Ctsr (cathepsin R) - Rat Genome Database

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Gene: Ctsr (cathepsin R) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ctsr
Name: cathepsin R
RGD ID: 631422
Description: Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be active in extracellular space and lysosome. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to human CTSL (cathepsin L); INTERACTS WITH ammonium chloride; bisphenol A; copper atom.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cathepsin 6; Cts6; MGC114553
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8173,527,990 - 3,536,753 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl173,527,990 - 3,536,746 (+)EnsemblGRCr8
mRatBN7.2173,522,365 - 3,531,128 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl173,522,365 - 3,531,121 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx173,541,865 - 3,550,628 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0175,083,541 - 5,092,304 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0173,538,334 - 3,547,097 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0173,885,684 - 3,894,447 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl173,885,684 - 3,894,440 (+)Ensemblrn6Rnor6.0
Rnor_5.0176,105,023 - 6,114,060 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4179,235,486 - 9,244,251 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera173,652,461 - 3,660,952 (+)NCBICelera
RGSC_v3.1179,235,485 - 9,244,249 (+)NCBI
Cytogenetic Map17p14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Characterization of mouse cathepsin R, a new member of a family of placentally expressed cysteine proteases. Sol-Church K, etal., Biochim Biophys Acta 2000 Jul 24;1492(2-3):488-92.
Additional References at PubMed
PMID:12477932  


Genomics

Variants

.
Variants in Ctsr
14 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:22
Count of miRNA genes:22
Interacting mature miRNAs:22
Transcripts:ENSRNOT00000024115
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131706603Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17212084322087569Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17121499218Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
1549900Iddm20Insulin dependent diabetes mellitus QTL 203.7pancreas integrity trait (VT:0010560)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)17122181410Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122877318Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat

Markers in Region
RH135005  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17p14UniSTS


Expression

RNA-SEQ Expression

ectoderm
endocrine system
endoderm
exocrine system
hepatobiliary system
mesenchyme
nervous system
reproductive system
9 1 1 1 1 1 9 21

Sequence


Ensembl Acc Id: ENSRNOT00000024115   ⟹   ENSRNOP00000024115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl173,527,990 - 3,536,746 (+)Ensembl
mRatBN7.2 Ensembl173,522,365 - 3,531,121 (+)Ensembl
Rnor_6.0 Ensembl173,885,684 - 3,894,440 (+)Ensembl
RefSeq Acc Id: NM_175581   ⟹   NP_783171
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8173,527,990 - 3,536,753 (+)NCBI
mRatBN7.2173,522,365 - 3,531,128 (+)NCBI
Rnor_6.0173,885,684 - 3,894,447 (+)NCBI
Rnor_5.0176,105,023 - 6,114,060 (+)NCBI
RGSC_v3.4179,235,486 - 9,244,251 (+)RGD
Celera173,652,461 - 3,660,952 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_783171 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH97484 (Get FASTA)   NCBI Sequence Viewer  
  AAO27843 (Get FASTA)   NCBI Sequence Viewer  
  EDL93847 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000024115
  ENSRNOP00000024115.6
RefSeq Acc Id: NP_783171   ⟸   NM_175581
- Peptide Label: precursor
- UniProtKB: Q4V894 (UniProtKB/TrEMBL),   E9PTT3 (UniProtKB/TrEMBL),   A0A9K3Y6T0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024115   ⟸   ENSRNOT00000024115
Protein Domains
Cathepsin propeptide inhibitor   Peptidase C1A papain C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4V894-F1-model_v2 AlphaFold Q4V894 1-334 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631422 AgrOrtholog
BioCyc Gene G2FUF-10481 BioCyc
Ensembl Genes ENSRNOG00000017888 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024115 ENTREZGENE
  ENSRNOT00000024115.8 UniProtKB/TrEMBL
Gene3D-CATH Cysteine proteinases UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7459242 IMAGE-MGC_LOAD
InterPro Papain_like_cys_pep_sf UniProtKB/TrEMBL
  Pept_asp_AS UniProtKB/TrEMBL
  Pept_his_AS UniProtKB/TrEMBL
  Peptidase_C1A UniProtKB/TrEMBL
  Peptidase_C1A_C UniProtKB/TrEMBL
  Peptidase_C1A_papain-like UniProtKB/TrEMBL
  Prot_inhib_I29 UniProtKB/TrEMBL
KEGG Report rno:290975 UniProtKB/TrEMBL
MGC_CLONE MGC:114553 IMAGE-MGC_LOAD
NCBI Gene 290975 ENTREZGENE
PANTHER CYSTEINE PROTEASE FAMILY C1-RELATED UniProtKB/TrEMBL
Pfam Inhibitor_I29 UniProtKB/TrEMBL
  Peptidase_C1 UniProtKB/TrEMBL
PhenoGen Ctsr PhenoGen
PRINTS PAPAIN UniProtKB/TrEMBL
PROSITE THIOL_PROTEASE_ASN UniProtKB/TrEMBL
  THIOL_PROTEASE_HIS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017888 RatGTEx
SMART Inhibitor_I29 UniProtKB/TrEMBL
  Pept_C1 UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/TrEMBL
UniProt A0A9K3Y6T0 ENTREZGENE, UniProtKB/TrEMBL
  E9PTT3 ENTREZGENE
  Q4V894 ENTREZGENE, UniProtKB/TrEMBL
  Q812B8_RAT UniProtKB/TrEMBL
UniProt Secondary E9PTT3 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-11 Ctsr  cathepsin R      Symbol and Name status set to approved 625702 APPROVED