Gpm6a (glycoprotein m6a) - Rat Genome Database

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Gene: Gpm6a (glycoprotein m6a) Rattus norvegicus
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Symbol: Gpm6a
Name: glycoprotein m6a
RGD ID: 631368
Description: Enables calcium channel activity. Involved in positive regulation of filopodium assembly; regulation of synapse organization; and synapse assembly. Located in several cellular components, including filopodium; neuron projection; and neuronal cell body. Is active in glutamatergic synapse; parallel fiber to Purkinje cell synapse; and presynaptic active zone membrane. Orthologous to human GPM6A (glycoprotein M6A); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: M6a; neuronal membrane glycoprotein M6-a
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81643,374,385 - 43,706,461 (-)NCBIGRCr8
mRatBN7.21636,641,282 - 36,973,377 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1636,641,284 - 36,973,475 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1642,008,018 - 42,338,043 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01645,368,826 - 45,698,861 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01640,750,344 - 41,066,575 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01639,367,697 - 39,719,292 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1639,367,692 - 39,719,187 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01639,144,853 - 39,493,517 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41639,670,748 - 39,783,384 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11639,670,823 - 39,783,459 (-)NCBI
Celera1634,795,943 - 34,908,788 (-)NCBICelera
Cytogenetic Map16p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gpm6aRatNeurodevelopmental Disorders  ISOGPM6A (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
Object Symbol
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Original Reference(s)
Gpm6aRathepatocellular carcinoma  ISOGPM6A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28284560

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Object Symbol
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Term
Qualifier
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Reference
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Original Reference(s)
Gpm6aRat(2,4,5-trichlorophenoxy)acetic acid decreases expressionISOGpm6a (Mus musculus)64804642 more ...CTDPMID:18579281
Gpm6aRat1,1-dichloroethene decreases expressionISOGpm6a (Mus musculus)6480464vinylidene chloride results in decreased expression of GPM6A mRNACTDPMID:26682919
Gpm6aRat1,2-dimethylhydrazine decreases expressionISOGpm6a (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of GPM6A mRNACTDPMID:22206623
Gpm6aRat17beta-estradiol multiple interactionsISOGPM6A (Homo sapiens)6480464[Estradiol co-treated with TGFB1 protein] results in decreased expression of GPM6A mRNACTDPMID:30165855
Gpm6aRat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionEXP 64804642 more ...CTDPMID:27291303
Gpm6aRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOGpm6a (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of GPM6A mRNACTDPMID:24680724
Gpm6aRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of GPM6A mRNACTDPMID:32109520 and PMID:33387578
Gpm6aRat2,3,7,8-Tetrachlorodibenzofuran decreases expressionEXP 64804642 more ...CTDPMID:32109520
Gpm6aRat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOGpm6a (Mus musculus)64804642 more ...CTDPMID:38648751
Gpm6aRat3,4-methylenedioxymethamphetamine decreases expressionEXP 6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of GPM6A mRNACTDPMID:30071829
Gpm6aRat4,4'-sulfonyldiphenol increases expressionISOGpm6a (Mus musculus)6480464bisphenol S results in increased expression of GPM6A mRNACTDPMID:31881267
Gpm6aRat4-hydroxyphenyl retinamide decreases expressionISOGpm6a (Mus musculus)6480464Fenretinide results in decreased expression of GPM6A mRNACTDPMID:28973697
Gpm6aRat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of GPM6A mRNACTDPMID:24780913
Gpm6aRataflatoxin B1 decreases expressionISOGPM6A (Homo sapiens)6480464Aflatoxin B1 results in decreased expression of GPM6A mRNACTDPMID:22100608 and PMID:32234424
Gpm6aRataflatoxin B1 affects methylationISOGPM6A (Homo sapiens)6480464Aflatoxin B1 affects the methylation of GPM6A intronCTDPMID:30157460
Gpm6aRatammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of GPM6A mRNACTDPMID:16483693
Gpm6aRataristolochic acid A multiple interactionsEXP 6480464[aristolochic acid I co-treated with aristolochic acid II] results in decreased expression of GPM6A mRNACTDPMID:23912714
Gpm6aRatarsenite(3-) multiple interactionsISOGPM6A (Homo sapiens)6480464arsenite inhibits the reaction [G3BP1 protein binds to GPM6A mRNA]CTDPMID:32406909
Gpm6aRatarsenous acid increases expressionISOGPM6A (Homo sapiens)6480464Arsenic Trioxide results in increased expression of GPM6A mRNACTDPMID:15761015
Gpm6aRatbenzo[a]pyrene increases methylationISOGPM6A (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of GPM6A 5' UTR and Benzo(a)pyrene results in increased methylation of GPM6A promoterCTDPMID:27901495

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Biological Process
1 to 20 of 21 rows

  
Object Symbol
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Original Reference(s)
Gpm6aRatcalcium ion transmembrane transport involved_inIEAGO:00052621600115GO_REF:0000108GOCGO_REF:0000108
Gpm6aRatnervous system development involved_inIEAUniProtKB-KW:KW-05241600115GO_REF:0000043UniProtGO_REF:0000043
Gpm6aRatneural retina development involved_inISSUniProtKB:P358021600115GO_REF:0000024UniProtGO_REF:0000024
Gpm6aRatneural retina development involved_inIEAUniProtKB:P35802 and ensembl:ENSMUSP000000339151600115GO_REF:0000107EnsemblGO_REF:0000107
Gpm6aRatneural retina development involved_inISOGpm6a (Mus musculus)1624291 PMID:18776950RGDPMID:18776950
Gpm6aRatneuron migration involved_inISSUniProtKB:P516741600115GO_REF:0000024UniProtGO_REF:0000024
Gpm6aRatneuron migration involved_inIEAUniProtKB:P51674 and ensembl:ENSP000003772681600115GO_REF:0000107EnsemblGO_REF:0000107
Gpm6aRatneuron migration involved_inISOGPM6A (Homo sapiens)1624291 PMID:19298174RGDPMID:19298174
Gpm6aRatneuron projection development involved_inIBAMGI:107671 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Gpm6aRatneuron projection morphogenesis involved_inISSUniProtKB:P358021600115GO_REF:0000024UniProtGO_REF:0000024
Gpm6aRatneuron projection morphogenesis involved_inIEAUniProtKB:P35802 and ensembl:ENSMUSP000000339151600115GO_REF:0000107EnsemblGO_REF:0000107
Gpm6aRatneuron projection morphogenesis involved_inISOGpm6a (Mus musculus)1624291 PMID:18776950RGDPMID:18776950
Gpm6aRatpositive regulation of filopodium assembly involved_inIDA 8553615PMID:21426347UniProt 
Gpm6aRatregulation of synapse organization involved_inIMP 13702167PMID:27793698SynGO 
Gpm6aRatregulation of synapse organization involved_inIDA 13702167PMID:27793698SynGO 
Gpm6aRatresponse to bacterium acts_upstream_of_or_withinISOGpm6a (Mus musculus)1624291 PMID:23012479RGDPMID:23012479
Gpm6aRatresponse to bacterium acts_upstream_of_or_withinIEAUniProtKB:P35802 and ensembl:ENSMUSP000000339151600115GO_REF:0000107EnsemblGO_REF:0000107
Gpm6aRatstem cell differentiation involved_inISSUniProtKB:P516741600115GO_REF:0000024UniProtGO_REF:0000024
Gpm6aRatstem cell differentiation involved_inIEAUniProtKB:P51674 and ensembl:ENSP000003772681600115GO_REF:0000107EnsemblGO_REF:0000107
Gpm6aRatstem cell differentiation involved_inISOGPM6A (Homo sapiens)1624291 PMID:19298174RGDPMID:19298174
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Cellular Component
1 to 20 of 33 rows

  
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Reference
Notes
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Original Reference(s)
Gpm6aRataxon located_inIEAUniProtKB-SubCell:SL-02791600115GO_REF:0000044UniProtGO_REF:0000044
Gpm6aRataxonal growth cone located_inISSUniProtKB:P358021600115GO_REF:0000024UniProtGO_REF:0000024
Gpm6aRataxonal growth cone is_active_inIBAMGI:107671 and PANTHER:PTN0026179021600115GO_REF:0000033GO_CentralGO_REF:0000033
Gpm6aRataxonal growth cone located_inIEAUniProtKB:P35802 and ensembl:ENSMUSP000000339151600115GO_REF:0000107EnsemblGO_REF:0000107
Gpm6aRataxonal growth cone located_inISOGpm6a (Mus musculus)1624291 PMID:21714103RGDPMID:21714103
Gpm6aRatcell projection located_inIEAUniProtKB-KW:KW-09661600115GO_REF:0000043UniProtGO_REF:0000043
Gpm6aRatdendritic spine located_inIEAUniProtKB-SubCell:SL-02841600115GO_REF:0000044UniProtGO_REF:0000044
Gpm6aRatfilopodium located_inIDA 8554337PMID:16286650UniProt 
Gpm6aRatfilopodium is_active_inIBAPANTHER:PTN002617902 and Gpm6a (Rattus norvegicus)1600115GO_REF:0000033GO_CentralGO_REF:0000033
Gpm6aRatfilopodium located_inIEAUniProtKB-SubCell:SL-02861600115GO_REF:0000044UniProtGO_REF:0000044
Gpm6aRatglutamatergic synapse is_active_inEXP 13702180PMID:23622064SynGO 
Gpm6aRatglutamatergic synapse is_active_inIDA 155230692PMID:10447243SynGO 
Gpm6aRatglutamatergic synapse is_active_inIDA 13702167PMID:27793698SynGO 
Gpm6aRatglutamatergic synapse is_active_inIMP 13702167PMID:27793698SynGO 
Gpm6aRatglutamatergic synapse is_active_inIDA 13702180PMID:23622064SynGO 
Gpm6aRatgrowth cone located_inIEAUniProtKB-SubCell:SL-02881600115GO_REF:0000044UniProtGO_REF:0000044
Gpm6aRatmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Gpm6aRatmembrane located_inIEAInterPro:IPR0016141600115GO_REF:0000002InterProGO_REF:0000002
Gpm6aRatmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Gpm6aRatneuron projection located_inIDA 8553615PMID:21426347UniProt 
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Molecular Function

  
Object Symbol
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Term
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Reference
Notes
Source
Original Reference(s)
Gpm6aRatcalcium channel activity  IDA 708586 RGD 
Gpm6aRatprotein binding enablesIPIUniProtKB:P335358554757PMID:17548356IntAct 
Gpm6aRatprotein binding enablesISOGPM6A (Homo sapiens)1624291UniProtKB:O14901 more ...RGDPMID:17500595 more ...


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Reference Title
Reference Citation
1. The stress-regulated protein M6a is a key modulator for neurite outgrowth and filopodium/spine formation. Alfonso J, etal., Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17196-201. Epub 2005 Nov 14.
2. Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses. Boyken J, etal., Neuron. 2013 Apr 24;78(2):285-97. doi: 10.1016/j.neuron.2013.02.027.
3. Evidence for a role of glycoprotein M6a in dendritic spine formation and synaptogenesis. Formoso K, etal., Mol Cell Neurosci. 2016 Dec;77:95-104. doi: 10.1016/j.mcn.2016.10.005. Epub 2016 Oct 26.
4. Cysteine residues in the large extracellular loop (EC2) are essential for the function of the stress-regulated glycoprotein M6a. Fuchsova B, etal., J Biol Chem. 2009 Nov 13;284(46):32075-88. doi: 10.1074/jbc.M109.012377. Epub 2009 Sep 8.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. M6a acts as a nerve growth factor-gated Ca(2+) channel in neuronal differentiation. Mukobata S, etal., Biochem Biophys Res Commun 2002 Oct 4;297(4):722-8.
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Immunoelectron microscopic localization of the M6a antigen in rat brain. Roussel G, etal., J Neurocytol. 1998 Sep;27(9):695-703. doi: 10.1023/a:1006924400768.
12. Neuronal glycoprotein M6a induces filopodia formation via association with cholesterol-rich lipid rafts. Scorticati C, etal., J Neurochem. 2011 Nov;119(3):521-31. doi: 10.1111/j.1471-4159.2011.07252.x. Epub 2011 Apr 13.
13. Membrane glycoprotein M6a interacts with the micro-opioid receptor and facilitates receptor endocytosis and recycling. Wu DF, etal., J Biol Chem. 2007 Jul 27;282(30):22239-47. Epub 2007 Jun 4.
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PMID:12477932   PMID:18241840   PMID:18776950   PMID:19056867   PMID:19180239   PMID:19298174   PMID:20074218   PMID:21714103   PMID:22871113   PMID:23012479   PMID:23959066   PMID:24769233  
PMID:25940868   PMID:26809475   PMID:36943192   PMID:37189342  



Gpm6a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81643,374,385 - 43,706,461 (-)NCBIGRCr8
mRatBN7.21636,641,282 - 36,973,377 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1636,641,284 - 36,973,475 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1642,008,018 - 42,338,043 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01645,368,826 - 45,698,861 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01640,750,344 - 41,066,575 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01639,367,697 - 39,719,292 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1639,367,692 - 39,719,187 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01639,144,853 - 39,493,517 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41639,670,748 - 39,783,384 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11639,670,823 - 39,783,459 (-)NCBI
Celera1634,795,943 - 34,908,788 (-)NCBICelera
Cytogenetic Map16p11NCBI
GPM6A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384175,632,937 - 176,002,393 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4175,632,934 - 176,002,664 (-)EnsemblGRCh38hg38GRCh38
GRCh374176,554,088 - 176,923,544 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364176,791,082 - 177,160,642 (-)NCBINCBI36Build 36hg18NCBI36
Build 344176,929,237 - 177,298,797NCBI
Celera4173,882,262 - 174,251,819 (-)NCBICelera
Cytogenetic Map4q34.2NCBI
HuRef4172,304,394 - 172,674,410 (-)NCBIHuRef
CHM1_14176,530,612 - 176,900,675 (-)NCBICHM1_1
T2T-CHM13v2.04178,971,366 - 179,340,845 (-)NCBIT2T-CHM13v2.0
Gpm6a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39855,232,469 - 55,513,913 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl855,407,878 - 55,513,906 (+)EnsemblGRCm39 Ensembl
GRCm38854,779,434 - 55,060,878 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl854,954,843 - 55,060,871 (+)EnsemblGRCm38mm10GRCm38
MGSCv37856,040,081 - 56,146,231 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36856,453,541 - 56,559,569 (+)NCBIMGSCv36mm8
Celera857,650,307 - 57,756,272 (+)NCBICelera
Cytogenetic Map8B1.3NCBI
cM Map829.33NCBI
Gpm6a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540331,861,945 - 31,997,382 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540331,704,540 - 31,997,382 (+)NCBIChiLan1.0ChiLan1.0
GPM6A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23173,359,853 - 173,727,990 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14173,740,237 - 174,109,774 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04167,826,285 - 168,194,244 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14180,059,938 - 180,428,838 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4180,059,938 - 180,428,459 (-)Ensemblpanpan1.1panPan2
GPM6A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11653,697,830 - 53,846,773 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1653,698,043 - 53,845,259 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1649,017,267 - 49,350,436 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01655,829,048 - 56,161,090 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1655,829,183 - 56,163,600 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11653,724,013 - 54,054,937 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01654,320,566 - 54,651,964 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01654,556,465 - 54,887,736 (+)NCBIUU_Cfam_GSD_1.0
Gpm6a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494325,924,766 - 26,232,887 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365166,338,819 - 6,481,425 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365166,339,058 - 6,647,412 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPM6A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1538,259,244 - 38,305,603 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11538,258,496 - 38,555,129 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21543,980,735 - 44,241,919 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GPM6A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17121,715,329 - 122,082,175 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7121,714,770 - 121,894,739 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037101,794,371 - 102,161,053 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpm6a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247696,762,743 - 6,904,757 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247696,763,158 - 7,082,764 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Gpm6a
1132 total Variants

Predicted Target Of
Summary Value
Count of predictions:562
Count of miRNA genes:278
Interacting mature miRNAs:354
Transcripts:ENSRNOT00000014312
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat

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alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 49 113 91 90 59 25 59 6 217 96 93 45 60 31



Ensembl Acc Id: ENSRNOT00000014312   ⟹   ENSRNOP00000014312
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1636,641,284 - 36,754,160 (-)Ensembl
Rnor_6.0 Ensembl1639,367,697 - 39,476,025 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092968   ⟹   ENSRNOP00000075966
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1636,641,776 - 36,754,519 (-)Ensembl
Rnor_6.0 Ensembl1639,368,185 - 39,476,384 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092971   ⟹   ENSRNOP00000075962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1636,641,284 - 36,973,475 (-)Ensembl
Rnor_6.0 Ensembl1639,367,692 - 39,719,187 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100181   ⟹   ENSRNOP00000095052
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1636,641,284 - 36,666,617 (-)Ensembl
RefSeq Acc Id: NM_001394533   ⟹   NP_001381462
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81643,374,385 - 43,706,461 (-)NCBI
mRatBN7.21636,641,282 - 36,973,377 (-)NCBI
RefSeq Acc Id: NM_001394534   ⟹   NP_001381463
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81643,374,385 - 43,487,812 (-)NCBI
mRatBN7.21636,641,282 - 36,754,710 (-)NCBI
RefSeq Acc Id: NM_178105   ⟹   NP_835206
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81643,374,385 - 43,487,812 (-)NCBI
mRatBN7.21636,641,282 - 36,754,710 (-)NCBI
Rnor_6.01639,367,697 - 39,476,025 (-)NCBI
Rnor_5.01639,144,853 - 39,493,517 (-)NCBI
RGSC_v3.41639,670,748 - 39,783,384 (-)RGD
Celera1634,795,943 - 34,908,788 (-)RGD
Sequence:
RefSeq Acc Id: XM_039094504   ⟹   XP_038950432
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81643,374,385 - 43,602,384 (-)NCBI
mRatBN7.21636,641,282 - 36,869,402 (-)NCBI
RefSeq Acc Id: XM_063275414   ⟹   XP_063131484
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81643,374,385 - 43,706,427 (-)NCBI
RefSeq Acc Id: XM_063275415   ⟹   XP_063131485
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81643,374,385 - 43,401,416 (-)NCBI
1 to 5 of 10 rows
1 to 5 of 10 rows
RefSeq Acc Id: NP_835206   ⟸   NM_178105
- Peptide Label: isoform 1
- UniProtKB: Q812E9 (UniProtKB/Swiss-Prot),   A0A8I6APM4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075962   ⟸   ENSRNOT00000092971
Ensembl Acc Id: ENSRNOP00000075966   ⟸   ENSRNOT00000092968
Ensembl Acc Id: ENSRNOP00000014312   ⟸   ENSRNOT00000014312
RefSeq Acc Id: XP_038950432   ⟸   XM_039094504
- Peptide Label: isoform X2
- UniProtKB: A0A1B0GWN8 (UniProtKB/TrEMBL)

Name Modeler Protein Id AA Range Protein Structure
AF-Q812E9-F1-model_v2 AlphaFold Q812E9 1-278 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13700091
Promoter ID:EPDNEW_R10604
Type:initiation region
Name:Gpm6a_1
Description:glycoprotein m6a
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01639,719,143 - 39,719,203EPDNEW


1 to 27 of 27 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-11476 BioCyc
Ensembl Genes ENSRNOG00000010731 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014312 ENTREZGENE
  ENSRNOT00000014312.8 UniProtKB/Swiss-Prot
  ENSRNOT00000092968 ENTREZGENE
  ENSRNOT00000092971 ENTREZGENE
  ENSRNOT00000092971.2 UniProtKB/Swiss-Prot
  ENSRNOT00000127343 ENTREZGENE
IMAGE_CLONE IMAGE:7313006 IMAGE-MGC_LOAD
InterPro Myelin_PLP UniProtKB/Swiss-Prot
  Myelin_PLP_CS UniProtKB/Swiss-Prot
KEGG Report rno:306439 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105292 IMAGE-MGC_LOAD
NCBI Gene 306439 ENTREZGENE
PANTHER NEURONAL MEMBRANE GLYCOPROTEIN M6-A UniProtKB/Swiss-Prot
  PTHR11683 UniProtKB/Swiss-Prot
Pfam Myelin_PLP UniProtKB/Swiss-Prot
PhenoGen Gpm6a PhenoGen
PRINTS MYELINPLP UniProtKB/Swiss-Prot
PROSITE MYELIN_PLP_1 UniProtKB/Swiss-Prot
  MYELIN_PLP_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010731 RatGTEx
SMART PLP UniProtKB/Swiss-Prot
UniProt A0A1B0GWN8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6APM4 ENTREZGENE, UniProtKB/TrEMBL
  A6JPG6 ENTREZGENE, UniProtKB/TrEMBL
  GPM6A_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 27 of 27 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-11 Gpm6a  glycoprotein m6a      Symbol and Name status set to approved 625702 APPROVED

Note Type Note Reference
gene_regulation gated selectively by phosphorylation with PKC in the downstream of NGF signaling pathway 708586