Gne (glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase) - Rat Genome Database

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Gene: Gne (glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase) Rattus norvegicus
Analyze
Symbol: Gne
Name: glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
RGD ID: 69239
Description: Enables N-acylmannosamine kinase activity and UDP-N-acetylglucosamine 2-epimerase activity. Predicted to be involved in CMP-N-acetylneuraminate biosynthetic process; N-acetylneuraminate biosynthetic process; and glycosylation. Is active in cytosol. Human ortholog(s) of this gene implicated in GNE myopathy; sialuria; and thrombocytopenia. Orthologous to human GNE (glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase); PARTICIPATES IN amino sugar metabolic pathway; french type sialuria pathway; sialic acid storage disease pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; glucosamine; Uae1; UDP-GlcNAc-2-epimerase/ManAc kinase; UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8563,062,953 - 63,103,320 (-)NCBIGRCr8
mRatBN7.2558,267,189 - 58,307,396 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl558,267,210 - 58,307,499 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx560,248,992 - 60,279,247 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0562,067,800 - 62,098,053 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0562,037,233 - 62,067,502 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0559,511,738 - 59,553,421 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl559,512,872 - 59,553,416 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0564,034,863 - 64,075,144 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4560,506,171 - 60,536,403 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1560,506,350 - 60,536,582 (-)NCBI
Celera556,845,530 - 56,875,714 (-)NCBICelera
Cytogenetic Map5q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
aceneuramic acid  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium dichloride  (EXP,ISO)
choline  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
gallic acid  (ISO)
gentamycin  (EXP)
glutathione  (EXP)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
leflunomide  (EXP)
mercury dibromide  (ISO)
methotrexate  (ISO)
N-acetylneuraminic acid  (EXP)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
paracetamol  (ISO)
parathion  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
Propiverine  (EXP)
rac-lactic acid  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IDA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Domain-specific characteristics of the bifunctional key enzyme of sialic acid biosynthesis, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase. Blume A, etal., Biochem J 2004 Dec 15;384(Pt 3):599-607.
2. Selective loss of either the epimerase or kinase activity of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase due to site-directed mutagenesis based on sequence alignments. Effertz K, etal., J Biol Chem. 1999 Oct 1;274(40):28771-8. doi: 10.1074/jbc.274.40.28771.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Purification and characterization of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase. Hinderlich S, etal., J Biol Chem. 1997 Sep 26;272(39):24313-8. doi: 10.1074/jbc.272.39.24313.
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. UDP-GlcNAc 2-epimerase: a regulator of cell surface sialylation. Keppler OT, etal., Science. 1999 May 21;284(5418):1372-6. doi: 10.1126/science.284.5418.1372.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Genetic dissection of increased urinary albumin excretion in the munich wistar fromter rat. Schulz A, etal., J Am Soc Nephrol 2002 Nov;13(11):2706-14.
18. A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Molecular cloning and functional expression of UDP-N-acetyl-glucosamine 2-epimerase/N-acetylmannosamine kinase. Stasche R, etal., J Biol Chem 1997 Sep 26;272(39):24319-24.
19. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
20. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
21. The collapsin response mediator protein 1 (CRMP-1) and the promyelocytic leukemia zinc finger protein (PLZF) bind to UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE), the key enzyme of sialic acid biosynthesis. Weidemann W, etal., FEBS Lett. 2006 Dec 11;580(28-29):6649-54. Epub 2006 Nov 14.
Additional References at PubMed
PMID:10103025   PMID:12927803   PMID:15489334   PMID:15498764   PMID:17448495   PMID:18628673   PMID:21873062   PMID:22871113   PMID:24625528   PMID:33608771  


Genomics

Comparative Map Data
Gne
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8563,062,953 - 63,103,320 (-)NCBIGRCr8
mRatBN7.2558,267,189 - 58,307,396 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl558,267,210 - 58,307,499 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx560,248,992 - 60,279,247 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0562,067,800 - 62,098,053 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0562,037,233 - 62,067,502 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0559,511,738 - 59,553,421 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl559,512,872 - 59,553,416 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0564,034,863 - 64,075,144 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4560,506,171 - 60,536,403 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1560,506,350 - 60,536,582 (-)NCBI
Celera556,845,530 - 56,875,714 (-)NCBICelera
Cytogenetic Map5q22NCBI
GNE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38936,214,441 - 36,276,978 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl936,214,441 - 36,277,042 (-)EnsemblGRCh38hg38GRCh38
GRCh37936,214,438 - 36,276,975 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36936,204,438 - 36,248,401 (-)NCBINCBI36Build 36hg18NCBI36
Build 34936,204,440 - 36,248,401NCBI
Celera936,148,023 - 36,210,614 (-)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef936,168,432 - 36,230,185 (-)NCBIHuRef
CHM1_1936,214,844 - 36,277,494 (-)NCBICHM1_1
T2T-CHM13v2.0936,236,447 - 36,298,980 (-)NCBIT2T-CHM13v2.0
Gne
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39444,034,075 - 44,084,177 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl444,034,075 - 44,084,177 (-)EnsemblGRCm39 Ensembl
GRCm38444,034,075 - 44,084,177 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl444,034,075 - 44,084,177 (-)EnsemblGRCm38mm10GRCm38
MGSCv37444,046,947 - 44,097,049 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36444,057,926 - 44,105,266 (-)NCBIMGSCv36mm8
Celera444,055,271 - 44,105,902 (-)NCBICelera
Cytogenetic Map4B1NCBI
cM Map423.1NCBI
Gne
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547245,926 - 97,082 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547256,623 - 92,553 (+)NCBIChiLan1.0ChiLan1.0
GNE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21188,331,427 - 88,375,166 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1988,337,369 - 88,381,103 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0936,064,128 - 36,107,822 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1936,867,094 - 36,908,212 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl936,867,096 - 36,926,588 (-)Ensemblpanpan1.1panPan2
GNE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11152,688,295 - 52,731,160 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1152,689,343 - 52,731,231 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1151,278,943 - 51,322,087 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01153,794,650 - 53,837,589 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1153,794,653 - 53,837,619 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11152,297,479 - 52,340,394 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01152,319,509 - 52,362,669 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01153,021,057 - 53,064,247 (-)NCBIUU_Cfam_GSD_1.0
Gne
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947167,637,251 - 167,686,478 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365244,196,830 - 4,252,163 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365244,184,831 - 4,234,257 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1236,998,757 - 237,065,767 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11236,998,754 - 237,065,819 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GNE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11244,300,321 - 44,340,917 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1244,282,809 - 44,344,311 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603841,390,535 - 41,432,094 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gne
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248684,361,752 - 4,417,604 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248684,362,144 - 4,417,604 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gne
260 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:81
Count of miRNA genes:71
Interacting mature miRNAs:71
Transcripts:ENSRNOT00000019532
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52851548973515489Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52795544072955440Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)53518915368564008Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52851548973515489Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)54946360094463600Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52122674466226744Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51887394763873947Rat

Markers in Region
D1Rat38  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21131,763,437 - 131,763,614 (+)MAPPERmRatBN7.2
Rnor_6.01139,523,928 - 139,524,104NCBIRnor6.0
Rnor_5.01140,507,063 - 140,507,239UniSTSRnor5.0
RGSC_v3.41133,566,530 - 133,567,105RGDRGSC3.4
RGSC_v3.41133,566,681 - 133,566,857UniSTSRGSC3.4
RGSC_v3.11133,645,024 - 133,645,200RGD
Celera1123,840,438 - 123,840,614UniSTS
RH 3.4 Map11054.8RGD
RH 3.4 Map11054.8UniSTS
RH 2.0 Map1696.0RGD
SHRSP x BN Map166.5799RGD
FHH x ACI Map165.78RGD
Cytogenetic Map5q22UniSTS
D1Rat27  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2190,508,614 - 90,508,767 (+)MAPPERmRatBN7.2
Rnor_6.0194,201,400 - 94,201,552NCBIRnor6.0
Rnor_5.0195,301,716 - 95,301,868UniSTSRnor5.0
RGSC_v3.4190,282,040 - 90,282,193RGDRGSC3.4
RGSC_v3.4190,282,041 - 90,282,193UniSTSRGSC3.4
RGSC_v3.1190,360,152 - 90,360,304RGD
Celera184,843,461 - 84,843,613UniSTS
RH 3.4 Map1886.8RGD
RH 3.4 Map1886.8UniSTS
RH 2.0 Map1578.1RGD
SHRSP x BN Map144.5299RGD
FHH x ACI Map148.9499RGD
Cytogenetic Map5q22UniSTS
D1Rat216  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01205,160,980 - 205,161,264NCBIRnor5.0
RGSC_v3.41185,923,336 - 185,923,619RGDRGSC3.4
RGSC_v3.11186,073,217 - 186,073,500RGD
RH 2.0 Map1961.9RGD
SHRSP x BN Map191.4399RGD
FHH x ACI Map186.55RGD
Cytogenetic Map5q22UniSTS
RH139094  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2558,267,426 - 58,267,615 (+)MAPPERmRatBN7.2
Rnor_6.0559,513,086 - 59,513,274NCBIRnor6.0
Rnor_5.0564,035,604 - 64,035,792UniSTSRnor5.0
RGSC_v3.4560,506,388 - 60,506,576UniSTSRGSC3.4
Celera556,845,747 - 56,845,935UniSTS
Cytogenetic Map5q22UniSTS
BI281338  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2558,267,358 - 58,267,556 (+)MAPPERmRatBN7.2
Rnor_6.0559,513,018 - 59,513,215NCBIRnor6.0
Rnor_5.0564,035,536 - 64,035,733UniSTSRnor5.0
RGSC_v3.4560,506,320 - 60,506,517UniSTSRGSC3.4
Celera556,845,679 - 56,845,876UniSTS
RH 3.4 Map5376.7UniSTS
Cytogenetic Map5q22UniSTS
RH130676  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2558,267,268 - 58,267,480 (+)MAPPERmRatBN7.2
Rnor_6.0559,512,928 - 59,513,139NCBIRnor6.0
Rnor_5.0564,035,446 - 64,035,657UniSTSRnor5.0
RGSC_v3.4560,506,230 - 60,506,441UniSTSRGSC3.4
Celera556,845,589 - 56,845,800UniSTS
RH 3.4 Map5395.0UniSTS
Cytogenetic Map5q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000019532   ⟹   ENSRNOP00000019532
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl558,267,213 - 58,297,444 (-)Ensembl
Rnor_6.0 Ensembl559,512,872 - 59,543,101 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090490   ⟹   ENSRNOP00000074334
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl558,267,210 - 58,307,499 (-)Ensembl
Rnor_6.0 Ensembl559,512,979 - 59,553,416 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115719   ⟹   ENSRNOP00000096472
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl558,267,213 - 58,297,367 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116467   ⟹   ENSRNOP00000083164
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl558,267,210 - 58,292,890 (-)Ensembl
RefSeq Acc Id: NM_053765   ⟹   NP_446217
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8563,062,953 - 63,093,185 (-)NCBI
mRatBN7.2558,267,210 - 58,297,444 (-)NCBI
Rnor_6.0559,512,869 - 59,543,101 (-)NCBI
Rnor_5.0564,034,863 - 64,075,144 (-)NCBI
RGSC_v3.4560,506,171 - 60,536,403 (-)RGD
Celera556,845,530 - 56,875,714 (-)RGD
Sequence:
RefSeq Acc Id: XM_006238006   ⟹   XP_006238068
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8563,062,953 - 63,103,320 (-)NCBI
mRatBN7.2558,267,198 - 58,307,396 (-)NCBI
Rnor_6.0559,511,738 - 59,553,421 (-)NCBI
Rnor_5.0564,034,863 - 64,075,144 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238008   ⟹   XP_006238070
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8563,062,953 - 63,096,010 (-)NCBI
mRatBN7.2558,267,198 - 58,300,273 (-)NCBI
Rnor_6.0559,512,869 - 59,545,899 (-)NCBI
Rnor_5.0564,034,863 - 64,075,144 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238009   ⟹   XP_006238071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8563,062,953 - 63,092,890 (-)NCBI
mRatBN7.2558,267,198 - 58,297,095 (-)NCBI
Rnor_6.0559,511,738 - 59,542,798 (-)NCBI
Rnor_5.0564,034,863 - 64,075,144 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039109125   ⟹   XP_038965053
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8563,062,953 - 63,093,766 (-)NCBI
mRatBN7.2558,267,198 - 58,298,027 (-)NCBI
RefSeq Acc Id: XM_039109127   ⟹   XP_038965055
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8563,062,953 - 63,092,890 (-)NCBI
mRatBN7.2558,267,198 - 58,297,095 (-)NCBI
RefSeq Acc Id: XM_063287060   ⟹   XP_063143130
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8563,067,376 - 63,103,150 (-)NCBI
RefSeq Acc Id: NP_446217   ⟸   NM_053765
- UniProtKB: O35826 (UniProtKB/Swiss-Prot),   A6IJ68 (UniProtKB/TrEMBL),   A0A8I5ZWN3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238068   ⟸   XM_006238006
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K7T2 (UniProtKB/TrEMBL),   A6IJ67 (UniProtKB/TrEMBL),   A0A8I5ZWN3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238071   ⟸   XM_006238009
- Peptide Label: isoform X2
- UniProtKB: O35826 (UniProtKB/Swiss-Prot),   A6IJ68 (UniProtKB/TrEMBL),   A0A8I5ZWN3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238070   ⟸   XM_006238008
- Peptide Label: isoform X2
- UniProtKB: O35826 (UniProtKB/Swiss-Prot),   A6IJ68 (UniProtKB/TrEMBL),   A0A8I5ZWN3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074334   ⟸   ENSRNOT00000090490
Ensembl Acc Id: ENSRNOP00000019532   ⟸   ENSRNOT00000019532
RefSeq Acc Id: XP_038965053   ⟸   XM_039109125
- Peptide Label: isoform X2
- UniProtKB: O35826 (UniProtKB/Swiss-Prot),   A6IJ68 (UniProtKB/TrEMBL),   A0A8I5ZWN3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965055   ⟸   XM_039109127
- Peptide Label: isoform X2
- UniProtKB: O35826 (UniProtKB/Swiss-Prot),   A6IJ68 (UniProtKB/TrEMBL),   A0A8I5ZWN3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000083164   ⟸   ENSRNOT00000116467
Ensembl Acc Id: ENSRNOP00000096472   ⟸   ENSRNOT00000115719
RefSeq Acc Id: XP_063143130   ⟸   XM_063287060
- Peptide Label: isoform X3
Protein Domains
UDP-N-acetylglucosamine 2-epimerase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35826-F1-model_v2 AlphaFold O35826 1-722 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693688
Promoter ID:EPDNEW_R4213
Type:initiation region
Name:Gne_1
Description:glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R4214  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0559,543,037 - 59,543,097EPDNEW
RGD ID:13693692
Promoter ID:EPDNEW_R4214
Type:single initiation site
Name:Gne_2
Description:glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R4213  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0559,553,439 - 59,553,499EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69239 AgrOrtholog
BioCyc Gene G2FUF-41478 BioCyc
BioCyc Pathway PWY-6138 [CMP-N-acetylneuraminate biosynthesis I (eukaryotes)] BioCyc
BioCyc Pathway Image PWY-6138 BioCyc
Ensembl Genes ENSRNOG00000014365 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055020776 UniProtKB/Swiss-Prot
  ENSRNOG00060004446 UniProtKB/Swiss-Prot
  ENSRNOG00065010137 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019532.6 UniProtKB/Swiss-Prot
  ENSRNOT00000090490.2 UniProtKB/TrEMBL
  ENSRNOT00000115719.1 UniProtKB/TrEMBL
  ENSRNOT00000116467.1 UniProtKB/TrEMBL
  ENSRNOT00055035487 UniProtKB/Swiss-Prot
  ENSRNOT00060007528 UniProtKB/Swiss-Prot
  ENSRNOT00065016357 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.420.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycogen Phosphorylase B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5621384 IMAGE-MGC_LOAD
InterPro ATPase_NBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ROK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UDP-GlcNAc_Epase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UDP_GlcNAc_Epimerase_2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114711 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72348 IMAGE-MGC_LOAD
NCBI Gene 114711 ENTREZGENE
PANTHER BIFUNCTIONAL UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE/N-ACETYLMANNOSAMINE KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR18964 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Epimerase_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ROK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gne PhenoGen
PRINTS HEXOKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014365 RatGTEx
  ENSRNOG00055020776 RatGTEx
  ENSRNOG00060004446 RatGTEx
  ENSRNOG00065010137 RatGTEx
Superfamily-SCOP SSF53067 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UDP-Glycosyltransferase/glycogen phosphorylase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC219300
UniProt A0A0G2K7T2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZWN3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GLL8_RAT UniProtKB/TrEMBL
  A6IJ67 ENTREZGENE, UniProtKB/TrEMBL
  A6IJ68 ENTREZGENE, UniProtKB/TrEMBL
  GLCNE_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-26 Gne  glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase  Gne  glucosamine  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Gne  glucosamine    glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase  Name updated 1299863 APPROVED
2005-07-08 Gne  glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase  Uae1  UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase   Symbol and Name updated 1299863 APPROVED
2002-06-10 Uae1  UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein 722 amino acids; 79 kDa 68786