Kcnk12 (potassium two pore domain channel subfamily K member 12) - Rat Genome Database

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Gene: Kcnk12 (potassium two pore domain channel subfamily K member 12) Rattus norvegicus
Analyze
Symbol: Kcnk12
Name: potassium two pore domain channel subfamily K member 12
RGD ID: 68940
Description: Predicted to enable identical protein binding activity; potassium channel activity; and protein heterodimerization activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Orthologous to human KCNK12 (potassium two pore domain channel subfamily K member 12); INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: potassium channel subfamily K member 12; potassium channel, subfamily K, member 12; potassium channel, two pore domain subfamily K, member 12; tandem pore domain halothane-inhibited potassium channel 2; tandem pore domain potassium channel THIK-2; THIK-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
NCBI Annotation Information: Note: There is an assembly problem in the Rnor_6.0 reference genome assembly, and therefore, annotation of this gene is split across NW_007905828.1 and NW_007905829.1 in NCBI's Rattus norvegicus Annotation Release 105. [17 Jun 2015]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8612,492,609 - 12,544,250 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl612,494,850 - 12,544,221 (+)EnsemblGRCr8
mRatBN7.266,740,147 - 6,790,664 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl66,739,991 - 6,790,661 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx67,023,487 - 7,072,825 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.067,332,899 - 7,382,229 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.066,860,027 - 6,909,361 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0611,373,917 - 11,494,459 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl611,373,917 - 11,494,459 (-)Ensemblrn6Rnor6.0
Rnor_5.0621,346,993 - 21,464,940 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4611,281,814 - 11,353,795 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera66,499,476 - 6,548,106 (+)NCBICelera
RGSC_v3.1611,281,813 - 11,353,795 (-)NCBI
Cytogenetic Map6q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
3. Thik-1 and thik-2, a novel subfamily of tandem pore domain k+ channels. Rajan S, etal., J Biol Chem 2001 Mar 9;276(10):7302-11.
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:18209473   PMID:24297522  


Genomics

Comparative Map Data
Kcnk12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8612,492,609 - 12,544,250 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl612,494,850 - 12,544,221 (+)EnsemblGRCr8
mRatBN7.266,740,147 - 6,790,664 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl66,739,991 - 6,790,661 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx67,023,487 - 7,072,825 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.067,332,899 - 7,382,229 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.066,860,027 - 6,909,361 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0611,373,917 - 11,494,459 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl611,373,917 - 11,494,459 (-)Ensemblrn6Rnor6.0
Rnor_5.0621,346,993 - 21,464,940 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4611,281,814 - 11,353,795 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera66,499,476 - 6,548,106 (+)NCBICelera
RGSC_v3.1611,281,813 - 11,353,795 (-)NCBI
Cytogenetic Map6q12NCBI
KCNK12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38247,509,290 - 47,570,985 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl247,509,290 - 47,570,985 (-)Ensemblhg38GRCh38
GRCh37247,736,429 - 47,798,124 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36247,601,418 - 47,650,974 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34247,659,567 - 47,709,121NCBI
Celera247,586,584 - 47,636,146 (-)NCBICelera
Cytogenetic Map2p16.3NCBI
HuRef247,483,265 - 47,533,353 (-)NCBIHuRef
CHM1_1247,678,567 - 47,728,124 (-)NCBICHM1_1
T2T-CHM13v2.0247,514,342 - 47,576,038 (-)NCBIT2T-CHM13v2.0
Kcnk12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391788,049,100 - 88,106,329 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1788,053,229 - 88,105,422 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381787,745,821 - 87,797,994 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1787,745,801 - 87,797,994 (-)Ensemblmm10GRCm38
MGSCv371788,145,161 - 88,197,334 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361787,654,147 - 87,706,320 (-)NCBIMGSCv36mm8
Celera1792,153,722 - 92,202,711 (-)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1757.87NCBI
Kcnk12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495544114,270,030 - 14,281,639 (-)NCBIChiLan1.0ChiLan1.0
KCNK12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21278,815,056 - 78,870,269 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A78,819,016 - 78,870,028 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A47,635,456 - 47,690,792 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A48,532,407 - 48,611,846 (-)NCBIPanPan1.1PanPan1.1panPan2
KCNK12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11049,618,476 - 49,672,539 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1049,606,354 - 49,671,387 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1049,473,652 - 49,526,397 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01050,491,995 - 50,544,739 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1050,479,802 - 50,544,739 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11050,199,254 - 50,251,980 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01050,485,932 - 50,538,669 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01050,673,799 - 50,726,546 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Kcnk12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629233,443,930 - 33,489,142 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365084,874,001 - 4,919,410 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365084,872,922 - 4,918,728 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNK12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl392,990,021 - 93,041,533 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1392,990,129 - 93,044,989 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2398,959,636 - 99,014,555 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCNK12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11459,641,852 - 59,692,705 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1459,641,874 - 59,692,568 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604552,153,382 - 52,206,778 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnk12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473828,889,241 - 28,935,936 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473828,892,710 - 28,935,876 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Kcnk12
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v175,186,691 - 5,234,340 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Kcnk12
658 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:62
Count of miRNA genes:58
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000021570
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6197587946975879Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6197587946975879Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6144788383Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6197587946975879Rat
2293706Bmd20Bone mineral density QTL 204.30.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6125740059Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6197587946975879Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6323998948239989Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6323998948239989Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6140163351Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6120510098Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6323998948239989Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6323998948239989Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6197587946975879Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 5 32 156 76 75 46 82 46 6 262 140 11 127 57 91 29 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000021570   ⟹   ENSRNOP00000021570
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl612,494,850 - 12,544,221 (+)Ensembl
mRatBN7.2 Ensembl66,741,271 - 6,790,645 (+)Ensembl
Rnor_6.0 Ensembl611,373,917 - 11,494,459 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113759   ⟹   ENSRNOP00000084526
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl66,739,991 - 6,790,661 (+)Ensembl
RefSeq Acc Id: NM_022292   ⟹   NP_071628
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8612,494,850 - 12,544,221 (+)NCBI
mRatBN7.266,741,271 - 6,790,645 (+)NCBI
Rnor_6.0611,373,917 - 11,494,459 (-)NCBI
Rnor_5.0621,346,993 - 21,464,940 (-)NCBI
RGSC_v3.4611,281,814 - 11,353,795 (-)RGD
Celera66,499,476 - 6,548,106 (+)RGD
Sequence:
RefSeq Acc Id: XM_039112871   ⟹   XP_038968799
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8612,492,609 - 12,544,250 (+)NCBI
mRatBN7.266,740,160 - 6,790,664 (+)NCBI
RefSeq Acc Id: XM_039112873   ⟹   XP_038968801
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8612,542,311 - 12,544,250 (+)NCBI
mRatBN7.266,788,139 - 6,790,664 (+)NCBI
Protein Sequences
Protein RefSeqs NP_071628 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968799 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968801 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG32311 (Get FASTA)   NCBI Sequence Viewer  
  EDM02633 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000021570
  ENSRNOP00000021570.1
GenBank Protein Q9ERS1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_071628   ⟸   NM_022292
- UniProtKB: Q9ERS1 (UniProtKB/Swiss-Prot),   A6H9C8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021570   ⟸   ENSRNOT00000021570
RefSeq Acc Id: XP_038968799   ⟸   XM_039112871
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZZT0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968801   ⟸   XM_039112873
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000084526   ⟸   ENSRNOT00000113759
Protein Domains
Potassium channel

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ERS1-F1-model_v2 AlphaFold Q9ERS1 1-430 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694397
Promoter ID:EPDNEW_R4922
Type:initiation region
Name:Kcnk12_1
Description:potassium two pore domain channel subfamily K member 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0611,494,534 - 11,494,594EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68940 AgrOrtholog
BioCyc Gene G2FUF-38748 BioCyc
Ensembl Genes ENSRNOG00000016110 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000021570 ENTREZGENE
  ENSRNOT00000021570.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
InterPro 2pore_dom_K_chnl UniProtKB/Swiss-Prot
  2pore_dom_K_chnl_THIK UniProtKB/Swiss-Prot
  K_chnl_dom UniProtKB/Swiss-Prot
KEGG Report rno:64119 UniProtKB/Swiss-Prot
NCBI Gene 64119 ENTREZGENE
PANTHER POTASSIUM CHANNEL SUBFAMILY K MEMBER 12 UniProtKB/Swiss-Prot
  PTHR11003 UniProtKB/Swiss-Prot
Pfam Ion_trans_2 UniProtKB/Swiss-Prot
PhenoGen Kcnk12 PhenoGen
PRINTS 2POREKCHANEL UniProtKB/Swiss-Prot
  THIKCHANNEL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016110 RatGTEx
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/Swiss-Prot
TIGR TC235238
UniProt A0A8I5ZZT0 ENTREZGENE
  A6H9C8 ENTREZGENE, UniProtKB/TrEMBL
  KCNKC_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnk12  potassium two pore domain channel subfamily K member 12  Kcnk12  potassium channel, two pore domain subfamily K, member 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnk12  potassium channel, two pore domain subfamily K, member 12  Kcnk12  potassium channel, subfamily K, member 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Kcnk12  potassium channel, subfamily K, member 12      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression abundant in brain; expressed in kidney, stomach, liver, and some non-neuronal cells such as the ependymal lining of the ventricles 67928