Lat2 (linker for activation of T cells family, member 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Lat2 (linker for activation of T cells family, member 2) Rattus norvegicus
Analyze
Symbol: Lat2
Name: linker for activation of T cells family, member 2
RGD ID: 631397
Description: Predicted to enable SH2 domain binding activity. Predicted to be involved in B cell activation; B cell receptor signaling pathway; and calcium-mediated signaling. Predicted to be located in membrane raft. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome. Orthologous to human LAT2 (linker for activation of T cells family member 2); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LAT-2 like; linker for activation of B-cells; linker for activation of T-cells family member 2; non-T cell activation linker; non-T-cell activation linker; Ntal; Wbscr5; Williams-Beuren syndrome chromosome region 5 homolog; Williams-Beuren syndrome chromosome region 5 homolog (human); Williams-Beuren syndrome chromosome region 5-like protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81227,740,647 - 27,754,760 (+)NCBIGRCr8
mRatBN7.21222,104,173 - 22,118,294 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1222,104,219 - 22,118,288 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1223,252,803 - 23,259,102 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01223,863,886 - 23,870,183 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01222,930,369 - 22,936,714 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01225,114,099 - 25,128,381 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1225,119,355 - 25,125,749 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01227,114,507 - 27,128,775 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41223,174,554 - 23,180,908 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11223,035,110 - 23,041,465 (+)NCBI
Celera1223,873,387 - 23,879,734 (+)NCBICelera
Cytogenetic Map12q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-bromohexadecanoic acid  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
DDE  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
graphite  (EXP)
ixazomib  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
methyl beta-cyclodextrin  (ISO)
methyl methanesulfonate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nickel atom  (ISO)
O-methyleugenol  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
pentanal  (ISO)
perifosine  (ISO)
pirinixic acid  (ISO)
propanal  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sotorasib  (ISO)
temozolomide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane raft  (ISO)
plasma membrane  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling. Brdicka T, etal., J Exp Med 2002 Dec 16;196(12):1617-26.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23. Martindale DW, etal., Mamm Genome 2000 Oct;11(10):890-8.
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12514734   PMID:14722116   PMID:15477348   PMID:17013982   PMID:17911602   PMID:20442417   PMID:20458337   PMID:21403644   PMID:23443658   PMID:26448619   PMID:29099056  


Genomics

Comparative Map Data
Lat2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81227,740,647 - 27,754,760 (+)NCBIGRCr8
mRatBN7.21222,104,173 - 22,118,294 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1222,104,219 - 22,118,288 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1223,252,803 - 23,259,102 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01223,863,886 - 23,870,183 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01222,930,369 - 22,936,714 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01225,114,099 - 25,128,381 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1225,119,355 - 25,125,749 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01227,114,507 - 27,128,775 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41223,174,554 - 23,180,908 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11223,035,110 - 23,041,465 (+)NCBI
Celera1223,873,387 - 23,879,734 (+)NCBICelera
Cytogenetic Map12q12NCBI
LAT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38774,210,006 - 74,229,834 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl774,199,652 - 74,229,834 (+)EnsemblGRCh38hg38GRCh38
GRCh37773,624,336 - 73,644,164 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36773,262,023 - 73,282,100 (+)NCBINCBI36Build 36hg18NCBI36
Build 34773,068,925 - 73,088,808NCBI
Celera769,103,651 - 69,123,730 (+)NCBICelera
Cytogenetic Map7q11.23NCBI
HuRef769,505,694 - 69,525,599 (+)NCBIHuRef
CHM1_1773,769,175 - 73,789,226 (+)NCBICHM1_1
T2T-CHM13v2.0775,412,292 - 75,432,128 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2772,957,159 - 72,977,236 (+)NCBI
Lat2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395134,628,957 - 134,648,637 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5134,628,876 - 134,643,879 (-)EnsemblGRCm39 Ensembl
GRCm385134,600,103 - 134,619,783 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5134,600,022 - 134,615,025 (-)EnsemblGRCm38mm10GRCm38
MGSCv375135,076,135 - 135,090,893 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365134,884,892 - 134,899,650 (-)NCBIMGSCv36mm8
Celera5131,608,314 - 131,623,075 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map574.7NCBI
Lat2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545613,674,190 - 13,688,611 (-)NCBIChiLan1.0ChiLan1.0
LAT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2690,667,421 - 90,698,260 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17138,932,089 - 138,962,892 (-)NCBINHGRI_mPanPan1
PanPan1.1781,350,666 - 81,377,115 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl781,350,666 - 81,377,115 (+)Ensemblpanpan1.1panPan2
LAT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.166,160,939 - 6,175,271 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl66,161,542 - 6,173,294 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha67,859,266 - 7,872,992 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.065,975,446 - 5,989,987 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl65,975,446 - 5,990,000 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.165,966,577 - 5,980,984 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.065,914,054 - 5,928,728 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.066,077,458 - 6,092,227 (-)NCBIUU_Cfam_GSD_1.0
Lat2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344130,774,449 - 130,785,905 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365433,250,956 - 3,262,668 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LAT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl311,352,579 - 11,372,092 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1311,353,213 - 11,372,100 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2311,036,844 - 11,055,323 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LAT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1288,848,971 - 8,865,558 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl288,848,638 - 8,865,574 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660707,714,089 - 7,732,600 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lat2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474013,745,949 - 13,764,869 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lat2
161 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:64
Count of miRNA genes:60
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000034629
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961088935682913Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382528064557Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121983578938193007Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)121961087024139202Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121107382524234895Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121363552330827399Rat
631521Pia12Pristane induced arthritis QTL 128.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)122025941723672083Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12136247923Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 45 111 91 90 59 25 59 6 214 93 91 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_173840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005491642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005491643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB219140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC091000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC135741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY170849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ294696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ294697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ294698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ294699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000034629   ⟹   ENSRNOP00000031304
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1222,104,219 - 22,118,275 (+)Ensembl
Rnor_6.0 Ensembl1225,119,355 - 25,125,749 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093800   ⟹   ENSRNOP00000083189
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1222,104,219 - 22,118,275 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098558   ⟹   ENSRNOP00000079065
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1222,109,832 - 22,118,288 (+)Ensembl
RefSeq Acc Id: NM_173840   ⟹   NP_776212
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,740,715 - 27,754,760 (+)NCBI
mRatBN7.21222,104,242 - 22,118,289 (+)NCBI
Rnor_6.01225,119,379 - 25,125,733 (+)NCBI
Rnor_5.01227,114,507 - 27,128,775 (+)NCBI
RGSC_v3.41223,174,554 - 23,180,908 (+)RGD
Celera1223,873,387 - 23,879,734 (+)RGD
Sequence:
RefSeq Acc Id: XM_017598358   ⟹   XP_017453847
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,740,653 - 27,754,755 (+)NCBI
mRatBN7.21222,104,179 - 22,118,294 (+)NCBI
Rnor_6.01225,119,846 - 25,128,381 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039089531   ⟹   XP_038945459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,740,654 - 27,754,755 (+)NCBI
mRatBN7.21222,104,180 - 22,118,289 (+)NCBI
RefSeq Acc Id: XM_039089532   ⟹   XP_038945460
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,740,647 - 27,751,122 (+)NCBI
mRatBN7.21222,104,173 - 22,114,650 (+)NCBI
RefSeq Acc Id: XM_039089533   ⟹   XP_038945461
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,740,647 - 27,751,122 (+)NCBI
mRatBN7.21222,104,173 - 22,114,650 (+)NCBI
RefSeq Acc Id: XM_039089534   ⟹   XP_038945462
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,740,691 - 27,754,755 (+)NCBI
mRatBN7.21222,104,223 - 22,118,289 (+)NCBI
RefSeq Acc Id: XR_005491642
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,740,648 - 27,751,776 (+)NCBI
mRatBN7.21222,104,174 - 22,115,308 (+)NCBI
RefSeq Acc Id: XR_005491643
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,740,648 - 27,751,776 (+)NCBI
mRatBN7.21222,104,174 - 22,115,308 (+)NCBI
RefSeq Acc Id: NP_776212   ⟸   NM_173840
- UniProtKB: A6J0I1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453847   ⟸   XM_017598358
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZWF7 (UniProtKB/TrEMBL),   A6J0I2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000031304   ⟸   ENSRNOT00000034629
RefSeq Acc Id: XP_038945460   ⟸   XM_039089532
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038945461   ⟸   XM_039089533
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038945459   ⟸   XM_039089531
- Peptide Label: isoform X1
- UniProtKB: Q8CGL2 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038945462   ⟸   XM_039089534
- Peptide Label: isoform X5
Ensembl Acc Id: ENSRNOP00000083189   ⟸   ENSRNOT00000093800
Ensembl Acc Id: ENSRNOP00000079065   ⟸   ENSRNOT00000098558

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CGL2-F1-model_v2 AlphaFold Q8CGL2 1-204 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631397 AgrOrtholog
BioCyc Gene G2FUF-19580 BioCyc
Ensembl Genes ENSRNOG00000021856 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00065001581 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000034629.5 UniProtKB/TrEMBL
  ENSRNOT00000093800.1 UniProtKB/TrEMBL
  ENSRNOT00000098558.1 UniProtKB/TrEMBL
  ENSRNOT00065002114 UniProtKB/Swiss-Prot
InterPro LAT2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:317676 UniProtKB/Swiss-Prot
NCBI Gene 317676 ENTREZGENE
PANTHER LINKER FOR ACTIVATION OF T-CELLS FAMILY MEMBER 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15646 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam LAT2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lat2 PhenoGen
RatGTEx ENSRNOG00000021856 RatGTEx
  ENSRNOG00065001581 RatGTEx
UniProt A0A8I5ZM71_RAT UniProtKB/TrEMBL
  A0A8I5ZWF7 ENTREZGENE, UniProtKB/TrEMBL
  A6J0I1 ENTREZGENE, UniProtKB/TrEMBL
  A6J0I2 ENTREZGENE, UniProtKB/TrEMBL
  A6J0I3_RAT UniProtKB/TrEMBL
  G3V8Z1_RAT UniProtKB/TrEMBL
  NTAL_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-11-17 Lat2  linker for activation of T cells family, member 2      Symbol and Name updated 1299863 APPROVED
2004-12-14 Wbscr5  Williams-Beuren syndrome chromosome region 5 homolog (human)      Symbol and Name status set to approved 1299863 APPROVED