Arfgef2 (ADP ribosylation factor guanine nucleotide exchange factor 2) - Rat Genome Database

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Gene: Arfgef2 (ADP ribosylation factor guanine nucleotide exchange factor 2) Rattus norvegicus
Analyze
Symbol: Arfgef2
Name: ADP ribosylation factor guanine nucleotide exchange factor 2
RGD ID: 631430
Description: Enables GABA receptor binding activity and myosin binding activity. Involved in exocytosis. Located in several cellular components, including axonemal microtubule; symmetric synapse; and trans-Golgi network. Is active in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and postsynapse. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human ARFGEF2 (ADP ribosylation factor guanine nucleotide exchange factor 2); INTERACTS WITH 17beta-estradiol; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited); Big2; brefeldin A-inhibited GEP 2; Brefeldin A-inhibited guanine nucleotide-exchange factor 2; brefeldin A-inhibited guanine nucleotide-exchange protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83175,966,575 - 176,052,715 (+)NCBIGRCr8
mRatBN7.23155,547,504 - 155,633,652 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3155,547,538 - 155,630,856 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3159,349,002 - 159,432,363 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03167,847,962 - 167,931,337 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03165,589,667 - 165,673,033 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03163,570,435 - 163,656,612 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3163,570,532 - 163,656,626 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03169,732,829 - 169,817,296 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43157,967,942 - 158,051,359 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13157,873,977 - 157,957,394 (+)NCBI
Celera3154,129,988 - 154,212,427 (+)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The brefeldin A-inhibited GDP/GTP exchange factor 2, a protein involved in vesicular trafficking, interacts with the beta subunits of the GABA receptors. Charych EI, etal., J Neurochem 2004 Jul;90(1):173-89.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity. Saeki N, etal., J Biol Chem. 2005 Mar 18;280(11):10128-34. Epub 2005 Jan 11.
9. Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex. Sheen VL, etal., Nat Genet 2004 Jan;36(1):69-76. Epub 2003 Nov 30.
10. Dominant-negative mutant of BIG2, an ARF-guanine nucleotide exchange factor, specifically affects membrane trafficking from the trans-Golgi network through inhibiting membrane association of AP-1 and GGA coat proteins. Shinotsuka C, etal., Biochem Biophys Res Commun 2002 Jun 7;294(2):254-60.
11. Localization of large ADP-ribosylation factor-guanine nucleotide exchange factors to different Golgi compartments: evidence for distinct functions in protein traffic. Zhao X, etal., Mol Biol Cell. 2002 Jan;13(1):119-33.
Additional References at PubMed
PMID:10212200   PMID:10716990   PMID:12571360   PMID:15385626   PMID:15705715   PMID:16477018   PMID:17276987   PMID:19946888   PMID:20360857  


Genomics

Comparative Map Data
Arfgef2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83175,966,575 - 176,052,715 (+)NCBIGRCr8
mRatBN7.23155,547,504 - 155,633,652 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3155,547,538 - 155,630,856 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3159,349,002 - 159,432,363 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03167,847,962 - 167,931,337 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03165,589,667 - 165,673,033 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03163,570,435 - 163,656,612 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3163,570,532 - 163,656,626 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03169,732,829 - 169,817,296 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43157,967,942 - 158,051,359 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13157,873,977 - 157,957,394 (+)NCBI
Celera3154,129,988 - 154,212,427 (+)NCBICelera
Cytogenetic Map3q42NCBI
ARFGEF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382048,921,711 - 49,036,693 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2048,921,711 - 49,036,693 (+)EnsemblGRCh38hg38GRCh38
GRCh372047,538,248 - 47,653,230 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362046,971,682 - 47,086,637 (+)NCBINCBI36Build 36hg18NCBI36
Build 342046,971,833 - 47,083,645NCBI
Celera2044,242,891 - 44,357,843 (+)NCBICelera
Cytogenetic Map20q13.13NCBI
HuRef2044,289,793 - 44,403,088 (+)NCBIHuRef
CHM1_12047,442,300 - 47,557,463 (+)NCBICHM1_1
T2T-CHM13v2.02050,690,875 - 50,806,194 (+)NCBIT2T-CHM13v2.0
Arfgef2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392166,647,371 - 166,739,972 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2166,647,508 - 166,739,972 (+)EnsemblGRCm39 Ensembl
GRCm382166,805,451 - 166,898,052 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2166,805,588 - 166,898,052 (+)EnsemblGRCm38mm10GRCm38
MGSCv372166,631,081 - 166,723,552 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362166,496,769 - 166,589,258 (+)NCBIMGSCv36mm8
Celera2172,745,033 - 172,837,457 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map287.22NCBI
Arfgef2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554459,070,234 - 9,153,213 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554459,069,803 - 9,153,746 (-)NCBIChiLan1.0ChiLan1.0
ARFGEF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22154,664,735 - 54,779,786 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12054,657,833 - 54,771,872 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02045,262,330 - 45,376,237 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12046,330,174 - 46,442,518 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2046,327,753 - 46,442,518 (+)Ensemblpanpan1.1panPan2
ARFGEF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12435,648,650 - 35,744,815 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2435,648,431 - 35,744,584 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2434,891,532 - 34,987,633 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02436,353,676 - 36,449,469 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2436,353,566 - 36,449,240 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12435,595,002 - 35,690,750 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02435,728,513 - 35,824,458 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02436,269,736 - 36,365,697 (+)NCBIUU_Cfam_GSD_1.0
Arfgef2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640189,719,109 - 189,809,174 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365145,172,584 - 5,262,836 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365145,172,752 - 5,262,823 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARFGEF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1750,631,092 - 50,732,243 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11750,631,844 - 50,732,253 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21756,982,797 - 57,082,784 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARFGEF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1214,947,347 - 15,058,217 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl214,947,351 - 15,030,772 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605063,449,416 - 63,561,858 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arfgef2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247906,290,881 - 6,381,461 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247906,290,021 - 6,381,492 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Arfgef2
356 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:64
Count of miRNA genes:57
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000010054
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141339236155617360Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3145925360166177555Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3145925360166177555Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3145925360166177555Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3145925360166177555Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3145925360166177555Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3145925360166177555Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145925360166177555Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145956084157309487Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3145956084161299569Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3149040888168026850Rat

Markers in Region
D3Mgh2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23155,617,360 - 155,617,519 (+)MAPPERmRatBN7.2
Rnor_6.03163,640,325 - 163,640,485NCBIRnor6.0
Rnor_5.03169,801,009 - 169,801,169UniSTSRnor5.0
RGSC_v3.43158,037,866 - 158,038,027RGDRGSC3.4
RGSC_v3.43158,037,867 - 158,038,027UniSTSRGSC3.4
RGSC_v3.13157,943,902 - 157,944,063RGD
Celera3154,198,939 - 154,199,099UniSTS
RH 3.4 Map31442.5UniSTS
RH 3.4 Map31442.5RGD
SHRSP x BN Map377.7599UniSTS
SHRSP x BN Map377.7599RGD
Cytogenetic Map3q42UniSTS
AU046990  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23155,553,925 - 155,554,202 (+)MAPPERmRatBN7.2
Rnor_6.03163,577,270 - 163,577,551NCBIRnor6.0
Rnor_5.03169,739,656 - 169,739,937UniSTSRnor5.0
RGSC_v3.43157,974,169 - 157,974,445UniSTSRGSC3.4
Celera3154,136,226 - 154,136,502UniSTS
Cytogenetic Map3q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 30 45 29 19 29 74 35 41 11
Low 13 12 12 12 8 11 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000010054   ⟹   ENSRNOP00000010054
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3155,547,538 - 155,630,856 (+)Ensembl
Rnor_6.0 Ensembl3163,570,532 - 163,656,626 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103177   ⟹   ENSRNOP00000096461
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3155,547,538 - 155,630,856 (+)Ensembl
RefSeq Acc Id: NM_181083   ⟹   NP_851597
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83175,966,769 - 176,049,920 (+)NCBI
mRatBN7.23155,547,699 - 155,630,857 (+)NCBI
Rnor_6.03163,570,622 - 163,653,817 (+)NCBI
Rnor_5.03169,732,829 - 169,817,296 (+)NCBI
RGSC_v3.43157,967,942 - 158,051,359 (+)RGD
Celera3154,129,988 - 154,212,427 (+)RGD
Sequence:
RefSeq Acc Id: XM_006235640   ⟹   XP_006235702
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83175,966,575 - 176,052,715 (+)NCBI
mRatBN7.23155,547,504 - 155,633,652 (+)NCBI
Rnor_6.03163,570,435 - 163,656,612 (+)NCBI
Rnor_5.03169,732,829 - 169,817,296 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063283411   ⟹   XP_063139481
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83175,966,575 - 176,034,412 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_851597   ⟸   NM_181083
- UniProtKB: Q7TSU1 (UniProtKB/Swiss-Prot),   A6JXH9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235702   ⟸   XM_006235640
- Peptide Label: isoform X1
- UniProtKB: A6JXH9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000010054   ⟸   ENSRNOT00000010054
RefSeq Acc Id: ENSRNOP00000096461   ⟸   ENSRNOT00000103177
RefSeq Acc Id: XP_063139481   ⟸   XM_063283411
- Peptide Label: isoform X2
Protein Domains
SEC7

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TSU1-F1-model_v2 AlphaFold Q7TSU1 1-1791 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692685
Promoter ID:EPDNEW_R3210
Type:multiple initiation site
Name:Arfgef2_1
Description:ADP ribosylation factor guanine nucleotide exchange factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03163,570,461 - 163,570,521EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631430 AgrOrtholog
BioCyc Gene G2FUF-46762 BioCyc
Ensembl Genes ENSRNOG00000007485 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055004109 UniProtKB/Swiss-Prot
  ENSRNOG00060001020 UniProtKB/Swiss-Prot
  ENSRNOG00065012343 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010054 ENTREZGENE
  ENSRNOT00000010054.6 UniProtKB/Swiss-Prot
  ENSRNOT00000103177.1 UniProtKB/TrEMBL
  ENSRNOT00055006573 UniProtKB/Swiss-Prot
  ENSRNOT00060001383 UniProtKB/Swiss-Prot
  ENSRNOT00065020101 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.1000.11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.220.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.25.10.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DCB_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec7/BIG1-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec7_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec7_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec7_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec7_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec7_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:296380 UniProtKB/Swiss-Prot
NCBI Gene 296380 ENTREZGENE
PANTHER BREFELDIN A-INHIBITED GUANINE NUCLEOTIDE-EXCHANGE PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GUANYL-NUCLEOTIDE EXCHANGE FACTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BIG2_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DCB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF1981 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec7_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Arfgef2 PhenoGen
PROSITE SEC7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007485 RatGTEx
  ENSRNOG00055004109 RatGTEx
  ENSRNOG00060001020 RatGTEx
  ENSRNOG00065012343 RatGTEx
SMART Sec7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48425 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AV44_RAT UniProtKB/TrEMBL
  A6JXH9 ENTREZGENE, UniProtKB/TrEMBL
  A6JXI0_RAT UniProtKB/TrEMBL
  BIG2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Arfgef2  ADP ribosylation factor guanine nucleotide exchange factor 2  Arfgef2  ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Arfgef2  ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)      Symbol and Name status set to approved 1299863 APPROVED