Cxxc4 Rat Gene (CXXC finger 4) - Rat Genome Database

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Keyword

Gene:
Cxxc4 ( Rattus norvegicus )
CXXC finger 4
Description: negatively regulates Wnt signaling by competing with Axin for binding to the PDZ domain of Dvl1
Synonyms: inhibitor of the Dvl and Axin complex; Idax; Dvl-binding protein IDAX (inhibition of the Dvl and Axin complex);
ArrayIDs: A_43_P12776; GE13531; 5997364; 6623926; 5987438; 1368801_at; 6557867; 6226419; 5759419; 5863800; A_44_P433120; 5618843;  (details...)
Gene Type: protein-coding

Additional Data

Candidate gene for: Eau5 - Experimental allergic uveoretinitis QTL 5

Homologs
Homo sapiens: CXXC4     See the Human gene in context in:     UCSC     NCBI MapViewer

Mus musculus: Cxxc4     See the Mouse gene in context in:     UCSC     NCBI MapViewer

Comparative Map Data
Species Symbol Map Name Chr. Position
Rattus norvegicus Cxxc4 genome assembly 3.1 2 231692299 - 231709701
Rat Celera Assembly 2 214890566 - 214907959
RGSC genome assembly v3.4 2 231705560 - 231722975
Cytogenetic 2 q43
Mus musculus Cxxc4 Mouse genome assembly build 36.1 3 133902609 - 133925054
Cytogenetic 3 3 G3
Homo sapiens CXXC4 human genome assembly 4 105750948 - 105770071
Human genome assembly build 36.2 4 105612779 - 105631916
Cytogenetic 4 q22-q24

View comparative maps:      NCBI MapViewer

Genome
View:

Browsers:

Annotation
Molecular Function

Gene Ontology

zinc ion binding,  DNA binding,  PDZ domain binding ... (details...)
Biological Process

Note Reference

inhibits the Dvl and Axin complex 68802

Gene Ontology

biological_process,  negative regulation of Wnt receptor signaling pathway,  Wnt receptor signaling pathway (details...)
Cellular Component

Gene Ontology

cytoplasm,  cytoplasmic membrane-bounded vesicle,  cellular_component (details...)

External Links
Databases
DATABASE ID SOURCE
Ensembl Protein: ENSRNOP00000016549 IPI
IPI: IPI00189861 IPI
PROSITE: ZF_CXXC IPI
Entrez Gene: Cxxc4 ENTREZGENE
UNIPARC: UPI000002538A IPI
KEGG Report: rno:83824 ENTREZGENE
Ensembl Genes: ENSRNOG00000012400 IPI
UniProt: CXXC4_RAT IPI
TIGR: TC210132
HomoloGene Group ID: 11878 ENTREZGENE
Germonline: 69228
Pfam: zf-CXXC IPI
KEGG Pathway: 04310 ENTREZGENE
InterPro: Znf_CXXC. IPI
Sequences
Nucleotide: NM_053342 Get FASTA Search GEO Profiles
Nucleotide: CH473952 Get FASTA Search GEO Profiles
Nucleotide: AF272158 Get FASTA Search GEO Profiles
(View all 3 Nucleotide Accessions)
Protein: AAG42071 Get FASTA
Protein: NP_445794 Get FASTA
Protein: Q9EQC9 Get FASTA
Protein: EDL82242 Get FASTA
(View all 4 Protein Accessions)
Clusters
UniGene: 209562

References
Curated References
8 references in RGD related to Cxxc4

Other References
2 other references at PubMed related to Cxxc4

Database Information
RGD ID 69228
History

Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference

10-SEP-04: Cxxc4 CXXC finger 4 Idax inhibitor of the Dvl and Axin complex APPROVED Symbol and Name updated 1299863

10-JUN-02: Idax inhibitor of the Dvl and Axin complex APPROVED Name updated 70584