Ppp5c (protein phosphatase 5, catalytic subunit) - Rat Genome Database

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Gene: Ppp5c (protein phosphatase 5, catalytic subunit) Rattus norvegicus
Analyze
Symbol: Ppp5c
Name: protein phosphatase 5, catalytic subunit
RGD ID: 68415
Description: Enables several functions, including G-protein alpha-subunit binding activity; heat shock protein binding activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in several processes, including cellular response to hydrogen peroxide; regulation of intracellular signal transduction; and response to arachidonate. Located in perikaryon and proximal dendrite. Orthologous to human PPP5C (protein phosphatase 5 catalytic subunit); PARTICIPATES IN Rho/Rac/Cdc42 mediated signaling pathway; ataxia telangiectasia-mutated (ATM) signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: PP5; PPT; protein phosphatase T; serine/threonine-protein phosphatase 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8186,818,297 - 86,842,505 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl186,818,297 - 86,842,950 (-)EnsemblGRCr8
mRatBN7.2177,690,203 - 77,714,507 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl177,690,208 - 77,714,456 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx183,070,376 - 83,094,770 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0191,634,443 - 91,658,837 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0184,825,481 - 84,849,875 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,944,054 - 78,968,361 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,944,040 - 78,968,329 (-)Ensemblrn6Rnor6.0
Rnor_5.0180,191,557 - 80,216,026 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4177,345,194 - 77,369,417 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera172,175,254 - 72,199,561 (-)NCBICelera
RGSC_v3.1177,423,304 - 77,447,528 (-)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
ADP  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
ATP  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bortezomib  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
CGP 52608  (ISO)
chlorogenic acid  (ISO)
clobetasol  (ISO)
clozapine  (ISO)
cocaine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
coumarin  (ISO)
coumestrol  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
flutamide  (EXP)
fulvestrant  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
haloperidol  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (EXP,ISO)
inulin  (ISO)
isoniazide  (ISO)
ivermectin  (ISO)
lead diacetate  (EXP)
Maduramicin  (EXP,ISO)
N-acetyl-L-cysteine  (EXP,ISO)
nitric oxide  (ISO)
Nutlin-3  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
potassium cyanide  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topiramate  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Molecular cloning of a protein serine/threonine phosphatase containing a putative regulatory tetratricopeptide repeat domain. Becker W, etal., J Biol Chem 1994 Sep 9;269(36):22586-92.
2. ATM protein kinase: the linchpin of cellular defenses to stress. Bhatti S, etal., Cell Mol Life Sci. 2011 Sep;68(18):2977-3006. doi: 10.1007/s00018-011-0683-9. Epub 2011 May 2.
3. Cadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5. Chen L, etal., Free Radic Biol Med. 2008 Oct 1;45(7):1035-44. doi: 10.1016/j.freeradbiomed.2008.07.011. Epub 2008 Jul 26.
4. Hydrogen peroxide-induced neuronal apoptosis is associated with inhibition of protein phosphatase 2A and 5, leading to activation of MAPK pathway. Chen L, etal., Int J Biochem Cell Biol. 2009 Jun;41(6):1284-95. doi: 10.1016/j.biocel.2008.10.029. Epub 2008 Nov 6.
5. The tetratricopeptide repeat domain of protein phosphatase 5 mediates binding to glucocorticoid receptor heterocomplexes and acts as a dominant negative mutant. Chen MS, etal., J Biol Chem. 1996 Dec 13;271(50):32315-20.
6. Targeting of a distinctive protein-serine phosphatase to the protein kinase-like domain of the atrial natriuretic peptide receptor. Chinkers M Proc Natl Acad Sci U S A 1994 Nov 8;91(23):11075-9.
7. Identification of pseudo 'phosphothreonyl-specific' protein phosphatase T with a fraction of polycation-stimulated protein phosphatase 2A. Deana AD and Pinna LA, Biochim Biophys Acta. 1988 Feb 22;968(2):179-85.
8. Inhibition of protein serine/threonine phosphatases by fumonisin B1, a mycotoxin. Fukuda H, etal., Biochem Biophys Res Commun. 1996 Mar 7;220(1):160-5.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rac GTPase signaling through the PP5 protein phosphatase. Gentile S, etal., Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5202-6. Epub 2006 Mar 20.
11. Modulation of cardiac contractility by serine/threonine protein phosphatase type 5. Gergs U, etal., Int J Cardiol. 2012 Jan 26;154(2):116-21. doi: 10.1016/j.ijcard.2010.09.009. Epub 2010 Sep 28.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Dephosphorylation of microtubule-associated protein tau by protein phosphatase 5. Gong CX, etal., J Neurochem. 2004 Jan;88(2):298-310.
14. Protein phosphatase with EF-hand domains 2 (PPEF2) is a potent negative regulator of apoptosis signal regulating kinase-1 (ASK1). Kutuzov MA, etal., Int J Biochem Cell Biol. 2010 Nov;42(11):1816-22. doi: 10.1016/j.biocel.2010.07.014. Epub 2010 Jul 30.
15. Dephosphorylation of tau by protein phosphatase 5: impairment in Alzheimer's disease. Liu F, etal., J Biol Chem. 2005 Jan 21;280(3):1790-6. doi: 10.1074/jbc.M410775200. Epub 2004 Nov 15.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. Early postnatal lead exposure induces tau phosphorylation in the brain of young rats. Rahman A, etal., Acta Biol Hung. 2012 Dec;63(4):411-25. doi: 10.1556/ABiol.63.2012.4.1.
20. Over activation of hippocampal serine/threonine protein phosphatases PP1 and PP2A is involved in lead-induced deficits in learning and memory in young rats. Rahman A, etal., Neurotoxicology. 2012 Jun;33(3):370-83. doi: 10.1016/j.neuro.2012.02.014. Epub 2012 Mar 1.
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Cellular co-localization of protein phosphatase 5 and glucocorticoid receptors in rat brain. Rossie S, etal., Brain Res. 2006 Sep 21;1111(1):1-11. Epub 2006 Aug 8.
25. Protein phosphatase 5 protects neurons against amyloid-beta toxicity. Sanchez-Ortiz E, etal., J Neurochem. 2009 Oct;111(2):391-402. doi: 10.1111/j.1471-4159.2009.06337.x. Epub 2009 Aug 17.
26. Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death. Shinoda S, etal., Eur J Neurosci. 2003 May;17(10):2065-76.
27. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
28. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
29. Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5. von Kriegsheim A, etal., Nat Cell Biol. 2006 Sep;8(9):1011-6. Epub 2006 Aug 6.
30. Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity. Yamaguchi Y, etal., Curr Biol. 2002 Aug 6;12(15):1353-8.
31. Human blue-light photoreceptor hCRY2 specifically interacts with protein serine/threonine phosphatase 5 and modulates its activity. Zhao S and Sancar A, Photochem Photobiol. 1997 Nov;66(5):727-31.
Additional References at PubMed
PMID:12761501   PMID:12885400   PMID:15713458   PMID:15967796   PMID:16102737   PMID:19948726   PMID:21360678   PMID:21936910   PMID:23184943   PMID:29127155   PMID:30053369   PMID:30699359  
PMID:35043508   PMID:36494772  


Genomics

Comparative Map Data
Ppp5c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8186,818,297 - 86,842,505 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl186,818,297 - 86,842,950 (-)EnsemblGRCr8
mRatBN7.2177,690,203 - 77,714,507 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl177,690,208 - 77,714,456 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx183,070,376 - 83,094,770 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0191,634,443 - 91,658,837 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0184,825,481 - 84,849,875 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,944,054 - 78,968,361 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,944,040 - 78,968,329 (-)Ensemblrn6Rnor6.0
Rnor_5.0180,191,557 - 80,216,026 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4177,345,194 - 77,369,417 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera172,175,254 - 72,199,561 (-)NCBICelera
RGSC_v3.1177,423,304 - 77,447,528 (-)NCBI
Cytogenetic Map1q21NCBI
PPP5C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381946,347,087 - 46,390,975 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1946,347,003 - 46,392,981 (+)Ensemblhg38GRCh38
GRCh371946,850,344 - 46,894,232 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361951,542,134 - 51,585,945 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341951,542,133 - 51,585,943NCBI
Celera1943,655,283 - 43,699,097 (+)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1943,278,270 - 43,321,600 (+)NCBIHuRef
CHM1_11946,852,100 - 46,896,253 (+)NCBICHM1_1
T2T-CHM13v2.01949,174,533 - 49,218,356 (+)NCBIT2T-CHM13v2.0
Ppp5c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39716,738,575 - 16,761,812 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl716,738,565 - 16,761,849 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38717,004,640 - 17,027,914 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl717,004,640 - 17,027,924 (-)Ensemblmm10GRCm38
MGSCv37717,589,989 - 17,613,263 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36716,163,174 - 16,186,392 (-)NCBIMGSCv36mm8
Celera714,212,052 - 14,235,384 (-)NCBICelera
Cytogenetic Map7A2NCBI
cM Map79.15NCBI
Ppp5c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955574523,005 - 546,923 (+)Ensembl
ChiLan1.0NW_004955574523,044 - 545,461 (+)NCBIChiLan1.0ChiLan1.0
PPP5C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22052,486,530 - 52,530,347 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11954,357,856 - 54,401,469 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01943,329,680 - 43,373,282 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11951,865,317 - 51,908,486 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1951,865,317 - 51,909,027 (+)EnsemblpanPan2panpan1.1
PPP5C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11109,453,768 - 109,470,933 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1109,454,107 - 109,467,087 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1108,932,919 - 108,952,331 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01109,980,222 - 109,999,640 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1109,980,225 - 109,999,646 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11109,656,345 - 109,675,726 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01109,290,676 - 109,310,075 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01110,159,739 - 110,179,155 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
PPP5C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl652,377,979 - 52,402,045 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1652,373,266 - 52,402,048 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2647,637,025 - 47,660,516 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPP5C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1639,726,627 - 39,767,467 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl639,726,623 - 39,767,464 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607319,404,799 - 19,445,738 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp5c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248327,100,216 - 7,126,500 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248327,100,309 - 7,126,296 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppp5c
142 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:82
Count of miRNA genes:59
Interacting mature miRNAs:72
Transcripts:ENSRNOT00000023078
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat

Markers in Region
AW558946  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2177,690,573 - 77,690,698 (+)MAPPERmRatBN7.2
Rnor_6.0178,944,425 - 78,944,549NCBIRnor6.0
Rnor_5.0180,191,928 - 80,192,052UniSTSRnor5.0
RGSC_v3.4177,345,557 - 77,345,681UniSTSRGSC3.4
Celera172,175,617 - 72,175,741UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000023078   ⟹   ENSRNOP00000023078
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl186,818,297 - 86,842,950 (-)Ensembl
mRatBN7.2 Ensembl177,690,208 - 77,714,456 (-)Ensembl
Rnor_6.0 Ensembl178,944,040 - 78,968,329 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096009   ⟹   ENSRNOP00000081383
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl177,690,208 - 77,714,456 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096185   ⟹   ENSRNOP00000079064
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl186,818,297 - 86,842,532 (-)Ensembl
mRatBN7.2 Ensembl177,690,208 - 77,714,456 (-)Ensembl
RefSeq Acc Id: NM_031729   ⟹   NP_113917
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8186,818,297 - 86,842,505 (-)NCBI
mRatBN7.2177,690,211 - 77,714,419 (-)NCBI
Rnor_6.0178,944,062 - 78,968,270 (-)NCBI
Rnor_5.0180,191,557 - 80,216,026 (-)NCBI
RGSC_v3.4177,345,194 - 77,369,417 (-)RGD
Celera172,175,254 - 72,199,561 (-)RGD
Sequence:
RefSeq Acc Id: NP_113917   ⟸   NM_031729
- UniProtKB: P53042 (UniProtKB/Swiss-Prot),   A6J8F0 (UniProtKB/TrEMBL),   Q68G16 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023078   ⟸   ENSRNOT00000023078
Ensembl Acc Id: ENSRNOP00000081383   ⟸   ENSRNOT00000096009
Ensembl Acc Id: ENSRNOP00000079064   ⟸   ENSRNOT00000096185
Protein Domains
Serine/threonine specific protein phosphatases

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P53042-F1-model_v2 AlphaFold P53042 1-499 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689748
Promoter ID:EPDNEW_R272
Type:initiation region
Name:Ppp5c_1
Description:protein phosphatase 5, catalytic subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0178,968,271 - 78,968,331EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68415 AgrOrtholog
BioCyc Gene G2FUF-60578 BioCyc
Ensembl Genes ENSRNOG00000016907 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023078 ENTREZGENE
  ENSRNOT00000023078.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot
  3.60.21.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7126555 IMAGE-MGC_LOAD
InterPro Calcineurin-like_PHP_ApaH UniProtKB/Swiss-Prot
  Metallo-depent_PP-like UniProtKB/Swiss-Prot
  PP5_C UniProtKB/Swiss-Prot
  PPP_dom UniProtKB/Swiss-Prot
  PPP_phosphatase UniProtKB/Swiss-Prot
  Ser/Thr-sp_prot-phosphatase UniProtKB/Swiss-Prot
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot
  TPR_repeat UniProtKB/Swiss-Prot
KEGG Report rno:65179 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93338 IMAGE-MGC_LOAD
NCBI Gene 65179 ENTREZGENE
PANTHER PTHR45668:SF5 UniProtKB/Swiss-Prot
  SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED UniProtKB/Swiss-Prot
Pfam Metallophos UniProtKB/Swiss-Prot
  PPP5 UniProtKB/Swiss-Prot
  TPR_1 UniProtKB/Swiss-Prot
PhenoGen Ppp5c PhenoGen
PIRSF PPPtase_5 UniProtKB/Swiss-Prot
PRINTS STPHPHTASE UniProtKB/Swiss-Prot
PROSITE SER_THR_PHOSPHATASE UniProtKB/Swiss-Prot
  TPR UniProtKB/Swiss-Prot
  TPR_REGION UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016907 RatGTEx
SMART PP2Ac UniProtKB/Swiss-Prot
  TPR UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48452 UniProtKB/Swiss-Prot
  SSF56300 UniProtKB/Swiss-Prot
TIGR TC217088
UniProt A0A8I5ZM93_RAT UniProtKB/TrEMBL
  A6J8F0 ENTREZGENE, UniProtKB/TrEMBL
  A6J8F1_RAT UniProtKB/TrEMBL
  A6J8F2_RAT UniProtKB/TrEMBL
  P53042 ENTREZGENE, UniProtKB/Swiss-Prot
  Q68G16 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ppp5c  protein phosphatase 5, catalytic subunit      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference