Fabp3 (fatty acid binding protein 3) - Rat Genome Database

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Gene: Fabp3 (fatty acid binding protein 3) Rattus norvegicus
Analyze
Symbol: Fabp3
Name: fatty acid binding protein 3
RGD ID: 69048
Description: Enables icosatetraenoic acid binding activity and long-chain fatty acid transmembrane transporter activity. Involved in several processes, including long-chain fatty acid transport; response to fatty acid; and response to insulin. Located in sarcoplasm. Human ortholog(s) of this gene implicated in hypertension and type 2 diabetes mellitus. Orthologous to human FABP3 (fatty acid binding protein 3); PARTICIPATES IN integrin mediated signaling pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; INTERACTS WITH (R)-adrenaline; (R)-carnitine; 11-deoxycorticosterone.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Fatty acid binding protein 3 heart; Fatty acid binding protein 3 muscle and heart; Fatty acid binding protein 3, heart; fatty acid binding protein 3, muscle and heart; fatty acid-binding protein 3; fatty acid-binding protein, heart; H-FABP; heart fatty acid binding protein; heart-type fatty acid-binding protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85147,936,027 - 147,942,870 (+)NCBIGRCr8
mRatBN7.25142,651,962 - 142,658,707 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5142,651,956 - 142,658,718 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5145,351,237 - 145,357,980 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05147,121,043 - 147,127,786 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05147,118,434 - 147,125,177 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05148,528,854 - 148,535,597 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5148,528,725 - 148,535,565 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05152,246,250 - 152,252,993 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45149,340,525 - 149,347,268 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15149,350,578 - 149,357,307 (+)NCBI
Celera5141,118,398 - 141,125,141 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (EXP)
(R)-carnitine  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
11-deoxycorticosterone  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (ISO)
2-Ethylhexanoic acid  (EXP)
2-palmitoylglycerol  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
7H-xanthine  (EXP)
9H-xanthine  (EXP)
aconitine  (EXP)
Allylamine  (EXP)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
belinostat  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bexarotene  (EXP)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP)
Brodifacoum  (EXP)
cadmium dichloride  (ISO)
cantharidin  (ISO)
carbofuran  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
corilagin  (EXP)
corticosterone  (EXP)
curcumin  (EXP)
cyclosporin A  (EXP,ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (ISO)
Diosbulbin B  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (EXP,ISO)
ethylparaben  (ISO)
fenofibrate  (EXP)
ferroheme b  (ISO)
fluoxetine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fructose  (EXP)
furan  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
graphite  (ISO)
haloperidol  (ISO)
heme b  (ISO)
ibuprofen  (ISO)
ifosfamide  (ISO)
iohexol  (ISO)
iopamidol  (ISO)
isoprenaline  (EXP,ISO)
ketoconazole  (EXP)
L-methionine  (ISO)
linoleic acid  (ISO)
maneb  (ISO)
metaproterenol  (EXP)
metformin  (EXP)
methamphetamine  (ISO)
methimazole  (EXP)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mitoxantrone  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP)
nickel sulfate  (ISO)
nitrofen  (EXP)
orciprenaline  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paraquat  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
plumbagin  (EXP)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (EXP)
resveratrol  (EXP)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP)
sodium nitrate  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP,ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
topiramate  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
triclosan  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Integrin inactivators: balancing cellular functions in vitro and in vivo. Bouvard D, etal., Nat Rev Mol Cell Biol. 2013 Jul;14(7):430-42. doi: 10.1038/nrm3599. Epub 2013 May 30.
2. Heart type fatty acid binding protein (H-FABP) is decreased in brains of patients with Down syndrome and Alzheimer's disease. Cheon MS, etal., J Neural Transm Suppl. 2003;(67):225-34.
3. Cloning and tissue distribution of rat heart fatty acid binding protein mRNA: identical forms in heart and skeletal muscle. Claffey KP, etal., Biochemistry 1987 Dec 1;26(24):7900-4.
4. Measurement of rat heart fatty acid binding protein by ELISA. Tissue distribution, developmental changes and subcellular distribution. Crisman TS, etal., J Mol Cell Cardiol. 1987 May;19(5):423-31.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Purification and characterization of fatty-acid-binding proteins from rat heart and liver. Glatz JF, etal., Biochim Biophys Acta. 1985 Oct 23;837(1):57-66.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Role of portal region lysine residues in electrostatic interactions between heart fatty acid binding protein and phospholipid membranes. Herr FM, etal., Biochemistry. 1996 Jan 30;35(4):1296-303.
9. Analysis of the tissue-specific expression, developmental regulation, and linkage relationships of a rodent gene encoding heart fatty acid binding protein. Heuckeroth RO, etal., J Biol Chem 1987 Jul 15;262(20):9709-17.
10. Mechanism of free fatty acid transfer from rat heart fatty acid-binding protein to phospholipid membranes. Evidence for a collisional process. Kim HK and Storch J, J Biol Chem. 1992 Oct 5;267(28):20051-6.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Characterization of a fatty acid-binding protein from rat heart. Offner GD, etal., J Biol Chem. 1986 Apr 25;261(12):5584-9.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. Fatty acid-dependent expression of the muscle FABP gene - comparative analysis of gene control in functionally related, but evolutionary distant animal systems. Qu H, etal., Mol Cell Biochem. 2007 May;299(1-2):45-53.
16. GOA pipeline RGD automated data pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Equilibrium constants for the binding of fatty acids with fatty acid-binding proteins from adipocyte, intestine, heart, and liver measured with the fluorescent probe ADIFAB. Richieri GV, etal., J Biol Chem. 1994 Sep 30;269(39):23918-30.
19. Molecular mechanisms of diabetes reversibility after bariatric surgery. Rosa G, etal., Int J Obes (Lond). 2007 Sep;31(9):1429-36. Epub 2007 May 22.
20. Rat heart fatty acid-binding protein is highly homologous to the murine adipocyte 422 protein and the P2 protein of peripheral nerve myelin. Sacchettini JC, etal., J Biol Chem. 1986 Jun 25;261(18):8218-23.
21. Fatty acid binding protein from rat heart. The fatty acid binding proteins from rat heart and liver are different proteins. Said B and Schulz H, J Biol Chem. 1984 Jan 25;259(2):1155-9.
22. Tissue-specific suppression of aortic fatty-acid-binding protein in streptozotocin-induced diabetic rats. Sakai K, etal., Eur J Biochem. 1995 Apr 1;229(1):201-6.
23. Partial gene deletion of heart-type fatty acid-binding protein limits the severity of dietary-induced insulin resistance. Shearer J, etal., Diabetes. 2005 Nov;54(11):3133-9.
24. Polymorphisms in fatty acid-binding protein-3 (FABP3) - putative association with type 2 diabetes mellitus. Shin HD, etal., Hum Mutat. 2003 Aug;22(2):180.
25. Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat. Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35
26. Association between fatty acid binding protein 3 gene variants and essential hypertension in humans. Ueno T, etal., Am J Hypertens. 2008 Jun;21(6):691-5. Epub 2008 Apr 10.
27. Immunohistochemical distribution of heart-type fatty acid-binding protein immunoreactivity in normal human tissues and in acute myocardial infarct. Watanabe K, etal., J Pathol. 1993 May;170(1):59-65.
28. Immunohistochemical studies on the localisation and ontogeny of heart fatty acid binding protein in the rat. Watanabe M, etal., J Anat. 1991 Feb;174:81-95.
29. Binding of cytochrome P450 monooxygenase and lipoxygenase pathway products by heart fatty acid-binding protein. Widstrom RL, etal., Biochemistry. 2001 Jan 30;40(4):1070-6.
30. Serum adiponectin as a biomarker for in vivo PPARgamma activation and PPARgamma agonist-induced efficacy on insulin sensitization/lipid lowering in rats. Yang B, etal., BMC Pharmacol. 2004 Oct 18;4:23.
31. Structure and chromosomal location of the rat gene encoding the heart fatty acid-binding protein. Zhang J, etal., Eur J Biochem 1999 Dec;266(2):347-51.
Additional References at PubMed
PMID:2005132   PMID:2775193   PMID:2806260   PMID:3162235   PMID:3415652   PMID:3421901   PMID:8117746   PMID:10224224   PMID:15164767   PMID:15835924   PMID:16502470   PMID:17987659  
PMID:19056867   PMID:20375122   PMID:21099311   PMID:21155221   PMID:23141496   PMID:23376485   PMID:23533145   PMID:26316108   PMID:26590355   PMID:28763438   PMID:34142475   PMID:34866110  
PMID:35509154  


Genomics

Comparative Map Data
Fabp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85147,936,027 - 147,942,870 (+)NCBIGRCr8
mRatBN7.25142,651,962 - 142,658,707 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5142,651,956 - 142,658,718 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5145,351,237 - 145,357,980 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05147,121,043 - 147,127,786 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05147,118,434 - 147,125,177 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05148,528,854 - 148,535,597 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5148,528,725 - 148,535,565 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05152,246,250 - 152,252,993 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45149,340,525 - 149,347,268 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15149,350,578 - 149,357,307 (+)NCBI
Celera5141,118,398 - 141,125,141 (+)NCBICelera
Cytogenetic Map5q36NCBI
FABP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38131,359,588 - 31,373,076 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl131,365,253 - 31,376,850 (-)EnsemblGRCh38hg38GRCh38
GRCh37131,838,100 - 31,845,923 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36131,610,687 - 31,618,510 (-)NCBINCBI36Build 36hg18NCBI36
Build 34131,507,593 - 31,514,985NCBI
Celera130,094,670 - 30,102,486 (-)NCBICelera
Cytogenetic Map1p35.2NCBI
HuRef129,944,876 - 29,952,692 (-)NCBIHuRef
CHM1_1131,954,007 - 31,961,831 (-)NCBICHM1_1
T2T-CHM13v2.0131,211,868 - 31,225,340 (-)NCBIT2T-CHM13v2.0
Fabp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394130,202,531 - 130,209,256 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4130,202,388 - 130,209,256 (+)EnsemblGRCm39 Ensembl
GRCm384130,308,738 - 130,315,463 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4130,308,595 - 130,315,463 (+)EnsemblGRCm38mm10GRCm38
MGSCv374129,986,022 - 129,992,707 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364129,811,082 - 129,817,767 (+)NCBIMGSCv36mm8
Celera4128,641,729 - 128,648,414 (+)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map463.43NCBI
Fabp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554529,846,689 - 9,861,971 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554529,851,182 - 9,858,735 (-)NCBIChiLan1.0ChiLan1.0
FABP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21195,456,558 - 195,473,533 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11194,579,251 - 194,592,583 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0130,640,595 - 30,653,450 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1131,660,924 - 31,673,689 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl131,665,270 - 31,673,689 (-)Ensemblpanpan1.1panPan2
FABP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1269,651,140 - 69,659,082 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl269,650,322 - 69,658,443 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha266,229,601 - 66,237,545 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0270,215,389 - 70,223,333 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl270,214,573 - 70,226,198 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1267,051,318 - 67,059,262 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0268,048,008 - 68,055,952 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0269,047,575 - 69,055,518 (+)NCBIUU_Cfam_GSD_1.0
Fabp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505848,751,795 - 48,760,226 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647414,574,891 - 14,585,706 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647414,576,582 - 14,584,362 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FABP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl687,942,790 - 87,951,610 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1687,943,003 - 87,950,708 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2681,714,138 - 81,715,645 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FABP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120101,464,899 - 101,472,223 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20101,464,960 - 101,474,350 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603315,202,100 - 15,209,969 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fabp3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476414,698,062 - 14,705,972 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476414,698,062 - 14,705,379 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fabp3
48 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:143
Count of miRNA genes:98
Interacting mature miRNAs:106
Transcripts:ENSRNOT00000017325
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5129132428143070159Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5120740824143608494Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat

Markers in Region
RH129910  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25142,651,053 - 142,651,259 (+)MAPPERmRatBN7.2
Rnor_6.05148,527,946 - 148,528,151NCBIRnor6.0
Rnor_5.05152,245,342 - 152,245,547UniSTSRnor5.0
RGSC_v3.45149,339,617 - 149,339,822UniSTSRGSC3.4
Celera5141,117,490 - 141,117,695UniSTS
Cytogenetic Map5q36UniSTS
RH134427  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25142,658,732 - 142,658,918 (+)MAPPERmRatBN7.2
Rnor_6.05148,535,625 - 148,535,810NCBIRnor6.0
Rnor_5.05152,253,021 - 152,253,206UniSTSRnor5.0
RGSC_v3.45149,347,296 - 149,347,481UniSTSRGSC3.4
Celera5141,125,169 - 141,125,354UniSTS
RH 3.4 Map5990.09UniSTS
Cytogenetic Map5q36UniSTS
RH94406  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25142,658,522 - 142,658,702 (+)MAPPERmRatBN7.2
mRatBN7.2515,110,318 - 15,110,494 (+)MAPPERmRatBN7.2
Rnor_6.0514,994,377 - 14,994,552NCBIRnor6.0
Rnor_6.05148,535,415 - 148,535,594NCBIRnor6.0
Rnor_5.0519,778,456 - 19,778,631UniSTSRnor5.0
Rnor_5.05152,252,811 - 152,252,990UniSTSRnor5.0
RGSC_v3.45149,347,086 - 149,347,265UniSTSRGSC3.4
RGSC_v3.4515,336,448 - 15,336,623UniSTSRGSC3.4
Celera514,492,133 - 14,492,308UniSTS
Celera5141,124,959 - 141,125,138UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000017325   ⟹   ENSRNOP00000017325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5142,651,956 - 142,658,718 (+)Ensembl
Rnor_6.0 Ensembl5148,528,725 - 148,535,565 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109377   ⟹   ENSRNOP00000084646
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5142,651,956 - 142,657,944 (+)Ensembl
RefSeq Acc Id: NM_024162   ⟹   NP_077076
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85147,936,125 - 147,942,868 (+)NCBI
mRatBN7.25142,651,962 - 142,658,705 (+)NCBI
Rnor_6.05148,528,854 - 148,535,597 (+)NCBI
Rnor_5.05152,246,250 - 152,252,993 (+)NCBI
RGSC_v3.45149,340,525 - 149,347,268 (+)RGD
Celera5141,118,398 - 141,125,141 (+)RGD
Sequence:
RefSeq Acc Id: XM_063288462   ⟹   XP_063144532
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85147,936,027 - 147,942,870 (+)NCBI
RefSeq Acc Id: NP_077076   ⟸   NM_024162
- UniProtKB: Q9QY04 (UniProtKB/Swiss-Prot),   P07483 (UniProtKB/Swiss-Prot),   A6ISN9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017325   ⟸   ENSRNOT00000017325
Ensembl Acc Id: ENSRNOP00000084646   ⟸   ENSRNOT00000109377
RefSeq Acc Id: XP_063144532   ⟸   XM_063288462
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A2E9 (UniProtKB/TrEMBL)
Protein Domains
Cytosolic fatty-acid binding proteins

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07483-F1-model_v2 AlphaFold P07483 1-133 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694082
Promoter ID:EPDNEW_R4607
Type:single initiation site
Name:Fabp3_1
Description:fatty acid binding protein 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05148,528,850 - 148,528,910EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69048 AgrOrtholog
BioCyc Gene G2FUF-39751 BioCyc
BioCyc Pathway PWY-6318 [L-phenylalanine degradation IV (mammalian, via side chain)] BioCyc
BioCyc Pathway Image PWY-6318 BioCyc
Ensembl Genes ENSRNOG00000012879 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055002125 UniProtKB/Swiss-Prot
  ENSRNOG00055024023 UniProtKB/Swiss-Prot
  ENSRNOG00060026907 UniProtKB/Swiss-Prot
  ENSRNOG00065026170 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000017325.6 UniProtKB/Swiss-Prot
  ENSRNOT00000109377.1 UniProtKB/TrEMBL
  ENSRNOT00055003410 UniProtKB/Swiss-Prot
  ENSRNOT00055041264 UniProtKB/Swiss-Prot
  ENSRNOT00060046628 UniProtKB/Swiss-Prot
  ENSRNOT00065045146 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.128.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Calycin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fatty_acid-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ILBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipocln_cytosolic_FA-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:79131 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 79131 ENTREZGENE
PANTHER FATTY ACID-BINDING PROTEIN, HEART UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11955 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lipocalin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fabp3 PhenoGen
PRINTS FATTYACIDBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FABP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012879 RatGTEx
  ENSRNOG00055002125 RatGTEx
  ENSRNOG00055024023 RatGTEx
  ENSRNOG00060026907 RatGTEx
  ENSRNOG00065026170 RatGTEx
Superfamily-SCOP SSF50814 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A2E9 ENTREZGENE, UniProtKB/TrEMBL
  A6ISN9 ENTREZGENE, UniProtKB/TrEMBL
  FABPH_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9QY04 ENTREZGENE
UniProt Secondary Q9QY04 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-27 Fabp3  fatty acid binding protein 3  Fabp3  fatty acid binding protein 3, muscle and heart  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Fabp3  fatty acid binding protein 3, muscle and heart  Fabp3  fatty acid binding protein 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Fabp3  fatty acid binding protein 3      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference