Aard (alanine and arginine rich domain containing protein) - Rat Genome Database

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Gene: Aard (alanine and arginine rich domain containing protein) Rattus norvegicus
Analyze
Symbol: Aard
Name: alanine and arginine rich domain containing protein
RGD ID: 631378
Description: Involved in lung development. Orthologous to human AARD (alanine and arginine rich domain containing protein); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: A5D3; alanine and arginine-rich domain-containing protein; rA5D3
RGD Orthologs
Human
Mouse
Bonobo
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8785,254,322 - 85,259,163 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl785,253,992 - 85,259,163 (+)EnsemblGRCr8
mRatBN7.2783,364,478 - 83,369,319 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl783,364,204 - 83,369,317 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx785,266,568 - 85,271,407 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0787,467,779 - 87,472,618 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0787,288,152 - 87,292,993 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0791,588,458 - 91,593,299 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl791,588,458 - 91,593,297 (+)Ensemblrn6Rnor6.0
Rnor_5.0792,232,534 - 92,237,375 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4788,346,189 - 88,351,030 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera780,241,346 - 80,246,187 (+)NCBICelera
RGSC_v3.1788,366,918 - 88,371,758 (+)NCBI
Cytogenetic Map7q31NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Molecular cloning and characterization of a novel gene upregulated early during postnatal rat lung development. Blomberg LA, etal., Biochim Biophys Acta 2002 Apr 12;1574(3):391-8.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Comprehensive gene review and curation RGD comprehensive gene curation

Genomics

Comparative Map Data
Aard
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8785,254,322 - 85,259,163 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl785,253,992 - 85,259,163 (+)EnsemblGRCr8
mRatBN7.2783,364,478 - 83,369,319 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl783,364,204 - 83,369,317 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx785,266,568 - 85,271,407 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0787,467,779 - 87,472,618 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0787,288,152 - 87,292,993 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0791,588,458 - 91,593,299 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl791,588,458 - 91,593,297 (+)Ensemblrn6Rnor6.0
Rnor_5.0792,232,534 - 92,237,375 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4788,346,189 - 88,351,030 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera780,241,346 - 80,246,187 (+)NCBICelera
RGSC_v3.1788,366,918 - 88,371,758 (+)NCBI
Cytogenetic Map7q31NCBI
AARD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388116,938,207 - 116,944,487 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8116,938,207 - 116,944,487 (+)Ensemblhg38GRCh38
GRCh378117,950,446 - 117,956,726 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368118,019,664 - 118,024,403 (+)NCBIBuild 36Build 36hg18NCBI36
Celera8114,139,154 - 114,144,929 (+)NCBICelera
Cytogenetic Map8q24.11NCBI
HuRef8113,276,873 - 113,282,648 (+)NCBIHuRef
CHM1_18117,990,693 - 117,996,449 (+)NCBICHM1_1
T2T-CHM13v2.08118,066,378 - 118,072,658 (+)NCBIT2T-CHM13v2.0
Aard
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391551,903,503 - 51,909,118 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1551,903,503 - 51,909,118 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381552,040,107 - 52,045,722 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1552,040,107 - 52,045,722 (+)Ensemblmm10GRCm38
MGSCv371551,871,653 - 51,877,269 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361551,870,181 - 51,875,795 (+)NCBIMGSCv36mm8
Celera1553,613,350 - 53,618,906 (+)NCBICelera
Cytogenetic Map15CNCBI
cM Map1519.55NCBI
AARD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27134,342,121 - 134,351,815 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18109,857,519 - 109,867,201 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08113,610,223 - 113,619,903 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18116,155,559 - 116,160,040 (+)NCBIPanPan1.1PanPan1.1panPan2
Aard
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530321,786,039 - 21,952,526 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647029,321,105 - 29,325,192 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647029,320,937 - 29,325,193 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AARD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl421,715,819 - 21,720,764 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1421,715,688 - 21,720,760 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2422,984,620 - 22,989,689 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AARD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18111,574,689 - 111,580,903 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8111,575,266 - 111,580,871 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603928,745,848 - 28,751,287 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aard
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11226,629,801 - 226,634,857 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Aard
30 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:404
Count of miRNA genes:242
Interacting mature miRNAs:274
Transcripts:ENSRNOT00000006257
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74511390390113903Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)771103011106126789Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)75170064396700643Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
1298525Cm1Cardiac mass QTL 12.7heart mass (VT:0007028)heart wet weight (CMO:0000069)756625161101625161Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)771621154114982716Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)763889858108889858Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)755498584105834451Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74847504993475049Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
1641908Teswt1Testicular weight QTL 13.28testis mass (VT:1000644)both testes wet weight (CMO:0000175)78211124596700643Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
724537Niddm52Non-insulin dependent diabetes mellitus QTL 520.02blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)78211124595485241Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)762963207107963207Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)763889858108889858Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
2303582Gluco53Glucose level QTL 533blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)74860308793603087Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
AI229720  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2783,368,425 - 83,368,592 (+)MAPPERmRatBN7.2
Rnor_6.0791,592,406 - 91,592,572NCBIRnor6.0
Rnor_5.0792,236,482 - 92,236,648UniSTSRnor5.0
RGSC_v3.4788,350,137 - 88,350,303UniSTSRGSC3.4
Celera780,245,294 - 80,245,460UniSTS
RH 3.4 Map7549.8UniSTS
Cytogenetic Map7q31UniSTS
AV328152  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2783,369,161 - 83,369,283 (+)MAPPERmRatBN7.2
Rnor_6.0791,593,142 - 91,593,263NCBIRnor6.0
Rnor_5.0792,237,218 - 92,237,339UniSTSRnor5.0
RGSC_v3.4788,350,873 - 88,350,994UniSTSRGSC3.4
Celera780,246,030 - 80,246,151UniSTS
Cytogenetic Map7q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 11 64 131 76 80 53 21 53 5 262 111 10 115 78 75 27 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000006257   ⟹   ENSRNOP00000006257
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl785,253,992 - 85,259,163 (+)Ensembl
mRatBN7.2 Ensembl783,364,204 - 83,369,317 (+)Ensembl
Rnor_6.0 Ensembl791,588,458 - 91,593,297 (+)Ensembl
RefSeq Acc Id: NM_145093   ⟹   NP_659561
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8785,254,322 - 85,259,163 (+)NCBI
mRatBN7.2783,364,478 - 83,369,319 (+)NCBI
Rnor_6.0791,588,458 - 91,593,299 (+)NCBI
Rnor_5.0792,232,534 - 92,237,375 (+)NCBI
RGSC_v3.4788,346,189 - 88,351,030 (+)RGD
Celera780,241,346 - 80,246,187 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_659561 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG15560 (Get FASTA)   NCBI Sequence Viewer  
  EDM16274 (Get FASTA)   NCBI Sequence Viewer  
  Q91ZF7 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_659561   ⟸   NM_145093
- UniProtKB: Q91ZF7 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006257   ⟸   ENSRNOT00000006257

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q91ZF7-F1-model_v2 AlphaFold Q91ZF7 1-165 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695324
Promoter ID:EPDNEW_R5849
Type:single initiation site
Name:Aard_1
Description:alanine and arginine rich domain containing protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0791,588,435 - 91,588,495EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631378 AgrOrtholog
BioCyc Gene G2FUF-33424 BioCyc
Ensembl Genes ENSRNOG00000004708 Ensembl
InterPro FAM167_domain UniProtKB/Swiss-Prot
KEGG Report rno:246323 UniProtKB/Swiss-Prot
NCBI Gene 246323 ENTREZGENE
PANTHER ALANINE AND ARGININE-RICH DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
  PROTEIN FAM167A UniProtKB/Swiss-Prot
PhenoGen Aard PhenoGen
RatGTEx ENSRNOG00000004708 RatGTEx
UniProt A0A8L2Q2N6_RAT UniProtKB/TrEMBL
  A6HRE7_RAT UniProtKB/TrEMBL
  AARD_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-07-08 Aard  alanine and arginine rich domain containing protein    A5D3 protein  Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains potential leucine zipper motifs and phosphorylation sites 632257
gene_protein 165 amino acids 632257