Matk (megakaryocyte-associated tyrosine kinase) - Rat Genome Database

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Gene: Matk (megakaryocyte-associated tyrosine kinase) Rattus norvegicus
Analyze
Symbol: Matk
Name: megakaryocyte-associated tyrosine kinase
RGD ID: 69058
Description: Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be located in cytoplasm and membrane. Predicted to be active in plasma membrane. Orthologous to human MATK (megakaryocyte-associated tyrosine kinase); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Batk; megakaryocyte-associated tyrosine kinase (non-receptor protein tyrosine kinase); megakaryocyte-associated tyrosine-protein kinase; MGC105436; non-receptor protein kinase protein; protein kinase BATK; tyrosine-protein kinase CTK
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,107,711 - 9,116,864 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl79,107,722 - 9,112,746 (-)EnsemblGRCr8
mRatBN7.278,456,990 - 8,465,947 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,456,998 - 8,462,022 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx711,341,194 - 11,346,217 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,216,677 - 13,221,700 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,084,145 - 11,089,168 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,325,246 - 11,334,311 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,325,254 - 11,330,278 (-)Ensemblrn6Rnor6.0
Rnor_5.0711,492,654 - 11,498,451 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.479,940,799 - 9,945,824 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera76,645,321 - 6,650,346 (-)NCBICelera
RGSC_v3.179,940,799 - 9,945,824 (-)NCBI
Cytogenetic Map7q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
COVID-19  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-aminopurine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP)
bisphenol F  (EXP,ISO)
cadmium dichloride  (ISO)
calcium silicate  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
D-glucose  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dichromium trioxide  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
ethylparaben  (ISO)
folic acid  (ISO)
fonofos  (ISO)
FR900359  (ISO)
furan  (EXP)
genistein  (ISO)
glucose  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
Moniliformin  (ISO)
okadaic acid  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
parathion  (ISO)
phenylmercury acetate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
terbufos  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA,ISO)
membrane  (IEA)
plasma membrane  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Identification and characterization of Batk, a predominantly brain-specific non-receptor protein tyrosine kinase related to Csk. Kuo SS, etal., J Neurosci Res 1994 Aug 15;38(6):705-15.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat. Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35
9. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:17999719   PMID:21393838   PMID:30053369  


Genomics

Comparative Map Data
Matk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,107,711 - 9,116,864 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl79,107,722 - 9,112,746 (-)EnsemblGRCr8
mRatBN7.278,456,990 - 8,465,947 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,456,998 - 8,462,022 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx711,341,194 - 11,346,217 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,216,677 - 13,221,700 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,084,145 - 11,089,168 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,325,246 - 11,334,311 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,325,254 - 11,330,278 (-)Ensemblrn6Rnor6.0
Rnor_5.0711,492,654 - 11,498,451 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.479,940,799 - 9,945,824 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera76,645,321 - 6,650,346 (-)NCBICelera
RGSC_v3.179,940,799 - 9,945,824 (-)NCBI
Cytogenetic Map7q11NCBI
MATK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38193,777,973 - 3,801,799 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl193,777,969 - 3,802,129 (-)Ensemblhg38GRCh38
GRCh37193,777,971 - 3,801,797 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36193,728,967 - 3,752,810 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34193,728,967 - 3,737,414NCBI
Celera193,715,610 - 3,739,451 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef193,542,732 - 3,566,615 (-)NCBIHuRef
CHM1_1193,777,602 - 3,801,471 (-)NCBICHM1_1
T2T-CHM13v2.0193,757,233 - 3,781,064 (-)NCBIT2T-CHM13v2.0
Matk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391081,088,769 - 81,098,819 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1081,088,769 - 81,099,199 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381081,252,935 - 81,262,985 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,252,935 - 81,263,365 (+)Ensemblmm10GRCm38
MGSCv371080,720,290 - 80,725,726 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361080,660,674 - 80,666,110 (+)NCBIMGSCv36mm8
Celera1082,277,893 - 82,283,329 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Matk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554955,663,768 - 5,669,654 (-)Ensembl
ChiLan1.0NW_0049554955,663,768 - 5,670,113 (-)NCBIChiLan1.0ChiLan1.0
MATK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2208,173,450 - 8,197,415 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1197,401,700 - 7,429,045 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0192,800,301 - 2,825,311 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1193,750,256 - 3,758,272 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl193,750,256 - 3,757,385 (-)EnsemblpanPan2panpan1.1
MATK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12055,697,377 - 55,704,212 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2055,698,350 - 55,704,022 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2055,422,757 - 55,429,545 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02056,357,401 - 56,364,179 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2056,357,860 - 56,365,740 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12055,413,344 - 55,420,706 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02055,895,262 - 55,902,025 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02056,094,009 - 56,100,857 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Matk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118215,689,105 - 215,696,796 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365882,137,663 - 2,144,512 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365882,137,987 - 2,144,274 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MATK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl274,911,143 - 74,918,966 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1274,911,119 - 74,921,636 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MATK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.163,533,363 - 3,542,034 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl63,533,236 - 3,542,011 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660814,707,784 - 4,716,456 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Matk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248286,415,120 - 6,419,822 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248286,414,859 - 6,420,924 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Matk
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11153,629,435 - 153,638,243 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Matk
21 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:67
Count of miRNA genes:61
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000027730
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat

Markers in Region
G67866  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.278,458,271 - 8,458,512 (+)MAPPERmRatBN7.2
Rnor_6.0711,326,528 - 11,326,768NCBIRnor6.0
Rnor_5.0711,493,936 - 11,494,176UniSTSRnor5.0
RGSC_v3.479,942,074 - 9,942,314UniSTSRGSC3.4
Celera76,646,596 - 6,646,836UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001437878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001437879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001437880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_021859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC094643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC087726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L34542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000027730   ⟹   ENSRNOP00000027730
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl79,107,722 - 9,112,746 (-)Ensembl
mRatBN7.2 Ensembl78,456,998 - 8,462,022 (-)Ensembl
Rnor_6.0 Ensembl711,325,254 - 11,330,278 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112957   ⟹   ENSRNOP00000096637
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl79,107,722 - 9,112,493 (-)Ensembl
mRatBN7.2 Ensembl78,456,998 - 8,461,774 (-)Ensembl
RefSeq Acc Id: NM_021859   ⟹   NP_068631
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,107,721 - 9,112,746 (-)NCBI
mRatBN7.278,456,997 - 8,462,022 (-)NCBI
Rnor_6.0711,325,253 - 11,330,278 (-)NCBI
Rnor_5.0711,492,654 - 11,498,451 (-)NCBI
RGSC_v3.479,940,799 - 9,945,824 (-)RGD
Celera76,645,321 - 6,650,346 (-)RGD
Sequence:
RefSeq Acc Id: XM_039079841   ⟹   XP_038935769
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,107,711 - 9,113,389 (-)NCBI
mRatBN7.278,456,990 - 8,462,665 (-)NCBI
RefSeq Acc Id: XM_039079842   ⟹   XP_038935770
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,107,711 - 9,116,864 (-)NCBI
mRatBN7.278,456,990 - 8,465,947 (-)NCBI
RefSeq Acc Id: XM_039079843   ⟹   XP_038935771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,107,711 - 9,112,658 (-)NCBI
mRatBN7.278,456,990 - 8,461,917 (-)NCBI
RefSeq Acc Id: XM_039079844   ⟹   XP_038935772
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,107,711 - 9,112,985 (-)NCBI
mRatBN7.278,456,990 - 8,462,257 (-)NCBI
RefSeq Acc Id: XM_039079845   ⟹   XP_038935773
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,107,711 - 9,113,389 (-)NCBI
mRatBN7.278,456,990 - 8,462,665 (-)NCBI
RefSeq Acc Id: XM_063264199   ⟹   XP_063120269
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,107,711 - 9,113,389 (-)NCBI
RefSeq Acc Id: XM_063264200   ⟹   XP_063120270
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,107,711 - 9,116,864 (-)NCBI
RefSeq Acc Id: XM_063264201   ⟹   XP_063120271
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,107,711 - 9,113,389 (-)NCBI
RefSeq Acc Id: NP_068631   ⟸   NM_021859
- UniProtKB: P41243 (UniProtKB/Swiss-Prot),   A6K8A4 (UniProtKB/TrEMBL),   A0A8I6GLP3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027730   ⟸   ENSRNOT00000027730
RefSeq Acc Id: XP_038935770   ⟸   XM_039079842
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GLP3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935773   ⟸   XM_039079845
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GLP3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935769   ⟸   XM_039079841
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GLP3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935772   ⟸   XM_039079844
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GLP3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935771   ⟸   XM_039079843
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GLP3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000096637   ⟸   ENSRNOT00000112957
RefSeq Acc Id: XP_063120270   ⟸   XM_063264200
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063120271   ⟸   XM_063264201
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063120269   ⟸   XM_063264199
- Peptide Label: isoform X3
Protein Domains
Protein kinase   SH2   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P41243-F1-model_v2 AlphaFold P41243 1-467 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69058 AgrOrtholog
BioCyc Gene G2FUF-35009 BioCyc
Ensembl Genes ENSRNOG00000020431 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027730 ENTREZGENE
  ENSRNOT00000027730.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7320205 IMAGE-MGC_LOAD
InterPro Csk-like_SH2 UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Non-receptor_tyrosine_kinases UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
  Tyr_kinase_AS UniProtKB/Swiss-Prot
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
KEGG Report rno:60450 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105436 IMAGE-MGC_LOAD
NCBI Gene 60450 ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE UniProtKB/Swiss-Prot
Pfam Pkinase_Tyr UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH3_1 UniProtKB/Swiss-Prot
PhenoGen Matk PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot
  TYRKINASE UniProtKB/Swiss-Prot
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020431 RatGTEx
SMART SH2 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
  TyrKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot
  SSF55550 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
TIGR TC235587
UniProt A0A8I6GLP3 ENTREZGENE, UniProtKB/TrEMBL
  A6K8A4 ENTREZGENE, UniProtKB/TrEMBL
  A6K8A6_RAT UniProtKB/TrEMBL
  A6K8A7_RAT UniProtKB/TrEMBL
  MATK_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Matk  megakaryocyte-associated tyrosine kinase      Name updated 70584 APPROVED
2002-02-20 Matk  Megakaryocyte-associated tyrosine kinase      Name updated to reflect Human and Mouse nomenclature 70282 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process may be involved in regulating brain development 68875