Fcgr2b (Fc gamma receptor 2B) - Rat Genome Database

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Gene: Fcgr2b (Fc gamma receptor 2B) Rattus norvegicus
Analyze
Symbol: Fcgr2b
Name: Fc gamma receptor 2B
RGD ID: 631331
Description: Enables IgG binding activity. Involved in several processes, including cellular response to amyloid-beta; negative regulation of neutrophil apoptotic process; and regulation of response to endoplasmic reticulum stress. Located in cell surface and recycling endosome. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dengue disease (multiple); hematologic cancer (multiple); leukopenia (multiple); and malaria (multiple). Orthologous to several human genes including FCGR2B (Fc gamma receptor IIb); PARTICIPATES IN clathrin-mediated endocytosis pathway; adaptive immune response pathway; B cell receptor signaling pathway; INTERACTS WITH (S)-colchicine; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,2,4-trimethylbenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CD32; Fc fragment of IgG receptor IIb; Fc fragment of IgG, low affinity IIb, receptor; Fc gamma receptor IIb; Fc receptor, IgG, low affinity IIb; FC-gamma RII; FcgammaRIIB2; Fcgr2; FCRII; igG Fc receptor II beta; low affinity immunoglobulin gamma Fc region receptor II; low affinity immunoglobulin gamma FC region receptor II precursor; low affinity immunoglobulin gamma Fc region receptor II-b
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Glom27
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81385,725,897 - 85,740,517 (-)NCBIGRCr8
mRatBN7.21383,191,253 - 83,207,778 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,193,163 - 83,207,778 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1385,812,894 - 85,827,509 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,106,375 - 87,120,989 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,344,287 - 84,358,917 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,329,298 - 89,343,916 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,327,794 - 89,433,815 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01393,968,425 - 93,983,043 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41386,809,011 - 86,823,599NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1382,845,906 - 82,860,494 (-)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-colchicine  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,6-dinitrotoluene  (EXP)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
bisphenol F  (ISO)
cadmium atom  (ISO)
carbofuran  (EXP)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
cefaloridine  (EXP)
chloroethene  (ISO)
clofibric acid  (EXP)
cocaine  (EXP)
Cuprizon  (EXP)
dexamethasone  (ISO)
dexamethasone phosphate  (EXP)
dextran sulfate  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (EXP,ISO)
doramapimod  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
eugenol  (ISO)
fipronil  (EXP)
formaldehyde  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
graphene oxide  (ISO)
irinotecan  (EXP)
isoprenaline  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
melatonin  (ISO)
menadione  (ISO)
mercury dichloride  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP,ISO)
methylphenidate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
ozone  (ISO)
paclitaxel  (EXP)
paracetamol  (ISO)
phenacetin  (EXP)
phenylhydrazine  (EXP)
pirinixic acid  (ISO)
quartz  (EXP)
quercetin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
SCH 23390  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulpiride  (ISO)
T-2 toxin  (EXP)
tamibarotene  (ISO)
tamoxifen  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
tremolite asbestos  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
undecane  (EXP)
ursolic acid  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (EXP)
vinclozolin  (EXP)
vincristine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antibody-dependent cellular cytotoxicity  (IBA)
antigen processing and presentation of exogenous peptide antigen via MHC class II  (ISO)
B cell proliferation  (ISO)
cell surface receptor signaling pathway  (IBA,IEA,ISO)
cellular response to amyloid-beta  (IMP,ISO)
cellular response to lipopolysaccharide  (IEP)
cellular response to molecule of bacterial origin  (ISO)
cerebellum development  (ISO)
defense response  (ISO)
dendrite development  (ISO)
endocytic recycling  (IDA)
establishment of localization in cell  (ISO)
Fc receptor-mediated immune complex endocytosis  (ISO)
Fc-gamma receptor signaling pathway  (ISO)
immune complex clearance  (IDA)
immune effector process  (ISO)
immunoglobulin mediated immune response  (ISO)
mast cell activation  (ISO)
negative regulation of acute inflammatory response to antigenic stimulus  (ISO)
negative regulation of B cell proliferation  (ISO)
negative regulation of B cell receptor signaling pathway  (ISO)
negative regulation of humoral immune response mediated by circulating immunoglobulin  (ISO)
negative regulation of immune response  (ISO)
negative regulation of immunoglobulin production  (ISO)
negative regulation of inflammatory response to antigenic stimulus  (ISO)
negative regulation of interleukin-10 production  (ISO)
negative regulation of neutrophil apoptotic process  (IMP)
negative regulation of phagocytosis  (ISO)
negative regulation of type I hypersensitivity  (ISO)
phagocytosis  (ISO)
phagocytosis, engulfment  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of phagocytosis  (IBA,ISO)
positive regulation of response to endoplasmic reticulum stress  (IMP,ISO)
positive regulation of tumor necrosis factor production  (IBA)
receptor-mediated endocytosis  (IDA,ISO)
regulation of dendritic spine maintenance  (ISO)
regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway  (IMP,ISO)
regulation of immune response  (IEA)
regulation of long-term neuronal synaptic plasticity  (ISO)
response to bacterium  (ISO)
response to estradiol  (IEP)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Decreased transcription of the human FCGR2B gene mediated by the -343 G/C promoter polymorphism and association with systemic lupus erythematosus. Blank MC, etal., Hum Genet 2005 Jul;117(2-3):220-7. Epub 2005 May 14.
2. Molecular biomarkers of phospholipidosis in rat blood and heart after amiodarone treatment. Bocchini N, etal., J Appl Toxicol. 2015 Jan;35(1):90-103.
3. Cloning and sequence of the cDNA coding for rat type II Fc gamma receptor of mast cells. Bocek P and Pecht I, FEBS Lett 1993 Sep 27;331(1-2):86-90.
4. IGG and complement receptor expression on peripheral white blood cells in uraemic children. Bouts AH, etal., Nephrol Dial Transplant. 2004 Sep;19(9):2296-301. Epub 2004 Jul 20.
5. Platelet count, previous infection and FCGR2B genotype predict development of chronic disease in newly diagnosed idiopathic thrombocytopenia in childhood: results of a prospective study. Bruin M, etal., Br J Haematol. 2004 Dec;127(5):561-7.
6. Amelioration of murine immune thrombocytopenia by CD44 antibodies: a potential therapy for ITP? Crow AR, etal., Blood. 2011 Jan 20;117(3):971-4. doi: 10.1182/blood-2010-05-280115. Epub 2010 Nov 2.
7. FcgammaRIIb inhibits allergic lung inflammation in a murine model of allergic asthma. Dharajiya N, etal., PLoS One. 2010 Feb 22;5(2):e9337. doi: 10.1371/journal.pone.0009337.
8. Target silencing of disease-associated B-lymphocytes by chimeric molecules in SCID model of pristane-induced autoimmunity. Dimitrova I, etal., Lupus. 2010 Oct;19(11):1261-71. doi: 10.1177/0961203310371153. Epub 2010 Jun 8.
9. Effect of FCGR2A and FCGR3A variants on CLL outcome. Dornan D, etal., Blood. 2010 Nov 18;116(20):4212-22. doi: 10.1182/blood-2010-03-272765. Epub 2010 Aug 12.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. The low affinity IgG receptor Fc gamma RIIB contributes to the binding of the mast cell specific antibody, mAb BGD6. Guiraldelli MF, etal., Mol Immunol. 2008 Apr;45(8):2411-8. doi: 10.1016/j.molimm.2007.07.041. Epub 2008 Mar 4.
13. [Relationship between polymorphisms of FCGR2B and susceptibility of children idiopathic thrombocytopenic purpura]. He LY, etal., Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009 Jun;17(3):729-33.
14. Fcgamma receptor deficiency confers protection against atherosclerosis in apolipoprotein E knockout mice. Hernandez-Vargas P, etal., Circ Res. 2006 Nov 24;99(11):1188-96. Epub 2006 Oct 19.
15. The rat neutrophil low-affinity Fc receptor for IgG: molecular cloning and functional characterization. Isashi Y, etal., Immunol Lett. 1995 May;46(1-2):157-63.
16. Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model. Iwasaki M, etal., Blood 2005 Jan 15;105(2):784-93. Epub 2004 Sep 28.
17. FcgammaRIIB Gene Polymorphisms Are Associated with Disease Risk and Clinical Manifestations of Systemic Lupus Erythematosus in Koreans. Jeon JY, etal., Tohoku J Exp Med. 2015;236(3):185-91. doi: 10.1620/tjem.236.185.
18. Fc¿RIIb mediates amyloid-ß neurotoxicity and memory impairment in Alzheimer's disease. Kam TI, etal., J Clin Invest. 2013 Jul;123(7):2791-802. doi: 10.1172/JCI66827. Epub 2013 Jun 10.
19. Thymic stromal lymphopoietin transgenic mice develop cryoglobulinemia and hepatitis with similarities to human hepatitis C liver disease. Kowalewska J, etal., Am J Pathol. 2007 Mar;170(3):981-9.
20. Inhibition of hyperacute transplant rejection by soluble proteins with the functional domains of CD46 and FcgammaRII. Lanteri MB, etal., Transplantation. 2000 Mar 27;69(6):1128-36.
21. Bcl-2 overexpression ameliorates immune complex-mediated arthritis by altering FcgammaRIIb expression and monocyte homeostasis. Lawlor KE, etal., J Leukoc Biol. 2013 Apr;93(4):585-97. doi: 10.1189/jlb.0412190. Epub 2013 Jan 22.
22. Fcgamma receptor IIB and IIIB polymorphisms and susceptibility to systemic lupus erythematosus and lupus nephritis: a meta-analysis. Lee YH, etal., Lupus. 2009 Jul;18(8):727-34. doi: 10.1177/0961203309104020.
23. Sialylation-independent mechanism involved in the amelioration of murine immune thrombocytopenia using intravenous gammaglobulin. Leontyev D, etal., Transfusion. 2012 Aug;52(8):1799-805. doi: 10.1111/j.1537-2995.2011.03517.x. Epub 2012 Jan 18.
24. High-dose dexamethasone shifts the balance of stimulatory and inhibitory Fcgamma receptors on monocytes in patients with primary immune thrombocytopenia. Liu XG, etal., Blood. 2011 Feb 10;117(6):2061-9. doi: 10.1182/blood-2010-07-295477. Epub 2010 Dec 3.
25. FcgammaRIIB deficiency leads to autoimmunity and a defective response to apoptosis in Mrl-MpJ mice. McGaha TL, etal., J Immunol. 2008 Apr 15;180(8):5670-9.
26. Restoration of tolerance in lupus by targeted inhibitory receptor expression. McGaha TL, etal., Science. 2005 Jan 28;307(5709):590-3.
27. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
28. Selective silencing of disease-associated B-lymphocytes by chimeric molecules targeting their Fc gamma IIb receptor. Mihaylova N, etal., Int Immunol. 2008 Feb;20(2):165-75. Epub 2007 Dec 21.
29. Receptor-mediated endocytosis of immune complexes in rat liver sinusoidal endothelial cells is mediated by FcgammaRIIb2. Mousavi SA, etal., Hepatology. 2007 Sep;46(3):871-84.
30. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
31. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
32. GOA pipeline RGD automated data pipeline
33. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. Estrogens regulate neuroinflammatory genes via estrogen receptors alpha and beta in the frontal cortex of middle-aged female rats. Sarvari M, etal., J Neuroinflammation. 2011 Jul 20;8:82. doi: 10.1186/1742-2094-8-82.
36. Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes. Sarvari M, etal., J Neuroinflammation. 2012 Dec 3;9:264. doi: 10.1186/1742-2094-9-264.
37. Human C-reactive protein promotes oxidized low density lipoprotein uptake and matrix metalloproteinase-9 release in Wistar rats. Singh U, etal., J Lipid Res. 2008 May;49(5):1015-23. doi: 10.1194/jlr.M700535-JLR200. Epub 2008 Feb 2.
38. A promoter haplotype of the immunoreceptor tyrosine-based inhibitory motif-bearing FcgammaRIIb alters receptor expression and associates with autoimmunity. I. Regulatory FCGR2B polymorphisms and their association with systemic lupus erythematosus. Su K, etal., J Immunol 2004 Jun 1;172(11):7186-91.
39. Delay of LPS-induced acute lung injury resolution by soluble immune complexes is neutrophil dependent. Wu CL, etal., Shock. 2009 Sep;32(3):276-85.
40. FCGR2B gene polymorphism rather than FCGR2A, FCGR3A and FCGR3B is associated with anti-GBM disease in Chinese. Zhou XJ, etal., Nephrol Dial Transplant. 2010 Jan;25(1):97-101. Epub 2009 Jul 29.
Additional References at PubMed
PMID:1692135   PMID:1710249   PMID:2142460   PMID:8482840   PMID:8552190   PMID:8769481   PMID:9551950   PMID:10395649   PMID:11970986   PMID:11994421   PMID:12385742   PMID:12477932  
PMID:14643301   PMID:16492738   PMID:17502348   PMID:24169826   PMID:26271972  


Genomics

Comparative Map Data
Fcgr2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81385,725,897 - 85,740,517 (-)NCBIGRCr8
mRatBN7.21383,191,253 - 83,207,778 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,193,163 - 83,207,778 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1385,812,894 - 85,827,509 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,106,375 - 87,120,989 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,344,287 - 84,358,917 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,329,298 - 89,343,916 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,327,794 - 89,433,815 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01393,968,425 - 93,983,043 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41386,809,011 - 86,823,599NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1382,845,906 - 82,860,494 (-)NCBICelera
Cytogenetic Map13q24NCBI
FCGR2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,647,243 - 161,678,654 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,663,143 - 161,678,654 (+)EnsemblGRCh38hg38GRCh38
GRCh371161,617,033 - 161,648,444 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,899,564 - 159,914,575 (+)NCBINCBI36Build 36hg18NCBI36
Build 341158,364,610 - 158,379,618NCBI
Celera1134,746,188 - 134,751,893 (+)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1132,877,468 - 132,892,993 (+)NCBIHuRef
CHM1_11163,054,757 - 163,070,270 (+)NCBICHM1_1
T2T-CHM13v2.01160,991,589 - 161,022,983 (+)NCBIT2T-CHM13v2.0
Fcgr2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,786,186 - 170,804,141 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,786,186 - 170,804,116 (-)EnsemblGRCm39 Ensembl
GRCm381170,960,558 - 170,976,071 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,958,617 - 170,976,547 (-)EnsemblGRCm38mm10GRCm38
MGSCv371172,890,689 - 172,906,202 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361172,797,258 - 172,812,708 (-)NCBIMGSCv36mm8
Celera1173,410,273 - 173,425,760 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map178.02NCBI
Fcgr2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495546214,639,396 - 14,653,801 (-)NCBIChiLan1.0ChiLan1.0
FCGR2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2188,107,912 - 88,123,421 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1187,776,270 - 87,791,796 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01137,074,342 - 137,090,962 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11140,882,104 - 140,890,036 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1140,882,043 - 140,890,637 (+)Ensemblpanpan1.1panPan2
FCGR2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13820,980,777 - 20,994,403 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3821,032,683 - 21,053,133 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03821,063,938 - 21,084,394 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13821,035,622 - 21,062,414 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03821,388,877 - 21,409,738 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03821,664,830 - 21,685,450 (-)NCBIUU_Cfam_GSD_1.0
Fcgr2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050587,560,625 - 7,575,166 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493713180,014 - 96,114 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FCGR2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1488,873,762 - 88,892,964 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2496,889,007 - 96,908,224 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103223672
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1202,398,425 - 2,413,328 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660381,453,854 - 1,469,432 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fcgr2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462482697,605 - 112,101 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fcgr2b
86 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:62
Count of miRNA genes:27
Interacting mature miRNAs:29
Transcripts:ENSRNOT00000035400, ENSRNOT00000058497
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)137486211785581182Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat

Markers in Region
AU046896  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21383,206,647 - 83,206,758 (+)MAPPERmRatBN7.2
Rnor_6.01389,342,788 - 89,342,898NCBIRnor6.0
Rnor_5.01393,981,915 - 93,982,025UniSTSRnor5.0
RGSC_v3.41386,822,495 - 86,822,605UniSTSRGSC3.4
Celera1382,859,390 - 82,859,500UniSTS
Cytogenetic Map13q24UniSTS
RH141624  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21383,193,278 - 83,193,474 (+)MAPPERmRatBN7.2
Rnor_6.01389,329,420 - 89,329,615NCBIRnor6.0
Rnor_5.01393,968,547 - 93,968,742UniSTSRnor5.0
RGSC_v3.41386,809,127 - 86,809,322UniSTSRGSC3.4
Celera1382,846,022 - 82,846,217UniSTS
RH 3.4 Map13553.4UniSTS
Cytogenetic Map13q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 21 21 11 21 3 3
Low 1 13 36 20 8 20 8 11 38 13 14 8 8
Below cutoff 20 36 16 19

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000035400   ⟹   ENSRNOP00000034321
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1383,193,164 - 83,207,778 (-)Ensembl
Rnor_6.0 Ensembl1389,329,304 - 89,343,899 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000058497   ⟹   ENSRNOP00000055293
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1383,193,163 - 83,207,728 (-)Ensembl
Rnor_6.0 Ensembl1389,329,304 - 89,343,868 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000091541   ⟹   ENSRNOP00000075099
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1383,193,353 - 83,207,778 (-)Ensembl
Rnor_6.0 Ensembl1389,327,794 - 89,433,815 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111978   ⟹   ENSRNOP00000085440
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1383,193,353 - 83,207,778 (-)Ensembl
RefSeq Acc Id: NM_175756   ⟹   NP_786932
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81385,725,897 - 85,740,517 (-)NCBI
mRatBN7.21383,193,157 - 83,207,778 (-)NCBI
Rnor_6.01389,329,304 - 89,343,892 (-)NCBI
Rnor_5.01393,968,425 - 93,983,043 (-)NCBI
RGSC_v3.41386,809,011 - 86,823,599 (-)RGD
Celera1382,845,906 - 82,860,494 (-)RGD
Sequence:
RefSeq Acc Id: XM_006250233   ⟹   XP_006250295
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81385,725,918 - 85,740,515 (-)NCBI
mRatBN7.21383,191,253 - 83,207,776 (-)NCBI
Rnor_6.01389,329,298 - 89,343,916 (-)NCBI
Rnor_5.01393,968,425 - 93,983,043 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006250235   ⟹   XP_006250297
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81385,725,918 - 85,740,515 (-)NCBI
mRatBN7.21383,191,253 - 83,207,776 (-)NCBI
Rnor_6.01389,329,298 - 89,343,916 (-)NCBI
Rnor_5.01393,968,425 - 93,983,043 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017598710   ⟹   XP_017454199
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81385,725,918 - 85,740,515 (-)NCBI
mRatBN7.21383,191,253 - 83,207,776 (-)NCBI
Rnor_6.01389,329,298 - 89,343,916 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039090504   ⟹   XP_038946432
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81385,725,918 - 85,740,515 (-)NCBI
mRatBN7.21383,191,253 - 83,207,776 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_786932   ⟸   NM_175756
- Peptide Label: precursor
- UniProtKB: Q63203 (UniProtKB/Swiss-Prot),   Q5BKD6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250297   ⟸   XM_006250235
- Peptide Label: isoform X3
- UniProtKB: Q63203 (UniProtKB/Swiss-Prot),   A6IDR2 (UniProtKB/TrEMBL),   Q5BKD6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250295   ⟸   XM_006250233
- Peptide Label: isoform X1
- UniProtKB: A3RLA8 (UniProtKB/TrEMBL),   A6IDR3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454199   ⟸   XM_017598710
- Peptide Label: isoform X2
- UniProtKB: A6IDR4 (UniProtKB/TrEMBL),   A6IDR3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075099   ⟸   ENSRNOT00000091541
RefSeq Acc Id: ENSRNOP00000055293   ⟸   ENSRNOT00000058497
RefSeq Acc Id: ENSRNOP00000034321   ⟸   ENSRNOT00000035400
RefSeq Acc Id: XP_038946432   ⟸   XM_039090504
- Peptide Label: isoform X4
- UniProtKB: A0A0G2K9R6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000085440   ⟸   ENSRNOT00000111978
Protein Domains
Ig-like   Ig-like C2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63203-F1-model_v2 AlphaFold Q63203 1-285 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698990
Promoter ID:EPDNEW_R9515
Type:initiation region
Name:Fcgr2b_1
Description:Fc fragment of IgG receptor IIb
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01389,343,918 - 89,343,978EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631331 AgrOrtholog
BioCyc Gene G2FUF-17458 BioCyc
Ensembl Genes ENSRNOG00000046452 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000035400.8 UniProtKB/TrEMBL
  ENSRNOT00000058497.4 UniProtKB/TrEMBL
  ENSRNOT00000091541.2 UniProtKB/TrEMBL
  ENSRNOT00000111978.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7323350 IMAGE-MGC_LOAD
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:289211 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108556 IMAGE-MGC_LOAD
NCBI Gene 289211 ENTREZGENE
PANTHER IMMUNOGLOBULIN FC RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LOW AFFINITY IMMUNOGLOBULIN GAMMA FC REGION RECEPTOR II-B-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ig_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fcgr2b PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000046452 RatGTEx
SMART SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K9R6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A3C8_RAT UniProtKB/TrEMBL
  A0A8L2QHQ8_RAT UniProtKB/TrEMBL
  A3RLA8 ENTREZGENE, UniProtKB/TrEMBL
  A6IDR2 ENTREZGENE, UniProtKB/TrEMBL
  A6IDR3 ENTREZGENE, UniProtKB/TrEMBL
  A6IDR4 ENTREZGENE, UniProtKB/TrEMBL
  FCGR2_RAT UniProtKB/Swiss-Prot
  Q5BKD6 ENTREZGENE, UniProtKB/TrEMBL
  Q63203 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-05-05 Fcgr2b  Fc gamma receptor 2B  Fcgr2b  Fc gamma receptor IIb  Name changed 629549 APPROVED
2021-11-11 Fcgr2b  Fc gamma receptor IIb  Fcgr2b  Fc fragment of IgG receptor IIb  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-11-29 Fcgr2b  Fc fragment of IgG receptor IIb  Fcgr2b  Fc fragment of IgG, low affinity IIb, receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-11-17 Fcgr2b  Fc fragment of IgG, low affinity IIb, receptor  Fcgr2b  Fc fragment of IgG, low affinity IIb, receptor (CD32)  Name changed 629549 APPROVED
2008-09-25 Fcgr2b  Fc fragment of IgG, low affinity IIb, receptor (CD32)  Fcgr2b  Fc receptor, IgG, low affinity IIb  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-11 Fcgr2b  Fc receptor, IgG, low affinity IIb  Fcgr2  low affinity immunoglobulin gamma FC region receptor II precursor  Symbol and Name updated to reflect Human and Mouse nomenclature 625702 APPROVED