Wfs1 (wolframin ER transmembrane glycoprotein) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Wfs1 (wolframin ER transmembrane glycoprotein) Rattus norvegicus
Analyze
Symbol: Wfs1
Name: wolframin ER transmembrane glycoprotein
RGD ID: 68954
Description: Enables several functions, including calmodulin binding activity; proteasome binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of ATF6-mediated unfolded protein response; olfactory behavior; and protein stabilization. Is active in synaptic vesicle membrane. Used to study cataract; diabetes mellitus; and glucose intolerance. Biomarker of post-traumatic stress disorder. Human ortholog(s) of this gene implicated in several diseases, including Wolfram syndrome (multiple); auditory system disease (multiple); cataract 41; diabetes mellitus (multiple); and optic atrophy (multiple). Orthologous to human WFS1 (wolframin ER transmembrane glycoprotein); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil; aconitine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Wolfram syndrome 1; Wolfram syndrome 1 (wolframin); Wolfram syndrome 1 homolog; Wolfram syndrome 1 homolog (human); wolframin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Wfs1em1Ptsn ; Wfs1em2Ptsn ; Wfs1em3Ptsn
Genetic Models: SD-Wfs1em1Ptsn ; SD-Wfs1em2Ptsn ; SD-Wfs1em3Ptsn
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81478,035,205 - 78,059,718 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1478,034,864 - 78,060,459 (+)EnsemblGRCr8
mRatBN7.21473,810,478 - 73,834,993 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1473,810,404 - 73,835,602 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1478,251,934 - 78,276,445 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01479,492,790 - 79,517,297 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01475,937,753 - 75,962,260 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01478,640,707 - 78,665,224 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1478,640,620 - 78,665,966 (+)Ensemblrn6Rnor6.0
Rnor_5.01478,606,172 - 78,630,689 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41479,379,680 - 79,404,003 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1472,756,725 - 72,781,236 (+)NCBICelera
RGSC_v3.11479,389,637 - 79,406,394 (+)NCBI
Cytogenetic Map14q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
aconitine  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fluoxetine  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
isoniazide  (ISO)
ivermectin  (ISO)
kainic acid  (ISO)
ketamine  (EXP)
lead(0)  (ISO)
maneb  (ISO)
methidathion  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
nitrofen  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
propanal  (ISO)
resveratrol  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
tolcapone  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Missense variations of the gene responsible for Wolfram syndrome (WFS1/wolframin) in Japanese: possible contribution of the Arg456His mutation to type 1 diabetes as a nonautoimmune genetic basis. Awata T, etal., Biochem Biophys Res Commun. 2000 Feb 16;268(2):612-6.
2. Mutations in the Wolfram syndrome 1 gene (WFS1) are a common cause of low frequency sensorineural hearing loss. Bespalova IN, etal., Hum Mol Genet. 2001 Oct 15;10(22):2501-8.
3. A WFS1 haplotype consisting of the minor alleles of rs752854, rs10010131, and rs734312 shows a protective role against type 2 diabetes in Russian patients. Chistiakov DA, etal., Rev Diabet Stud. 2010 Winter;7(4):285-92. doi: 10.1900/RDS.2010.7.285. Epub 2011 Feb 10.
4. The wolframin His611Arg polymorphism influences medication overuse headache. Di Lorenzo C, etal., Neurosci Lett. 2007 Sep 13;424(3):179-84. Epub 2007 Aug 6.
5. WFS1 mutations in Spanish patients with diabetes mellitus and deafness. Domenech E, etal., Eur J Hum Genet. 2002 Jul;10(7):421-6.
6. Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program. Florez JC, etal., Diabetologia. 2008 Mar;51(3):451-7. Epub 2007 Dec 4.
7. Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells. Fonseca SG, etal., J Clin Invest. 2010 Mar;120(3):744-55. doi: 10.1172/JCI39678. Epub 2010 Feb 15.
8. Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations. Franks PW, etal., Diabetologia. 2008 Mar;51(3):458-63. Epub 2007 Nov 27.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome). Inoue H, etal., Nat Genet. 1998 Oct;20(2):143-8.
12. Disruption of the WFS1 gene in mice causes progressive beta-cell loss and impaired stimulus-secretion coupling in insulin secretion. Ishihara H, etal., Hum Mol Genet. 2004 Jun 1;13(11):1159-70. Epub 2004 Mar 31.
13. WFS1 gene as a putative biomarker for development of post-traumatic syndrome in an animal model. Kesner Y, etal., Mol Psychiatry. 2009 Jan;14(1):86-94. Epub 2007 Oct 30.
14. Cat odour exposure increases the expression of wolframin gene in the amygdaloid area of rat. Koks S, etal., Neurosci Lett. 2002 Apr 5;322(2):116-20.
15. WFS1 variants in Finnish patients with diabetes mellitus, sensorineural hearing impairment or optic atrophy, and in suicide victims. Kytovuori L, etal., J Hum Genet. 2013 Aug;58(8):495-500. doi: 10.1038/jhg.2013.29. Epub 2013 Apr 18.
16. Evidence for linkage on chromosome 4p16.1 in Type 1 diabetes Danish families and complete mutation scanning of the WFS1 (Wolframin) gene. Larsen ZM, etal., Diabet Med. 2004 Mar;21(3):218-22.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Association studies of genetic variation in the WFS1 gene and type 2 diabetes in U.K. populations. Minton JA, etal., Diabetes. 2002 Apr;51(4):1287-90.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
21. CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes. Peng D, etal., Sci Rep. 2017 Aug 18;7(1):8812. doi: 10.1038/s41598-017-09010-w.
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. Wfs1- deficient rats develop primary symptoms of Wolfram syndrome: insulin-dependent diabetes, optic nerve atrophy and medullary degeneration. Plaas M, etal., Sci Rep. 2017 Aug 31;7(1):10220. doi: 10.1038/s41598-017-09392-x.
24. Identification of p.A684V missense mutation in the WFS1 gene as a frequent cause of autosomal dominant optic atrophy and hearing impairment. Rendtorff ND, etal., Am J Med Genet A. 2011 Jun;155A(6):1298-313. doi: 10.1002/ajmg.a.33970. Epub 2011 Apr 28.
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Comprehensive gene review and curation RGD comprehensive gene curation
28. Molecular anatomy of a trafficking organelle. Takamori S, etal., Cell. 2006 Nov 17;127(4):831-46.
29. WFS1 (Wolfram syndrome 1) gene product: predominant subcellular localization to endoplasmic reticulum in cultured cells and neuronal expression in rat brain. Takeda K, etal., Hum Mol Genet 2001 Mar 1;10(5):477-84.
30. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
31. Preventive treatment with liraglutide protects against development of glucose intolerance in a rat model of Wolfram syndrome. Toots M, etal., Sci Rep. 2018 Jul 5;8(1):10183. doi: 10.1038/s41598-018-28314-z.
32. Expression and localization of Wolfram syndrome 1 gene in the developing rat pancreas. Xu R, etal., World J Gastroenterol. 2009 Nov 21;15(43):5425-31.
33. Identification and characterization of wolframin, the product of the wolfram syndrome gene (WFS1), as a novel calmodulin-binding protein. Yurimoto S, etal., Biochemistry. 2009 May 12;48(18):3946-55. doi: 10.1021/bi900260y.
34. The microtubule interacting drug candidate NAP protects against kainic acid toxicity in a rat model of epilepsy. Zemlyak I, etal., J Neurochem. 2009 Dec;111(5):1252-63. doi: 10.1111/j.1471-4159.2009.06415.x. Epub 2009 Oct 3.
Additional References at PubMed
PMID:9817917   PMID:14527944   PMID:15994758   PMID:16087305   PMID:16571599   PMID:16989814   PMID:17110338   PMID:17492394   PMID:17947299   PMID:19293327   PMID:19911006   PMID:32632005  
PMID:34495404   PMID:34828323   PMID:36725880  


Genomics

Comparative Map Data
Wfs1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81478,035,205 - 78,059,718 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1478,034,864 - 78,060,459 (+)EnsemblGRCr8
mRatBN7.21473,810,478 - 73,834,993 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1473,810,404 - 73,835,602 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1478,251,934 - 78,276,445 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01479,492,790 - 79,517,297 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01475,937,753 - 75,962,260 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01478,640,707 - 78,665,224 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1478,640,620 - 78,665,966 (+)Ensemblrn6Rnor6.0
Rnor_5.01478,606,172 - 78,630,689 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41479,379,680 - 79,404,003 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1472,756,725 - 72,781,236 (+)NCBICelera
RGSC_v3.11479,389,637 - 79,406,394 (+)NCBI
Cytogenetic Map14q21NCBI
WFS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3846,269,850 - 6,303,265 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl46,269,839 - 6,303,265 (+)Ensemblhg38GRCh38
GRCh3746,271,577 - 6,304,992 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3646,322,478 - 6,355,893 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3446,389,648 - 6,423,064NCBI
Celera46,172,234 - 6,205,670 (+)NCBICelera
Cytogenetic Map4p16.1NCBI
HuRef46,205,316 - 6,238,436 (+)NCBIHuRef
CHM1_146,269,525 - 6,302,942 (+)NCBICHM1_1
T2T-CHM13v2.046,243,866 - 6,277,297 (+)NCBIT2T-CHM13v2.0
Wfs1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39537,123,448 - 37,146,326 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl537,123,448 - 37,146,549 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38536,966,104 - 36,988,982 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl536,966,104 - 36,989,205 (-)Ensemblmm10GRCm38
MGSCv37537,357,343 - 37,380,221 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36537,254,356 - 37,277,158 (-)NCBIMGSCv36mm8
Celera534,417,849 - 34,440,871 (-)NCBICelera
Cytogenetic Map5B3NCBI
cM Map519.46NCBI
Wfs1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555143,902,454 - 3,924,610 (-)Ensembl
ChiLan1.0NW_0049555143,902,508 - 3,924,281 (-)NCBIChiLan1.0ChiLan1.0
WFS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v236,541,382 - 6,574,914 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan146,470,175 - 6,503,684 (+)NCBINHGRI_mPanPan1
PanPan1.146,345,960 - 6,379,094 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl46,345,864 - 6,379,287 (+)EnsemblpanPan2panpan1.1
WFS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11338,451,722 - 38,466,481 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1338,451,710 - 38,475,827 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1338,428,703 - 38,449,916 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01338,942,257 - 38,963,449 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1338,942,257 - 38,968,827 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11338,633,035 - 38,659,609 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01338,742,939 - 38,764,184 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01339,217,791 - 39,239,032 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Wfs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528564,638,197 - 64,663,281 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647718,339,827 - 18,364,998 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647718,339,915 - 18,364,973 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WFS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl84,362,680 - 4,385,273 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.184,362,678 - 4,405,185 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.282,954,118 - 2,962,286 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WFS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12742,404,028 - 42,437,988 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2742,404,084 - 42,438,005 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604789,197,417 - 89,231,280 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wfs1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475522,824,143 - 22,841,850 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475522,818,653 - 22,841,717 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Wfs1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11168,159,630 - 68,184,200 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Wfs1
129 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:85
Count of miRNA genes:81
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000034730
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143802371083023710Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1459848686104848686Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1477914838104348525Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143900944484009444Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)147297021087582095Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143067446985041098Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1433424686102238540Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1474255551109089856Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147764007196755654Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143802371083023710Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1462398852107398852Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1477640071100078267Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1460854936105854936Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1474255551109089856Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147764007196755654Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1459848686104848686Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143802371083023710Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144261625899224555Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)146592028399224555Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143941117087582095Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143802371083023710Rat


Genetic Models
This gene Wfs1 is modified in the following models/strains:
SD-Wfs1em1Ptsn     SD-Wfs1em2Ptsn     SD-Wfs1em3Ptsn    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 67 161 91 90 59 92 59 6 355 191 9 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000034730   ⟹   ENSRNOP00000032218
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1478,034,864 - 78,060,459 (+)Ensembl
mRatBN7.2 Ensembl1473,810,404 - 73,835,602 (+)Ensembl
Rnor_6.0 Ensembl1478,640,620 - 78,665,966 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109032   ⟹   ENSRNOP00000087329
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1473,810,413 - 73,835,364 (+)Ensembl
RefSeq Acc Id: NM_031823   ⟹   NP_114011
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81478,035,205 - 78,059,718 (+)NCBI
mRatBN7.21473,810,478 - 73,834,993 (+)NCBI
Rnor_6.01478,640,707 - 78,665,224 (+)NCBI
Rnor_5.01478,606,172 - 78,630,689 (+)NCBI
RGSC_v3.41479,379,680 - 79,404,003 (+)RGD
Celera1472,756,725 - 72,781,236 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_114011 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF61423 (Get FASTA)   NCBI Sequence Viewer  
  EDM00031 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000032218
  ENSRNOP00000032218.4
RefSeq Acc Id: NP_114011   ⟸   NM_031823
- UniProtKB: Q9JLT5 (UniProtKB/TrEMBL),   A6IJW7 (UniProtKB/TrEMBL),   E9PT53 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000032218   ⟸   ENSRNOT00000034730
Ensembl Acc Id: ENSRNOP00000087329   ⟸   ENSRNOT00000109032
Protein Domains
Wolframin cysteine-rich   Wolframin EF-hand   Wolframin OB-fold

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PT53-F1-model_v2 AlphaFold E9PT53 1-890 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699375
Promoter ID:EPDNEW_R9900
Type:initiation region
Name:Wfs1_1
Description:wolframin ER transmembrane glycoprotein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01478,640,642 - 78,640,702EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68954 AgrOrtholog
BioCyc Gene G2FUF-15350 BioCyc
Ensembl Genes ENSRNOG00000005108 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000034730 ENTREZGENE
  ENSRNOT00000034730.6 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/TrEMBL
InterPro TPR-like_helical_dom_sf UniProtKB/TrEMBL
  Wolframin UniProtKB/TrEMBL
  Wolframin_Cys-rich UniProtKB/TrEMBL
  Wolframin_EF-hand UniProtKB/TrEMBL
  Wolframin_fam UniProtKB/TrEMBL
  Wolframin_OB_fold UniProtKB/TrEMBL
  Wolframin_Sel1-like_rpt UniProtKB/TrEMBL
KEGG Report rno:83725 UniProtKB/TrEMBL
NCBI Gene 83725 ENTREZGENE
PANTHER PTHR13098 UniProtKB/TrEMBL
  WOLFRAMIN UniProtKB/TrEMBL
Pfam WC-rich UniProtKB/TrEMBL
  WCOB UniProtKB/TrEMBL
  WEF-hand UniProtKB/TrEMBL
  WSLR UniProtKB/TrEMBL
PhenoGen Wfs1 PhenoGen
PRINTS WOLFFAMILY UniProtKB/TrEMBL
  WOLFRAMIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005108 RatGTEx
TIGR TC230134
UniProt A6IJW7 ENTREZGENE, UniProtKB/TrEMBL
  E9PT53 ENTREZGENE, UniProtKB/TrEMBL
  Q9JLT5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Wfs1  wolframin ER transmembrane glycoprotein  Wfs1  Wolfram syndrome 1 (wolframin)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-02-04 Wfs1  Wolfram syndrome 1 (wolframin)  Wfs1  Wolfram syndrome 1 homolog (human)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Wfs1  Wolfram syndrome 1 homolog (human)    Wolfram syndrome 1  Name updated 1299863 APPROVED
2002-06-10 Wfs1  Wolfram syndrome 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease associated with Wolfram (DIDMOAD) syndrome 62397
gene_expression expressed in neurons in the hippocampus CA1, amygdaloid areas, olfactory tubercle and superficial layer of the allocortex 62397
gene_process may function in emotional, behavioral and visceral control 62397
gene_process may be involved in membrane trafficking, protein processing and/or regulation of ER calcium homeostasis 62397