Tpsg1 (tryptase gamma 1) - Rat Genome Database

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Gene: Tpsg1 (tryptase gamma 1) Rattus norvegicus
Analyze
Symbol: Tpsg1
Name: tryptase gamma 1
RGD ID: 631355
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in membrane. Predicted to be active in extracellular space. Orthologous to human TPSG1 (tryptase gamma 1); INTERACTS WITH 4,4'-sulfonyldiphenol; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: tryptase gamma
RGD Orthologs
Human
Mouse
Bonobo
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,889,838 - 14,895,605 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1014,890,734 - 14,894,786 (+)EnsemblGRCr8
mRatBN7.21014,386,352 - 14,390,258 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1014,386,352 - 14,390,258 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1019,127,064 - 19,130,970 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01018,615,933 - 18,619,839 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01014,115,112 - 14,119,018 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01014,724,531 - 14,731,259 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,727,180 - 14,731,086 (+)Ensemblrn6Rnor6.0
Rnor_5.01014,542,963 - 14,547,658 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41014,617,611 - 14,621,517 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1014,058,017 - 14,061,923 (+)NCBICelera
RGSC_v3.11014,617,610 - 14,621,517 (+)NCBI
Cytogenetic Map10q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IBA,IEA)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Information Derived from GenBank Report RGD, Sept. 2003

Genomics

Comparative Map Data
Tpsg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,889,838 - 14,895,605 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1014,890,734 - 14,894,786 (+)EnsemblGRCr8
mRatBN7.21014,386,352 - 14,390,258 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1014,386,352 - 14,390,258 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1019,127,064 - 19,130,970 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01018,615,933 - 18,619,839 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01014,115,112 - 14,119,018 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01014,724,531 - 14,731,259 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,727,180 - 14,731,086 (+)Ensemblrn6Rnor6.0
Rnor_5.01014,542,963 - 14,547,658 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41014,617,611 - 14,621,517 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1014,058,017 - 14,061,923 (+)NCBICelera
RGSC_v3.11014,617,610 - 14,621,517 (+)NCBI
Cytogenetic Map10q12NCBI
TPSG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38161,221,651 - 1,225,268 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl161,221,651 - 1,225,793 (-)Ensemblhg38GRCh38
GRCh37161,271,651 - 1,275,268 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36161,211,652 - 1,215,255 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34161,211,654 - 1,405,893NCBI
Celera161,487,545 - 1,491,148 (-)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef161,204,710 - 1,208,313 (-)NCBIHuRef
CHM1_1161,271,325 - 1,274,928 (-)NCBICHM1_1
T2T-CHM13v2.0161,236,961 - 1,240,578 (-)NCBIT2T-CHM13v2.0
Tpsg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391725,588,169 - 25,593,416 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1725,588,235 - 25,593,417 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381725,369,195 - 25,374,442 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1725,369,273 - 25,374,442 (+)Ensemblmm10GRCm38
MGSCv371725,507,498 - 25,511,387 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361725,098,184 - 25,102,042 (+)NCBIMGSCv36mm8
Celera1725,898,349 - 25,902,242 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.53NCBI
LOC100983474
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2181,511,306 - 1,513,899 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1165,291,622 - 5,294,101 (+)NCBINHGRI_mPanPan1
PanPan1.1161,222,801 - 1,231,364 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl161,229,423 - 1,231,364 (-)EnsemblpanPan2panpan1.1
PanPan1.1 Ensembl161,222,933 - 1,226,415 (-)EnsemblpanPan2panpan1.1
LOC110256121
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11260,158,818 - 60,162,073 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TPSG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.151,105,802 - 1,109,613 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606829,982,190 - 29,986,126 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tpsg1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v192,634,269 - 2,638,508 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tpsg1
27 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:131
Count of miRNA genes:106
Interacting mature miRNAs:113
Transcripts:ENSRNOT00000025236
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10117749933Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat

Markers in Region
RH128070  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21014,390,232 - 14,390,447 (+)MAPPERmRatBN7.2
Rnor_6.01014,731,061 - 14,731,275NCBIRnor6.0
Rnor_5.01014,547,585 - 14,547,799UniSTSRnor5.0
RGSC_v3.41014,621,492 - 14,621,706UniSTSRGSC3.4
Celera1014,061,898 - 14,062,112UniSTS
Cytogenetic Map10q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 4 32 48 39 34 8 15 8 6 103 67 28 8 56 26 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000025236   ⟹   ENSRNOP00000025236
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1014,890,880 - 14,894,786 (+)Ensembl
mRatBN7.2 Ensembl1014,386,352 - 14,390,258 (+)Ensembl
Rnor_6.0 Ensembl1014,727,180 - 14,731,086 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106650   ⟹   ENSRNOP00000097494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1014,890,880 - 14,894,786 (+)Ensembl
mRatBN7.2 Ensembl1014,386,352 - 14,390,258 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117883   ⟹   ENSRNOP00000089063
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1014,890,734 - 14,894,786 (+)Ensembl
mRatBN7.2 Ensembl1014,387,403 - 14,390,258 (+)Ensembl
RefSeq Acc Id: NM_175593   ⟹   NP_783183
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,890,880 - 14,894,786 (+)NCBI
mRatBN7.21014,386,352 - 14,390,258 (+)NCBI
Rnor_6.01014,727,180 - 14,731,086 (+)NCBI
Rnor_5.01014,542,963 - 14,547,658 (+)NCBI
RGSC_v3.41014,617,611 - 14,621,517 (+)RGD
Celera1014,058,017 - 14,061,923 (+)RGD
Sequence:
RefSeq Acc Id: XM_063268927   ⟹   XP_063124997
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,889,838 - 14,895,605 (+)NCBI
RefSeq Acc Id: NP_783183   ⟸   NM_175593
- Peptide Label: precursor
- UniProtKB: Q80XZ3 (UniProtKB/TrEMBL),   F7ELK9 (UniProtKB/TrEMBL),   A0A8I6AAZ3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025236   ⟸   ENSRNOT00000025236
Ensembl Acc Id: ENSRNOP00000089063   ⟸   ENSRNOT00000117883
Ensembl Acc Id: ENSRNOP00000097494   ⟸   ENSRNOT00000106650
RefSeq Acc Id: XP_063124997   ⟸   XM_063268927
- Peptide Label: isoform X1
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80XZ3-F1-model_v2 AlphaFold Q80XZ3 1-311 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631355 AgrOrtholog
BioCyc Gene G2FUF-25782 BioCyc
Ensembl Genes ENSRNOG00000018701 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025236 ENTREZGENE
  ENSRNOT00000025236.5 UniProtKB/TrEMBL
  ENSRNOT00000106650.2 UniProtKB/TrEMBL
  ENSRNOT00000117883 ENTREZGENE
  ENSRNOT00000117883.2 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
InterPro Peptidase_S1/S6_AS UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1_S6 UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Ser/Cys_Pept_Trypsin-like UniProtKB/TrEMBL
KEGG Report rno:302990 UniProtKB/TrEMBL
NCBI Gene 302990 ENTREZGENE
PANTHER PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEASE SERINE UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/TrEMBL
PhenoGen Tpsg1 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018701 RatGTEx
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP Pept_Ser_Cys UniProtKB/TrEMBL
UniProt A0A8I6AAZ3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AT24_RAT UniProtKB/TrEMBL
  A6HD25_RAT UniProtKB/TrEMBL
  F7ELK9 ENTREZGENE, UniProtKB/TrEMBL
  Q80XZ3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-11 Tpsg1  tryptase gamma 1      Symbol and Name status set to approved 625702 APPROVED