Serpina3a (serine (or cysteine) peptidase inhibitor, clade A, member 3A) - Rat Genome Database

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Gene: Serpina3a (serine (or cysteine) peptidase inhibitor, clade A, member 3A) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Serpina3a
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3A
RGD ID: 6502633
Description: Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; cystic fibrosis; and vasculitis. Orthologous to human SERPINA3 (serpin family A member 3); INTERACTS WITH bisphenol A.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC100909605; LOC299279; RGD1565462; serine protease inhibitor A3F; serine protease inhibitor A3F-like; similar to BC049975 protein
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86128,940,900 - 128,947,378 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6128,940,886 - 128,947,547 (+)EnsemblGRCr8
mRatBN7.26123,176,131 - 123,183,731 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6123,176,204 - 123,182,617 (+)EnsemblmRatBN7.2
mRatBN7.2 Ensembl6123,323,629 - 123,332,433 (+)EnsemblmRatBN7.2
Rnor_6.06129,052,476 - 129,060,050 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6127,927,650 - 127,934,162 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl6129,052,503 - 129,059,050 (+)Ensemblrn6Rnor6.0
Rnor_5.06138,250,485 - 138,254,234 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46128,312,593 - 128,318,437 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6120,656,240 - 120,663,674 (+)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
bisphenol A  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Serpina3a
76 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
8 3 31 29 31 19 2 19 12 42 10 1 19 5 31 12 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000014073   ⟹   ENSRNOP00000014073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6129,088,401 - 129,097,415 (+)Ensembl
mRatBN7.2 Ensembl6123,323,629 - 123,332,433 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000044152   ⟹   ENSRNOP00000050666
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl6129,052,503 - 129,059,050 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000057271   ⟹   ENSRNOP00000054092
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6128,940,886 - 128,947,547 (+)Ensembl
mRatBN7.2 Ensembl6123,176,204 - 123,182,617 (+)Ensembl
Rnor_6.0 Ensembl6127,927,650 - 127,934,162 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077517   ⟹   ENSRNOP00000075693
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6129,088,398 - 129,095,277 (+)Ensembl
mRatBN7.2 Ensembl6123,325,269 - 123,330,508 (+)Ensembl
RefSeq Acc Id: XM_006240519   ⟹   XP_006240581
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86128,940,900 - 128,947,378 (+)NCBI
mRatBN7.26123,176,131 - 123,183,731 (+)NCBI
Rnor_6.06129,052,476 - 129,060,050 (+)NCBI
Rnor_5.06138,250,485 - 138,254,234 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_006240581 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000054092
  ENSRNOP00000054092.4
  ENSRNOP00000075693.3
RefSeq Acc Id: XP_006240581   ⟸   XM_006240519
- UniProtKB: F1M8F5 (UniProtKB/TrEMBL),   F1LVP4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000050666   ⟸   ENSRNOT00000044152
Ensembl Acc Id: ENSRNOP00000054092   ⟸   ENSRNOT00000057271
Ensembl Acc Id: ENSRNOP00000014073   ⟸   ENSRNOT00000014073
Ensembl Acc Id: ENSRNOP00000075693   ⟸   ENSRNOT00000077517
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M8F5-F1-model_v2 AlphaFold F1M8F5 1-410 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694812
Promoter ID:EPDNEW_R5335
Type:single initiation site
Name:LOC100909605_1
Description:serine protease inhibitor A3F-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06129,052,492 - 129,052,552EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:6502633 AgrOrtholog
BioCyc Gene G2FUF-36388 BioCyc
Ensembl Genes ENSRNOG00000029949 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000048191 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000057271 ENTREZGENE
  ENSRNOT00000057271.6 UniProtKB/TrEMBL
  ENSRNOT00000077517.3 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/TrEMBL
InterPro Protease_inhib_I4_serpin_CS UniProtKB/TrEMBL
  Serpin_dom UniProtKB/TrEMBL
  Serpin_fam UniProtKB/TrEMBL
  Serpin_sf UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/TrEMBL
KEGG Report rno:100909605 UniProtKB/TrEMBL
NCBI Gene LOC100909605 ENTREZGENE
PANTHER ALPHA-1-ANTICHYMOTRYPSIN UniProtKB/TrEMBL
  PTHR11461 UniProtKB/TrEMBL
Pfam Serpin UniProtKB/TrEMBL
PhenoGen Serpina3a PhenoGen
PROSITE SERPIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029949 RatGTEx
  ENSRNOG00000048191 RatGTEx
SMART SERPIN UniProtKB/TrEMBL
Superfamily-SCOP Prot_inh_serpin UniProtKB/TrEMBL
UniProt A0A0G2KB85_RAT UniProtKB/TrEMBL
  F1LVP4 ENTREZGENE
  F1M8F5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1LVP4 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-11-05 Serpina3a  serine (or cysteine) peptidase inhibitor, clade A, member 3A  LOC100909605  serine protease inhibitor A3F-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2021-03-09 LOC100909605  serine protease inhibitor A3F-like  RGD1565462  similar to BC049975 protein  Data merged from RGD:1565462 737654 PROVISIONAL
2012-07-05 LOC100909605  serine protease inhibitor A3F-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 RGD1565462  similar to BC049975 protein   RGD1565462_predicted  similar to BC049975 protein (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1565462_predicted  similar to BC049975 protein (predicted)  LOC299279  similar to BC049975 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC299279  similar to BC049975 protein      Symbol and Name status set to provisional 70820 PROVISIONAL