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Gene: Smug1 (single-strand-selective monofunctional uracil-DNA glycosylase 1) Rattus norvegicus

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Symbol:

Smug1

Name:

single-strand-selective monofunctional uracil-DNA glycosylase 1

RGD ID:

631403

Description:

Enables oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity and single-strand selective uracil DNA N-glycosylase activity. Involved in base-excision repair. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Orthologous to human SMUG1 (single-strand-selective monofunctional uracil-DNA glycosylase 1); PARTICIPATES IN base excision repair pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; amphetamine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

single-strand selective monofunctional uracil DNA glycosylase; single-strand selective monofunctional uracil-DNA glycosylase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	136,166,157 - 136,177,673 (-)	NCBI		GRCr8
mRatBN7.2	7	134,288,565 - 134,302,179 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	134,287,675 - 134,297,226 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	136,045,289 - 136,047,414 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	138,274,666 - 138,276,791 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	138,260,724 - 138,262,849 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	144,774,155 - 144,788,333 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	144,774,160 - 144,778,656 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	142,560,270 - 142,569,924 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	142,064,428 - 142,066,553 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	142,144,616 - 142,151,752 (-)	NCBI
Celera	7	130,715,767 - 130,717,892 (-)	NCBI		Celera
Cytogenetic Map	7	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Smug1	Rat	Neurodevelopmental Disorders		ISO	SMUG1 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Neurodevelopmental disorder	ClinVar	PMID:25741868
Smug1	Rat	prostate cancer		ISO	SMUG1 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Malignant tumor of prostate	ClinVar	PMID:23265383

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Smug1	Rat	(-)-epigallocatechin 3-gallate	multiple interactions	ISO	SMUG1 (Homo sapiens)	6480464	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SMUG1 mRNA and epigallocatechin gallate inhibits the reaction [potassium chromate(VI) results in decreased expression of SMUG1 mRNA]	CTD	PMID:22079256
Smug1	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	Smug1 (Mus musculus)	6480464	Tetrachlorodibenzodioxin affects the expression of SMUG1 mRNA	CTD	PMID:21570461
Smug1	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	EXP		6480464	Tetrachlorodibenzodioxin results in decreased expression of SMUG1 mRNA	CTD	PMID:33387578
Smug1	Rat	3,4-methylenedioxymethamphetamine	decreases expression	ISO	Smug1 (Mus musculus)	6480464	N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of SMUG1 mRNA	CTD	PMID:26251327
Smug1	Rat	4,4'-sulfonyldiphenol	increases expression	ISO	Smug1 (Mus musculus)	6480464	bisphenol S results in increased expression of SMUG1 mRNA	CTD	PMID:39298647
Smug1	Rat	5-aza-2'-deoxycytidine	affects expression	ISO	SMUG1 (Homo sapiens)	6480464	Decitabine affects the expression of SMUG1 mRNA	CTD	PMID:23300844
Smug1	Rat	5-chlorouracil	affects metabolic processing	ISO	SMUG1 (Homo sapiens)	6480464	SMUG1 protein affects the metabolism of 5-chlorouracil	CTD	PMID:20104909
Smug1	Rat	acrolein	multiple interactions	ISO	SMUG1 (Homo sapiens)	6480464	[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of SMUG1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of SMUG1 mRNA	CTD	PMID:32699268
Smug1	Rat	acrylamide	decreases expression	ISO	SMUG1 (Homo sapiens)	6480464	Acrylamide results in decreased expression of SMUG1 mRNA	CTD	PMID:32763439
Smug1	Rat	aflatoxin B1	increases methylation	ISO	SMUG1 (Homo sapiens)	6480464	Aflatoxin B1 results in increased methylation of SMUG1 gene	CTD	PMID:27153756
Smug1	Rat	all-trans-retinoic acid	increases expression	ISO	SMUG1 (Homo sapiens)	6480464	Tretinoin results in increased expression of SMUG1 mRNA	CTD	PMID:33167477
Smug1	Rat	alpha-pinene	multiple interactions	ISO	SMUG1 (Homo sapiens)	6480464	[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of SMUG1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of SMUG1 mRNA	CTD	PMID:32699268
Smug1	Rat	ammonium chloride	affects expression	EXP		6480464	Ammonium Chloride affects the expression of SMUG1 mRNA	CTD	PMID:16483693
Smug1	Rat	amphetamine	decreases expression	EXP		6480464	Amphetamine results in decreased expression of SMUG1 mRNA	CTD	PMID:30779732
Smug1	Rat	antirheumatic drug	increases expression	ISO	SMUG1 (Homo sapiens)	6480464	Antirheumatic Agents results in increased expression of SMUG1 mRNA	CTD	PMID:24449571
Smug1	Rat	arsane	multiple interactions	ISO	SMUG1 (Homo sapiens)	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of SMUG1 mRNA	CTD	PMID:39836092
Smug1	Rat	arsenic atom	multiple interactions	ISO	SMUG1 (Homo sapiens)	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of SMUG1 mRNA	CTD	PMID:39836092
Smug1	Rat	atrazine	decreases expression	ISO	SMUG1 (Homo sapiens)	6480464	Atrazine results in decreased expression of SMUG1 mRNA	CTD	PMID:22378314
Smug1	Rat	atrazine	affects methylation	EXP		6480464	Atrazine affects the methylation of SMUG1 gene	CTD	PMID:35440735
Smug1	Rat	benzo[a]pyrene	decreases methylation	ISO	SMUG1 (Homo sapiens)	6480464	Benzo(a)pyrene results in decreased methylation of SMUG1 promoter	CTD	PMID:27901495
Smug1	Rat	bisphenol A	increases methylation	ISO	Smug1 (Mus musculus)	6480464	bisphenol A results in increased methylation of SMUG1 promoter	CTD	PMID:27312807
Smug1	Rat	bisphenol A	increases expression	ISO	SMUG1 (Homo sapiens)	6480464	bisphenol A results in increased expression of SMUG1 mRNA	CTD	PMID:36232920
Smug1	Rat	bisphenol A	increases expression	EXP		6480464	bisphenol A results in increased expression of SMUG1 mRNA	CTD	PMID:30816183 and PMID:32528016
Smug1	Rat	bisphenol A	increases methylation	EXP		6480464	bisphenol A results in increased methylation of SMUG1 gene	CTD	PMID:28505145
Smug1	Rat	bisphenol F	increases expression	ISO	Smug1 (Mus musculus)	6480464	bisphenol F results in increased expression of SMUG1 mRNA	CTD	PMID:38685157
Smug1	Rat	C60 fullerene	decreases expression	EXP		6480464	fullerene C60 results in decreased expression of SMUG1 mRNA	CTD	PMID:19167457
Smug1	Rat	cadmium atom	multiple interactions	ISO	SMUG1 (Homo sapiens)	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SMUG1 mRNA	CTD	PMID:35301059
Smug1	Rat	cadmium dichloride	increases expression	ISO	SMUG1 (Homo sapiens)	6480464	Cadmium Chloride results in increased expression of SMUG1 mRNA	CTD	PMID:38382870
Smug1	Rat	cadmium dichloride	multiple interactions	ISO	SMUG1 (Homo sapiens)	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SMUG1 mRNA	CTD	PMID:35301059
Smug1	Rat	ceric oxide	increases expression	EXP		6480464	ceric oxide results in increased expression of SMUG1 mRNA	CTD	PMID:29463257
Smug1	Rat	chlordecone	decreases expression	ISO	Smug1 (Mus musculus)	6480464	Chlordecone results in decreased expression of SMUG1 mRNA	CTD	PMID:29980752
Smug1	Rat	cisplatin	affects expression	ISO	SMUG1 (Homo sapiens)	6480464	Cisplatin affects the expression of SMUG1 mRNA	CTD	PMID:23300844
Smug1	Rat	cisplatin	multiple interactions	ISO	SMUG1 (Homo sapiens)	6480464	[Cisplatin co-treated with jinfukang] results in increased expression of SMUG1 mRNA	CTD	PMID:27392435
Smug1	Rat	cisplatin	increases expression	ISO	SMUG1 (Homo sapiens)	6480464	Cisplatin results in increased expression of SMUG1 mRNA	CTD	PMID:27392435
Smug1	Rat	copper(II) sulfate	decreases expression	ISO	SMUG1 (Homo sapiens)	6480464	Copper Sulfate results in decreased expression of SMUG1 mRNA	CTD	PMID:19549813
Smug1	Rat	Dibutyl phosphate	affects expression	ISO	SMUG1 (Homo sapiens)	6480464	di-n-butylphosphoric acid affects the expression of SMUG1 mRNA	CTD	PMID:37042841
Smug1	Rat	doxorubicin	decreases expression	ISO	SMUG1 (Homo sapiens)	6480464	Doxorubicin results in decreased expression of SMUG1 mRNA	CTD	PMID:29803840
Smug1	Rat	endosulfan	increases expression	EXP		6480464	Endosulfan results in increased expression of SMUG1 mRNA	CTD	PMID:29391264
Smug1	Rat	folic acid	decreases expression	ISO	Smug1 (Mus musculus)	6480464	Folic Acid results in decreased expression of SMUG1 mRNA	CTD	PMID:25629700
Smug1	Rat	genistein	decreases expression	ISO	Smug1 (Mus musculus)	6480464	Genistein results in decreased expression of SMUG1 mRNA	CTD	PMID:32186404
Smug1	Rat	gentamycin	decreases expression	EXP		6480464	Gentamicins results in decreased expression of SMUG1 mRNA	CTD	PMID:33387578
Smug1	Rat	ketoconazole	decreases expression	ISO	SMUG1 (Homo sapiens)	6480464	Ketoconazole results in decreased expression of SMUG1 mRNA	CTD	PMID:36621641
Smug1	Rat	lead(0)	increases expression	ISO	SMUG1 (Homo sapiens)	6480464	Lead results in increased expression of SMUG1 mRNA	CTD	PMID:19921347
Smug1	Rat	manganese atom	multiple interactions	ISO	SMUG1 (Homo sapiens)	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of SMUG1 mRNA	CTD	PMID:39836092
Smug1	Rat	manganese(0)	multiple interactions	ISO	SMUG1 (Homo sapiens)	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of SMUG1 mRNA	CTD	PMID:39836092
Smug1	Rat	manganese(II) chloride	multiple interactions	ISO	SMUG1 (Homo sapiens)	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of SMUG1 mRNA	CTD	PMID:39836092
Smug1	Rat	ozone	multiple interactions	ISO	SMUG1 (Homo sapiens)	6480464	[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of SMUG1 mRNA more ...	CTD	PMID:32699268
Smug1	Rat	potassium chromate	multiple interactions	ISO	SMUG1 (Homo sapiens)	6480464	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SMUG1 mRNA and epigallocatechin gallate inhibits the reaction [potassium chromate(VI) results in decreased expression of SMUG1 mRNA]	CTD	PMID:22079256
Smug1	Rat	potassium chromate	decreases expression	ISO	SMUG1 (Homo sapiens)	6480464	potassium chromate(VI) results in decreased expression of SMUG1 mRNA	CTD	PMID:22079256
Smug1	Rat	sodium arsenite	decreases expression	ISO	SMUG1 (Homo sapiens)	6480464	sodium arsenite results in decreased expression of SMUG1 mRNA	CTD	PMID:38568856
Smug1	Rat	sodium arsenite	multiple interactions	ISO	SMUG1 (Homo sapiens)	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of SMUG1 mRNA	CTD	PMID:39836092
Smug1	Rat	sodium fluoride	decreases expression	ISO	Smug1 (Mus musculus)	6480464	Sodium Fluoride results in decreased expression of SMUG1 protein	CTD	PMID:28918527
Smug1	Rat	temozolomide	increases expression	ISO	SMUG1 (Homo sapiens)	6480464	Temozolomide results in increased expression of SMUG1 mRNA	CTD	PMID:31758290
Smug1	Rat	tetrachloromethane	increases expression	ISO	Smug1 (Mus musculus)	6480464	Carbon Tetrachloride results in increased expression of SMUG1 mRNA	CTD	PMID:31919559
Smug1	Rat	thiram	decreases expression	ISO	SMUG1 (Homo sapiens)	6480464	Thiram results in decreased expression of SMUG1 mRNA	CTD	PMID:38568856
Smug1	Rat	titanium dioxide	increases expression	ISO	Smug1 (Mus musculus)	6480464	titanium dioxide results in increased expression of SMUG1 mRNA	CTD	PMID:29264374
Smug1	Rat	titanium dioxide	decreases methylation	ISO	Smug1 (Mus musculus)	6480464	titanium dioxide results in decreased methylation of SMUG1 promoter	CTD	PMID:35295148
Smug1	Rat	triphenyl phosphate	affects expression	ISO	SMUG1 (Homo sapiens)	6480464	triphenyl phosphate affects the expression of SMUG1 mRNA	CTD	PMID:37042841
Smug1	Rat	tungsten	increases expression	ISO	Smug1 (Mus musculus)	6480464	Tungsten results in increased expression of SMUG1 mRNA	CTD	PMID:30912803
Smug1	Rat	urethane	decreases expression	ISO	SMUG1 (Homo sapiens)	6480464	Urethane results in decreased expression of SMUG1 mRNA	CTD	PMID:28818685
Smug1	Rat	valproic acid	increases expression	ISO	SMUG1 (Homo sapiens)	6480464	Valproic Acid results in increased expression of SMUG1 mRNA	CTD	PMID:23179753
Smug1	Rat	valproic acid	decreases methylation	ISO	SMUG1 (Homo sapiens)	6480464	Valproic Acid results in decreased methylation of SMUG1 gene	CTD	PMID:29154799
Smug1	Rat	valproic acid	affects expression	ISO	SMUG1 (Homo sapiens)	6480464	Valproic Acid affects the expression of SMUG1 mRNA	CTD	PMID:25979313

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Smug1	Rat	base-excision repair	involved_in	IDA		634191	PMID:12718543	HGNC-UCL
Smug1	Rat	base-excision repair	involved_in	IEA	InterPro:IPR039134	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Smug1	Rat	base-excision repair	involved_in	ISO	SMUG1 (Homo sapiens)	1624291	PMID:12161446	RGD	PMID:12161446
Smug1	Rat	DNA damage response	involved_in	IEA	UniProtKB-KW:KW-0227	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Smug1	Rat	DNA repair		IDA		2317001		RGD
Smug1	Rat	DNA repair	involved_in	IEA	UniProtKB-KW:KW-0234	1600115	GO_REF:0000043	UniProt	GO_REF:0000043

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Smug1	Rat	cytosol	located_in	ISO	SMUG1 (Homo sapiens) more ...	1624291		RGD	GO_REF:0000052
Smug1	Rat	fibrillar center	located_in	ISO	SMUG1 (Homo sapiens) and UniProtKB:Q53HV7-1	1624291		RGD	GO_REF:0000052
Smug1	Rat	nucleolus	located_in	ISS	UniProtKB:Q53HV7	634191	PMID:12718543	HGNC-UCL
Smug1	Rat	nucleolus	located_in	ISO	SMUG1 (Homo sapiens)	1624291	PMID:12161446	RGD	PMID:12161446
Smug1	Rat	nucleoplasm	located_in	ISO	SMUG1 (Homo sapiens) more ...	1624291		RGD	GO_REF:0000052
Smug1	Rat	nucleus	located_in	IEA	UniProtKB-KW:KW-0539	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Smug1	Rat	nucleus	located_in	IEA	UniProtKB-SubCell:SL-0191	1600115	GO_REF:0000044	UniProt	GO_REF:0000044

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Smug1	Rat	DNA binding	enables	IEA	UniProtKB-KW:KW-0238	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Smug1	Rat	DNA N-glycosylase activity	enables	ISO	SMUG1 (Homo sapiens)	1624291	PMID:11526119	RGD	PMID:11526119
Smug1	Rat	DNA N-glycosylase activity	enables	IEA	ARBA:ARBA00028980	1600115	GO_REF:0000117	UniProt	GO_REF:0000117
Smug1	Rat	hydrolase activity	enables	IEA	UniProtKB-KW:KW-0378	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Smug1	Rat	identical protein binding	enables	ISO	SMUG1 (Homo sapiens) and UniProtKB:Q53HV7-2	1624291	UniProtKB:Q53HV7-2 and PMID:32296183	RGD	PMID:32296183
Smug1	Rat	oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity		IDA		2317001		RGD
Smug1	Rat	oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity	enables	IBA	PANTHER:PTN000996960 and Smug1 (Rattus norvegicus)	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Smug1	Rat	protein binding	enables	ISO	SMUG1 (Homo sapiens) and UniProtKB:Q53HV7-2	1624291	UniProtKB:A8MQ03 more ...	RGD	PMID:32296183 and PMID:32814053
Smug1	Rat	protein binding	enables	ISO	SMUG1 (Homo sapiens)	1624291	UniProtKB:O43186 more ...	RGD	PMID:16189514 more ...
Smug1	Rat	single-strand selective uracil DNA N-glycosylase activity	enables	IDA		634191	PMID:12718543	HGNC-UCL
Smug1	Rat	single-strand selective uracil DNA N-glycosylase activity	enables	IEA	InterPro:IPR039134	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Smug1	Rat	single-strand selective uracil DNA N-glycosylase activity	enables	ISO	SMUG1 (Homo sapiens)	1624291	PMID:12161446 and PMID:12718543	RGD	PMID:12161446 and PMID:12718543
Smug1	Rat	uracil DNA N-glycosylase activity		IDA		2317001		RGD
Smug1	Rat	uracil DNA N-glycosylase activity	enables	IBA	PANTHER:PTN000996960 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Smug1	Rat	uracil DNA N-glycosylase activity	enables	ISO	SMUG1 (Homo sapiens)	1624291	PMID:12718543	RGD	PMID:12718543
Smug1	Rat	uracil DNA N-glycosylase activity	enables	IDA		634191	PMID:12718543	HGNC-UCL

Imported Annotations - KEGG (archival)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Smug1	Rat	base excision repair pathway		IEA		6907045		KEGG	rno:03410

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Mammalian 5-formyluracil-DNA glycosylase. 2. Role of SMUG1 uracil-DNA glycosylase in repair of 5-formyluracil and other oxidized and deaminated base lesions.	Masaoka A, etal., Biochemistry 2003 May 6;42(17):5003-12.
3.	Mammalian 5-formyluracil-DNA glycosylase. 1. Identification and characterization of a novel activity that releases 5-formyluracil from DNA.	Matsubara M, etal., Biochemistry. 2003 May 6;42(17):4993-5002.
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Testicular protein Spag5 has similarity to mitotic spindle protein Deepest and binds outer dense fiber protein Odf1.	Shao X, etal., Mol Reprod Dev 2001 Aug;59(4):410-6.

PMID:11526119	PMID:12161446

Smug1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	136,166,157 - 136,177,673 (-)	NCBI		GRCr8
mRatBN7.2	7	134,288,565 - 134,302,179 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	134,287,675 - 134,297,226 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	136,045,289 - 136,047,414 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	138,274,666 - 138,276,791 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	138,260,724 - 138,262,849 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	144,774,155 - 144,788,333 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	144,774,160 - 144,778,656 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	142,560,270 - 142,569,924 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	142,064,428 - 142,066,553 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	142,144,616 - 142,151,752 (-)	NCBI
Celera	7	130,715,767 - 130,717,892 (-)	NCBI		Celera
Cytogenetic Map	7	q36	NCBI

SMUG1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	54,158,235 - 54,188,985 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	54,121,277 - 54,189,008 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	54,574,150 - 54,582,769 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	52,861,519 - 52,869,024 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	12	54,226,170 - 54,233,675 (-)	NCBI		Celera
Cytogenetic Map	12	q13.13	NCBI
HuRef	12	51,611,811 - 51,620,446 (-)	NCBI		HuRef
CHM1_1	12	54,540,762 - 54,549,526 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	54,119,277 - 54,154,492 (-)	NCBI		T2T-CHM13v2.0

Smug1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	103,061,717 - 103,077,360 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	103,061,717 - 103,075,519 (-)	Ensembl		GRCm39 Ensembl
GRCm38	15	103,153,290 - 103,168,939 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	103,153,290 - 103,167,092 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	102,983,721 - 102,993,715 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	102,981,324 - 102,991,318 (-)	NCBI		MGSCv36	mm8
Celera	15	105,314,542 - 105,324,536 (-)	NCBI		Celera
Cytogenetic Map	15	F3	NCBI
cM Map	15	58.2	NCBI

Smug1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955458	1,431,721 - 1,447,292 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955458	1,432,988 - 1,449,019 (-)	NCBI	ChiLan1.0	ChiLan1.0

SMUG1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	39,991,866 - 39,999,340 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	39,988,635 - 39,996,093 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	34,564,624 - 34,572,063 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	35,288,412 - 35,296,670 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	35,288,412 - 35,296,670 (+)	Ensembl	panpan1.1		panPan2

SMUG1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	1,086,675 - 1,093,175 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	1,089,808 - 1,111,129 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	45,157,542 - 45,164,017 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	1,088,178 - 1,094,647 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	1,088,357 - 1,235,362 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	1,107,011 - 1,113,490 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	1,088,345 - 1,094,825 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	45,561,546 - 45,568,018 (-)	NCBI		UU_Cfam_GSD_1.0

Smug1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	61,762,394 - 61,796,876 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936512	11,395,834 - 11,402,377 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936512	11,395,513 - 11,416,426 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SMUG1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	19,398,252 - 19,412,648 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	19,375,244 - 19,412,656 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	20,035,790 - 20,050,156 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SMUG1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	50,292,780 - 50,307,828 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	50,289,154 - 50,300,492 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	195,741,787 - 195,751,095 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Smug1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624904	2,223,600 - 2,231,642 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624904	2,185,959 - 2,232,541 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Smug1
13 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	65
Count of miRNA genes:	62
Interacting mature miRNAs:	64
Transcripts:	ENSRNOT00000055290
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	43747012	135012528	Rat
1354582	Stl11	Serum triglyceride level QTL 11	3.42		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	119513385	135012528	Rat
731176	Glom5	Glomerulus QTL 5	2.5	0.0035	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	7	96670164	135012528	Rat
1300112	Bp183	Blood pressure QTL 183	3.51		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	111182207	135012528	Rat
1358914	Bp266	Blood pressure QTL 266			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat
2306821	Bp335	Blood pressure QTL 335		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	106571501	135012528	Rat
631663	Bw6	Body weight QTL 6	3.4		body mass (VT:0001259)	body weight (CMO:0000012)	7	111075573	134976056	Rat
2299163	Iddm34	Insulin dependent diabetes mellitus QTL 34	2.71		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	7	91281130	135012528	Rat
70173	Niddm19	Non-insulin dependent diabetes mellitus QTL 19	4.33	0.00005	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	64002457	135012528	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	90482196	135012528	Rat
731174	Uae23	Urinary albumin excretion QTL 23	2.4	0.0042	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	7	104603555	135012528	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31


RefSeq Transcripts	NM_177934	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008765749	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017594900	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017594901	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017594902	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039079348	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY191521	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474035	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000055290 ⟹ ENSRNOP00000052164

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	7	144,776,531 - 144,778,656 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000082149 ⟹ ENSRNOP00000069685

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	134,287,675 - 134,297,226 (-)	Ensembl
Rnor_6.0 Ensembl	7	144,774,160 - 144,778,339 (-)	Ensembl

RefSeq Acc Id:

NM_177934 ⟹ NP_808795

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	136,168,533 - 136,170,658 (-)	NCBI
mRatBN7.2	7	134,290,048 - 134,292,173 (-)	NCBI
Rnor_6.0	7	144,776,531 - 144,778,656 (-)	NCBI
Rnor_5.0	7	142,560,270 - 142,569,924 (-)	NCBI
RGSC_v3.4	7	142,064,428 - 142,066,553 (-)	RGD
Celera	7	130,715,767 - 130,717,892 (-)	RGD

Sequence:

show sequence

TCATGCAGCCATGACCCACCATGATGAACTGTACTCTCTGAGAGCTGAGATAAACCCTTCCTTCTCCTGCCTTTACGGGTTGCGTTGTAGCCACAAGACCAGTAGCTAAGGTAGGATGCTTGGTGTAT
CAGAAAGAGGGAGGACTCTGGAGTTGGGAAGCAAAAACATCATTCCATACCAGGTCACAACGGCATGGCTGTGTCCCAGACTTTCCCACCGGGGCCTGCCCATGAGCCTGCCAGTGCCCTGATGGAGC
CTTGCGCTCGAAGCTTAGCTGAGGGCTTCCTGGAGGAAGAGCTTCGGCTCAATGCTGAGCTGAGCCAGCTGCAGTTTCCAGAGCCTGTGGGTGTCATCTACAACCCAGTGGATTATGCTTGGGAGCCA
CACCGGAACTACGTGACTCGCTACTGCCAAGGCCCCAAGGAAGTGCTGTTCCTGGGCATGAATCCAGGACCTTTTGGCATGGCCCAAACTGGGGTACCTTTTGGGGAAGTGAATGTGGTCCGGGACTG
GTTGGGCATTGGGGGCTCTGTGCTGTCCCCTCCCCAAGAGCACCCTAAGCGACCAGTGTTGGGACTGGAGTGCCCGCAGTCAGAGGTGAGCGGAGCCCGATTCTGGGGCTTTTTTCGGACCCTCTGCG
GACAGCCTCAAGTCTTCTTCCGGCACTGCTTTGTCCACAATCTGTGTCCTCTACTCTTCTTGGCTCCCAGCGGGCGAAACCTTACCCCGGCTGATCTGCCCGCCAAGCACCGGGAGCAGCTACTGTCG
ATCTGCGACGCCGCCCTCTGCCGGCAGGTGCAGCTGCTAGGGGTGCGGCTGGTAGTGGGAGTGGGGCGGCTGGCAGAGCAGAGAGCTCGAAGAGCTCTAGCAGGGCTGACCCCGGAGGTGCAGGTGGA
GGGGCTCCTGCATCCATCTCCTCGAAGCCCGCAGGCCAACAAAGGCTGGGAAACAGCAGCCAGGGAAAGACTCCAAGAGTTGGGGCTGCTGCCTCTGCTAACGGATGAGGGTTCAGTCAGGCCTACAC
CATAG

hide sequence

RefSeq Acc Id:

XM_008765749 ⟹ XP_008763971

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	136,166,157 - 136,177,669 (-)	NCBI
mRatBN7.2	7	134,288,565 - 134,299,453 (-)	NCBI
Rnor_6.0	7	144,776,467 - 144,788,330 (-)	NCBI

Sequence:

show sequence

GGGAGGCTGTGGGAGAAGGCTGGTGACAGAACAGGATTAAGTGTGGCCTGCAAGTACCACGGGA
GGACTCAAGTCTTCCTTTGTGTCTGACTGGCTATGGACACAGCCAGGGTGTTTGGGTGATGGCTAGGTGGCATGTTGGGTCTCAGAGCACCTTCTCACTTGGCTTAGTGGCCTTGCTCCCAGGCTGAA
CCTCCTCCCTCTCCTACTTGCTCAGCCCAGCTCAACTGTGGGCAATGTTCTCAGTCTGCAAAATCTAACATCCATTTTTCTCTCTCCAAGACCTGGGGATCAGTTCCCCCAACCCGGAACACTGTCTT
TCTGATGTCTGTGTGGCCCACTCAGGATAACCGCTTTGGACAACTATAATACCACTCAGACAGATTATGCAGCCTCCTCCCCTCCCGGACATCTCCTACCACTGCATCAAGCCAAATTACTCAGTACC
CCCTCCCCCAGCCTGGGGCTCCGATGAAATCCGATTAGTGAGAACTGAGCCTCACTGAGCTGACGGCTCCTCCGATAATTGCTTCCCAAGTAAGCAATGTCAGCTCTGTAGCTGCCCATCCCTCTCCT
GGGTATCAAGGAAGGCATCCAGAGCCAGGAGACTGGGGACACCTGAGTTGTAAGATTAGGAAGCTGCCACCTGTCTCCAGTTAAGTGGGTTGTGTTGTGTGGTCTTGGGATTGAGGGTCAGAGTAAGG
CCTTAGCCAACGGAGGCCCACATTTCTGCCCACATTTCTGCCTTCTCACCCCTTGGGTAAATCTATGTACCCATTTCTCTTTCGAGATACAGGAAGGTTAACACAAAGATTAGATGTCAGGAAAAGGC
TTGATATGAACTCGGCTGCTCTGCTTCCCCAACTCTGGGAGAGGAAGTAGAGACATTGAGGTACACCCAGGGGAAGACAGAGGCACCTGGAGACAGAAAGCAAGCTATGGAAGAGCGACCCATGGAGC
TCTTTTCGCAAGCTTTCCGGGATTTGGCATTTCCGGCGGAAGCGGACGCTGCTAGCCATTCTCCTTATTCAAATGCTGTTGACTACGATTCCCAGTGTCCTCAGCGCCAGGACGAAGAAAGGAAGCGG
AAGCTGCATGGGGAGCTCATGCAGCCATGACCCACCATGATGAACTGTACTCTCTGAGAGCTGAGATAAACCCTTCCTTCTCCTGCCTTTACGGGTTGCGTTGTAGCCACAAGACCAGTAGCTAAGGT
CACAACGGCATGGCTGTGTCCCAGACTTTCCCACCGGGGCCTGCCCATGAGCCTGCCAGTGCCCTGATGGAGCCTTGCGCTCGAAGCTTAGCTGAGGGCTTCCTGGAGGAAGAGCTTCGGCTCAATGC
TGAGCTGAGCCAGCTGCAGTTTCCAGAGCCTGTGGGTGTCATCTACAACCCAGTGGATTATGCTTGGGAGCCACACCGGAACTACGTGACTCGCTACTGCCAAGGCCCCAAGGAAGTGCTGTTCCTGG
GCATGAATCCAGGACCTTTTGGCATGGCCCAAACTGGGGTACCTTTTGGGGAAGTGAATGTGGTCCGGGACTGGTTGGGCATTGGGGGCTCTGTGCTGTCCCCTCCCCAAGAGCACCCTAAGCGACCA
GTGTTGGGACTGGAGTGCCCGCAGTCAGAGGTGAGCGGAGCCCGATTCTGGGGCTTTTTTCGGACCCTCTGCGGACAGCCTCAAGTCTTCTTCCGGCACTGCTTTGTCCACAATCTGTGTCCTCTACT
CTTCTTGGCTCCCAGCGGGCGAAACCTTACCCCGGCTGATCTGCCCGCCAAGCACCGGGAGCAGCTACTGTCGATCTGCGACGCCGCCCTCTGCCGGCAGGTGCAGCTGCTAGGGGTGCGGCTGGTAG
TGGGAGTGGGGCGGCTGGCAGAGCAGAGAGCTCGAAGAGCTCTAGCAGGGCTGACCCCGGAGGTGCAGGTGGAGGGGCTCCTGCATCCATCTCCTCGAAGCCCGCAGGCCAACAAAGGCTGGGAAACA
GCAGCCAGGGAAAGACTCCAAGAGTTGGGGCTGCTGCCTCTGCTAACGGATGAGGGTTCAGTCAGGCCTACACCATAGAGACCCAGTCAGTGTTGCACAGCTGATGACTGCACAGGTCTTGCTGGGCT
CCATGCTGCATTCA

hide sequence

RefSeq Acc Id:

XM_017594900 ⟹ XP_017450389

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	136,166,157 - 136,177,669 (-)	NCBI
mRatBN7.2	7	134,288,565 - 134,300,990 (-)	NCBI
Rnor_6.0	7	144,774,155 - 144,788,329 (-)	NCBI

Sequence:

show sequence

GGAGGCTGTGGGAGAAGGCTGGTGACAGAACAGGATTAAGTGTGGCCTGCAAGTACCACGGGAG
GACTCAAGTCTTCCTTTGTGTCTGACTGGCTATGGACACAGCCAGGGTGTTTGGGTGATGGCTAGGTGGCATGTTGGGTCTCAGAGCACCTTCTCACTTGGCTTAGTGGCCTTGCTCCCAGGCTGAAC
CTCCTCCCTCTCCTACTTGCTCAGCCCAGCTCAACTGTGGGCAATGTTCTCAGTCTGCAAAATCTAACATCCATTTTTCTCTCTCCAAGACCTGGGGATCAGTTCCCCCAACCCGGAACACTGTCTTT
CTGATGTCTGTGTGGCCCACTCAGGATAACCGCTTTGGACAACTATAATACCACTCAGACAGATTATGCAGCCTCCTCCCCTCCCGGACATCTCCTACCACTGCATCAAGCCAAATTACTCAGTACCC
CCTCCCCCAGCCTGGGGCTCCGATGAAATCCGATTAGTGAGAACTGAGCCTCACTGAGCTGACGGCTCCTCCGATAATTGCTTCCCAAGTAAGCAATGTCAGCTCTGTAGCTGCCCATCCCTCTCCTG
GGTATCAAGGAAGGCATCCAGAGCCAGGAGACTGGGGACACCTGAGTTGTAAGATTAGGAAGCTGCCACCTGTCTCCAGTTAAGTGGGTTGTGTTGTGTGGTCTTGGGATTGAGGGTCAGAGTAAGGC
CTTAGCCAACGGAGGCCCACATTTCTGCCCACATTTCTGCCTTCTCACCCCTTGGGTAAATCTATGTACCCATTTCTCTTTCGAGATACAGGAAGGTTAACACAAAGATTAGATGTCAGGAAAAGGCT
TGATATGAACTCGGCTGCTCTGCTTCCCCAACTCTGGGAGAGGAAGTAGAGACATTGAGGTACACCCAGGGGAAGACAGAGGCACCTGGAGACAGAAAGCAAGCTATGGAAGAGCGACCCATGGAGCT
CTTTTCGCAAGCTTTCCGGGATTTGGCATTTCCGGCGGAAGCGGACGCTGCTAGCCATTCTCCTTATTCAAATGCTGTTGACTACGATTCCCAGTGTCCTCAGCGCCAGGACGAAGAAAGGAAGCGGA
AGCTGCATGGGGAGCTCATGCAGCCATGACCCACCATGATGAACTGTACTCTCTGAGAGCTGAGATAAACCCTTCCTTCTCCTGCCTTTACGGGTTGCGTTGTAGCCACAAGACCAGTAGCTAAGGTA
GGATGCTTGGTGTATCAGAAAGAGGGAGGACTCTGGAGTTGGGAAGCAAAAACATCATTCCATACCAGGTCACAACGGCATGGCTGTGTCCCAGACTTTCCCACCGGGGCCTGCCCATGAGCCTGCCA
GTGCCCTGATGGAGCCTTGCGCTCGAAGCTTAGCTGAGGGCTTCCTGGAGGAAGAGCTTCGGCTCAATGCTGAGCTGAGCCAGCTGCAGTTTCCAGAGCCTGTGGGTGTCATCTACAACCCAGTGGAT
TATGCTTGGGAGCCACACCGGAACTACGTGACTCGCTACTGCCAAGGCCCCAAGGAAGTGCTGTTCCTGGGCATGAATCCAGGACCTTTTGGCATGGCCCAAACTGGGGTACCTTTTGGGGAAGTGAA
TGTGGTCCGGGACTGGTTGGGCATTGGGGGCTCTGTGCTGTCCCCTCCCCAAGAGCACCCTAAGCGACCAGTGTTGGGACTGGAGTGCCCGCAGTCAGAGGTGAGCGGAGCCCGATTCTGGGGCTTTT
TTCGGACCCTCTGCGGACAGCCTCAAGTCTTCTTCCGGCACTGCTTTGTCCACAATCTGTGTCCTCTACTCTTCTTGGCTCCCAGCGGGCGAAACCTTACCCCGGCTGATCTGCCCGCCAAGCACCGG
GAGCAGCTACTGTCGATCTGCGACGCCGCCCTCTGCCGGCAGGTGCAGCTGCTAGGGGTGCGGCTGGTAGTGGGAGTGGGGCGGCTGGCAGAGCAGAGAGCTCGAAGAGCTCTAGCAGGGCTGACCCC
GGAGGTGCAGGTGGAGGGGCTCCTGCATCCATCTCCTCGAAGCCCGCAGGCCAACAAAGGCTGGGAAACAGCAGCCAGGGAAAGACTCCAAGAGTTGGGGCTGCTGCCTCTGCTAACGGATGAGGGTT
CAGTCAGGCCTACACCATAGAGACCCAGTCAGTGTTGCACAGCTGATGACTGCACAGGTCTTGCTGGGCTCCATGCTGCATTCAGCTTACTGGGCCATCCTCTAATGGCCCAGAGTGGGCAGCTCTCC
TGCTGTCTTCCCCTTCCCTCGAGCCTCACCCTCTTGTCTCCAGTGCCTGGTCATGCACAGCATCGGCAGAGGGTTGGGCTTGTGCACTCCACCTACCACACATCCTTGCCTGGGGATCCCCCTGTGTG
CAGAAGGTCCCAGATCAGGATGTCTGAAGTCATAGTCACAGTTTTGGAGGAAAGAGAGTTTTCGTTTTAATCTTTCCTGTTTTGCTTTTTATTGGCATTATGTTTGGCATTGAGTCATGCACACTAGG
GAAGTTCTCCAATGCTGATCTACCTCAGCCTTTTTTTGACACTAATTGTGCATACTAGTGGGGTTCAGTGTGATGCTTCCACACACTGATGGAGTCCAGCCTCCCTTATCAGTCCTCTTCCCCAGTCA
GTGGGTGATCTTTTCAGGATCCTTACTCATCCTTACAGAGCACCTGGCAGACTCCTGTCCTTCCAGGGTCTAGGACAGACATCATGTTGAGAATGGACTTCTTAGCCAGGTGTCTGGCACACTCCTAT
AATCCAAGCACTCAGAGGCAGGAGGATCAGGAGTTCAAGGCCACCTCCAGCTACATATTGAGTTCAAGGCCGGCCTGGAATATATTAGTCTCTGTCTCAAAAATAAGTAAATAAGTAATAAAAAAGTG
AACTTCAGGGAGACTGAAGCTGTATCTGAGGGAGACTTCTGTGTGGTGGACTAGGAAAGATCTAGATTTTCATCCCTCACCCCTTTTTCCCCTCCCTATAAGGCCTGTGAACTTTTTAAAAAAAATTA
TTTATTTTGGTTTTTTGACACAGGGTTTCTCTGTGTTGCCCTTGCTGTCCTAGAACTCACTTTGTAGACCAGGCTGGCCTCAAACTCAGAAAACTTATATTTTAAAAGAAGAAACAAAAAAACACAAC
TCCCTCTGTTTGGGTTCTGTTAATGTTGTCTGTTTGTTTTTAAATTTTGAAACAAGGTCTCATTGTGTTGGCCCTTAACTCATTATGGAGACCAGGTCCACTTTGACCTCTGCCTACCTCTGCCTCTT
GAGTGCTGGGATTAAAAGGAGGTGCCGCCCTGCCTGCCCTGCTTGTGAACAACCTCTCTAAGCACCAAGATCCTTTTTTTAAAAGGGGGTGGGGGATTGTTGCTGCACTGGTGTGAGGTGAGGATCAA
CTGAGATAACACTGCAGAGTGCTTTGCAAAGGACTGTCTTATGGTCCTCACTACACACTCCTGCTCCCCTCCCTTTGAGGTGGGGCGTATCCGTGCTCTACAAGGGAATTCCCTGTCCATGCTGAACA
CCTTTGCCTATAGCCCCACTGGAGAAGGACCAACGCTATGCGAAGCTCGGCCTCTGATTTTTTTTAGACTAAGCATTAAAGACTCCTAAGCCATATGTTGGTTCTCTCTTCCTGCACTTTATTGGTGG
GAGAATGATGGTTTTAGGATATTTCCTCCCTTTTCCTACCTACTCACTGCTTGCAAAAACTTTTCTCAGGTAGCTTGGGGAGGGGTGACAGAGACCTCTGTCCTAGCCAAGCTACAGGGGTTCTGGTA
GTGGCCTGTCCTGAAGTTCATCAGGACACTGTTGGGCACTGTTGGGGACAGTGGGGAACCGGTGTCTCACCTGTCTCTTTGATAGTTGGTTGGATGATCTGTGATAAGGGCTGGAAAGTGAGCCACAG
TGGGAGCAGGTCTTGGGACCATCTTAATGAAGACATGTTGTCTCCCTATCTCCTGGGATACAAGTCATCTCCAACATTCTAAACATTAGTATATTTCTATCTCAGCTCTAGAGAGGGAGACTAAATCT
TCAAGGATTCCCCAGTGATAGAAGTGTTGTAATTATTGATGTTGGAGTCTCAGAGTGTCCCAGGATTTGTCGAGGTCTGGCTCAGGATGGAGGCCAGCCCTCCAGAAAGACCCTCCGAGTGTTGGGGC
TCAGCCTGAATGCCAGGATGGGACAAGGATAGAGATTGAGTTCAGCCTCATGGCCAATGGTCTCAACCAGTTATACCTCCACAGTAACCCTGACCAGCTCTCTTCTAAGCTTGCTGGTTGGTGAGCAC
ATGTATATGTGTTTCTTTTTGGCTATTTGGTGCTTGTTTGTGTATTCATTCATTCATTCATTCATTCATTCATTCATTCATTCATATGCTCTGTATGTCATTTTGGAATTCTGAGTATGGAGCCCAGG
ATTTTGCGGGTGAGTTTCTATGACTGAGCTACATTCCTTGATTTTTATTTGTAGTACATTTTAATAAATAAACATAGTGTTTTCCCCCCTGA

hide sequence

RefSeq Acc Id:

XM_039079348 ⟹ XP_038935276

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	136,166,157 - 136,177,673 (-)	NCBI
mRatBN7.2	7	134,288,565 - 134,299,462 (-)	NCBI


Protein RefSeqs	NP_808795	(Get FASTA)	NCBI Sequence Viewer
	XP_008763971	(Get FASTA)	NCBI Sequence Viewer
	XP_017450389	(Get FASTA)	NCBI Sequence Viewer
	XP_038935276	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAO38671	(Get FASTA)	NCBI Sequence Viewer
	EDL86797	(Get FASTA)	NCBI Sequence Viewer
	EDL86798	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000069685
	ENSRNOP00000069685.1
GenBank Protein	Q811Q1	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_808795 ⟸ NM_177934

- UniProtKB:

Q811Q1 (UniProtKB/Swiss-Prot), A6KCZ5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAVSQTFPPGPAHEPASALMEPCARSLAEGFLEEELRLNAELSQLQFPEPVGVIYNPVDYAWEPHRNYVTRYCQGPKEVLFLGMNPGPFGMAQTGVPFGEVNVVRDWLGIGGSVLSPPQEHPKRPVLG
LECPQSEVSGARFWGFFRTLCGQPQVFFRHCFVHNLCPLLFLAPSGRNLTPADLPAKHREQLLSICDAALCRQVQLLGVRLVVGVGRLAEQRARRALAGLTPEVQVEGLLHPSPRSPQANKGWETAAR
ERLQELGLLPLLTDEGSVRPTP

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RefSeq Acc Id:	XP_008763971 ⟸ XM_008765749
- Peptide Label:	isoform X1
- UniProtKB:	Q811Q1 (UniProtKB/Swiss-Prot), A6KCZ5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAVSQTFPPGPAHEPASALMEPCARSLAEGFLEEELRLNAELSQLQFPEPVGVIYNPVDYAWEP HRNYVTRYCQGPKEVLFLGMNPGPFGMAQTGVPFGEVNVVRDWLGIGGSVLSPPQEHPKRPVLGLECPQSEVSGARFWGFFRTLCGQPQVFFRHCFVHNLCPLLFLAPSGRNLTPADLPAKHREQLLS ICDAALCRQVQLLGVRLVVGVGRLAEQRARRALAGLTPEVQVEGLLHPSPRSPQANKGWETAARERLQELGLLPLLTDEGSVRPTP hide sequence

RefSeq Acc Id:	XP_017450389 ⟸ XM_017594900
- Peptide Label:	isoform X1
- UniProtKB:	Q811Q1 (UniProtKB/Swiss-Prot), A6KCZ5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAVSQTFPPGPAHEPASALMEPCARSLAEGFLEEELRLNAELSQLQFPEPVGVIYNPVDYAWEPHRNYVTRYCQGPKEVLFLGMNPGPFGMAQTGVPFGEVNVVRDWLGIGGSVLSPPQEHPKRPVLG LECPQSEVSGARFWGFFRTLCGQPQVFFRHCFVHNLCPLLFLAPSGRNLTPADLPAKHREQLLSICDAALCRQVQLLGVRLVVGVGRLAEQRARRALAGLTPEVQVEGLLHPSPRSPQANKGWETAAR ERLQELGLLPLLTDEGSVRPTP hide sequence

Ensembl Acc Id:

ENSRNOP00000052164 ⟸ ENSRNOT00000055290

Ensembl Acc Id:

ENSRNOP00000069685 ⟸ ENSRNOT00000082149

Protein Domains

Uracil-DNA glycosylase-like

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q811Q1-F1-model_v2	AlphaFold	Q811Q1	1-278	view protein structure

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-31886	BioCyc
Ensembl Genes	ENSRNOG00000036842	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000082149	ENTREZGENE
	ENSRNOT00000082149.2	UniProtKB/Swiss-Prot
Gene3D-CATH	3.40.470.10	UniProtKB/Swiss-Prot
InterPro	SMUG1	UniProtKB/Swiss-Prot
	Uracil-DNA_glycosylase-like	UniProtKB/Swiss-Prot
	Uracil-DNA_glycosylase-like_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:315344	UniProtKB/Swiss-Prot
NCBI Gene	315344	ENTREZGENE
PANTHER	PTHR13235	UniProtKB/Swiss-Prot
	SINGLE-STRAND SELECTIVE MONOFUNCTIONAL URACIL DNA GLYCOSYLASE	UniProtKB/Swiss-Prot
Pfam	UDG	UniProtKB/Swiss-Prot
PharmGKB	SMUG1	RGD
PhenoGen	Smug1	PhenoGen
RatGTEx	ENSRNOG00000036842	RatGTEx
Superfamily-SCOP	SSF52141	UniProtKB/Swiss-Prot
UniProt	A6KCZ5	ENTREZGENE, UniProtKB/TrEMBL
	Q811Q1	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-10-23	Smug1	single-strand-selective monofunctional uracil-DNA glycosylase 1	Smug1	single-strand selective monofunctional uracil DNA glycosylase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-02-11	Smug1	single-strand selective monofunctional uracil DNA glycosylase			Symbol and Name status set to approved	625702	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)