Cdo1 (cysteine dioxygenase type 1) - Rat Genome Database

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Gene: Cdo1 (cysteine dioxygenase type 1) Rattus norvegicus
Analyze
Symbol: Cdo1
Name: cysteine dioxygenase type 1
RGD ID: 69262
Description: Enables cysteine dioxygenase activity and ferrous iron binding activity. Involved in several processes, including L-cysteine catabolic process; lactation; and response to glucagon. Predicted to be located in cytosol. Biomarker of hypertension. Orthologous to human CDO1 (cysteine dioxygenase type 1); PARTICIPATES IN cysteine metabolic pathway; mercaptolactate-cysteine disulfiduria pathway; ocular nonnephropathic cystinosis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CDO; CDO-I; cysteine dioxygenase; cysteine dioxygenase 1, cytosolic; cysteine dioxygenase, type I; cytosolic cysteine dioxygenase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81841,619,076 - 41,633,719 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1841,619,070 - 41,633,891 (-)EnsemblGRCr8
mRatBN7.21839,432,473 - 39,447,253 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1839,432,474 - 39,447,296 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1841,465,686 - 41,480,329 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01842,167,931 - 42,182,574 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01839,961,030 - 39,975,676 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01840,702,027 - 40,716,901 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1840,701,984 - 40,716,686 (-)Ensemblrn6Rnor6.0
Rnor_5.01840,348,054 - 40,362,746 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41840,914,028 - 40,928,671 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1837,683,907 - 37,698,550 (-)NCBICelera
RGSC_v3.11840,951,568 - 40,966,212 (-)NCBI
Cytogenetic Map18q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-octylphenol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (EXP)
arsenite(3-)  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chloroprene  (EXP)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP)
clofibrate  (EXP)
clofibric acid  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
corticosterone  (EXP)
coumarin  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
glafenine  (EXP)
glutathione  (EXP)
hypotaurine  (EXP)
indometacin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
isoprenaline  (ISO)
L-ethionine  (EXP)
L-methionine  (ISO)
m-xylene  (EXP)
maneb  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methylisothiazolinone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nickel sulfate  (ISO)
nimesulide  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
omeprazole  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP,ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
raloxifene  (ISO)
serpentine asbestos  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP,ISO)
succimer  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
taurine  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triptonide  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Probes of the catalytic site of cysteine dioxygenase. Chai SC, etal., J Biol Chem. 2006 Jun 9;281(23):15774-9. Epub 2006 Apr 11.
2. Cysteine is the metabolic signal responsible for dietary regulation of hepatic cysteine dioxygenase and glutamate cysteine ligase in intact rats. Cresenzi CL, etal., J Nutr 2003 Sep;133(9):2697-702.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Isolation and characterization of a cDNA for rat liver cysteine dioxygenase. Hosokawa Y, etal., Biochem Biophys Res Commun 1990 Apr 30;168(2):473-8.
6. Decrease of rat liver cysteine dioxygenase (cysteine oxidase) activity mediated by glucagon. Hosokawa Y, etal., J Biochem. 1978 Aug;84(2):419-24.
7. Immaturity of the enzyme activity and the response to inducers of rat liver cysteine dioxygenase during development. Hosokawa Y, etal., J Biochem. 1980 Aug;88(2):389-94.
8. Effect of acute ethanol administration on S-amino acid metabolism: increased utilization of cysteine for synthesis of taurine rather than glutathione. Jung YS, etal., Adv Exp Med Biol. 2003;526:245-52.
9. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
10. Changes in cysteine dioxygenase and cysteinesulfinate decarboxylase activities and taurine levels in tissues of pregnant or lactating rat dams and their fetuses or pups. Kuo SM and Stipanuk MH, Biol Neonate. 1984;46(5):237-48.
11. Alteration of cerebral taurine biosynthesis in spontaneously hypertensive rats. Kuriyama K, etal., J Neurochem. 1984 Jun;42(6):1600-6.
12. Cysteine regulates expression of cysteine dioxygenase and gamma-glutamylcysteine synthetase in cultured rat hepatocytes. Kwon YH and Stipanuk MH, Am J Physiol Endocrinol Metab. 2001 May;280(5):E804-15.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Hepatic localisation of rat cysteine dioxygenase. Parsons RB, etal., J Hepatol. 1998 Oct;29(4):595-602.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Dealing with methionine/homocysteine sulfur: cysteine metabolism to taurine and inorganic sulfur. Stipanuk MH and Ueki I, J Inherit Metab Dis. 2011 Feb;34(1):17-32. doi: 10.1007/s10545-009-9006-9. Epub 2010 Feb 17.
22. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
23. Structural organization and tissue-specific expression of the gene encoding rat cysteine dioxygenase. Tsuboyama N, etal., Gene 1996 Nov 28;181(1-2):161-5.
24. Taurine (2-aminoethanesulfonic acid) deficiency creates a vicious circle promoting obesity. Tsuboyama-Kasaoka N, etal., Endocrinology. 2006 Jul;147(7):3276-84. Epub 2006 Apr 20.
Additional References at PubMed
PMID:11602353   PMID:15489334   PMID:15623508   PMID:16262602   PMID:16325423   PMID:16511222   PMID:16611640   PMID:17153587   PMID:17634260   PMID:18308719   PMID:18847220   PMID:21839860  
PMID:22122511   PMID:24084026   PMID:24929188   PMID:25390690  


Genomics

Comparative Map Data
Cdo1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81841,619,076 - 41,633,719 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1841,619,070 - 41,633,891 (-)EnsemblGRCr8
mRatBN7.21839,432,473 - 39,447,253 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1839,432,474 - 39,447,296 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1841,465,686 - 41,480,329 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01842,167,931 - 42,182,574 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01839,961,030 - 39,975,676 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01840,702,027 - 40,716,901 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1840,701,984 - 40,716,686 (-)Ensemblrn6Rnor6.0
Rnor_5.01840,348,054 - 40,362,746 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41840,914,028 - 40,928,671 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1837,683,907 - 37,698,550 (-)NCBICelera
RGSC_v3.11840,951,568 - 40,966,212 (-)NCBI
Cytogenetic Map18q11NCBI
CDO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385115,804,733 - 115,816,659 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5115,804,733 - 115,816,660 (-)Ensemblhg38GRCh38
GRCh375115,140,430 - 115,152,356 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365115,168,329 - 115,180,304 (-)NCBIBuild 36Build 36hg18NCBI36
Build 345115,168,330 - 115,180,304NCBI
Celera5111,088,830 - 111,100,805 (-)NCBICelera
Cytogenetic Map5q22.3NCBI
HuRef5110,321,120 - 110,333,095 (-)NCBIHuRef
CHM1_15114,573,041 - 114,585,035 (-)NCBICHM1_1
T2T-CHM13v2.05116,317,131 - 116,330,485 (-)NCBIT2T-CHM13v2.0
Cdo1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391846,846,260 - 46,861,569 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1846,846,260 - 46,861,462 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381846,713,193 - 46,728,502 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1846,713,193 - 46,728,395 (-)Ensemblmm10GRCm38
MGSCv371846,872,859 - 46,887,996 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361846,838,536 - 46,853,673 (-)NCBIMGSCv36mm8
Celera1848,072,450 - 48,087,588 (-)NCBICelera
Cytogenetic Map18CNCBI
cM Map1824.75NCBI
Cdo1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540835,593,767 - 35,605,189 (-)Ensembl
ChiLan1.0NW_00495540835,593,981 - 35,605,189 (-)NCBIChiLan1.0ChiLan1.0
CDO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24111,049,670 - 111,061,831 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15109,203,331 - 109,215,493 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05111,159,041 - 111,170,965 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15116,955,295 - 116,967,506 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5116,955,295 - 116,967,506 (-)EnsemblpanPan2panpan1.1
CDO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1115,512,996 - 5,524,556 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl115,371,378 - 5,524,562 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha115,663,614 - 5,675,242 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0115,504,785 - 5,516,418 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl115,363,481 - 5,516,371 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1115,459,998 - 5,471,611 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0115,531,165 - 5,542,773 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0115,783,374 - 5,794,991 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cdo1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213128,281,092 - 128,292,536 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936742979,368 - 993,257 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936742981,863 - 993,271 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2119,927,772 - 119,940,665 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12119,927,768 - 119,940,690 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22124,815,757 - 124,827,728 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CDO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12319,049,612 - 19,061,783 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2319,049,262 - 19,061,740 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603459,346,740 - 59,359,207 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdo1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247336,062,502 - 6,075,210 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247336,062,716 - 6,074,583 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Cdo1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11540,325,147 - 40,340,048 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cdo1
67 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:435
Count of miRNA genes:237
Interacting mature miRNAs:274
Transcripts:ENSRNOT00000000172
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)182201556261600538Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)183857591983575919Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182682218671822186Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182682218671822186Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182682218671822186Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050563968306Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182682218671822186Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182682218671822186Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182682218671822186Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183199089176990891Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183161050585493247Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)183337915878379158Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)184046238385462383Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18448264849482648Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)183199089176990891Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18154490981Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
11565454Kidm59Kidney mass QTL 590.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)18706572852065728Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)18430735449307354Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)183337915878379158Rat
2301409Cm70Cardiac mass QTL 700.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)18706572852065728Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)183337915878379158Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)183337915878379158Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182682218671822186Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183152278376522783Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)183337915878379158Rat
12904716Am21Aortic mass QTL 210.005aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)18706572852065728Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183337915878379158Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)183337915878379158Rat
12904714Cm131Cardiac mass QTL 1310.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)18706572852065728Rat
12904715Cm132Cardiac mass QTL 1320.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)18706572852065728Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183161050577371277Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183612162681121626Rat
6903345Bp349Blood pressure QTL 3493.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181522610142690662Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)183199089176990891Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18546045542690191Rat
6903349Bp351Blood pressure QTL 3513.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)182641582171415821Rat
6903351Bp352Blood pressure QTL 3523.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183164450879484311Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18144930869Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181206648257066482Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)183199089176990891Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183161050572538878Rat

Markers in Region
D18Wox19  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21839,433,272 - 39,433,416 (+)MAPPERmRatBN7.2
Rnor_6.01840,702,827 - 40,702,970NCBIRnor6.0
Rnor_5.01840,348,854 - 40,348,997UniSTSRnor5.0
RGSC_v3.41840,914,821 - 40,914,964UniSTSRGSC3.4
Celera1837,684,700 - 37,684,843UniSTS
Cytogenetic Map18q11UniSTS
D18Wox20  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21839,442,611 - 39,442,747 (+)MAPPERmRatBN7.2
Rnor_6.01840,712,166 - 40,712,301NCBIRnor6.0
Rnor_5.01840,358,193 - 40,358,328UniSTSRnor5.0
RGSC_v3.41840,924,160 - 40,924,295UniSTSRGSC3.4
Celera1837,694,039 - 37,694,174UniSTS
Cytogenetic Map18q11UniSTS
RH127714  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21839,432,624 - 39,432,808 (+)MAPPERmRatBN7.2
Rnor_6.01840,702,179 - 40,702,362NCBIRnor6.0
Rnor_5.01840,348,206 - 40,348,389UniSTSRnor5.0
RGSC_v3.41840,914,173 - 40,914,356UniSTSRGSC3.4
Celera1837,684,052 - 37,684,235UniSTS
Cytogenetic Map18q11UniSTS
RH139615  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21839,445,603 - 39,445,817 (+)MAPPERmRatBN7.2
Rnor_6.01840,715,157 - 40,715,370NCBIRnor6.0
Rnor_5.01840,361,184 - 40,361,397UniSTSRnor5.0
RGSC_v3.41840,927,151 - 40,927,364UniSTSRGSC3.4
Celera1837,697,030 - 37,697,243UniSTS
Cytogenetic Map18q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 89 59 6 353 189 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000000172   ⟹   ENSRNOP00000000172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1841,619,076 - 41,633,719 (-)Ensembl
mRatBN7.2 Ensembl1839,432,480 - 39,447,124 (-)Ensembl
Rnor_6.0 Ensembl1840,701,984 - 40,716,686 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096478   ⟹   ENSRNOP00000079228
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1841,619,070 - 41,633,729 (-)Ensembl
mRatBN7.2 Ensembl1839,432,474 - 39,446,935 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107879   ⟹   ENSRNOP00000077468
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1841,620,590 - 41,633,891 (-)Ensembl
mRatBN7.2 Ensembl1839,433,994 - 39,447,296 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000161467   ⟹   ENSRNOP00000099930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1841,622,365 - 41,633,891 (-)Ensembl
RefSeq Acc Id: NM_052809   ⟹   NP_434696
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81841,619,076 - 41,633,719 (-)NCBI
mRatBN7.21839,432,480 - 39,447,124 (-)NCBI
Rnor_6.01840,702,034 - 40,716,677 (-)NCBI
Rnor_5.01840,348,054 - 40,362,746 (-)NCBI
RGSC_v3.41840,914,028 - 40,928,671 (-)RGD
Celera1837,683,907 - 37,698,550 (-)RGD
Sequence:
RefSeq Acc Id: NP_434696   ⟸   NM_052809
- UniProtKB: Q6NS32 (UniProtKB/Swiss-Prot),   P21816 (UniProtKB/Swiss-Prot),   A6IWW6 (UniProtKB/TrEMBL),   A0A8I5ZKB1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000000172   ⟸   ENSRNOT00000000172
Ensembl Acc Id: ENSRNOP00000077468   ⟸   ENSRNOT00000107879
Ensembl Acc Id: ENSRNOP00000079228   ⟸   ENSRNOT00000096478
Ensembl Acc Id: ENSRNOP00000099930   ⟸   ENSRNOT00000161467

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21816-F1-model_v2 AlphaFold P21816 1-200 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700767
Promoter ID:EPDNEW_R11291
Type:single initiation site
Name:Cdo1_1
Description:cysteine dioxygenase type 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01840,716,701 - 40,716,761EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69262 AgrOrtholog
BioCyc Gene G2FUF-7623 BioCyc
BioCyc Pathway CYSTEINE-DEG-PWY [L-cysteine degradation I] BioCyc
  PWY-5331 [taurine biosynthesis I] BioCyc
BioCyc Pathway Image CYSTEINE-DEG-PWY BioCyc
  PWY-5331 BioCyc
Ensembl Genes ENSRNOG00000000158 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000000172 ENTREZGENE
  ENSRNOT00000000172.6 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7100321 IMAGE-MGC_LOAD
InterPro CDO_1 UniProtKB/Swiss-Prot
  RmlC-like_jellyroll UniProtKB/Swiss-Prot
  RmlC_Cupin_sf UniProtKB/Swiss-Prot
KEGG Report rno:81718 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91599 IMAGE-MGC_LOAD
NCBI Gene 81718 ENTREZGENE
PANTHER CYSTEINE DIOXYGENASE TYPE 1 UniProtKB/Swiss-Prot
  PTHR12918 UniProtKB/Swiss-Prot
Pfam CDO_I UniProtKB/Swiss-Prot
PhenoGen Cdo1 PhenoGen
RatGTEx ENSRNOG00000000158 RatGTEx
Superfamily-SCOP SSF51182 UniProtKB/Swiss-Prot
UniProt A0A8I5ZKB1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZMI6_RAT UniProtKB/TrEMBL
  A0ABK0L5M3_RAT UniProtKB/TrEMBL
  A6IWW4_RAT UniProtKB/TrEMBL
  A6IWW5_RAT UniProtKB/TrEMBL
  A6IWW6 ENTREZGENE, UniProtKB/TrEMBL
  A6IWW7_RAT UniProtKB/TrEMBL
  A6IWW8_RAT UniProtKB/TrEMBL
  CDO1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6NS32 ENTREZGENE
UniProt Secondary Q6NS32 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-07-09 Cdo1  cysteine dioxygenase type 1  Cdo1  cysteine dioxygenase, type I  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Cdo1  cysteine dioxygenase, type I  Cdo1  cysteine dioxygenase 1, cytosolic  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Cdo1  cysteine dioxygenase 1, cytosolic      Name updated 1299863 APPROVED
2002-06-10 Cdo1  cytosolic cysteine dioxygenase 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver, kidney, lung, and brain 632438
gene_protein predicted protein consists of 200 aa residues and masses 23 kDa 68765
gene_transcript gene spans around 15 kb and comprises 5 exons 632438