Taar4 (trace amine-associated receptor 4) - Rat Genome Database

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Gene: Taar4 (trace amine-associated receptor 4) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Taar4
Name: trace amine-associated receptor 4
RGD ID: 631382
Description: Enables trace-amine receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; behavioral fear response; and chemosensory behavior. Predicted to be located in membrane. Predicted to be active in plasma membrane; INTERACTS WITH copper atom; copper(0).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 2-phenylethylamine receptor; Ta2; taR-2; taR-4; trace amine receptor 2; trace amine receptor 4; trace-amine-associated receptor 4
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8123,300,288 - 23,301,331 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl123,300,345 - 23,311,832 (-)EnsemblGRCr8
mRatBN7.2121,481,050 - 21,482,093 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl121,481,050 - 21,482,093 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx121,258,002 - 21,259,045 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0127,258,047 - 27,259,090 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0121,457,713 - 21,458,756 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd122,863,884 - 22,864,927 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive122,188,652 - 22,189,695 (-)NCBILyon_Normotensive
Lyon_Hypertensive123,354,872 - 23,355,915 (-)NCBILyon_Hypertensive
F344_StmMcwi121,677,701 - 21,678,744 (-)NCBIF344_StmMcwi
Rnor_6.0122,558,787 - 22,559,830 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,558,787 - 22,559,830 (-)Ensemblrn6Rnor6.0
Rnor_5.0124,033,714 - 24,034,757 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4122,008,118 - 22,009,161 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera120,224,818 - 20,225,861 (-)NCBICelera
RGSC_v3.1122,011,062 - 22,012,106 (-)NCBI
Cytogenetic Map1p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
copper atom  (EXP)
copper(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Trace amines: identification of a family of mammalian G protein-coupled receptors. Borowsky B, etal., Proc Natl Acad Sci U S A 2001 Jul 31;98(16):8966-71.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. Lindemann L, etal., Genomics 2005 Mar;85(3):372-85.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. GOA pipeline RGD automated data pipeline
Additional References at PubMed
PMID:20559446   PMID:23072560  


Genomics

Variants

.
Variants in Taar4
3 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:37
Count of miRNA genes:35
Interacting mature miRNAs:37
Transcripts:ENSRNOT00000047810
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1529322934184556Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1774611852746118Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1774612152746121Rat
70179Xhs2X-ray hypersensitivity QTL 23.2intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)1143965634Rat
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1126564886Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)11037949255379492Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1694102251941022Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1529322934184556Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)1690935351909353Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11731537851816258Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1126564886Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)1690935351909353Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)1690935351909353Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11282049457820494Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)1134184556Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)12065642065656420Rat
1300170Rf6Renal function QTL 63.14renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)1128483164Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12050832665508326Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11168446456684464Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1529322934184556Rat

Markers in Region
Taar4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2121,481,104 - 21,481,917 (+)MAPPERmRatBN7.2
Rnor_6.0122,558,842 - 22,559,654NCBIRnor6.0
Rnor_5.0124,033,769 - 24,034,581UniSTSRnor5.0
RGSC_v3.4122,008,173 - 22,008,985UniSTSRGSC3.4
Celera120,224,873 - 20,225,685UniSTS
Cytogenetic Map1p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
4 4 2 16 13 11 4 15 4 6 63 30 1 4 23 54 7

Sequence


Ensembl Acc Id: ENSRNOT00000047810   ⟹   ENSRNOP00000050289
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl123,300,345 - 23,311,832 (-)Ensembl
mRatBN7.2 Ensembl121,481,050 - 21,482,093 (-)Ensembl
Rnor_6.0 Ensembl122,558,787 - 22,559,830 (-)Ensembl
RefSeq Acc Id: NM_175583   ⟹   NP_783173
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8123,300,288 - 23,301,331 (-)NCBI
mRatBN7.2121,481,050 - 21,482,093 (-)NCBI
Dahl_SR_JrHsd122,863,884 - 22,864,927 (-)NCBI
Lyon_Normotensive122,188,652 - 22,189,695 (-)NCBI
Lyon_Hypertensive123,354,872 - 23,355,915 (-)NCBI
F344_StmMcwi121,677,701 - 21,678,744 (-)NCBI
Rnor_6.0122,558,787 - 22,559,830 (-)NCBI
Rnor_5.0124,033,714 - 24,034,757 (-)NCBI
RGSC_v3.4122,008,118 - 22,009,161 (-)RGD
Celera120,224,818 - 20,225,861 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_783173 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK71239 (Get FASTA)   NCBI Sequence Viewer  
  ACP18756 (Get FASTA)   NCBI Sequence Viewer  
  EDL87750 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000050289.1
GenBank Protein Q923Y7 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_783173   ⟸   NM_175583
- UniProtKB: Q923Y7 (UniProtKB/Swiss-Prot),   D8KZP7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000050289   ⟸   ENSRNOT00000047810
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q923Y7-F1-model_v2 AlphaFold Q923Y7 1-347 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631382 AgrOrtholog
BioCyc Gene G2FUF-62083 BioCyc
Ensembl Genes ENSRNOG00000029877 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000047810.2 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  TAAR UniProtKB/Swiss-Prot
  TAAR_fam UniProtKB/Swiss-Prot
KEGG Report rno:294122 UniProtKB/Swiss-Prot
NCBI Gene 294122 ENTREZGENE
PANTHER HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot
  TRACE AMINE-ASSOCIATED RECEPTOR 4 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Taar4 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  TRACEAMINER UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000029877 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt D8KZP7 ENTREZGENE, UniProtKB/TrEMBL
  Q923Y7 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-20 Taar4  trace amine-associated receptor 4  Taar4  trace-amine-associated receptor 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-02-23 Taar4  trace-amine-associated receptor 4  Ta2  trace amine receptor 2  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2004-02-11 Tar2  trace amine receptor 2      Symbol and Name status set to approved 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the kidneys and testis 634071
gene_function functions as neurotransmitters for biogenic amines along with the orphan receptor PNR 634071
gene_homology 82% amino acid similarity with the human 5-HT4 pseudogene 634071
gene_product member of the rhodopsin mammalian G protein-coupled receptor family 634071
gene_regulation activated by beta-phenylethylamine and tryptamine 634071