Cd244l1 (CD244 molecule like 1) - Rat Genome Database

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Gene: Cd244l1 (CD244 molecule like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cd244l1
Name: CD244 molecule like 1
RGD ID: 68400
Description: Predicted to enable MHC class I protein binding activity. Predicted to be involved in natural killer cell activation involved in immune response. Predicted to be located in membrane raft and plasma membrane. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in rheumatoid arthritis. Orthologous to human CD244 (CD244 molecule).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2B4; Cd244; CD244 molecule; Cd244 molecule, natural killer cell receptor 2B4; CD244 natural killer cell receptor 2B4; LOC685808; natural killer cell receptor 2B4; NK cell type I receptor protein 2B4; NKR2B4; Nmrk; non MHC restricted killing associated; non-MHC restricted killing associated; similar to transmembrane NK cell receptor 2B4; transmembrane NK cell receptor 2B4
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81386,547,250 - 86,569,026 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1386,551,430 - 86,569,026 (+)EnsemblGRCr8
mRatBN7.21384,018,887 - 84,036,612 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1384,020,095 - 84,036,100 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1386,525,877 - 86,541,884 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,924,115 - 87,939,720 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01385,124,263 - 85,139,746 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1385,920,305 - 85,936,895 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1386,131,380 - 86,147,959 (+)NCBILyon_Normotensive
Lyon_Hypertensive1386,061,942 - 86,078,522 (+)NCBILyon_Hypertensive
F344_StmMcwi1386,126,493 - 86,142,680 (+)NCBIF344_StmMcwi
Rnor_6.01389,959,091 - 89,995,993 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,975,267 - 89,995,974 (+)Ensemblrn6Rnor6.0
Rnor_5.01394,596,434 - 94,618,284 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41387,513,413 - 87,531,211 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1383,694,456 - 83,704,305 (+)NCBICelera
RGSC_v3.11387,702,296 - 87,720,095 (+)NCBI
Cytogenetic Map13q24NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Molecular cloning of transmembrane and soluble forms of a novel rat natural killer cell receptor related to 2B4. Kumaresan PR, etal., Immunogenetics 2000 Apr;51(4-5):306-13.
4. Molecular characterization of the rat NK cell receptor 2B4. Kumaresan PR, etal., Mol Immunol 2000 Aug-Sep;37(12-13):735-44.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8376943   PMID:10072077   PMID:11714776   PMID:11739483   PMID:15850375   PMID:15905190   PMID:16803907   PMID:17213291   PMID:20164429   PMID:25643613  


Genomics

Variants

.
Variants in Cd244l1
110 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:339
Count of miRNA genes:197
Interacting mature miRNAs:228
Transcripts:ENSRNOT00000000053, ENSRNOT00000006266
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1383286150109350286Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137161080489333251Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137161080489333251Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137161080489333251Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_022259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001840790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF156988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF156989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000000053   ⟹   ENSRNOP00000000053
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1386,551,430 - 86,568,575 (+)Ensembl
mRatBN7.2 Ensembl1384,020,095 - 84,036,100 (+)Ensembl
Rnor_6.0 Ensembl1389,975,405 - 89,990,731 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000006266   ⟹   ENSRNOP00000006266
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1389,975,267 - 89,995,974 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000152303   ⟹   ENSRNOP00000100801
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1386,552,449 - 86,569,026 (+)Ensembl
RefSeq Acc Id: NM_022259   ⟹   NP_071595
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,552,449 - 86,569,026 (+)NCBI
mRatBN7.21384,020,035 - 84,036,612 (+)NCBI
Dahl_SR_JrHsd1385,920,305 - 85,936,895 (+)NCBI
Lyon_Normotensive1386,131,380 - 86,147,959 (+)NCBI
Lyon_Hypertensive1386,061,942 - 86,078,522 (+)NCBI
F344_StmMcwi1386,126,493 - 86,142,680 (+)NCBI
Rnor_6.01389,975,405 - 89,990,731 (+)NCBI
Rnor_5.01394,596,434 - 94,618,284 (+)NCBI
RGSC_v3.41387,513,413 - 87,531,211 (+)RGD
Sequence:
RefSeq Acc Id: XM_039091060   ⟹   XP_038946988
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,551,275 - 86,566,077 (+)NCBI
mRatBN7.21384,018,887 - 84,033,660 (+)NCBI
RefSeq Acc Id: XM_039091061   ⟹   XP_038946989
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,551,279 - 86,566,078 (+)NCBI
mRatBN7.21384,018,894 - 84,032,836 (+)NCBI
RefSeq Acc Id: XM_063272572   ⟹   XP_063128642
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,547,250 - 86,568,132 (+)NCBI
RefSeq Acc Id: XM_063272573   ⟹   XP_063128643
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,547,255 - 86,568,132 (+)NCBI
RefSeq Acc Id: XM_063272574   ⟹   XP_063128644
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,551,273 - 86,566,078 (+)NCBI
RefSeq Acc Id: XM_063272575   ⟹   XP_063128645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,551,280 - 86,566,077 (+)NCBI
RefSeq Acc Id: NP_071595   ⟸   NM_022259
- Peptide Label: precursor
- UniProtKB: Q9JLM3 (UniProtKB/Swiss-Prot),   Q9JLM2 (UniProtKB/Swiss-Prot),   F1LME3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006266   ⟸   ENSRNOT00000006266
Ensembl Acc Id: ENSRNOP00000000053   ⟸   ENSRNOT00000000053
RefSeq Acc Id: XP_038946988   ⟸   XM_039091060
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038946989   ⟸   XM_039091061
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063128642   ⟸   XM_063272572
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063128643   ⟸   XM_063272573
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063128644   ⟸   XM_063272574
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063128645   ⟸   XM_063272575
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000100801   ⟸   ENSRNOT00000152303
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JLM2-F1-model_v2 AlphaFold Q9JLM2 1-311 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699011
Promoter ID:EPDNEW_R9536
Type:initiation region
Name:Cd244_1
Description:CD244 molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01389,975,406 - 89,975,466EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68400 AgrOrtholog
BioCyc Gene G2FUF-17358 BioCyc
Ensembl Genes ENSRNOG00000004698 Ensembl
  ENSRNOG00000068754 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000152303 ENTREZGENE
Gene3D-CATH Immunoglobulins UniProtKB/Swiss-Prot
InterPro CD2/SLAM_rcpt UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  NK_rcpt_2B4_Ig_dom UniProtKB/Swiss-Prot
KEGG Report rno:64025 UniProtKB/Swiss-Prot
NCBI Gene Cd244l1 ENTREZGENE
PANTHER NATURAL KILLER CELL RECEPTOR 2B4 UniProtKB/Swiss-Prot
  SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE UniProtKB/Swiss-Prot
Pfam Receptor_2B4 UniProtKB/Swiss-Prot
PhenoGen Cd244l1 PhenoGen
RatGTEx ENSRNOG00000004698 RatGTEx
  ENSRNOG00000068754 RatGTEx
Superfamily-SCOP Immunoglobulin UniProtKB/Swiss-Prot
UniProt A0ABK0LDB6_RAT UniProtKB/TrEMBL
  CD244_RAT UniProtKB/Swiss-Prot
  F1LME3 ENTREZGENE, UniProtKB/TrEMBL
  Q9JLM2 ENTREZGENE
  Q9JLM3 ENTREZGENE
UniProt Secondary Q9JLM3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-08-11 Cd244l1  CD244 molecule like 1  Cd244  CD244 molecule  Name and Symbol changed 629549 APPROVED
2016-01-13 Cd244  CD244 molecule  Cd244  Cd244 molecule, natural killer cell receptor 2B4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-04-17 Cd244  Cd244 molecule, natural killer cell receptor 2B4  LOC685808  similar to transmembrane NK cell receptor 2B4  Data merged from RGD:1589078 737654 PROVISIONAL
2008-09-29 Cd244  Cd244 molecule, natural killer cell receptor 2B4  Cd244  CD244 natural killer cell receptor 2B4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC685808  similar to transmembrane NK cell receptor 2B4      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Cd244  CD244 natural killer cell receptor 2B4  Nmrk  non MHC restricted killing associated  Symbol and Name updated 1299863 APPROVED
2002-06-10 Nmrk  non MHC restricted killing associated      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains two Ig domains in the extracellular region and three unique tyrosine motifs (TxYxxV/I/A) in the cytoplasmic region 633332
gene_protein 395 amino acid residues 633332