Lat2 (linker for activation of T cells family, member 2) - Rat Genome Database

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Gene: Lat2 (linker for activation of T cells family, member 2) Rattus norvegicus
Analyze
Symbol: Lat2
Name: linker for activation of T cells family, member 2
RGD ID: 631397
Description: Predicted to enable SH2 domain binding activity. Predicted to be involved in B cell activation; B cell receptor signaling pathway; and calcium-mediated signaling. Predicted to be located in membrane raft. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome. Orthologous to human LAT2 (linker for activation of T cells family member 2); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LAT-2 like; linker for activation of B-cells; linker for activation of T-cells family member 2; non-T cell activation linker; non-T-cell activation linker; Ntal; Wbscr5; Williams-Beuren syndrome chromosome region 5 homolog; Williams-Beuren syndrome chromosome region 5 homolog (human); Williams-Beuren syndrome chromosome region 5-like protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81227,740,647 - 27,754,760 (+)NCBIGRCr8
mRatBN7.21222,104,173 - 22,118,294 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1222,104,219 - 22,118,288 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1223,252,803 - 23,259,102 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01223,863,886 - 23,870,183 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01222,930,369 - 22,936,714 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01225,114,099 - 25,128,381 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1225,119,355 - 25,125,749 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01227,114,507 - 27,128,775 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41223,174,554 - 23,180,908 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11223,035,110 - 23,041,465 (+)NCBI
Celera1223,873,387 - 23,879,734 (+)NCBICelera
Cytogenetic Map12q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Lat2RatWilliams-Beuren syndrome  ISOLAT2 (Homo sapiens)1549872 RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
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Original Reference(s)
Lat2Ratautism spectrum disorder  ISOLAT2 (Homo sapiens)8554872ClinVar Annotator: match by term: Autism spectrum disorderClinVarPMID:21658581 more ...
Lat2Ratautistic disorder  ISOLAT2 (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106 and PMID:30208311
Lat2Ratintestinal volvulus  ISOLAT2 (Homo sapiens)8554872ClinVar Annotator: match by term: INTESTINAL MALROTATION and FAMILIALClinVarPMID:25741868
Lat2RatNeurodevelopmental Disorders  ISOLAT2 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
Lat2Ratpleomorphic xanthoastrocytoma  ISOLAT2 (Homo sapiens)8554872ClinVar Annotator: match by term: Pleomorphic xanthoastrocytomaClinVarPMID:28299358
Lat2Ratschizophrenia  ISOLAT2 (Homo sapiens)8554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106 and PMID:30208311
Lat2RatVolvulus Of Midgut  ISOLAT2 (Homo sapiens)8554872ClinVar Annotator: match by term: Volvulus of midgutClinVarPMID:25741868
Lat2RatWilliams-Beuren syndrome  ISOLAT2 (Homo sapiens)8554872ClinVar Annotator: match by term: Williams syndromeClinVarPMID:25741868
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Lat2Ratacute promyelocytic leukemia  ISOLAT2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:32587277
Lat2RatDisease Progression  ISOLAT2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:32587277
Lat2RatExperimental Leukemia  ISOLAT2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:32587277

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Object Symbol
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Term
Qualifier
Evidence
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Reference
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Source
Original Reference(s)
Lat2Rat1,2-dimethylhydrazine increases expressionISOLat2 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of LAT2 mRNACTDPMID:22206623
Lat2Rat17beta-estradiol multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of LAT2 mRNACTDPMID:32741896
Lat2Rat17beta-estradiol 3-benzoate multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of LAT2 mRNACTDPMID:32741896
Lat2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOLat2 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of LAT2 mRNACTDPMID:21570461
Lat2Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of LAT2 mRNACTDPMID:33387578
Lat2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of LAT2 mRNACTDPMID:34747641
Lat2Rat2-bromohexadecanoic acid decreases expressionISOLAT2 (Homo sapiens)64804642-bromopalmitate results in decreased expression of LAT2 proteinCTDPMID:23001822
Lat2Rat8-Br-cAMP increases expressionISOLAT2 (Homo sapiens)64804648-Bromo Cyclic Adenosine Monophosphate results in increased expression of LAT2 mRNACTDPMID:22079614
Lat2Ratacetamide increases expressionEXP 6480464acetamide results in increased expression of LAT2 mRNACTDPMID:31881176
Lat2Ratacrolein multiple interactionsISOLAT2 (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of LAT2 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of LAT2 mRNACTDPMID:32699268
Lat2Ratacrylamide increases expressionISOLAT2 (Homo sapiens)6480464Acrylamide results in increased expression of LAT2 mRNACTDPMID:32763439
Lat2Rataflatoxin B1 increases methylationISOLAT2 (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of LAT2 intronCTDPMID:30157460
Lat2Ratall-trans-retinoic acid decreases expressionISOLAT2 (Homo sapiens)6480464Tretinoin results in decreased expression of LAT2 mRNACTDPMID:23724009
Lat2Ratall-trans-retinoic acid multiple interactionsISOLAT2 (Homo sapiens)6480464LAT2 protein inhibits the reaction [Tretinoin results in increased expression of ITGAM protein] and LAT2 protein inhibits the reaction [Tretinoin results in increased expression of ITGAX protein]CTDPMID:32587277
Lat2Ratalpha-pinene multiple interactionsISOLAT2 (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of LAT2 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of LAT2 mRNACTDPMID:32699268
Lat2Ratammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of LAT2 mRNACTDPMID:16483693
Lat2Ratantirheumatic drug decreases expressionISOLAT2 (Homo sapiens)6480464Antirheumatic Agents results in decreased expression of LAT2 mRNACTDPMID:24449571
Lat2Rataristolochic acid A increases expressionISOLAT2 (Homo sapiens)6480464aristolochic acid I results in increased expression of LAT2 mRNACTDPMID:33212167
Lat2Ratarsenous acid decreases expressionISOLAT2 (Homo sapiens)6480464Arsenic Trioxide results in decreased expression of LAT2 mRNA and Arsenic Trioxide results in decreased expression of LAT2 proteinCTDPMID:19128835 and PMID:32587277
Lat2Ratarsenous acid decreases response to substanceISOLAT2 (Homo sapiens)6480464LAT2 protein results in decreased susceptibility to Arsenic TrioxideCTDPMID:23001822

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Biological Process
1 to 16 of 16 rows

  
Object Symbol
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Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Lat2Ratadaptive immune response involved_inIEAUniProtKB-KW:KW-10641600115GO_REF:0000043UniProtGO_REF:0000043
Lat2RatB cell activation involved_inIEAInterPro:IPR0314281600115GO_REF:0000002InterProGO_REF:0000002
Lat2RatB cell activation involved_inIEAUniProtKB:Q9GZY6 and ensembl:ENSP000004204941600115GO_REF:0000107EnsemblGO_REF:0000107
Lat2RatB cell activation involved_inIBAPANTHER:PTN000402057 and UniProtKB:Q9GZY61600115GO_REF:0000033GO_CentralGO_REF:0000033
Lat2RatB cell activation involved_inISOLAT2 (Homo sapiens)1624291 PMID:12514734RGDPMID:12514734
Lat2RatB cell receptor signaling pathway involved_inISOLAT2 (Homo sapiens)1624291 PMID:12514734RGDPMID:12514734
Lat2RatB cell receptor signaling pathway involved_inIEAUniProtKB:Q9GZY6 and ensembl:ENSP000004204941600115GO_REF:0000107EnsemblGO_REF:0000107
Lat2RatB cell receptor signaling pathway involved_inIBAPANTHER:PTN000402057 and UniProtKB:Q9GZY61600115GO_REF:0000033GO_CentralGO_REF:0000033
Lat2Ratcalcium-mediated signaling involved_inISOLAT2 (Homo sapiens)1624291 PMID:14722116RGDPMID:14722116
Lat2Ratcalcium-mediated signaling involved_inIEAUniProtKB:Q9GZY6 and ensembl:ENSP000004204941600115GO_REF:0000107EnsemblGO_REF:0000107
Lat2Ratcalcium-mediated signaling involved_inIBAPANTHER:PTN000402057 and UniProtKB:Q9GZY61600115GO_REF:0000033GO_CentralGO_REF:0000033
Lat2Ratimmune response-regulating signaling pathway involved_inIEAInterPro:IPR0314281600115GO_REF:0000002InterProGO_REF:0000002
Lat2Ratimmune system process involved_inIEAUniProtKB-KW:KW-03911600115GO_REF:0000043UniProtGO_REF:0000043
Lat2Ratintracellular signal transduction involved_inISOLAT2 (Homo sapiens)1624291 PMID:14722116RGDPMID:14722116
Lat2Ratintracellular signal transduction involved_inIEAUniProtKB:Q9GZY6 and ensembl:ENSP000004204941600115GO_REF:0000107EnsemblGO_REF:0000107
Lat2Ratmast cell degranulation involved_inIEAUniProtKB-KW:KW-04671600115GO_REF:0000043UniProtGO_REF:0000043
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Cellular Component

  
Object Symbol
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Term
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Evidence
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Reference
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Source
Original Reference(s)
Lat2Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Lat2Ratmembrane raft located_inISOLAT2 (Homo sapiens)1624291 PMID:12486104 and PMID:12514734RGDPMID:12486104 and PMID:12514734
Lat2Ratmembrane raft located_inIEAUniProtKB:Q9GZY6 and ensembl:ENSP000004204941600115GO_REF:0000107EnsemblGO_REF:0000107
Lat2Ratplasma membrane located_inISOLAT2 (Homo sapiens) and UniProtKB:Q9GZY6-11624291 RGDGO_REF:0000052
Lat2Ratplasma membrane located_inIEAUniProtKB:Q9GZY6 and ensembl:ENSP000004204941600115GO_REF:0000107EnsemblGO_REF:0000107
Lat2Ratplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044
Lat2Ratplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043
Lat2Ratplasma membrane is_active_inIBAPANTHER:PTN000402057 and UniProtKB:Q9GZY61600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function

  
Object Symbol
Species
Term
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Evidence
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Reference
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Source
Original Reference(s)
Lat2Ratprotein binding enablesISOLAT2 (Homo sapiens)1624291UniProtKB:P62993 and PMID:14722116RGDPMID:14722116
Lat2RatSH2 domain binding enablesISOLAT2 (Homo sapiens)1624291UniProtKB:Q9ULZ2 more ...RGDPMID:14722116 and PMID:20442417
Lat2RatSH2 domain binding enablesIEAUniProtKB:Q9GZY6 and ensembl:ENSP000004204941600115GO_REF:0000107EnsemblGO_REF:0000107


#
Reference Title
Reference Citation
1. Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling. Brdicka T, etal., J Exp Med 2002 Dec 16;196(12):1617-26.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23. Martindale DW, etal., Mamm Genome 2000 Oct;11(10):890-8.
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:12514734   PMID:14722116   PMID:15477348   PMID:17013982   PMID:17911602   PMID:20442417   PMID:20458337   PMID:21403644   PMID:23443658   PMID:26448619   PMID:29099056  



Lat2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81227,740,647 - 27,754,760 (+)NCBIGRCr8
mRatBN7.21222,104,173 - 22,118,294 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1222,104,219 - 22,118,288 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1223,252,803 - 23,259,102 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01223,863,886 - 23,870,183 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01222,930,369 - 22,936,714 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01225,114,099 - 25,128,381 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1225,119,355 - 25,125,749 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01227,114,507 - 27,128,775 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41223,174,554 - 23,180,908 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11223,035,110 - 23,041,465 (+)NCBI
Celera1223,873,387 - 23,879,734 (+)NCBICelera
Cytogenetic Map12q12NCBI
LAT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38774,210,006 - 74,229,834 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl774,199,652 - 74,229,834 (+)EnsemblGRCh38hg38GRCh38
GRCh37773,624,336 - 73,644,164 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36773,262,023 - 73,282,100 (+)NCBINCBI36Build 36hg18NCBI36
Build 34773,068,925 - 73,088,808NCBI
Celera769,103,651 - 69,123,730 (+)NCBICelera
Cytogenetic Map7q11.23NCBI
HuRef769,505,694 - 69,525,599 (+)NCBIHuRef
CHM1_1773,769,175 - 73,789,226 (+)NCBICHM1_1
T2T-CHM13v2.0775,412,292 - 75,432,128 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2772,957,159 - 72,977,236 (+)NCBI
Lat2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395134,628,957 - 134,648,637 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5134,628,876 - 134,643,879 (-)EnsemblGRCm39 Ensembl
GRCm385134,600,103 - 134,619,783 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5134,600,022 - 134,615,025 (-)EnsemblGRCm38mm10GRCm38
MGSCv375135,076,135 - 135,090,893 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365134,884,892 - 134,899,650 (-)NCBIMGSCv36mm8
Celera5131,608,314 - 131,623,075 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map574.7NCBI
Lat2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545613,674,190 - 13,688,611 (-)NCBIChiLan1.0ChiLan1.0
LAT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2690,667,421 - 90,698,260 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17138,932,089 - 138,962,892 (-)NCBINHGRI_mPanPan1
PanPan1.1781,350,666 - 81,377,115 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl781,350,666 - 81,377,115 (+)Ensemblpanpan1.1panPan2
LAT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.166,160,939 - 6,175,271 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl66,161,542 - 6,173,294 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha67,859,266 - 7,872,992 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.065,975,446 - 5,989,987 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl65,975,446 - 5,990,000 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.165,966,577 - 5,980,984 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.065,914,054 - 5,928,728 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.066,077,458 - 6,092,227 (-)NCBIUU_Cfam_GSD_1.0
Lat2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344130,774,449 - 130,785,905 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365433,250,956 - 3,262,668 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LAT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl311,352,548 - 11,372,101 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1311,353,213 - 11,372,100 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2311,036,844 - 11,055,323 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LAT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1288,848,971 - 8,865,558 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl288,848,638 - 8,865,574 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660707,714,089 - 7,732,600 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lat2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474013,745,949 - 13,764,869 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Lat2
161 total Variants

Predicted Target Of
Summary Value
Count of predictions:64
Count of miRNA genes:60
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000034629
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat

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alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 45 111 91 90 59 25 59 6 214 93 91 45 60 31


1 to 24 of 24 rows
RefSeq Transcripts NM_173840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005491642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005491643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB219140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC091000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC135741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY170849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ294696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ294697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ294698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ294699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 24 of 24 rows

Ensembl Acc Id: ENSRNOT00000034629   ⟹   ENSRNOP00000031304
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1222,104,219 - 22,118,275 (+)Ensembl
Rnor_6.0 Ensembl1225,119,355 - 25,125,749 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093800   ⟹   ENSRNOP00000083189
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1222,104,219 - 22,118,275 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098558   ⟹   ENSRNOP00000079065
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1222,109,832 - 22,118,288 (+)Ensembl
RefSeq Acc Id: NM_173840   ⟹   NP_776212
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,740,715 - 27,754,760 (+)NCBI
mRatBN7.21222,104,242 - 22,118,289 (+)NCBI
Rnor_6.01225,119,379 - 25,125,733 (+)NCBI
Rnor_5.01227,114,507 - 27,128,775 (+)NCBI
RGSC_v3.41223,174,554 - 23,180,908 (+)RGD
Celera1223,873,387 - 23,879,734 (+)RGD
Sequence:
RefSeq Acc Id: XM_017598358   ⟹   XP_017453847
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,740,653 - 27,754,755 (+)NCBI
mRatBN7.21222,104,179 - 22,118,294 (+)NCBI
Rnor_6.01225,119,846 - 25,128,381 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039089531   ⟹   XP_038945459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,740,654 - 27,754,755 (+)NCBI
mRatBN7.21222,104,180 - 22,118,289 (+)NCBI
RefSeq Acc Id: XM_039089532   ⟹   XP_038945460
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,740,647 - 27,751,122 (+)NCBI
mRatBN7.21222,104,173 - 22,114,650 (+)NCBI
RefSeq Acc Id: XM_039089533   ⟹   XP_038945461
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,740,647 - 27,751,122 (+)NCBI
mRatBN7.21222,104,173 - 22,114,650 (+)NCBI
RefSeq Acc Id: XM_039089534   ⟹   XP_038945462
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,740,691 - 27,754,755 (+)NCBI
mRatBN7.21222,104,223 - 22,118,289 (+)NCBI
RefSeq Acc Id: XR_005491642
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,740,648 - 27,751,776 (+)NCBI
mRatBN7.21222,104,174 - 22,115,308 (+)NCBI
RefSeq Acc Id: XR_005491643
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,740,648 - 27,751,776 (+)NCBI
mRatBN7.21222,104,174 - 22,115,308 (+)NCBI
RefSeq Acc Id: NP_776212   ⟸   NM_173840
- UniProtKB: Q8CGL2 (UniProtKB/Swiss-Prot),   A6J0I1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453847   ⟸   XM_017598358
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZWF7 (UniProtKB/TrEMBL),   A6J0I2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000031304   ⟸   ENSRNOT00000034629
RefSeq Acc Id: XP_038945460   ⟸   XM_039089532
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038945461   ⟸   XM_039089533
- Peptide Label: isoform X4

Name Modeler Protein Id AA Range Protein Structure
AF-Q8CGL2-F1-model_v2 AlphaFold Q8CGL2 1-204 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 19 of 19 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-19580 BioCyc
Ensembl Genes ENSRNOG00000021856 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000034629 ENTREZGENE
  ENSRNOT00000093800 ENTREZGENE
InterPro LAT2 UniProtKB/Swiss-Prot
KEGG Report rno:317676 UniProtKB/Swiss-Prot
NCBI Gene 317676 ENTREZGENE
PANTHER LINKER FOR ACTIVATION OF T-CELLS FAMILY MEMBER 2 UniProtKB/Swiss-Prot
  PTHR15646 UniProtKB/Swiss-Prot
Pfam LAT2 UniProtKB/Swiss-Prot
PhenoGen Lat2 PhenoGen
RatGTEx ENSRNOG00000021856 RatGTEx
UniProt A0A8I5ZM71_RAT UniProtKB/TrEMBL
  A0A8I5ZWF7 ENTREZGENE, UniProtKB/TrEMBL
  A6J0I1 ENTREZGENE, UniProtKB/TrEMBL
  A6J0I2 ENTREZGENE, UniProtKB/TrEMBL
  A6J0I3_RAT UniProtKB/TrEMBL
  G3V8Z1_RAT UniProtKB/TrEMBL
  NTAL_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 19 of 19 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-11-17 Lat2  linker for activation of T cells family, member 2      Symbol and Name updated 1299863 APPROVED
2004-12-14 Wbscr5  Williams-Beuren syndrome chromosome region 5 homolog (human)      Symbol and Name status set to approved 1299863 APPROVED