Dio3 (iodothyronine deiodinase 3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Dio3 (iodothyronine deiodinase 3) Rattus norvegicus
Analyze
Symbol: Dio3
Name: iodothyronine deiodinase 3
RGD ID: 68420
Description: Predicted to enable thyroxine 5'-deiodinase activity and thyroxine 5-deiodinase activity. Involved in brown fat cell proliferation and response to hypoxia. Predicted to be located in endosome membrane and plasma membrane. Biomarker of congestive heart failure and fetal alcohol spectrum disorder. Orthologous to human DIO3 (iodothyronine deiodinase 3); INTERACTS WITH (+)-schisandrin B; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 5DIII; deiodinase iodothyronine type 3; deiodinase iodothyronine type III; deiodinase, iodothyronine, type 3; deiodinase, iodothyronine, type III; DIOIII; thyroxine 5-deiodinase; type 3 DI; type III iodothyronine deiodinase; type-III 5'-deiodinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Thshl1
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86135,107,072 - 135,108,933 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6135,107,074 - 135,107,985 (+)EnsemblGRCr8
mRatBN7.26129,285,747 - 129,287,608 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6129,285,749 - 129,286,660 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6129,464,249 - 129,466,110 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06129,760,113 - 129,761,974 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06129,123,269 - 129,125,130 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06134,627,278 - 134,629,139 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6134,627,278 - 134,629,138 (+)Ensemblrn6Rnor6.0
Rnor_5.06143,766,523 - 143,768,383 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera6126,858,528 - 126,860,389 (+)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-dinitrotoluene  (EXP)
2-Ethylhexyl acrylate  (ISO)
2-palmitoylglycerol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,5-dichloro-2-n-octyl-3(2H)-isothiazolone  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (EXP)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
actinomycin D  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-hexylcinnamaldehyde  (ISO)
alpha-linolenic acid  (ISO)
ammonium chloride  (EXP)
Aurothioglucose  (ISO)
benzalkonium chloride  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-lapachone  (ISO)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
C60 fullerene  (EXP)
captafol  (ISO)
chlordecone  (ISO)
chlorothalonil  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (EXP)
clothianidin  (ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (EXP)
cycloheximide  (EXP)
Cyclopamine  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
Didecyldimethylammonium  (ISO)
diethyl hydrogen phosphate  (EXP)
diiodine  (ISO)
dinocap  (ISO)
disodium selenite  (EXP)
dorsomorphin  (ISO)
entinostat  (ISO)
Ethylenethiourea  (ISO)
fenvalerate  (EXP)
fipronil  (EXP,ISO)
flavonoids  (EXP)
fluazinam  (ISO)
fluoxetine  (EXP)
folic acid  (ISO)
furan  (EXP)
glyphosate  (EXP)
hydrogen peroxide  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
Licochalcone B  (ISO)
lidocaine  (EXP)
linoleic acid  (ISO)
lipopolysaccharide  (EXP)
lithocholic acid  (ISO)
masoprocol  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
methyltrioctylammonium chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morin  (ISO)
N-acetyl-L-cysteine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naphthalene  (ISO)
octhilinone  (ISO)
ozone  (ISO)
pentachlorophenol  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phthalaldehyde  (ISO)
pioglitazone  (ISO)
potassium bromate  (ISO)
pravastatin  (EXP,ISO)
propiconazole  (EXP)
quinoxyfen  (ISO)
ranitidine  (EXP)
resveratrol  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
streptozocin  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
thyroxine  (EXP)
titanium dioxide  (EXP,ISO)
triadimefon  (EXP)
triflumizole  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vemurafenib  (ISO)
xanthohumol  (ISO)
zoxamide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Cloning and expression of a cDNA for a mammalian type III iodothyronine deiodinase. Croteau W, etal., J Biol Chem 1995 Jul 14;270(28):16569-75.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Gene expression from the imprinted Dio3 locus is associated with cell proliferation of cultured brown adipocytes. Hernandez A, etal., Endocrinology. 2007 Aug;148(8):3968-76. Epub 2007 May 17.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats. Simonides WS, etal., J Clin Invest. 2008 Mar;118(3):975-83.
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
13. Low-dose thyroxine attenuates autism-associated adverse effects of fetal alcohol in male offspring's social behavior and hippocampal gene expression. Tunc-Ozcan E, etal., Alcohol Clin Exp Res. 2013 Nov;37(11):1986-95. doi: 10.1111/acer.12183. Epub 2013 Jun 13.
Additional References at PubMed
PMID:12399446   PMID:12586753   PMID:12959985   PMID:16410833   PMID:17628010   PMID:18566113   PMID:18787028   PMID:19916870   PMID:20203194   PMID:21429942   PMID:22723689   PMID:23586759  
PMID:25002520   PMID:33746903   PMID:39238408  


Genomics

Comparative Map Data
Dio3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86135,107,072 - 135,108,933 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6135,107,074 - 135,107,985 (+)EnsemblGRCr8
mRatBN7.26129,285,747 - 129,287,608 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6129,285,749 - 129,286,660 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6129,464,249 - 129,466,110 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06129,760,113 - 129,761,974 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06129,123,269 - 129,125,130 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06134,627,278 - 134,629,139 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6134,627,278 - 134,629,138 (+)Ensemblrn6Rnor6.0
Rnor_5.06143,766,523 - 143,768,383 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera6126,858,528 - 126,860,389 (+)NCBICelera
Cytogenetic Map6q32NCBI
DIO3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814101,561,495 - 101,563,452 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14101,560,139 - 101,563,452 (+)Ensemblhg38GRCh38
GRCh3714102,027,832 - 102,029,789 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614101,097,441 - 101,099,542 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3414101,097,440 - 101,099,540NCBI
Celera1482,082,777 - 82,084,878 (+)NCBICelera
Cytogenetic Map14q32.31NCBI
HuRef1482,210,257 - 82,212,139 (+)NCBIHuRef
CHM1_114101,966,169 - 101,968,270 (+)NCBICHM1_1
T2T-CHM13v2.01495,796,749 - 95,798,706 (+)NCBIT2T-CHM13v2.0
Dio3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912110,245,664 - 110,247,531 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12110,245,502 - 110,247,531 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3812110,279,230 - 110,281,097 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12110,279,068 - 110,281,097 (+)Ensemblmm10GRCm38
MGSCv3712111,517,440 - 111,519,307 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3612110,727,040 - 110,728,902 (+)NCBIMGSCv36mm8
Celera12111,469,979 - 111,471,846 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1260.56NCBI
Dio3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555381,042,949 - 1,045,038 (+)NCBIChiLan1.0ChiLan1.0
DIO3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215102,720,139 - 102,722,215 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114101,936,634 - 101,938,710 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01482,188,126 - 82,190,220 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114101,496,027 - 101,497,958 (+)NCBIPanPan1.1PanPan1.1panPan2
DIO3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1869,696,779 - 69,698,880 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha869,212,787 - 69,214,888 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0869,976,717 - 69,978,827 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1869,640,338 - 69,642,442 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0869,705,306 - 69,707,410 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0870,104,995 - 70,107,102 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dio3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086404,838,557 - 4,840,570 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366045,242,006 - 5,242,509 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366045,241,877 - 5,243,910 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DIO3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.27130,202,342 - 130,204,449 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DIO3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12479,538,264 - 79,544,448 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605366,683,231 - 66,685,324 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dio3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247342,611,864 - 2,613,932 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Dio3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v17127,842,023 - 127,844,080 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dio3
17 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6131392689143944780Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat

Markers in Region
RH128338  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26129,286,330 - 129,287,557 (+)MAPPERmRatBN7.2
Rnor_6.06134,627,862 - 134,629,088NCBIRnor6.0
Rnor_5.06143,767,107 - 143,768,333UniSTSRnor5.0
Celera6126,859,112 - 126,860,338UniSTS
RH 3.4 Map6785.19UniSTS
UniSTS:489530  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26129,285,776 - 129,287,221 (+)MAPPERmRatBN7.2
Rnor_6.06134,627,308 - 134,628,752NCBIRnor6.0
Rnor_5.06143,766,553 - 143,767,997UniSTSRnor5.0
Celera6126,858,558 - 126,860,002UniSTS
UniSTS:532166  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26129,286,009 - 129,286,137 (+)MAPPERmRatBN7.2
Rnor_6.06134,627,541 - 134,627,668NCBIRnor6.0
Rnor_5.06143,766,786 - 143,766,913UniSTSRnor5.0
Celera6126,858,791 - 126,858,918UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 9 40 124 75 72 44 49 44 6 223 117 7 98 43 89 28 4 4

Sequence


Ensembl Acc Id: ENSRNOT00000078113
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6135,107,074 - 135,107,985 (+)Ensembl
mRatBN7.2 Ensembl6129,285,749 - 129,286,660 (+)Ensembl
Rnor_6.0 Ensembl6134,627,278 - 134,629,138 (+)Ensembl
RefSeq Acc Id: NM_017210   ⟹   NP_058906
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86135,107,072 - 135,108,933 (+)NCBI
mRatBN7.26129,285,747 - 129,287,608 (+)NCBI
Rnor_6.06134,627,278 - 134,629,139 (+)NCBI
Rnor_5.06143,766,523 - 143,768,383 (+)NCBI
Celera6126,858,528 - 126,860,389 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_058906 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52241 (Get FASTA)   NCBI Sequence Viewer  
  EDL97515 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000093110
  ENSRNOP00000093110.1
GenBank Protein P49897 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058906   ⟸   NM_017210
- UniProtKB: P49897 (UniProtKB/Swiss-Prot)
- Sequence:

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68420 AgrOrtholog
BioCyc Gene G2FUF-35897 BioCyc
BioCyc Pathway PWY-6260 [thyroid hormone metabolism I (via deiodination)] BioCyc
  PWY-6261 [thyroid hormone metabolism II (via conjugation and/or degradation)] BioCyc
BioCyc Pathway Image PWY-6260 BioCyc
  PWY-6261 BioCyc
Ensembl Genes ENSRNOG00000052017 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000078113 ENTREZGENE
  ENSRNOT00000078113.2 UniProtKB/Swiss-Prot
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot
InterPro Iodothyronine_deiodinase UniProtKB/Swiss-Prot
  Iodothyronine_deiodinase_AS UniProtKB/Swiss-Prot
  Iodothyronine_deiodinase_I/III UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:29475 UniProtKB/Swiss-Prot
NCBI Gene 29475 ENTREZGENE
PANTHER PTHR11781 UniProtKB/Swiss-Prot
  THYROXINE 5-DEIODINASE UniProtKB/Swiss-Prot
Pfam T4_deiodinase UniProtKB/Swiss-Prot
PhenoGen Dio3 PhenoGen
PIRSF IOD UniProtKB/Swiss-Prot
  IODI_III UniProtKB/Swiss-Prot
PROSITE T4_DEIODINASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000052017 RatGTEx
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot
TIGR TC238557
UniProt A6KBL6_RAT UniProtKB/TrEMBL
  IOD3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-10-26 Dio3  iodothyronine deiodinase 3  Dio3  deiodinase, iodothyronine, type III  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Dio3  deiodinase, iodothyronine, type III    deiodinase, iodothyronine, type 3  Name updated 629478 APPROVED
2002-06-10 Dio3  deiodinase, iodothyronine, type 3      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed in placenta and several fetal tissues during embryonic development 68236
gene_function catalyzes the inner ring deiodination of the prohormone thyroxine (T4) and of the bioactive hormone 3,3',5-triiodothyronine (T3) to 3,3'-T2 inactive metabolites 68236
gene_homology cDNA displays significant homology with amphibian (Xenopus laevis) 68236