSC_v3.48113,065,789 - 113,065,962UniSTSRGSC3.4
RGSC_v3.41208,136,081 - 208,136,813UniSTSRGSC3.4
Celera8107,796,645 - 107,796,818UniSTS
Celera1200,335,480 - 200,336,212UniSTS
Cytogenetic Map1q43UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_017147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC109096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC059143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC086533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X62908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000015962   ⟹   ENSRNOP00000059624
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1202,797,796 - 202,801,333 (+)Ensembl
Rnor_6.0 Ensembl1220,869,805 - 220,873,337 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104618   ⟹   ENSRNOP00000081565
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1202,786,627 - 202,802,960 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117088   ⟹   ENSRNOP00000093902
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1212,226,121 - 212,231,353 (+)Ensembl
mRatBN7.2 Ensembl1202,797,753 - 202,817,587 (+)Ensembl
RefSeq Acc Id: NM_017147   ⟹   NP_058843
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81212,227,124 - 212,230,656 (+)NCBI
mRatBN7.21202,797,799 - 202,801,331 (+)NCBI
Rnor_6.01220,869,805 - 220,873,337 (+)NCBI
Rnor_5.01227,799,126 - 227,802,658 (+)NCBI
RGSC_v3.41208,133,876 - 208,137,408 (+)RGD
Celera1200,333,275 - 200,336,807 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058843 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH59143 (Get FASTA)   NCBI Sequence Viewer  
  AAH86533 (Get FASTA)   NCBI Sequence Viewer  
  CAA44694 (Get FASTA)   NCBI Sequence Viewer  
  EDM12501 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000093902.1
GenBank Protein P45592 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058843   ⟸   NM_017147
- UniProtKB: P45592 (UniProtKB/Swiss-Prot),   A6HZ71 (UniProtKB/TrEMBL),   A0A8I5ZT72 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000059624   ⟸   ENSRNOT00000015962
Ensembl Acc Id: ENSRNOP00000093902   ⟸   ENSRNOT00000117088
Ensembl Acc Id: ENSRNOP00000081565   ⟸   ENSRNOT00000104618
Protein Domains
ADF-H

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P45592-F1-model_v2 AlphaFold P45592 1-166 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690661
Promoter ID:EPDNEW_R1186
Type:multiple initiation site
Name:Cfl1_1
Description:cofilin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01220,869,802 - 220,869,862EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69285 AgrOrtholog
BioCyc Gene G2FUF-56675 BioCyc
Ensembl Genes ENSRNOG00000020660 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000117088.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.20.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6889053 IMAGE-MGC_LOAD
  IMAGE:7305422 IMAGE-MGC_LOAD
InterPro ADF-H UniProtKB/Swiss-Prot
  ADF-H/Gelsolin-like_dom_sf UniProtKB/Swiss-Prot
  ADF/Cofilin UniProtKB/Swiss-Prot
KEGG Report rno:29271 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105258 IMAGE-MGC_LOAD
  MGC:72892 IMAGE-MGC_LOAD
NCBI Gene 29271 ENTREZGENE
PANTHER PTHR11913 UniProtKB/Swiss-Prot
Pfam Cofilin_ADF UniProtKB/Swiss-Prot
PhenoGen Cfl1 PhenoGen
PRINTS COFILIN UniProtKB/Swiss-Prot
PROSITE ADF_H UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020660 RatGTEx
SMART ADF UniProtKB/Swiss-Prot
Superfamily-SCOP Actin depolymerizing proteins UniProtKB/Swiss-Prot
TIGR TC228547
UniProt A0A8I5ZT72 ENTREZGENE
  A6HZ71 ENTREZGENE, UniProtKB/TrEMBL
  COF1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-27 Cfl1  cofilin 1  Cfl1  cofilin 1, non-muscle  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Cfl1  cofilin 1, non-muscle    cofilin 1  Name updated 1299863 APPROVED
2002-06-10 Cfl1  cofilin 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference