Igfals (insulin-like growth factor binding protein, acid labile subunit) - Rat Genome Database

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Gene: Igfals (insulin-like growth factor binding protein, acid labile subunit) Rattus norvegicus
Analyze
Symbol: Igfals
Name: insulin-like growth factor binding protein, acid labile subunit
RGD ID: 68429
Description: Enables insulin-like growth factor binding activity. Involved in several processes, including cellular response to dexamethasone stimulus; cellular response to epidermal growth factor stimulus; and cellular response to growth hormone stimulus. Part of insulin-like growth factor ternary complex. Orthologous to human IGFALS (insulin like growth factor binding protein acid labile subunit); PARTICIPATES IN insulin-like growth factor signaling pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Als; insulin-like growth factor binding protein complex acid-labile subunit; insulin-like growth factor-binding protein complex acid labile chain; insulin-like growth factor-binding protein complex acid labile subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,397,076 - 14,408,439 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1014,403,399 - 14,407,138 (+)EnsemblGRCr8
mRatBN7.21013,897,468 - 13,903,920 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,898,395 - 13,902,677 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1018,646,372 - 18,649,662 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01018,135,232 - 18,138,522 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01013,634,449 - 13,637,739 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01014,240,308 - 14,243,554 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,240,219 - 14,243,597 (+)Ensemblrn6Rnor6.0
Rnor_5.01014,056,324 - 14,059,570 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41014,127,416 - 14,130,662 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1013,578,539 - 13,581,785 (+)NCBICelera
RGSC_v3.11014,127,516 - 14,130,444 (+)NCBI
Cytogenetic Map10q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
amiodarone  (EXP,ISO)
ammonium chloride  (EXP)
arsenous acid  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP)
clofibrate  (EXP)
clofibric acid  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (EXP)
cyclosporin A  (ISO)
cyproconazole  (ISO)
deoxynivalenol  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenzofurans  (ISO)
dichlorine  (EXP)
diquat  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
fenthion  (ISO)
flutamide  (EXP)
fumonisin B1  (ISO)
furan  (EXP)
glafenine  (EXP)
glutathione  (ISO)
griseofulvin  (ISO)
GW 4064  (ISO)
indole-3-methanol  (EXP)
L-ethionine  (EXP)
leflunomide  (EXP)
methapyrilene  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
obeticholic acid  (ISO)
omeprazole  (EXP)
oxycodone  (EXP)
ozone  (EXP)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenformin  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
propiconazole  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
tamoxifen  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
trichloroethene  (EXP,ISO)
triclosan  (ISO)
triptonide  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Diagnostic interest of acid-labile subunit measurement in relationship to other components of the IGF system in pediatric patients with growth or eating disorders. Barrios V, etal., Eur J Endocrinol. 2001 Mar;144(3):245-50.
2. Regulation of the acid-labile subunit of the insulin-like growth factor complex in cultured rat hepatocytes. Dai J, etal., Endocrinology. 1994 Sep;135(3):1066-72.
3. Cloning and characterization of the rat gene for the acid-labile subunit of the insulin-like growth factor binding protein complex. Delhanty PJ and Baxter RC, J Mol Endocrinol 1997 Dec;19(3):267-77.
4. Interleukin-1 beta suppresses growth hormone-induced acid-labile subunit mRNA levels and secretion in primary hepatocytes. Delhanty PJ, Biochem Biophys Res Commun. 1998 Feb 4;243(1):269-72.
5. Roles of insulin-like growth factor (IGF) binding proteins in regulating IGF actions. Duan C and Xu Q, Gen Comp Endocrinol. 2005 May 15;142(1-2):44-52. Epub 2005 Feb 5.
6. Associations of insulin-like growth factors, insulin-like growth factor binding proteins and acid-labile subunit with coronary heart disease. Fischer F, etal., Clin Endocrinol (Oxf). 2004 Nov;61(5):595-602.
7. Changes in the circulating IGF system during short-term fasting and refeeding in rats. Frystyk J, etal., Am J Physiol. 1999 Aug;277(2 Pt 1):E245-52.
8. Developmental changes in serum levels of free and total insulin-like growth factor I (IGF-I), IGF-binding protein-1 and -3, and the acid-labile subunit in rats. Frystyk J, etal., Endocrinology. 1998 Oct;139(10):4286-92.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. A graded model of dietary zinc deficiency: effects on growth, insulin-like growth factor-I, and the glucose/insulin axis in weanling rats. Hall AG, etal., J Pediatr Gastroenterol Nutr. 2005 Jul;41(1):72-80.
12. Binding sites and binding properties of binary and ternary complexes of insulin-like growth factor-II (IGF-II), IGF-binding protein-3, and acid-labile subunit. Hashimoto R, etal., J Biol Chem. 1997 Oct 31;272(44):27936-42.
13. A novel mutation in IGFALS, c.380T>C (p.L127P), associated with short stature, delayed puberty, osteopenia and hyperinsulinaemia in two siblings: insights into the roles of insulin growth factor-1 (IGF1). Hess O, etal., Clin Endocrinol (Oxf). 2013 Dec;79(6):838-44. doi: 10.1111/cen.12200. Epub 2013 Apr 13.
14. Regulation of the acid-labile subunit in sustained endotoxemia. Kong SE, etal., Am J Physiol Endocrinol Metab 2002 Oct;283(4):E692-701.
15. Age-dependent regulation of the acid-labile subunit in response to fasting-refeeding in rats. Kong SE, etal., Endocrinology 2002 Dec;143(12):4505-12.
16. Acute response of IGF-I and IGF binding proteins induced by thermal injury. Lang CH, etal., Am J Physiol Endocrinol Metab. 2000 Jun;278(6):E1087-96.
17. Noonan syndrome: relationships between genotype, growth, and growth factors. Limal JM, etal., J Clin Endocrinol Metab. 2006 Jan;91(1):300-6. Epub 2005 Nov 1.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. IGF system in children with congenital disorders of glycosylation. Miller BS, etal., Clin Endocrinol (Oxf). 2009 Jun;70(6):892-7. doi: 10.1111/j.1365-2265.2009.03531.x. Epub 2009 Jan 22.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. GOA pipeline RGD automated data pipeline
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
25. IGF-I-IGFBP-3-acid-labile subunit (ALS) complex in children and adolescents with classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency (CAH). Völkl TM, etal., Growth Horm IGF Res. 2011 Aug;21(4):191-8. doi: 10.1016/j.ghir.2011.05.001. Epub 2011 Jun 1.
26. IGFs and IGF-binding proteins in short children with steroid-dependent nephrotic syndrome on chronic glucocorticoids: changes with 1 year exogenous GH. Zhou X, etal., Eur J Endocrinol. 2001 Mar;144(3):237-43.
Additional References at PubMed
PMID:1384485   PMID:7507839   PMID:9497324   PMID:19056867   PMID:23376485   PMID:23533145  


Genomics

Comparative Map Data
Igfals
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,397,076 - 14,408,439 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1014,403,399 - 14,407,138 (+)EnsemblGRCr8
mRatBN7.21013,897,468 - 13,903,920 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,898,395 - 13,902,677 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1018,646,372 - 18,649,662 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01018,135,232 - 18,138,522 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01013,634,449 - 13,637,739 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01014,240,308 - 14,243,554 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,240,219 - 14,243,597 (+)Ensemblrn6Rnor6.0
Rnor_5.01014,056,324 - 14,059,570 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41014,127,416 - 14,130,662 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1013,578,539 - 13,581,785 (+)NCBICelera
RGSC_v3.11014,127,516 - 14,130,444 (+)NCBI
Cytogenetic Map10q12NCBI
IGFALS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38161,790,413 - 1,794,908 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl161,790,413 - 1,794,971 (-)Ensemblhg38GRCh38
GRCh37161,840,414 - 1,844,909 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36161,780,420 - 1,783,710 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34161,780,421 - 1,783,710NCBI
Celera162,052,696 - 2,057,191 (-)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef161,763,315 - 1,767,810 (-)NCBIHuRef
CHM1_1161,840,362 - 1,844,857 (-)NCBICHM1_1
T2T-CHM13v2.0161,806,253 - 1,810,748 (-)NCBIT2T-CHM13v2.0
Igfals
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391725,096,818 - 25,100,985 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1725,084,971 - 25,100,984 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381724,877,844 - 24,882,011 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,865,997 - 24,882,010 (+)Ensemblmm10GRCm38
MGSCv371725,015,715 - 25,018,953 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361724,606,370 - 24,609,608 (+)NCBIMGSCv36mm8
Celera1725,405,538 - 25,408,777 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.53NCBI
Igfals
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544215,478,202 - 15,482,115 (+)Ensembl
ChiLan1.0NW_00495544215,469,602 - 15,482,115 (+)NCBIChiLan1.0ChiLan1.0
IGFALS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2182,057,109 - 2,075,532 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1165,838,546 - 5,841,632 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v016412,671 - 418,351 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1161,843,979 - 1,847,313 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl161,843,979 - 1,848,442 (-)EnsemblpanPan2panpan1.1
IGFALS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1639,115,744 - 39,118,831 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl639,114,315 - 39,119,652 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha640,351,263 - 40,357,736 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0639,428,804 - 39,435,271 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl639,432,251 - 39,435,092 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1639,108,949 - 39,111,968 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0639,078,076 - 39,084,548 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0639,556,554 - 39,563,011 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Igfals
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344104,502,118 - 104,511,278 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366942,204,182 - 2,207,328 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366942,205,294 - 2,207,343 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IGFALS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl340,174,764 - 40,177,784 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1340,173,595 - 40,177,789 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2341,634,233 - 41,640,585 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IGFALS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.151,698,787 - 1,704,205 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl51,698,978 - 1,701,972 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606829,382,141 - 29,387,558 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Igfals
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624913458,844 - 465,193 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624913460,862 - 464,457 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Igfals
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v192,158,409 - 2,162,472 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Igfals
15 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:53
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000020233
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10117749933Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat

Markers in Region
D5S619  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.05173,086,343 - 173,086,624NCBIRnor5.0
Rnor_5.01014,056,298 - 14,056,408NCBIRnor5.0
RGSC_v3.41014,127,391 - 14,127,500UniSTSRGSC3.4
RGSC_v3.45169,584,067 - 169,584,347UniSTSRGSC3.4
Celera1013,578,514 - 13,578,623UniSTS
Celera5161,092,523 - 161,092,803UniSTS
Cytogenetic Map10q12UniSTS
Cytogenetic Map5q36UniSTS
RH128916  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21013,902,421 - 13,902,610 (+)MAPPERmRatBN7.2
Rnor_6.01014,243,399 - 14,243,587NCBIRnor6.0
Rnor_5.01014,059,415 - 14,059,603UniSTSRnor5.0
RGSC_v3.41014,130,507 - 14,130,695UniSTSRGSC3.4
Celera1013,581,630 - 13,581,818UniSTS
RH 3.4 Map31000.4UniSTS
Cytogenetic Map10q12UniSTS
RH138690  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21013,901,148 - 13,901,277 (+)MAPPERmRatBN7.2
Rnor_6.01014,242,126 - 14,242,254NCBIRnor6.0
Rnor_5.01014,058,142 - 14,058,270UniSTSRnor5.0
RGSC_v3.41014,129,234 - 14,129,362UniSTSRGSC3.4
Celera1013,580,357 - 13,580,485UniSTS
RH 3.4 Map10173.7UniSTS
Cytogenetic Map10q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 52 130 91 90 59 82 59 6 329 167 11 108 79 82 31 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000020233   ⟹   ENSRNOP00000020233
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1014,403,399 - 14,407,138 (+)Ensembl
mRatBN7.2 Ensembl1013,899,331 - 13,902,621 (+)Ensembl
Rnor_6.0 Ensembl1014,240,219 - 14,243,597 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096529   ⟹   ENSRNOP00000077501
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1013,898,395 - 13,902,677 (+)Ensembl
RefSeq Acc Id: NM_053329   ⟹   NP_445781
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,403,850 - 14,407,140 (+)NCBI
mRatBN7.21013,899,331 - 13,902,621 (+)NCBI
Rnor_6.01014,240,308 - 14,243,554 (+)NCBI
Rnor_5.01014,056,324 - 14,059,570 (+)NCBI
RGSC_v3.41014,127,416 - 14,130,662 (+)RGD
Celera1013,578,539 - 13,581,785 (+)RGD
Sequence:
RefSeq Acc Id: XM_039086922   ⟹   XP_038942850
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,397,076 - 14,408,439 (+)NCBI
mRatBN7.21013,897,468 - 13,903,920 (+)NCBI
RefSeq Acc Id: XM_063269930   ⟹   XP_063126000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,403,140 - 14,408,439 (+)NCBI
RefSeq Acc Id: NP_445781   ⟸   NM_053329
- Peptide Label: precursor
- UniProtKB: F1LRE2 (UniProtKB/TrEMBL),   A6HCX9 (UniProtKB/TrEMBL),   O70211 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020233   ⟸   ENSRNOT00000020233
RefSeq Acc Id: XP_038942850   ⟸   XM_039086922
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y6E1 (UniProtKB/TrEMBL),   A6HCX8 (UniProtKB/TrEMBL),   O70211 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000077501   ⟸   ENSRNOT00000096529
RefSeq Acc Id: XP_063126000   ⟸   XM_063269930
- Peptide Label: isoform X2
Protein Domains
LRRCT   LRRNT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35859-F1-model_v2 AlphaFold P35859 1-603 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697031
Promoter ID:EPDNEW_R7556
Type:initiation region
Name:Igfals_1
Description:insulin-like growth factor binding protein, acid labile subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01014,240,359 - 14,240,419EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68429 AgrOrtholog
BioCyc Gene G2FUF-25818 BioCyc
Ensembl Genes ENSRNOG00000015061 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000020233 ENTREZGENE
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot
InterPro Cys-rich_flank_reg_C UniProtKB/Swiss-Prot
  Dev_Immune_Receptor UniProtKB/Swiss-Prot
  Leu-rich_rpt UniProtKB/Swiss-Prot
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
  LRRNT UniProtKB/Swiss-Prot
KEGG Report rno:79438 UniProtKB/Swiss-Prot
NCBI Gene 79438 ENTREZGENE
PANTHER INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT UniProtKB/Swiss-Prot
  SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN UniProtKB/Swiss-Prot
Pfam LRR_8 UniProtKB/Swiss-Prot
  LRRNT UniProtKB/Swiss-Prot
PhenoGen Igfals PhenoGen
RatGTEx ENSRNOG00000015061 RatGTEx
SMART LRR_BAC UniProtKB/Swiss-Prot
  LRR_SD22 UniProtKB/Swiss-Prot
  LRR_TYP UniProtKB/Swiss-Prot
  LRRCT UniProtKB/Swiss-Prot
  LRRNT UniProtKB/Swiss-Prot
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot
TIGR TC206522
UniProt A0A8I5Y6E1 ENTREZGENE
  A6HCX8 ENTREZGENE, UniProtKB/TrEMBL
  A6HCX9 ENTREZGENE, UniProtKB/TrEMBL
  ALS_RAT UniProtKB/Swiss-Prot
  F1LRE2 ENTREZGENE, UniProtKB/TrEMBL
  O70211 ENTREZGENE, UniProtKB/TrEMBL
  P35859 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Igfals  insulin-like growth factor binding protein, acid labile subunit       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver 625688
gene_protein 85 kDa glycoprotein 625688
gene_regulation food restriction inhibits gene expression 625688
gene_regulation induced by insulin and GH 625688
gene_regulation mRNA level is regulated through modulation of hepatic insulin sensitivity in sustained endotoxemia 625688
gene_regulation expression regulated by growth hormone 68264
gene_regulation expression is supressed by malnutrition 1299153