Cyp2j3 (cytochrome P450, family 2, subfamily j, polypeptide 3) - Rat Genome Database

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Gene: Cyp2j3 (cytochrome P450, family 2, subfamily j, polypeptide 3) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cyp2j3 (Ensembl: Cyp2j9)
Name: cytochrome P450, family 2, subfamily j, polypeptide 3 (Ensembl:cytochrome P450, family 2, subfamily j, polypeptide 9)
RGD ID: 631442
Description: Predicted to enable heme binding activity and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Predicted to be involved in organic acid metabolic process and xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in hypertension; myocardial infarction; pulmonary hypertension; renal fibrosis; and renal hypertension. Orthologous to human CYP2J2 (cytochrome P450 family 2 subfamily J member 2); PARTICIPATES IN arachidonic acid metabolic pathway; linoleic acid metabolic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cyp2j9; CYPIIJ3; cytochrome P450 2J3; cytochrome P450 monooxygenase; cytochrome P450, 2j9; cytochrome P450, family 2, subfamily j, polypeptide 9
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85116,335,755 - 116,360,677 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5116,335,755 - 116,360,499 (-)EnsemblGRCr8
mRatBN7.25111,219,921 - 111,244,987 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5111,178,703 - 111,244,794 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5113,788,271 - 113,812,954 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05115,513,647 - 115,538,330 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05115,576,173 - 115,600,856 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd5116,263,655 - 116,288,409 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive5118,110,263 - 118,135,015 (-)NCBILyon_Normotensive
Lyon_Hypertensive5117,285,547 - 117,310,303 (-)NCBILyon_Hypertensive
F344_StmMcwi5110,980,138 - 111,004,860 (-)NCBIF344_StmMcwi
Rnor_6.05115,196,982 - 115,222,084 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05119,143,620 - 119,167,902 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45116,744,337 - 116,766,822 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5109,810,413 - 109,834,833 (-)NCBICelera
RGSC_v3.15116,749,562 - 116,772,048 (-)NCBI
Cytogenetic Map5q33NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Molecular cloning, expression, and functional significance of a cytochrome P450 highly expressed in rat heart myocytes. Wu S, etal., J Biol Chem 1997 May 9;272(19):12551-9.
Additional References at PubMed
PMID:8889548   PMID:12477932   PMID:15026419   PMID:20068141   PMID:21105892   PMID:22189162   PMID:22717287   PMID:22885143   PMID:23515292   PMID:28237619   PMID:31271766   PMID:32707261  


Genomics

Variants

.
Variants in Cyp2j3
183 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)573779642118779642Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)584630798129630798Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
1298077Bp157Blood pressure QTL 157arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5114474223121056531Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)584630798129630798Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
1582212Livw2Liver weight QTL 23.50.0004liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)5104018576124314782Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)592583776137583776Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)598972960143972960Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
7394708Emca11Estrogen-induced mammary cancer QTL 11mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)573176602118176602Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584630798129630798Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)594034903139034903Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)595062526133270832Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
1600362Mcs19Mammary carcinoma susceptibility QTL 192.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)582032155127032155Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)589369373134369373Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)570969494136328156Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)597492524133270832Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)573779642118779642Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)592881678137881678Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)595062526133270832Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
RH132385  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25111,220,079 - 111,220,268 (+)MAPPERmRatBN7.2
Rnor_6.05115,197,017 - 115,197,205NCBIRnor6.0
Rnor_5.05119,143,655 - 119,143,843UniSTSRnor5.0
RGSC_v3.45116,742,474 - 116,742,662UniSTSRGSC3.4
Celera5109,810,448 - 109,810,636UniSTS
RH 3.4 Map5785.8UniSTS
Cytogenetic Map5q33UniSTS
AI145952  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25111,222,023 - 111,222,208 (+)MAPPERmRatBN7.2
Rnor_6.05115,198,961 - 115,199,145NCBIRnor6.0
Rnor_5.05119,145,599 - 119,145,783UniSTSRnor5.0
RGSC_v3.45116,744,418 - 116,744,602UniSTSRGSC3.4
Celera5109,812,392 - 109,812,576UniSTS
RH 3.4 Map5785.5UniSTS
Cytogenetic Map5q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 38 51 117 79 11 37 31 32 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000012503   ⟹   ENSRNOP00000012503
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5111,178,703 - 111,244,794 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000012977   ⟹   ENSRNOP00000012977
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5116,295,694 - 116,323,042 (-)Ensembl
mRatBN7.2 Ensembl5111,179,984 - 111,207,332 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000058163   ⟹   ENSRNOP00000054968
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5116,335,755 - 116,360,499 (-)Ensembl
mRatBN7.2 Ensembl5111,220,049 - 111,244,789 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079786   ⟹   ENSRNOP00000074827
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5111,179,984 - 111,198,902 (-)Ensembl
RefSeq Acc Id: NM_175766   ⟹   NP_786942
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85116,335,755 - 116,360,499 (-)NCBI
mRatBN7.25111,220,045 - 111,244,789 (-)NCBI
Dahl_SR_JrHsd5116,263,655 - 116,288,409 (-)NCBI
Lyon_Normotensive5118,110,263 - 118,135,015 (-)NCBI
Lyon_Hypertensive5117,285,547 - 117,310,303 (-)NCBI
F344_StmMcwi5110,980,138 - 111,004,860 (-)NCBI
Rnor_6.05115,196,982 - 115,222,084 (-)NCBI
Rnor_5.05119,143,620 - 119,167,902 (-)NCBI
RGSC_v3.45116,744,337 - 116,766,822 (-)RGD
Celera5109,810,413 - 109,834,833 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039109901   ⟹   XP_038965829
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85116,335,755 - 116,360,418 (-)NCBI
mRatBN7.25111,219,921 - 111,244,708 (-)NCBI
RefSeq Acc Id: XR_005504441
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85116,338,063 - 116,360,677 (-)NCBI
mRatBN7.25111,221,894 - 111,244,786 (-)NCBI
Protein Sequences
Protein RefSeqs NP_786942 (Get FASTA)   NCBI Sequence Viewer  
  XP_038965829 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB48545 (Get FASTA)   NCBI Sequence Viewer  
  AAH89766 (Get FASTA)   NCBI Sequence Viewer  
  EDL97784 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000054968
  ENSRNOP00000054968.4
GenBank Protein P51590 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_786942   ⟸   NM_175766
- UniProtKB: Q5EBD7 (UniProtKB/Swiss-Prot),   P51590 (UniProtKB/Swiss-Prot),   A6JRJ0 (UniProtKB/TrEMBL),   F1M032 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038965829   ⟸   XM_039109901
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000074827   ⟸   ENSRNOT00000079786
Ensembl Acc Id: ENSRNOP00000012503   ⟸   ENSRNOT00000012503
Ensembl Acc Id: ENSRNOP00000054968   ⟸   ENSRNOT00000058163
Ensembl Acc Id: ENSRNOP00000012977   ⟸   ENSRNOT00000012977

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51590-F1-model_v2 AlphaFold P51590 1-502 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631442 AgrOrtholog
BioCyc Gene G2FUF-40623 BioCyc
Ensembl Genes ENSRNOG00000031004 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00000077186 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000058163 ENTREZGENE
  ENSRNOT00000058163.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7368342 IMAGE-MGC_LOAD
InterPro Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I_CYP2J-like UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
  Cytochrome_P450_fam2 UniProtKB/Swiss-Prot
KEGG Report rno:313375 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108550 IMAGE-MGC_LOAD
NCBI Gene 313375 ENTREZGENE
PANTHER CYTOCHROME P450 508A4-RELATED UniProtKB/Swiss-Prot
  CYTOCHROME P450 CYP2J9-RELATED UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PhenoGen Cyp2j3 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot
  EP450ICYP2J UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000031004 RatGTEx
  ENSRNOG00000077186 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt A6JRJ0 ENTREZGENE, UniProtKB/TrEMBL
  CP2J3_RAT UniProtKB/Swiss-Prot
  F1M032 ENTREZGENE, UniProtKB/TrEMBL
  P51590 ENTREZGENE
  Q5EBD7 ENTREZGENE
UniProt Secondary Q5EBD7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-07-06 Cyp2j3  cytochrome P450, family 2, subfamily j, polypeptide 3  Cyp2j9  cytochrome P450, family 2, subfamily j, polypeptide 9  Name updated 1299863 APPROVED
2004-09-10 Cyp2j9  cytochrome P450, family 2, subfamily j, polypeptide 9  Cyp2J3  cytochrome P450 monooxygenase  Symbol and Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function metabolized arachidonic acid to 14,15-, 11,12-, and 8, 9-epoxyeicosatrienoic acids and 19-hydroxyeicosatetraenoic acid as the principal reaction products 1299362
gene_process important for oxidation of endogenous arachidonic acid pools in rat heart myocytes 1299362