Igfals (insulin-like growth factor binding protein, acid labile subunit) - Rat Genome Database

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Gene: Igfals (insulin-like growth factor binding protein, acid labile subunit) Rattus norvegicus
Analyze
Symbol: Igfals
Name: insulin-like growth factor binding protein, acid labile subunit
RGD ID: 68429
Description: Enables insulin-like growth factor binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; cellular response to hormone stimulus; and cellular response to interleukin-1. Part of insulin-like growth factor ternary complex. Orthologous to human IGFALS (insulin like growth factor binding protein acid labile subunit); PARTICIPATES IN insulin-like growth factor signaling pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Als; insulin-like growth factor binding protein complex acid-labile subunit; insulin-like growth factor-binding protein complex acid labile chain; insulin-like growth factor-binding protein complex acid labile subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,397,076 - 14,408,439 (+)NCBIGRCr8
mRatBN7.21013,897,468 - 13,903,920 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,898,395 - 13,902,677 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1018,646,372 - 18,649,662 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01018,135,232 - 18,138,522 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01013,634,449 - 13,637,739 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01014,240,308 - 14,243,554 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,240,219 - 14,243,597 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01014,056,324 - 14,059,570 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41014,127,416 - 14,130,662 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11014,127,516 - 14,130,444 (+)NCBI
Celera1013,578,539 - 13,581,785 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
amiodarone  (EXP,ISO)
ammonium chloride  (EXP)
arsenous acid  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP)
clofibrate  (EXP)
clofibric acid  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (EXP)
cyclosporin A  (ISO)
cyproconazole  (ISO)
deoxynivalenol  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenzofurans  (ISO)
dichlorine  (EXP)
diquat  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
fenthion  (ISO)
flutamide  (EXP)
fumonisin B1  (ISO)
furan  (EXP)
glafenine  (EXP)
glutathione  (ISO)
griseofulvin  (ISO)
GW 4064  (ISO)
indole-3-methanol  (EXP)
L-ethionine  (EXP)
leflunomide  (EXP)
methapyrilene  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
obeticholic acid  (ISO)
omeprazole  (EXP)
oxycodone  (EXP)
ozone  (EXP)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenformin  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
propiconazole  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
tamoxifen  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
trichloroethene  (EXP,ISO)
triclosan  (ISO)
triptonide  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Diagnostic interest of acid-labile subunit measurement in relationship to other components of the IGF system in pediatric patients with growth or eating disorders. Barrios V, etal., Eur J Endocrinol. 2001 Mar;144(3):245-50.
2. Regulation of the acid-labile subunit of the insulin-like growth factor complex in cultured rat hepatocytes. Dai J, etal., Endocrinology. 1994 Sep;135(3):1066-72.
3. Cloning and characterization of the rat gene for the acid-labile subunit of the insulin-like growth factor binding protein complex. Delhanty PJ and Baxter RC, J Mol Endocrinol 1997 Dec;19(3):267-77.
4. Interleukin-1 beta suppresses growth hormone-induced acid-labile subunit mRNA levels and secretion in primary hepatocytes. Delhanty PJ, Biochem Biophys Res Commun. 1998 Feb 4;243(1):269-72.
5. Roles of insulin-like growth factor (IGF) binding proteins in regulating IGF actions. Duan C and Xu Q, Gen Comp Endocrinol. 2005 May 15;142(1-2):44-52. Epub 2005 Feb 5.
6. Associations of insulin-like growth factors, insulin-like growth factor binding proteins and acid-labile subunit with coronary heart disease. Fischer F, etal., Clin Endocrinol (Oxf). 2004 Nov;61(5):595-602.
7. Changes in the circulating IGF system during short-term fasting and refeeding in rats. Frystyk J, etal., Am J Physiol. 1999 Aug;277(2 Pt 1):E245-52.
8. Developmental changes in serum levels of free and total insulin-like growth factor I (IGF-I), IGF-binding protein-1 and -3, and the acid-labile subunit in rats. Frystyk J, etal., Endocrinology. 1998 Oct;139(10):4286-92.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. A graded model of dietary zinc deficiency: effects on growth, insulin-like growth factor-I, and the glucose/insulin axis in weanling rats. Hall AG, etal., J Pediatr Gastroenterol Nutr. 2005 Jul;41(1):72-80.
12. Binding sites and binding properties of binary and ternary complexes of insulin-like growth factor-II (IGF-II), IGF-binding protein-3, and acid-labile subunit. Hashimoto R, etal., J Biol Chem. 1997 Oct 31;272(44):27936-42.
13. A novel mutation in IGFALS, c.380T>C (p.L127P), associated with short stature, delayed puberty, osteopenia and hyperinsulinaemia in two siblings: insights into the roles of insulin growth factor-1 (IGF1). Hess O, etal., Clin Endocrinol (Oxf). 2013 Dec;79(6):838-44. doi: 10.1111/cen.12200. Epub 2013 Apr 13.
14. Regulation of the acid-labile subunit in sustained endotoxemia. Kong SE, etal., Am J Physiol Endocrinol Metab 2002 Oct;283(4):E692-701.
15. Age-dependent regulation of the acid-labile subunit in response to fasting-refeeding in rats. Kong SE, etal., Endocrinology 2002 Dec;143(12):4505-12.
16. Acute response of IGF-I and IGF binding proteins induced by thermal injury. Lang CH, etal., Am J Physiol Endocrinol Metab. 2000 Jun;278(6):E1087-96.
17. Noonan syndrome: relationships between genotype, growth, and growth factors. Limal JM, etal., J Clin Endocrinol Metab. 2006 Jan;91(1):300-6. Epub 2005 Nov 1.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. IGF system in children with congenital disorders of glycosylation. Miller BS, etal., Clin Endocrinol (Oxf). 2009 Jun;70(6):892-7. doi: 10.1111/j.1365-2265.2009.03531.x. Epub 2009 Jan 22.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. GOA pipeline RGD automated data pipeline
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
25. IGF-I-IGFBP-3-acid-labile subunit (ALS) complex in children and adolescents with classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency (CAH). Völkl TM, etal., Growth Horm IGF Res. 2011 Aug;21(4):191-8. doi: 10.1016/j.ghir.2011.05.001. Epub 2011 Jun 1.
26. IGFs and IGF-binding proteins in short children with steroid-dependent nephrotic syndrome on chronic glucocorticoids: changes with 1 year exogenous GH. Zhou X, etal., Eur J Endocrinol. 2001 Mar;144(3):237-43.
Additional References at PubMed
PMID:1384485   PMID:7507839   PMID:9497324   PMID:19056867   PMID:23376485   PMID:23533145  


Genomics

Comparative Map Data
Igfals
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,397,076 - 14,408,439 (+)NCBIGRCr8
mRatBN7.21013,897,468 - 13,903,920 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,898,395 - 13,902,677 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1018,646,372 - 18,649,662 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01018,135,232 - 18,138,522 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01013,634,449 - 13,637,739 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01014,240,308 - 14,243,554 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,240,219 - 14,243,597 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01014,056,324 - 14,059,570 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41014,127,416 - 14,130,662 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11014,127,516 - 14,130,444 (+)NCBI
Celera1013,578,539 - 13,581,785 (+)NCBICelera
Cytogenetic Map10q12NCBI
IGFALS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38161,790,413 - 1,794,908 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl161,790,413 - 1,794,971 (-)EnsemblGRCh38hg38GRCh38
GRCh37161,840,414 - 1,844,909 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36161,780,420 - 1,783,710 (-)NCBINCBI36Build 36hg18NCBI36
Build 34161,780,421 - 1,783,710NCBI
Celera162,052,696 - 2,057,191 (-)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef161,763,315 - 1,767,810 (-)NCBIHuRef
CHM1_1161,840,362 - 1,844,857 (-)NCBICHM1_1
T2T-CHM13v2.0161,806,253 - 1,810,748 (-)NCBIT2T-CHM13v2.0
Igfals
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391725,096,818 - 25,100,985 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1725,084,971 - 25,100,984 (+)EnsemblGRCm39 Ensembl
GRCm381724,877,844 - 24,882,011 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,865,997 - 24,882,010 (+)EnsemblGRCm38mm10GRCm38
MGSCv371725,015,715 - 25,018,953 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361724,606,370 - 24,609,608 (+)NCBIMGSCv36mm8
Celera1725,405,538 - 25,408,777 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.53NCBI
Igfals
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544215,478,202 - 15,482,115 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544215,469,602 - 15,482,115 (+)NCBIChiLan1.0ChiLan1.0
IGFALS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2182,057,109 - 2,075,532 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1165,838,546 - 5,841,632 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v016412,671 - 418,351 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1161,843,979 - 1,847,313 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl161,843,979 - 1,848,442 (-)Ensemblpanpan1.1panPan2
IGFALS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1639,115,744 - 39,118,831 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl639,114,315 - 39,119,652 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha640,351,263 - 40,357,736 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0639,428,804 - 39,435,271 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl639,432,251 - 39,435,092 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1639,108,949 - 39,111,968 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0639,078,076 - 39,084,548 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0639,556,554 - 39,563,011 (+)NCBIUU_Cfam_GSD_1.0
Igfals
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344104,502,118 - 104,511,278 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366942,204,182 - 2,207,328 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366942,205,294 - 2,207,343 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IGFALS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl340,174,764 - 40,177,784 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1340,173,595 - 40,177,789 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2341,634,233 - 41,640,585 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IGFALS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.151,698,787 - 1,704,205 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl51,698,978 - 1,701,972 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606829,382,141 - 29,387,558 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Igfals
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624913458,844 - 465,193 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624913460,862 - 464,457 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Igfals
15 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:53
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000020233
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402717245662Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10615418215990232Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat

Markers in Region
D5S619  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.05173,086,343 - 173,086,624NCBIRnor5.0
Rnor_5.01014,056,298 - 14,056,408NCBIRnor5.0
RGSC_v3.41014,127,391 - 14,127,500UniSTSRGSC3.4
RGSC_v3.45169,584,067 - 169,584,347UniSTSRGSC3.4
Celera1013,578,514 - 13,578,623UniSTS
Celera5161,092,523 - 161,092,803UniSTS
Cytogenetic Map10q12UniSTS
Cytogenetic Map5q36UniSTS
RH128916  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21013,902,421 - 13,902,610 (+)MAPPERmRatBN7.2
Rnor_6.01014,243,399 - 14,243,587NCBIRnor6.0
Rnor_5.01014,059,415 - 14,059,603UniSTSRnor5.0
RGSC_v3.41014,130,507 - 14,130,695UniSTSRGSC3.4
Celera1013,581,630 - 13,581,818UniSTS
RH 3.4 Map31000.4UniSTS
Cytogenetic Map10q12UniSTS
RH138690  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21013,901,148 - 13,901,277 (+)MAPPERmRatBN7.2
Rnor_6.01014,242,126 - 14,242,254NCBIRnor6.0
Rnor_5.01014,058,142 - 14,058,270UniSTSRnor5.0
RGSC_v3.41014,129,234 - 14,129,362UniSTSRGSC3.4
Celera1013,580,357 - 13,580,485UniSTS
RH 3.4 Map10173.7UniSTS
Cytogenetic Map10q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 23 23 23 4
Low 28 18 16 18 3 21 16 5
Below cutoff 3 31 6 3 8 8 54 8 20 6 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000020233   ⟹   ENSRNOP00000020233
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1013,899,331 - 13,902,621 (+)Ensembl
Rnor_6.0 Ensembl1014,240,219 - 14,243,597 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096529   ⟹   ENSRNOP00000077501
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1013,898,395 - 13,902,677 (+)Ensembl
RefSeq Acc Id: NM_053329   ⟹   NP_445781
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,403,850 - 14,407,140 (+)NCBI
mRatBN7.21013,899,331 - 13,902,621 (+)NCBI
Rnor_6.01014,240,308 - 14,243,554 (+)NCBI
Rnor_5.01014,056,324 - 14,059,570 (+)NCBI
RGSC_v3.41014,127,416 - 14,130,662 (+)RGD
Celera1013,578,539 - 13,581,785 (+)RGD
Sequence:
RefSeq Acc Id: XM_039086922   ⟹   XP_038942850
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,397,076 - 14,408,439 (+)NCBI
mRatBN7.21013,897,468 - 13,903,920 (+)NCBI
RefSeq Acc Id: XM_063269930   ⟹   XP_063126000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,403,140 - 14,408,439 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_445781   ⟸   NM_053329
- Peptide Label: precursor
- UniProtKB: F1LRE2 (UniProtKB/TrEMBL),   A6HCX9 (UniProtKB/TrEMBL),   O70211 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000020233   ⟸   ENSRNOT00000020233
RefSeq Acc Id: XP_038942850   ⟸   XM_039086922
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y6E1 (UniProtKB/TrEMBL),   A6HCX8 (UniProtKB/TrEMBL),   O70211 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000077501   ⟸   ENSRNOT00000096529
RefSeq Acc Id: XP_063126000   ⟸   XM_063269930
- Peptide Label: isoform X2
Protein Domains
LRRCT   LRRNT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35859-F1-model_v2 AlphaFold P35859 1-603 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697031
Promoter ID:EPDNEW_R7556
Type:initiation region
Name:Igfals_1
Description:insulin-like growth factor binding protein, acid labile subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01014,240,359 - 14,240,419EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68429 AgrOrtholog
BioCyc Gene G2FUF-25818 BioCyc
Ensembl Genes ENSRNOG00000015061 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020233 ENTREZGENE
  ENSRNOT00000020233.6 UniProtKB/TrEMBL
  ENSRNOT00000096529.1 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cys-rich_flank_reg_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:79438 UniProtKB/Swiss-Prot
NCBI Gene 79438 ENTREZGENE
PANTHER AGAP008170-PA UniProtKB/TrEMBL
  KEKKON 5, ISOFORM A UniProtKB/Swiss-Prot
  LEUCINE RICH REPEAT FAMILY PROTEIN UniProtKB/TrEMBL
  SYNAPTIC ADHESION-LIKE MOLECULE SALM UniProtKB/Swiss-Prot
Pfam LRR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Igfals PhenoGen
RatGTEx ENSRNOG00000015061 RatGTEx
SMART LRR_BAC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_SD22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_TYP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC206522
UniProt A0A8I5Y6E1 ENTREZGENE, UniProtKB/TrEMBL
  A6HCX8 ENTREZGENE, UniProtKB/TrEMBL
  A6HCX9 ENTREZGENE, UniProtKB/TrEMBL
  ALS_RAT UniProtKB/Swiss-Prot
  F1LRE2 ENTREZGENE, UniProtKB/TrEMBL
  O70211 ENTREZGENE, UniProtKB/TrEMBL
  P35859 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Igfals  insulin-like growth factor binding protein, acid labile subunit       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver 625688
gene_protein 85 kDa glycoprotein 625688
gene_regulation food restriction inhibits gene expression 625688
gene_regulation induced by insulin and GH 625688
gene_regulation mRNA level is regulated through modulation of hepatic insulin sensitivity in sustained endotoxemia 625688
gene_regulation expression regulated by growth hormone 68264
gene_regulation expression is supressed by malnutrition 1299153