Insig2 (insulin induced gene 2) - Rat Genome Database

Name: Insig2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Insig2 (insulin induced gene 2) Rattus norvegicus

Analyze

Symbol:

Insig2

Name:

insulin induced gene 2

RGD ID:

631417

Description:

Predicted to enable oxysterol binding activity and protein sequestering activity. Involved in response to fatty acid and response to insulin. Predicted to be part of SREBP-SCAP-Insig complex. Predicted to be active in endoplasmic reticulum membrane. Biomarker of end stage renal disease. Orthologous to human INSIG2 (insulin induced gene 2); PARTICIPATES IN sterol regulatory element-binding protein signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

INSIG-2; insulin-induced gene 2 protein

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	INSIG2 (insulin induced gene 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Insig2 (insulin induced gene 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Insig2 (insulin induced gene 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	INSIG2 (insulin induced gene 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	INSIG2 (insulin induced gene 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Insig2 (insulin induced gene 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	INSIG2 (insulin induced gene 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	INSIG2 (insulin induced gene 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Insig2 (insulin induced gene 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	WIPI2 (WD repeat domain, phosphoinositide interacting 2)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	INSIG2 (insulin induced gene 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Insig2 (insulin induced gene 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	insig2 (insulin induced gene 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	NSG2	Alliance	DIOPT (Ensembl Compara\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	35,025,160 - 35,052,937 (-)	NCBI		GRCr8
mRatBN7.2	13	32,472,390 - 32,500,139 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	32,473,742 - 32,494,923 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	35,042,312 - 35,055,633 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	36,330,238 - 36,343,556 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	33,604,703 - 33,618,041 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	37,264,818 - 37,292,718 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	37,266,312 - 37,287,458 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	42,366,075 - 42,393,747 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	33,331,951 - 33,345,132 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	33,333,183 - 33,355,516 (-)	NCBI
Celera	13	32,342,137 - 32,355,402 (-)	NCBI		Celera
Cytogenetic Map	13	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

end stage renal disease (IEP)

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

Hypertriglyceridemia (ISO)

steatotic liver disease (ISO)

Weight Gain (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,6-trinitrotoluene (EXP)

2,4-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

2-methylcholine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (EXP)

4,4'-sulfonyldiphenol (EXP,ISO)

4-hydroxynon-2-enal (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

acetamide (EXP)

afimoxifene (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

Archazolid B (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

Benoxacor (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

beta-naphthoflavone (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP,ISO)

bromobenzene (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

chloroacetaldehyde (ISO)

chlorpromazine (EXP)

ciguatoxin CTX1B (ISO)

clofibrate (EXP,ISO)

clofibric acid (EXP)

cobalt dichloride (EXP,ISO)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

curcumin (ISO)

cyclosporin A (EXP,ISO)

dexamethasone (ISO)

dibenz[a,h]anthracene (ISO)

dibutyl phthalate (ISO)

dicrotophos (ISO)

dieldrin (EXP)

dioxygen (ISO)

epoxiconazole (ISO)

ethanol (ISO)

fenofibrate (EXP)

fipronil (EXP)

flusilazole (ISO)

folic acid (ISO)

formaldehyde (ISO)

fructose (ISO)

furan (EXP)

Ganoderic acid A (ISO)

gentamycin (EXP)

glafenine (EXP)

hexaconazole (ISO)

ifosfamide (ISO)

indometacin (ISO)

inulin (ISO)

linalool (ISO)

lipopolysaccharide (EXP,ISO)

lovastatin (ISO)

menadione (ISO)

metformin (EXP)

methapyrilene (EXP)

methotrexate (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

methylparaben (ISO)

mifepristone (EXP)

N-nitrosodiethylamine (EXP)

N-nitrosodimethylamine (EXP)

N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine (EXP)

nefazodone (EXP)

nevirapine (EXP)

nickel sulfate (ISO)

p-toluidine (EXP)

paracetamol (ISO)

parathion (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenformin (EXP)

phenobarbital (ISO)

pirinixic acid (EXP,ISO)

pregnenolone 16alpha-carbonitrile (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

ranitidine (EXP)

resorcinol (ISO)

rotenone (EXP)

silicon dioxide (ISO)

simvastatin (EXP)

sodium arsenite (ISO)

sodium dichromate (EXP,ISO)

streptozocin (EXP)

sunitinib (ISO)

tamoxifen (ISO)

testosterone (ISO)

tetracycline (ISO)

thioacetamide (EXP)

tributylstannane (ISO)

trichostatin A (ISO)

triphenyl phosphate (EXP)

triptonide (ISO)

troglitazone (EXP)

valdecoxib (EXP)

valproic acid (ISO)

vandetanib (ISO)

vinclozolin (EXP)

vitamin D (ISO)

zinc dichloride (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to insulin stimulus (IBA,IEA)

cholesterol biosynthetic process (IBA,IEA,ISO,ISS)

cholesterol metabolic process (ISO)

cranial suture morphogenesis (IEA,ISO)

inner ear morphogenesis (IEA,ISO)

middle ear morphogenesis (IEA,ISO)

negative regulation of fatty acid biosynthetic process (IEA,ISO)

negative regulation of steroid biosynthetic process (IEA,ISO)

response to fatty acid (IEP)

response to insulin (IEP)

response to lipid (IEP)

response to sterol depletion (ISO)

roof of mouth development (IEA,ISO)

SREBP signaling pathway (IBA,IEA,ISO,ISS)

SREBP-SCAP complex retention in endoplasmic reticulum (IBA,IEA,ISO,ISS)

sterol biosynthetic process (ISO)

triglyceride metabolic process (IEA,ISO)

Cellular Component

endoplasmic reticulum (IBA,ISO)

endoplasmic reticulum membrane (ISO)

SREBP-SCAP-Insig complex (IBA,IEA,ISO)

Molecular Function

oxysterol binding (IEA,ISO,ISS)

protein binding (ISO)

protein sequestering activity (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

sterol regulatory element-binding protein signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Docosahexaneoic acid (22:6,n-3) regulates rat hepatocyte SREBP-1 nuclear abundance by Erk- and 26S proteasome-dependent pathways.	Botolin D, etal., J Lipid Res. 2006 Jan;47(1):181-92. Epub 2005 Oct 12.
2.	Niacin improves renal lipid metabolism and slows progression in chronic kidney disease.	Cho KH, etal., Biochim Biophys Acta. 2010 Jan;1800(1):6-15. Epub 2009 Oct 28.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Thermally oxidized oil increases the expression of insulin-induced genes and inhibits activation of sterol regulatory element-binding protein-2 in rat liver.	Koch A, etal., J Nutr. 2007 Sep;137(9):2018-23.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been.	Osborne TF and Espenshade PJ, Genes Dev. 2009 Nov 15;23(22):2578-91.
7.	GOA pipeline	RGD automated data pipeline
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Hepatic insig-1 or -2 overexpression reduces lipogenesis in obese Zucker diabetic fatty rats and in fasted/refed normal rats.	Takaishi K, etal., Proc Natl Acad Sci U S A. 2004 May 4;101(18):7106-11. Epub 2004 Apr 19.
10.	Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis.	Yabe D, etal., Proc Natl Acad Sci U S A 2003 Mar 18;100(6):3155-60.

Additional References at PubMed

PMID:12242332	PMID:12354157	PMID:12477932	PMID:16100574	PMID:16955138	PMID:26007286

Genomics

Comparative Map Data

Insig2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	35,025,160 - 35,052,937 (-)	NCBI		GRCr8
mRatBN7.2	13	32,472,390 - 32,500,139 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	32,473,742 - 32,494,923 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	35,042,312 - 35,055,633 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	36,330,238 - 36,343,556 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	33,604,703 - 33,618,041 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	37,264,818 - 37,292,718 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	37,266,312 - 37,287,458 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	42,366,075 - 42,393,747 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	33,331,951 - 33,345,132 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	33,333,183 - 33,355,516 (-)	NCBI
Celera	13	32,342,137 - 32,355,402 (-)	NCBI		Celera
Cytogenetic Map	13	q11	NCBI

INSIG2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	118,088,471 - 118,110,997 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	118,088,452 - 118,110,997 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	118,846,047 - 118,868,573 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	118,562,520 - 118,584,067 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	118,562,279 - 118,583,826	NCBI
Celera	2	112,173,296 - 112,194,866 (+)	NCBI		Celera
Cytogenetic Map	2	q14.1-q14.2	NCBI
HuRef	2	111,173,146 - 111,193,705 (+)	NCBI		HuRef
CHM1_1	2	118,849,883 - 118,871,052 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	118,521,717 - 118,544,171 (+)	NCBI		T2T-CHM13v2.0

Insig2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	121,232,082 - 121,260,391 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	121,232,082 - 121,260,318 (-)	Ensembl		GRCm39 Ensembl
GRCm38	1	121,304,353 - 121,332,662 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	121,304,353 - 121,332,589 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	123,200,930 - 123,229,157 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	123,131,899 - 123,160,126 (-)	NCBI		MGSCv36	mm8
Celera	1	123,943,057 - 123,971,749 (-)	NCBI		Celera
Cytogenetic Map	1	E2.3	NCBI
cM Map	1	52.91	NCBI

Insig2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955459	11,571,145 - 11,592,146 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955459	11,571,582 - 11,596,069 (-)	NCBI	ChiLan1.0	ChiLan1.0

INSIG2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	20,115,269 - 20,137,088 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	20,130,316 - 20,152,060 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	5,046,971 - 5,068,757 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	118,632,105 - 118,652,650 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	118,632,402 - 118,652,647 (+)	Ensembl	panpan1.1		panPan2

INSIG2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	19	31,796,984 - 31,811,556 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	19	31,791,710 - 31,811,386 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	19	32,063,758 - 32,083,699 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	19	33,190,437 - 33,210,363 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	19	33,190,674 - 33,210,268 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	19	31,864,844 - 31,884,780 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	19	32,033,058 - 32,052,956 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	19	33,222,123 - 33,242,041 (-)	NCBI		UU_Cfam_GSD_1.0

Insig2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	89,477,055 - 89,505,055 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936469	52,117,733 - 52,140,765 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936469	52,120,063 - 52,140,646 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

INSIG2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	23,676,683 - 23,699,582 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	23,676,684 - 23,699,591 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

INSIG2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	12,198,390 - 12,219,002 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	12,196,990 - 12,219,023 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666061	10,404,780 - 10,425,500 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Insig2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624732	27,087,674 - 27,104,181 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624732	27,089,776 - 27,110,170 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Insig2
106 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	600
Count of miRNA genes:	297
Interacting mature miRNAs:	387
Transcripts:	ENSRNOT00000003391
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2317027	Aia22	Adjuvant induced arthritis QTL 22	2.29		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	13	1	34266636	Rat
738036	Lnnr4	Liver neoplastic nodule remodeling QTL 4	3.64		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	1	42356786	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	1	101056920	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	1	101056920	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	101056920	Rat
631672	Iddm12	Insulin dependent diabetes mellitus QTL 12	2.2	0.0032	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	5994668	34535351	Rat
61339	Bp24	Blood pressure QTL 24		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	5994668	44807491	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	5994833	77046787	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	5994833	77046787	Rat
1581570	Eae17	Experimental allergic encephalomyelitis QTL 17	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	8897350	101631289	Rat
7411662	Foco29	Food consumption QTL 29	20.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	13	9313465	54313465	Rat
9589141	Insul28	Insulin level QTL 28	10.82	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	13	9313465	54313465	Rat
2317040	Aia21	Adjuvant induced arthritis QTL 21	2.75		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	9831541	54831541	Rat
2317046	Aia8	Adjuvant induced arthritis QTL 8	3.9700000286102295		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	9831541	54831541	Rat
1300163	Cardf1	Cardiac cell morphology QTL 1	4.18		aorta morphology trait (VT:0000272)	artery lesion measurement (CMO:0000975)	13	11929449	45417941	Rat
2302275	Gluco37	Glucose level QTL 37	3.8		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	13	11929449	46193066	Rat
631645	Bp121	Blood pressure QTL 121	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	14915655	59915655	Rat
9589164	Gluco66	Glucose level QTL 66	6.67	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	15158722	60158722	Rat
1331784	Bp222	Blood pressure QTL 222	2.944		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	17694436	53050594	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	20605871	101339738	Rat
61391	Bp5	Blood pressure QTL 5	5.6		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	22301875	67301875	Rat
70170	Eae14	Experimental allergic encephalomyelitis QTL 14		0.0024	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	23203448	68203448	Rat
6893338	Cm76	Cardiac mass QTL 76	0	0.99	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	13	23692969	68692969	Rat
1558644	Cm45	Cardiac mass QTL 45	3.6	0.002	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	13	23692969	68692969	Rat
2303030	Bp327	Blood pressure QTL 327			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	30395351	41184251	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	30395351	101056920	Rat
2301962	Cm72	Cardiac mass QTL 72	4.12		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	13	31241331	58363171	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	31241331	93395974	Rat
2303563	Bw89	Body weight QTL 89	6		body mass (VT:0001259)	body weight (CMO:0000012)	13	32284471	77284471	Rat

Markers in Region

RH142395

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	32,472,723 - 32,472,888 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	37,265,152 - 37,265,316	NCBI	Rnor6.0
Rnor_5.0	13	42,366,409 - 42,366,573	UniSTS	Rnor5.0
RGSC_v3.4	13	33,330,690 - 33,330,854	UniSTS	RGSC3.4
Celera	13	32,340,876 - 32,341,040	UniSTS
Cytogenetic Map	13	q11	UniSTS

RH128587

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	32,472,554 - 32,472,748 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	37,264,983 - 37,265,176	NCBI	Rnor6.0
Rnor_5.0	13	42,366,240 - 42,366,433	UniSTS	Rnor5.0
RGSC_v3.4	13	33,330,521 - 33,330,714	UniSTS	RGSC3.4
Celera	13	32,340,707 - 32,340,900	UniSTS
Cytogenetic Map	13	q11	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2	43	41	29	15	29	8	11	74	35	41	11	8
Low	1		16	12	4	12
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_178091	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006249667	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006249668	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006249669	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598687	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090419	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090420	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090421	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272061	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272062	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY152392	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY156086	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY156087	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC085682	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474028	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000003391 ⟹ ENSRNOP00000003391

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	32,473,742 - 32,494,923 (-)	Ensembl
Rnor_6.0 Ensembl	13	37,266,312 - 37,287,458 (-)	Ensembl

RefSeq Acc Id:

NM_178091 ⟹ NP_835192

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	35,026,755 - 35,040,098 (-)	NCBI
mRatBN7.2	13	32,473,985 - 32,487,328 (-)	NCBI
Rnor_6.0	13	37,266,413 - 37,279,866 (-)	NCBI
Rnor_5.0	13	42,366,075 - 42,393,747 (-)	NCBI
RGSC_v3.4	13	33,331,951 - 33,345,132 (-)	RGD
Celera	13	32,342,137 - 32,355,402 (-)	RGD

Sequence:

show sequence

TTAGGCCTCCTGAACTTATGAAACCATGGCGGAAGGAGAGACGGAGTCACCTCGGCCTAAAAAG
CGTGGCCCCTACATTTCCTCTGTCACCAGCCAGAGCGTGAACGTGGTGATCCGGGGAGTGGTGC
TCTTCTTCATTGGCGTGTTCCTGGCTTTAGTGTTGAACTTGCTTCAGATTCAGAGAAATGTGAC
ACTGTTCCCACCAGATGTGATCACCAGCATCTTCTCATCTGCATGGTGGGTTCCACCGTGCTGC
GGTACAGCCTCAGCTGTGATTGGACTATTGTACCCCTGCATTGACAGGCATCTAGGAGAGCCAC
ATAAATTTAAGAGAGAGTGGTCCAGTGTTATGCGCTGCGTGGCCGTGTTCGTGGGTATAAATCA
CGCCAGTGCTAAAGTCGACTTCGACAACAACTTCCAGTTTTCCCTCACACTGGCTGCACTGTCA
GTAGGACTATGGTGGACTTTTGACAGATCTAGAAGTGGTTTTGGCCTTGGTGTTGGAATTGCTT
TCTTAGCAACCGTTGTCACCCAACTGTTAGTCTACAATGGTGTTTATCAATACACATCTCCAGA
TTTTCTCTATGTCCGCTCTTGGTTGCCATGTATATTTTTTGCTGGAGGCATAACGATGGGAAAC
ATTGGTCGTCAGCTAGCAATGTATGAATGTAAAGTTATTGCTGAAAAATCTCATCAAGAATGAA
GAGGGCAGAAGTCTCA

hide sequence

RefSeq Acc Id:

XM_006249667 ⟹ XP_006249729

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	35,025,160 - 35,049,146 (-)	NCBI
mRatBN7.2	13	32,472,390 - 32,495,265 (-)	NCBI
Rnor_6.0	13	37,264,818 - 37,287,751 (-)	NCBI
Rnor_5.0	13	42,366,075 - 42,393,747 (-)	NCBI

Sequence:

show sequence

CGCACGATTCCCTCACTCCACCCACAGAGTCAGGGCACCCGTCAGAACCCTTGACTACCGAGGC
CACCAACAACAGCTGATTTCGCAGCCTCTCATCCTCCACAAGGTCCCCGCCTCCTTCCAGCCCG
GAGTTTCCCGAACACCGGAAGTCCTTTTGCCCCGACTCCGTAGAGCGGAGGCGGTGCGCTCAGC
GGCAACCGGAAGCTCCTCTGCCCCGACCGTCAGCCAGTAGCGCCCCGGCCGCGCAGGCGCAGTT
CGGTTCAGGCGGAGCTGTGGGAGGGGAGTAGGTTTGGGGGCCGGTCCCTGAAGATGGCGGAGGC
GGGGGTGAACTGGGGGTCTCCCGGCAGAGCTCAGGATTTCTGGTAGGCTCCACGTTCAGACAGG
ATGTGGTACCATTGAGACATTGGTCTGCTTCAGTCCACAGTTCACCTTTTCCACTGGGAGCCTC
ATTTCATTTCTCGGCTTAGGCCTCCTGAACTTATGAAACCATGGCGGAAGGAGAGACGGAGTCA
CCTCGGCCTAAAAAGCGTGGCCCCTACATTTCCTCTGTCACCAGCCAGAGCGTGAACGTGGTGA
TCCGGGGAGTGGTGCTCTTCTTCATTGGCGTGTTCCTGGCTTTAGTGTTGAACTTGCTTCAGAT
TCAGAGAAATGTGACACTGTTCCCACCAGATGTGATCACCAGCATCTTCTCATCTGCATGGTGG
GTTCCACCGTGCTGCGGTACAGCCTCAGCTGTGATTGGACTATTGTACCCCTGCATTGACAGGC
ATCTAGGAGAGCCACATAAATTTAAGAGAGAGTGGTCCAGTGTTATGCGCTGCGTGGCCGTGTT
CGTGGGTATAAATCACGCCAGTGCTAAAGTCGACTTCGACAACAACTTCCAGTTTTCCCTCACA
CTGGCTGCACTGTCAGTAGGACTATGGTGGACTTTTGACAGATCTAGAAGTGGTTTTGGCCTTG
GTGTTGGAATTGCTTTCTTAGCAACCGTTGTCACCCAACTGTTAGTCTACAATGGTGTTTATCA
ATACACATCTCCAGATTTTCTCTATGTCCGCTCTTGGTTGCCATGTATATTTTTTGCTGGAGGC
ATAACGATGGGAAACATTGGTCGTCAGCTAGCAATGTATGAATGTAAAGTTATTGCTGAAAAAT
CTCATCAAGAATGAAGAGGGCAGAAGTCTCAGCTGTTGTGTGGAAGCCATGGGAAAGCACCGTG
GGTGCGAGAGGCGCACCAACAGAACTTTGGACTGGAAAATTTCGAGGACACAGTTTTTCCTTGA
TTGGGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGACACACATGTTTTT
GCAGTCTGTGATTGCTTCTGTAAATCAGTTACCAACGTTTCGGTATTTGATTTCAATAAATGTA
AGATATCTGTGCACTACATGAAAGATATGTTTATGGGTACATGAAATTTCTAAATTTTTTTTTA
CATACCATACATTGTACATACAATGTTGATGTGCCAAACTGTTCTGTTACTGACACAGAGAATA
AGAATGCTTTGAACAATTTAGAGTTTAGTGAAAGAGAAAAAGAAAGCTAAAAACAAAGCGAACA
GAAAGCAACTGTGTAGCTGGCCGTTCCCTCTTGCGGCTGGTGTGCCTTTTCCTGTTTCTAATCA
GCTGTGCTGTCACAGCACCCACATGCGTGTTGTCTCTGTTGCTGTTGCTTCAGAGTTTCAATCT
TACTATATGGTAACAGTGAACTTCCCTAGAATGGTTTTAAGCCTGCACTACTGTAGGGACCCAA
AGAATACTTTTCAGATTTCTCCAGAGGGAATATGTAATGGACAGGGGTGGTTATCAGCATCACC
CTGCTTTGAGTCTACATTTGGAAAAGTATAAATGACTAAAATTAGGGGATTTGACTGGATAACT
ATGTTTGGGAATACTGTGTGGTCCTCTCTCTGCTACAGAAGCCAAAGTGACATTAGCTATCATT
TGCTACTGAAGCTCACTGCTTCAGCACATGGATGAGTAAGAAACACAGGCAGATCAAGGTGACA
GCCGAAACCTGTTGGATTCTAGAAAGCAGGCCGTACTGGTGGGATCATGCCATGTGACTGGCCA
GCTATGGCGGGCCTGAGTTTGTGACCTTCACCAGTGCAGTCTGAGGATGCTGGAACGTGTGTGC
TGATGTGTACTACAAGGTCCGTCCTTGGAGAGTGTGGAGAGCGCACTTTGCACCCCATTAACAA
CCCCTGCCACGTACTTACGGGTTAAGTGTATCGGCCGACTCTCCACTCACTCTGCATTTCTGAA
ATTGTTAATTGTCTGGCACACAAGGGTAAATTCTTCTGACTTCTGTGGTGTGCGTGTGCTTCTG
TTTGAGTGTGAGAGAAAATGCAGACACGTGTCTGTGTGCGCGTGTGCCCATGCTTCCCTGCAGT
GTCAAGTAGACATTTTAATTTTCTTTCTTGTAGAGCAATGCTGTCAGACTGAAGTCTTGTACAC
TGGAGTGTAATATGCTCTGTGTTCTCAGGCGGAGAGTGTGAACATCCCACGAGTAGTCCATACA
GAATGCGTGTACACAAGCCTAGTGGCAGTAGTGGTGAGCGCACTGCTATATTTATTATTCTGTC
TTTCAGATGTTATTCATTTAGAACAAATAAGGTATATTTTTAGAATCAAATTTGTAAACACTAT
AAAATCTTTAATAAGTTATAAGGTCTATGATATGTTTACTTTGAAAATTGCTGTTGAAAGCAAG
TTGTATTAAATATGTAATTATCACCA

hide sequence

RefSeq Acc Id:

XM_006249668 ⟹ XP_006249730

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	35,025,160 - 35,052,937 (-)	NCBI
mRatBN7.2	13	32,472,390 - 32,500,138 (-)	NCBI
Rnor_6.0	13	37,264,818 - 37,292,718 (-)	NCBI
Rnor_5.0	13	42,366,075 - 42,393,747 (-)	NCBI

Sequence:

show sequence

CCATCTCCTAGCTGACACCTGCAATCTTGCCTTCCTCCATGCCCTGCCATTGGTCACCTTCCAC
ACCAACTTAGATTAAAACAGGACGTGTCTTATCTCGATGGCAGGTCTCCATCAGCTTGTGTCTG
TTTATGTGAGCTCGACTGGCTTGCTTTACTGACACCTCTGCTCCCCTAGACGGATGTGTTGAAG
GATTTCTGGTAGGCTCCACGTTCAGACAGGATGTGGTACCATTGAGACATTGGTCTGCTTCAGT
CCACAGTTCACCTTTTCCACTGGGAGCCTCATTTCATTTCTCGGCTTAGGCCTCCTGAACTTAT
GAAACCATGGCGGAAGGAGAGACGGAGTCACCTCGGCCTAAAAAGCGTGGCCCCTACATTTCCT
CTGTCACCAGCCAGAGCGTGAACGTGGTGATCCGGGGAGTGGTGCTCTTCTTCATTGGCGTGTT
CCTGGCTTTAGTGTTGAACTTGCTTCAGATTCAGAGAAATGTGACACTGTTCCCACCAGATGTG
ATCACCAGCATCTTCTCATCTGCATGGTGGGTTCCACCGTGCTGCGGTACAGCCTCAGCTGTGA
TTGGACTATTGTACCCCTGCATTGACAGGCATCTAGGAGAGCCACATAAATTTAAGAGAGAGTG
GTCCAGTGTTATGCGCTGCGTGGCCGTGTTCGTGGGTATAAATCACGCCAGTGCTAAAGTCGAC
TTCGACAACAACTTCCAGTTTTCCCTCACACTGGCTGCACTGTCAGTAGGACTATGGTGGACTT
TTGACAGATCTAGAAGTGGTTTTGGCCTTGGTGTTGGAATTGCTTTCTTAGCAACCGTTGTCAC
CCAACTGTTAGTCTACAATGGTGTTTATCAATACACATCTCCAGATTTTCTCTATGTCCGCTCT
TGGTTGCCATGTATATTTTTTGCTGGAGGCATAACGATGGGAAACATTGGTCGTCAGCTAGCAA
TGTATGAATGTAAAGTTATTGCTGAAAAATCTCATCAAGAATGAAGAGGGCAGAAGTCTCAGCT
GTTGTGTGGAAGCCATGGGAAAGCACCGTGGGTGCGAGAGGCGCACCAACAGAACTTTGGACTG
GAAAATTTCGAGGACACAGTTTTTCCTTGATTGGGGTGTGTGTGTGTGTGTGTGTGTGTGTGTG
TGTGTGTGTGTGTGTGACACACATGTTTTTGCAGTCTGTGATTGCTTCTGTAAATCAGTTACCA
ACGTTTCGGTATTTGATTTCAATAAATGTAAGATATCTGTGCACTACATGAAAGATATGTTTAT
GGGTACATGAAATTTCTAAATTTTTTTTTACATACCATACATTGTACATACAATGTTGATGTGC
CAAACTGTTCTGTTACTGACACAGAGAATAAGAATGCTTTGAACAATTTAGAGTTTAGTGAAAG
AGAAAAAGAAAGCTAAAAACAAAGCGAACAGAAAGCAACTGTGTAGCTGGCCGTTCCCTCTTGC
GGCTGGTGTGCCTTTTCCTGTTTCTAATCAGCTGTGCTGTCACAGCACCCACATGCGTGTTGTC
TCTGTTGCTGTTGCTTCAGAGTTTCAATCTTACTATATGGTAACAGTGAACTTCCCTAGAATGG
TTTTAAGCCTGCACTACTGTAGGGACCCAAAGAATACTTTTCAGATTTCTCCAGAGGGAATATG
TAATGGACAGGGGTGGTTATCAGCATCACCCTGCTTTGAGTCTACATTTGGAAAAGTATAAATG
ACTAAAATTAGGGGATTTGACTGGATAACTATGTTTGGGAATACTGTGTGGTCCTCTCTCTGCT
ACAGAAGCCAAAGTGACATTAGCTATCATTTGCTACTGAAGCTCACTGCTTCAGCACATGGATG
AGTAAGAAACACAGGCAGATCAAGGTGACAGCCGAAACCTGTTGGATTCTAGAAAGCAGGCCGT
ACTGGTGGGATCATGCCATGTGACTGGCCAGCTATGGCGGGCCTGAGTTTGTGACCTTCACCAG
TGCAGTCTGAGGATGCTGGAACGTGTGTGCTGATGTGTACTACAAGGTCCGTCCTTGGAGAGTG
TGGAGAGCGCACTTTGCACCCCATTAACAACCCCTGCCACGTACTTACGGGTTAAGTGTATCGG
CCGACTCTCCACTCACTCTGCATTTCTGAAATTGTTAATTGTCTGGCACACAAGGGTAAATTCT
TCTGACTTCTGTGGTGTGCGTGTGCTTCTGTTTGAGTGTGAGAGAAAATGCAGACACGTGTCTG
TGTGCGCGTGTGCCCATGCTTCCCTGCAGTGTCAAGTAGACATTTTAATTTTCTTTCTTGTAGA
GCAATGCTGTCAGACTGAAGTCTTGTACACTGGAGTGTAATATGCTCTGTGTTCTCAGGCGGAG
AGTGTGAACATCCCACGAGTAGTCCATACAGAATGCGTGTACACAAGCCTAGTGGCAGTAGTGG
TGAGCGCACTGCTATATTTATTATTCTGTCTTTCAGATGTTATTCATTTAGAACAAATAAGGTA
TATTTTTAGAATCAAATTTGTAAACACTATAAAATCTTTAATAAGTTATAAGGTCTATGATATG
TTTACTTTGAAAATTGCTGTTGAAAGCAAGTTGTATTAAATATGTAATTATCACCA

hide sequence

RefSeq Acc Id:

XM_039090419 ⟹ XP_038946347

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	35,025,160 - 35,049,146 (-)	NCBI
mRatBN7.2	13	32,472,390 - 32,495,280 (-)	NCBI

RefSeq Acc Id:

XM_039090420 ⟹ XP_038946348

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	35,025,160 - 35,052,910 (-)	NCBI
mRatBN7.2	13	32,472,390 - 32,500,139 (-)	NCBI

RefSeq Acc Id:

XM_039090421 ⟹ XP_038946349

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	35,025,160 - 35,047,680 (-)	NCBI
mRatBN7.2	13	32,472,390 - 32,494,867 (-)	NCBI

RefSeq Acc Id:

XM_063272061 ⟹ XP_063128131

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	35,025,160 - 35,047,695 (-)	NCBI

RefSeq Acc Id:

XM_063272062 ⟹ XP_063128132

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	35,025,160 - 35,047,615 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_835192	(Get FASTA)	NCBI Sequence Viewer
	XP_006249729	(Get FASTA)	NCBI Sequence Viewer
	XP_006249730	(Get FASTA)	NCBI Sequence Viewer
	XP_038946347	(Get FASTA)	NCBI Sequence Viewer
	XP_038946348	(Get FASTA)	NCBI Sequence Viewer
	XP_038946349	(Get FASTA)	NCBI Sequence Viewer
	XP_063128131	(Get FASTA)	NCBI Sequence Viewer
	XP_063128132	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH85682	(Get FASTA)	NCBI Sequence Viewer
	AAN78347	(Get FASTA)	NCBI Sequence Viewer
	EDL87948	(Get FASTA)	NCBI Sequence Viewer
	EDL87949	(Get FASTA)	NCBI Sequence Viewer
	EDL87950	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000003391
	ENSRNOP00000003391.5
GenBank Protein	Q80UA9	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_835192 ⟸ NM_178091

- UniProtKB:

Q80UA9 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MAEGETESPRPKKRGPYISSVTSQSVNVVIRGVVLFFIGVFLALVLNLLQIQRNVTLFPPDVIT
SIFSSAWWVPPCCGTASAVIGLLYPCIDRHLGEPHKFKREWSSVMRCVAVFVGINHASAKVDFD
NNFQFSLTLAALSVGLWWTFDRSRSGFGLGVGIAFLATVVTQLLVYNGVYQYTSPDFLYVRSWL
PCIFFAGGITMGNIGRQLAMYECKVIAEKSHQE

hide sequence

RefSeq Acc Id:	XP_006249730 ⟸ XM_006249668
- Peptide Label:	isoform X2
- UniProtKB:	Q80UA9 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MAEGETESPRPKKRGPYISSVTSQSVNVVIRGVVLFFIGVFLALVLNLLQIQRNVTLFPPDVIT SIFSSAWWVPPCCGTASAVIGLLYPCIDRHLGEPHKFKREWSSVMRCVAVFVGINHASAKVDFD NNFQFSLTLAALSVGLWWTFDRSRSGFGLGVGIAFLATVVTQLLVYNGVYQYTSPDFLYVRSWL PCIFFAGGITMGNIGRQLAMYECKVIAEKSHQE hide sequence

RefSeq Acc Id:	XP_006249729 ⟸ XM_006249667
- Peptide Label:	isoform X2
- UniProtKB:	Q80UA9 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MAEGETESPRPKKRGPYISSVTSQSVNVVIRGVVLFFIGVFLALVLNLLQIQRNVTLFPPDVIT SIFSSAWWVPPCCGTASAVIGLLYPCIDRHLGEPHKFKREWSSVMRCVAVFVGINHASAKVDFD NNFQFSLTLAALSVGLWWTFDRSRSGFGLGVGIAFLATVVTQLLVYNGVYQYTSPDFLYVRSWL PCIFFAGGITMGNIGRQLAMYECKVIAEKSHQE hide sequence

RefSeq Acc Id:

ENSRNOP00000003391 ⟸ ENSRNOT00000003391

RefSeq Acc Id:	XP_038946348 ⟸ XM_039090420
- Peptide Label:	isoform X1
- UniProtKB:	A0A8L2Q1M5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038946347 ⟸ XM_039090419
- Peptide Label:	isoform X1
- UniProtKB:	A0A8L2Q1M5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038946349 ⟸ XM_039090421
- Peptide Label:	isoform X1
- UniProtKB:	A0A8L2Q1M5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063128131 ⟸ XM_063272061
- Peptide Label:	isoform X2
- UniProtKB:	Q80UA9 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_063128132 ⟸ XM_063272062
- Peptide Label:	isoform X2
- UniProtKB:	Q80UA9 (UniProtKB/Swiss-Prot)

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q80UA9-F1-model_v2	AlphaFold	Q80UA9	1-225	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698770

Promoter ID:

EPDNEW_R9294

Type:

multiple initiation site

Name:

Insig2_1

Description:

insulin induced gene 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	37,287,466 - 37,287,526	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:631417	AgrOrtholog
BioCyc Gene	G2FUF-18499	BioCyc
Ensembl Genes	ENSRNOG00000002478	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000003391.6	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7189822	IMAGE-MGC_LOAD
InterPro	INSIG_fam	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:288985	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93054	IMAGE-MGC_LOAD
NCBI Gene	288985	ENTREZGENE
PANTHER	INSULIN-INDUCED GENE 2 PROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR15301	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	INSIG	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Insig2	PhenoGen
RatGTEx	ENSRNOG00000002478	RatGTEx
UniProt	A0A8L2Q1M5	ENTREZGENE, UniProtKB/TrEMBL
	A6K803_RAT	UniProtKB/TrEMBL
	A6K805_RAT	UniProtKB/TrEMBL
	INSI2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-02-11	Insig2	insulin induced gene 2			Symbol and Name status set to approved	625702	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_regulation	expression is downregulated by insulin	724448

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations