Nr5a1 (nuclear receptor subfamily 5, group A, member 1) - Rat Genome Database

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Gene: Nr5a1 (nuclear receptor subfamily 5, group A, member 1) Rattus norvegicus
Analyze
Symbol: Nr5a1
Name: nuclear receptor subfamily 5, group A, member 1
RGD ID: 68350
Description: Enables DNA-binding transcription factor activity; double-stranded DNA binding activity; and sequence-specific DNA binding activity. Involved in several processes, including calcineurin-mediated signaling; positive regulation of male gonad development; and response to gonadotropin-releasing hormone. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Used to study gonadal dysgenesis. Human ortholog(s) of this gene implicated in 46,XX sex reversal 4; 46,XY sex reversal 3; Zellweger syndrome; primary ovarian insufficiency 7; and spermatogenic failure 8. Orthologous to human NR5A1 (nuclear receptor subfamily 5 group A member 1); INTERACTS WITH (S)-nicotine; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ad4bp; Ad4BP/SF-1; adrenal 4-binding protein; Ftzf1; fushi tarazu factor homolog 1; nuclear receptor subfamily 5 group A member 1; Sf-1; steroid hormone receptor Ad4BP; steroidogenic factor 1; STF-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8342,874,505 - 42,896,109 (-)NCBIGRCr8
mRatBN7.2322,464,786 - 22,486,328 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl322,465,502 - 22,486,328 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx325,933,801 - 25,954,690 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0334,518,798 - 34,539,688 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0332,331,170 - 32,351,980 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0322,998,900 - 23,020,441 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl322,999,616 - 23,020,441 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0328,223,427 - 28,244,968 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4318,498,913 - 18,519,738 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1318,395,933 - 18,412,441 (-)NCBI
Celera320,898,726 - 20,919,551 (-)NCBICelera
Cytogenetic Map3q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
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Original Reference(s)
Nr5a1Ratgonadal dysgenesis treatmentIMP 12904919 RGD 
Nr5a1RatZellweger syndrome  ISONR5A1 (Homo sapiens)11062374DNA:deletions more ...RGD 
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Nr5a1Rat46, XY Disorders of Sex Development  ISONR5A1 (Homo sapiens)8554872ClinVar Annotator: match by term: 46 and XY disorder of sex developmentClinVarPMID:17694559 more ...
Nr5a1Rat46,XX sex reversal 4  ISONR5A1 (Homo sapiens)8554872ClinVar Annotator: match by term: 46 and XX sex reversal 4ClinVarPMID:11932325 more ...
Nr5a1Rat46,XY sex reversal 3  ISONR5A1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11932325 more ...
Nr5a1Ratdisorder of sexual development  ISONR5A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Disorder of sexual differentiationClinVarPMID:25741868 more ...
Nr5a1Ratgenetic disease  ISONR5A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:28492532
Nr5a1Rathereditary breast ovarian cancer syndrome  ISONR5A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Genetic non-acquired premature ovarian failureClinVarPMID:25741868 and PMID:28492532
Nr5a1Rathereditary breast ovarian cancer syndrome  ISONR5A1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:22028768 more ...
Nr5a1Rathereditary breast ovarian cancer syndrome  ISONR5A1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:22028768 more ...
Nr5a1Ratmale infertility  ISONR5A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Male infertilityClinVarPMID:17940071 more ...
Nr5a1Ratprimary ovarian insufficiency 16  ISONR5A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Genetic non-acquired premature ovarian failureClinVarPMID:22028768 more ...
Nr5a1Ratprimary ovarian insufficiency 7  ISONR5A1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11038323 more ...
Nr5a1Ratspermatogenic failure 1  ISONR5A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Oligosynaptic infertilityClinVarPMID:10369247 more ...
Nr5a1Ratspermatogenic failure 3  ISONR5A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Non-obstructive azoospermiaClinVarPMID:18414213 more ...
Nr5a1Ratspermatogenic failure 57  ISONR5A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Male infertility with azoospermia or oligozoospermia due to single gene mutationClinVarPMID:10369247 more ...
Nr5a1Ratspermatogenic failure 8  ISONR5A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Spermatogenic failure 8ClinVarPMID:20887963 more ...
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Original Reference(s)
Nr5a1Rat46 XX gonadal dysgenesis  ISONR5A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19246354
Nr5a1Rat46, XY Disorders of Sex Development  ISONR5A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Nr5a1Rat46,XY complete gonadal dysgenesis  ISONR5A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:10369247 more ...
Nr5a1RatAdrenal Insufficiency  ISONR5A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:10369247
Nr5a1Ratendometriosis  ISONR5A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17519303
Nr5a1Ratmale infertility  ISONR5A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20887963
Nr5a1RatOvarian Neoplasms  ISONR5A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23291911
Nr5a1Ratprimary ovarian insufficiency  ISONR5A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19246354
Nr5a1Ratprimary ovarian insufficiency 7  ISONR5A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
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Nr5a1Rathypogonadotropic hypogonadism  ISSNr5a1 (Mus musculus)13592920 MouseDO 

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Nr5a1Rat(25R)-cholest-5-ene-3beta,26-diol increases activityISONR5A1 (Homo sapiens)648046427-hydroxycholesterol results in increased activity of NR5A1 proteinCTDPMID:9144161
Nr5a1Rat(25R)-cholest-5-ene-3beta,26-diol multiple interactionsISONR5A1 (Homo sapiens)648046427-hydroxycholesterol promotes the reaction [NR5A1 protein results in increased expression of STAR protein]CTDPMID:9804848
Nr5a1Rat(S)-nicotine decreases expressionISONR5A1 (Homo sapiens)6480464Nicotine results in decreased expression of NR5A1 mRNA and Nicotine results in decreased expression of NR5A1 proteinCTDPMID:24709674
Nr5a1Rat(S)-nicotine multiple interactionsISONR5A1 (Homo sapiens)6480464trichostatin A inhibits the reaction [Nicotine results in decreased expression of NR5A1 mRNA]CTDPMID:24709674
Nr5a1Rat(S)-nicotine decreases expressionEXP 6480464Nicotine results in decreased expression of NR5A1 mRNA and Nicotine results in decreased expression of NR5A1 proteinCTDPMID:24709674 and PMID:28986172
Nr5a1Rat1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane multiple interactionsEXP 64804642 more ...CTDPMID:19414516
Nr5a1Rat1,2-dimethylhydrazine decreases expressionISONr5a1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of NR5A1 mRNACTDPMID:22206623
Nr5a1Rat17alpha-ethynylestradiol multiple interactionsISONr5a1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NR5A1 mRNACTDPMID:17942748
Nr5a1Rat17beta-estradiol increases activityISONR5A1 (Homo sapiens)6480464Estradiol results in increased activity of NR5A1 proteinCTDPMID:19549922
Nr5a1Rat17beta-estradiol affects expressionISONr5a1 (Mus musculus)6480464Estradiol affects the expression of NR5A1 mRNACTDPMID:29092056
Nr5a1Rat17beta-estradiol decreases response to substanceISONR5A1 (Homo sapiens)6480464NR5A1 protein results in decreased susceptibility to EstradiolCTDPMID:20045459
Nr5a1Rat17beta-estradiol multiple interactionsISONr5a1 (Mus musculus)6480464[NR5A1 protein co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased abundance of EstradiolCTDPMID:21610156
Nr5a1Rat17beta-estradiol multiple interactionsISONR5A1 (Homo sapiens)6480464U 0126 inhibits the reaction [Estradiol results in increased activity of NR5A1 protein] and wortmannin inhibits the reaction [Estradiol results in increased activity of NR5A1 protein]CTDPMID:19549922
Nr5a1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISONr5a1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of NR5A1 mRNACTDPMID:24058054
Nr5a1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of NR5A1 mRNACTDPMID:16254025
Nr5a1Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISONr5a1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NR5A1 mRNACTDPMID:17942748
Nr5a1Rat20-hydroxycholesterol multiple interactionsISONr5a1 (Mus musculus)6480464[20-hydroxycholesterol co-treated with Tretinoin co-treated with 8-Bromo Cyclic Adenosine Monophosphate] promotes the reaction [NR5A1 protein binds to MC2R promoter] more ...CTDPMID:21610156
Nr5a1Rat22-Hydroxycholesterol multiple interactionsISONR5A1 (Homo sapiens)648046422-hydroxycholesterol promotes the reaction [NR5A1 protein results in increased expression of STAR protein]CTDPMID:9804848
Nr5a1Rat25-hydroxycholesterol increases activityISONR5A1 (Homo sapiens)648046425-hydroxycholesterol results in increased activity of NR5A1 proteinCTDPMID:9144161
Nr5a1Rat25-hydroxycholesterol multiple interactionsISONR5A1 (Homo sapiens)648046425-hydroxycholesterol promotes the reaction [NR5A1 protein results in increased expression of STAR protein]CTDPMID:9804848

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Biological Process
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Original Reference(s)
Nr5a1Ratadrenal gland development acts_upstream_of_or_withinIEAUniProtKB:P33242 and ensembl:ENSMUSP000001085041600115GO_REF:0000107EnsemblGO_REF:0000107
Nr5a1Ratadrenal gland development acts_upstream_of_or_withinISONr5a1 (Mus musculus)1624291MGI:1352460 more ...RGDPMID:11796523 more ...
Nr5a1Ratcalcineurin-mediated signaling  IMP 12904895 RGD 
Nr5a1Ratfemale gonad development  IEP 1598968 RGD 
Nr5a1Ratfemale gonad development involved_inIEAUniProtKB:Q13285 and ensembl:ENSP000003626901600115GO_REF:0000107EnsemblGO_REF:0000107
Nr5a1Ratfemale gonad development involved_inISONR5A1 (Homo sapiens)1624291 PMID:27378692RGDPMID:27378692
Nr5a1Ratfemale gonad development involved_inISSUniProtKB:Q132851600115GO_REF:0000024UniProtGO_REF:0000024
Nr5a1Rathormone metabolic process acts_upstream_of_or_withinISONr5a1 (Mus musculus)1624291MGI:5292676 PMID:21820362RGDPMID:21820362
Nr5a1Rathormone metabolic process acts_upstream_of_or_withinIEAUniProtKB:P33242 and ensembl:ENSMUSP000001085041600115GO_REF:0000107EnsemblGO_REF:0000107
Nr5a1Rathormone-mediated signaling pathway  IDA 12904895 RGD 
Nr5a1Rathormone-mediated signaling pathway involved_inIBAFB:FBgn0001078 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Nr5a1Ratintracellular receptor signaling pathway involved_inIEAGO:00048791600115GO_REF:0000108GOCGO_REF:0000108
Nr5a1RatLeydig cell differentiation acts_upstream_of_or_withinISONr5a1 (Mus musculus)1624291MGI:1352460 PMID:15829514RGDPMID:15829514
Nr5a1RatLeydig cell differentiation acts_upstream_of_or_withinIEAUniProtKB:P33242 and ensembl:ENSMUSP000001085041600115GO_REF:0000107EnsemblGO_REF:0000107
Nr5a1Ratluteinization acts_upstream_of_or_withinISONr5a1 (Mus musculus)1624291MGI:2179995 more ...RGDPMID:15118069
Nr5a1Ratluteinization acts_upstream_of_or_withinIEAUniProtKB:P33242 and ensembl:ENSMUSP000001085041600115GO_REF:0000107EnsemblGO_REF:0000107
Nr5a1Ratmaintenance of protein location in nucleus acts_upstream_of_or_withinISONr5a1 (Mus musculus)1624291 PMID:12610109RGDPMID:12610109
Nr5a1Ratmaintenance of protein location in nucleus acts_upstream_of_or_withinIEAUniProtKB:P33242 and ensembl:ENSMUSP000001085041600115GO_REF:0000107EnsemblGO_REF:0000107
Nr5a1Ratmale gonad development involved_inISSUniProtKB:Q132851600115GO_REF:0000024UniProtGO_REF:0000024
Nr5a1Ratmale gonad development acts_upstream_of_or_withinISONr5a1 (Mus musculus)1624291MGI:1306784 more ...RGDPMID:15118069 more ...
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Cellular Component
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Nr5a1Ratcytosol located_inISONR5A1 (Homo sapiens)1624291 RGDGO_REF:0000052
Nr5a1Ratcytosol located_inIEAUniProtKB:F1D8R8 and ensembl:ENSP000003626901600115GO_REF:0000107EnsemblGO_REF:0000107
Nr5a1Ratcytosol located_inIEAUniProtKB:Q13285 and ensembl:ENSP000003626901600115GO_REF:0000107EnsemblGO_REF:0000107
Nr5a1Ratnucleoplasm located_inISONR5A1 (Homo sapiens)1624291 RGDGO_REF:0000052
Nr5a1Ratnucleoplasm located_inIEAUniProtKB:F1D8R8 and ensembl:ENSP000003626901600115GO_REF:0000107EnsemblGO_REF:0000107
Nr5a1Ratnucleoplasm located_inIEAUniProtKB:Q13285 and ensembl:ENSP000003626901600115GO_REF:0000107EnsemblGO_REF:0000107
Nr5a1Ratnucleus located_inISONR5A1 (Homo sapiens)1624291 PMID:10567391 more ...RGDPMID:10567391 more ...
Nr5a1Ratnucleus located_inIEAUniProtKB:P33242 and ensembl:ENSMUSP000001085041600115GO_REF:0000107EnsemblGO_REF:0000107
Nr5a1Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Nr5a1Ratnucleus located_inIEAUniProtKB:Q13285 and ensembl:ENSP000003626901600115GO_REF:0000107EnsemblGO_REF:0000107
Nr5a1Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Nr5a1Ratnucleus located_inISONr5a1 (Mus musculus)1624291 PMID:10848616RGDPMID:10848616
Nr5a1RatRNA polymerase II transcription regulator complex part_ofISONr5a1 (Mus musculus)1624291 PMID:19389484RGDPMID:19389484
Nr5a1RatRNA polymerase II transcription regulator complex part_ofIEAUniProtKB:P33242 and ensembl:ENSMUSP000001085041600115GO_REF:0000107EnsemblGO_REF:0000107
Nr5a1RatRNA polymerase II transcription regulator complex part_ofIBAMGI:1346833 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
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Molecular Function
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Nr5a1Ratchromatin binding enablesIEAUniProtKB:P33242 and ensembl:ENSMUSP000001085041600115GO_REF:0000107EnsemblGO_REF:0000107
Nr5a1Ratchromatin binding enablesISONr5a1 (Mus musculus)1624291 PMID:16109736 and PMID:19389484RGDPMID:16109736 and PMID:19389484
Nr5a1RatDNA binding enablesISONR5A1 (Homo sapiens)1624291 PMID:10567391RGDPMID:10567391
Nr5a1RatDNA binding enablesIEAInterPro:IPR0163551600115GO_REF:0000002InterProGO_REF:0000002
Nr5a1RatDNA binding enablesIEAUniProtKB-KW:KW-02381600115GO_REF:0000043UniProtGO_REF:0000043
Nr5a1RatDNA binding enablesIEAUniProtKB:Q13285 and ensembl:ENSP000003626901600115GO_REF:0000107EnsemblGO_REF:0000107
Nr5a1RatDNA binding enablesIEAARBA:ARBA000292241600115GO_REF:0000117UniProtGO_REF:0000117
Nr5a1RatDNA-binding transcription factor activity  IMP 1624302 RGD 
Nr5a1RatDNA-binding transcription factor activity enablesIEAInterPro:IPR0016281600115GO_REF:0000002InterProGO_REF:0000002
Nr5a1RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesISONR5A1 (Homo sapiens)1624291 PMID:21412441RGDPMID:21412441
Nr5a1RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIEAUniProtKB:Q13285 and ensembl:ENSP000003626901600115GO_REF:0000107EnsemblGO_REF:0000107
Nr5a1Ratdouble-stranded DNA binding  IDA 1624302 RGD 
Nr5a1Ratenzyme binding enablesISONR5A1 (Homo sapiens)1624291UniProtKB:P52824 more ...RGDPMID:17664281
Nr5a1Ratenzyme binding enablesIEAUniProtKB:Q13285 and ensembl:ENSP000003626901600115GO_REF:0000107EnsemblGO_REF:0000107
Nr5a1Ratlipid binding enablesIEAUniProtKB-KW:KW-04461600115GO_REF:0000043UniProtGO_REF:0000043
Nr5a1Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Nr5a1Ratnuclear receptor activity  NAS 1598968 RGD 
Nr5a1Ratnuclear receptor activity enablesIEAUniProtKB:Q13285 and ensembl:ENSP000003626901600115GO_REF:0000107EnsemblGO_REF:0000107
Nr5a1Ratnuclear receptor activity enablesIEAInterPro:IPR0163551600115GO_REF:0000002InterProGO_REF:0000002
Nr5a1Ratnuclear receptor activity enablesISONR5A1 (Homo sapiens)1624291 PMID:23610160 and PMID:8205615RGDPMID:23610160 and PMID:8205615
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Reference Title
Reference Citation
1. Gonadal determination and adrenal development are regulated by the orphan nuclear receptor steroidogenic factor-1, in a dose-dependent manner. Achermann JC, etal., J Clin Endocrinol Metab. 2002 Apr;87(4):1829-33.
2. Differential expression of steroidogenic factor-1 and FTF/LRH-1 in the rodent ovary. Falender AE, etal., Endocrinology. 2003 Aug;144(8):3598-610.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Transgenic rescue of SF-1-null mice. Karpova T, etal., Ann N Y Acad Sci. 2005 Dec;1061:55-64.
6. Calcineurin and CRTC2 mediate FSH and TGFß1 upregulation of Cyp19a1 and Nr5a in ovary granulosa cells. Lai WA, etal., J Mol Endocrinol. 2014 Oct;53(2):259-70. doi: 10.1530/JME-14-0048. Epub 2014 Jul 23.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. An E box element is required for the expression of the ad4bp gene, a mammalian homologue of ftz-f1 gene, which is essential for adrenal and gonadal development. Nomura M, etal., J Biol Chem 1995 Mar 31;270(13):7453-61.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Genetic and clinical aspects of Zellweger spectrum patients with PEX1 mutations. Rosewich H, etal., J Med Genet. 2005 Sep;42(9):e58.
15. Regulation of the orphan nuclear receptor steroidogenic factor 1 by Sox proteins. Shen JH and Ingraham HA, Mol Endocrinol 2002 Mar;16(3):529-40.
16. Involvement of cyclic adenosine 5'-monophosphate response element-binding protein, steroidogenic factor 1, and Dax-1 in the regulation of gonadotropin-inducible ovarian transcription factor 1 gene expression by follicle-stimulating hormone in ovarian granulosa cells. Yazawa T, etal., Endocrinology. 2003 May;144(5):1920-30.
17. Anterior pituitary gene expression with reproductive aging in the female rat. Zheng W, etal., Biol Reprod. 2007 Jun;76(6):1091-102. Epub 2007 Mar 7.
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PMID:8395654   PMID:10369247   PMID:10446902   PMID:10567391   PMID:10848616   PMID:11071856   PMID:11796523   PMID:12610109   PMID:12651892   PMID:12730328   PMID:12732652   PMID:12861022  
PMID:14726490   PMID:14988433   PMID:15118069   PMID:15146959   PMID:15590666   PMID:15829514   PMID:16109736   PMID:16176945   PMID:16469813   PMID:17526944   PMID:17664281   PMID:17804753  
PMID:18004794   PMID:18992787   PMID:19301398   PMID:19389484   PMID:19457926   PMID:19814654   PMID:20026603   PMID:20924043   PMID:21412441   PMID:21734262   PMID:21757499   PMID:21820362  
PMID:22447829   PMID:23610160   PMID:23637637   PMID:24405868   PMID:27378692   PMID:27490115   PMID:27610946   PMID:27855412   PMID:28964809   PMID:30342431   PMID:31041823   PMID:36857632  
PMID:39024550   PMID:39094930  



Nr5a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8342,874,505 - 42,896,109 (-)NCBIGRCr8
mRatBN7.2322,464,786 - 22,486,328 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl322,465,502 - 22,486,328 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx325,933,801 - 25,954,690 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0334,518,798 - 34,539,688 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0332,331,170 - 32,351,980 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0322,998,900 - 23,020,441 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl322,999,616 - 23,020,441 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0328,223,427 - 28,244,968 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4318,498,913 - 18,519,738 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1318,395,933 - 18,412,441 (-)NCBI
Celera320,898,726 - 20,919,551 (-)NCBICelera
Cytogenetic Map3q12NCBI
NR5A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389124,481,236 - 124,507,399 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9124,481,236 - 124,507,420 (-)EnsemblGRCh38hg38GRCh38
GRCh379127,243,515 - 127,269,678 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369126,283,336 - 126,309,520 (-)NCBINCBI36Build 36hg18NCBI36
Build 349124,323,069 - 124,349,253NCBI
Celera997,890,732 - 97,916,915 (-)NCBICelera
Cytogenetic Map9q33.3NCBI
HuRef996,856,059 - 96,882,213 (-)NCBIHuRef
CHM1_19127,392,508 - 127,418,653 (-)NCBICHM1_1
T2T-CHM13v2.09136,679,465 - 136,705,624 (-)NCBIT2T-CHM13v2.0
Nr5a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39238,582,668 - 38,604,554 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl238,582,668 - 38,604,554 (-)EnsemblGRCm39 Ensembl
GRCm38238,692,656 - 38,714,542 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl238,692,656 - 38,714,542 (-)EnsemblGRCm38mm10GRCm38
MGSCv37238,548,180 - 38,570,062 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36238,514,636 - 38,536,512 (-)NCBIMGSCv36mm8
Celera240,416,849 - 40,438,726 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map224.42NCBI
Nr5a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554193,632,220 - 3,654,375 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554193,632,248 - 3,654,367 (+)NCBIChiLan1.0ChiLan1.0
NR5A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21114,852,025 - 14,874,137 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1914,854,371 - 14,875,019 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0995,605,282 - 95,628,773 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19124,122,968 - 124,149,292 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9124,122,968 - 124,149,292 (-)Ensemblpanpan1.1panPan2
Nr5a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947192,970,909 - 193,007,215 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648712,739,439 - 12,763,734 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648712,739,445 - 12,763,729 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR5A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1265,284,493 - 265,311,417 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11265,284,491 - 265,311,547 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21299,123,683 - 299,135,326 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1q210-q211NCBI
NR5A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11213,640,453 - 13,666,748 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1213,640,473 - 13,666,863 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660792,411,630 - 2,438,042 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nr5a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476010,605,877 - 10,626,386 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476010,603,504 - 10,626,259 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Nr5a1
89 total Variants

Predicted Target Of
Summary Value
Count of predictions:311
Count of miRNA genes:182
Interacting mature miRNAs:219
Transcripts:ENSRNOT00000017651
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 37 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)31737470335528639Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)31043430624512004Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat

1 to 10 of 37 rows
PMC140651P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2322,480,005 - 22,480,126 (+)MAPPERmRatBN7.2
Rnor_6.0323,014,119 - 23,014,239NCBIRnor6.0
Rnor_5.0328,238,646 - 28,238,766UniSTSRnor5.0
RGSC_v3.4318,513,416 - 18,513,536UniSTSRGSC3.4
Celera320,913,229 - 20,913,349UniSTS
Cytogenetic Map3q11UniSTS
RH132410  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2322,464,929 - 22,465,134 (+)MAPPERmRatBN7.2
Rnor_6.0322,999,044 - 22,999,248NCBIRnor6.0
Rnor_5.0328,223,571 - 28,223,775UniSTSRnor5.0
RGSC_v3.4318,498,341 - 18,498,545UniSTSRGSC3.4
Celera320,898,154 - 20,898,358UniSTS
RH 3.4 Map3213.12UniSTS
Cytogenetic Map3q11UniSTS
UniSTS:464684  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2322,466,078 - 22,466,196 (+)MAPPERmRatBN7.2
Rnor_6.0323,000,192 - 23,000,309NCBIRnor6.0
Rnor_5.0328,224,719 - 28,224,836UniSTSRnor5.0
RGSC_v3.4318,499,489 - 18,499,606UniSTSRGSC3.4
Celera320,899,302 - 20,899,419UniSTS
Cytogenetic Map3q11UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 11 13 100 50 47 21 23 21 6 116 59 80 22 59 26



Ensembl Acc Id: ENSRNOT00000017651   ⟹   ENSRNOP00000017651
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl322,465,502 - 22,486,328 (-)Ensembl
Rnor_6.0 Ensembl322,999,616 - 23,020,441 (-)Ensembl
RefSeq Acc Id: NM_001191099   ⟹   NP_001178028
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8342,875,221 - 42,896,046 (-)NCBI
mRatBN7.2322,465,502 - 22,486,328 (-)NCBI
Rnor_6.0322,999,616 - 23,020,441 (-)NCBI
Rnor_5.0328,223,427 - 28,244,968 (-)NCBI
Celera320,898,726 - 20,919,551 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063284685   ⟹   XP_063140755
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8342,874,505 - 42,896,109 (-)NCBI
RefSeq Acc Id: XM_063284686   ⟹   XP_063140756
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8342,874,505 - 42,893,664 (-)NCBI
RefSeq Acc Id: XM_063284687   ⟹   XP_063140757
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8342,874,505 - 42,893,644 (-)NCBI
RefSeq Acc Id: NP_001178028   ⟸   NM_001191099
- UniProtKB: P50569 (UniProtKB/Swiss-Prot),   A6JEU9 (UniProtKB/TrEMBL),   A6JEU8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017651   ⟸   ENSRNOT00000017651
RefSeq Acc Id: XP_063140755   ⟸   XM_063284685
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063140756   ⟸   XM_063284686
- Peptide Label: isoform X1
- UniProtKB: A6JEU8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140757   ⟸   XM_063284687
- Peptide Label: isoform X2
NR LBD   Nuclear receptor

Name Modeler Protein Id AA Range Protein Structure
AF-P50569-F1-model_v2 AlphaFold P50569 1-462 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 33 of 33 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-49906 BioCyc
Ensembl Genes ENSRNOG00000012682 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000017651 ENTREZGENE
  ENSRNOT00000017651.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot
  3.30.50.10 UniProtKB/Swiss-Prot
InterPro NHR-like_dom_sf UniProtKB/Swiss-Prot
  NR5_fam UniProtKB/Swiss-Prot
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot
  Znf_NHR/GATA UniProtKB/Swiss-Prot
KEGG Report rno:83826 UniProtKB/Swiss-Prot
NCBI Gene 83826 ENTREZGENE
PANTHER PTHR24086 UniProtKB/Swiss-Prot
  STEROIDOGENIC FACTOR 1 UniProtKB/Swiss-Prot
Pfam Hormone_recep UniProtKB/Swiss-Prot
  zf-C4 UniProtKB/Swiss-Prot
PhenoGen Nr5a1 PhenoGen
PIRSF Nuc_orph_FTZ-F1 UniProtKB/Swiss-Prot
PRINTS STRDHORMONER UniProtKB/Swiss-Prot
  STROIDFINGER UniProtKB/Swiss-Prot
PROSITE NR_LBD UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012682 RatGTEx
SMART HOLI UniProtKB/Swiss-Prot
  ZnF_C4 UniProtKB/Swiss-Prot
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot
  SSF48508 UniProtKB/Swiss-Prot
UniProt A6JEU8 ENTREZGENE, UniProtKB/TrEMBL
  A6JEU9 ENTREZGENE, UniProtKB/TrEMBL
  P50569 ENTREZGENE, UniProtKB/Swiss-Prot
1 to 33 of 33 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Nr5a1  nuclear receptor subfamily 5, group A, member 1      Name updated 70584 APPROVED

Note Type Note Reference
gene_regulation expression is transcriptionally regulated through an E box element 68249