Camk1 (calcium/calmodulin-dependent protein kinase I) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Camk1 (calcium/calmodulin-dependent protein kinase I) Rattus norvegicus
Analyze
Symbol: Camk1
Name: calcium/calmodulin-dependent protein kinase I
RGD ID: 629473
Description: Enables calmodulin-dependent protein kinase activity. Involved in regulation of synapse organization. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human CAMK1 (calcium/calmodulin dependent protein kinase I); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: calcium/calmodulin-dependent protein kinase type 1; caM kinase I alpha; caM-KI; Camki; caMKI-alpha; G alpha interacting protein; Gaip; regulator of G-protein signalling 19
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84148,036,843 - 148,047,675 (-)NCBIGRCr8
mRatBN7.24146,481,196 - 146,492,039 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4146,481,196 - 146,492,081 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4151,865,404 - 151,875,694 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04147,646,247 - 147,656,537 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04146,267,793 - 146,278,095 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04145,289,300 - 145,300,146 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4145,288,996 - 145,300,177 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04208,586,449 - 208,597,283 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44149,220,661 - 149,229,168 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14149,465,501 - 149,474,009 (-)NCBI
Celera4135,038,512 - 135,048,763 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Characterization of a rat cDNA clone encoding calcium/calmodulin-dependent protein kinase I. Cho FS, etal., Biochim Biophys Acta 1994 Oct 20;1224(1):156-60.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Calcium/calmodulin-dependent protein kinase I. cDNA cloning and identification of autophosphorylation site. Picciotto MR, etal., J Biol Chem 1993 Dec 15;268(35):26512-21.
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Activity-dependent synaptogenesis: regulation by a CaM-kinase kinase/CaM-kinase I/betaPIX signaling complex. Saneyoshi T, etal., Neuron. 2008 Jan 10;57(1):94-107. doi: 10.1016/j.neuron.2007.11.016.
8. SIK1 is part of a cell sodium-sensing network that regulates active sodium transport through a calcium-dependent process. Sjostrom M, etal., Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16922-7. Epub 2007 Oct 15.
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
10. Activation of Ca2+/calmodulin-dependent protein kinase I in cultured rat hippocampal neurons. Uezu A, etal., J Neurochem 2002 Aug;82(3):585-93.
Additional References at PubMed
PMID:1646483   PMID:7624832   PMID:7698321   PMID:8386178   PMID:8601311   PMID:8621702   PMID:8631893   PMID:8702851   PMID:10936699   PMID:11081517   PMID:11114197   PMID:11264466  
PMID:12081505   PMID:12130539   PMID:12475216   PMID:15084659   PMID:15147908   PMID:15150258   PMID:15251453   PMID:15489334   PMID:15793568   PMID:16054096   PMID:16683702   PMID:17442826  
PMID:18332106   PMID:18524905   PMID:19200342   PMID:19292454   PMID:20534813   PMID:20810878   PMID:21255668   PMID:22745633   PMID:22833565   PMID:23867755   PMID:26386307   PMID:27323839  
PMID:27369073   PMID:34875535  


Genomics

Comparative Map Data
Camk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84148,036,843 - 148,047,675 (-)NCBIGRCr8
mRatBN7.24146,481,196 - 146,492,039 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4146,481,196 - 146,492,081 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4151,865,404 - 151,875,694 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04147,646,247 - 147,656,537 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04146,267,793 - 146,278,095 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04145,289,300 - 145,300,146 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4145,288,996 - 145,300,177 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04208,586,449 - 208,597,283 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44149,220,661 - 149,229,168 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14149,465,501 - 149,474,009 (-)NCBI
Celera4135,038,512 - 135,048,763 (-)NCBICelera
Cytogenetic Map4q42NCBI
CAMK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3839,757,347 - 9,769,947 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl39,757,347 - 9,769,992 (-)EnsemblGRCh38hg38GRCh38
GRCh3739,799,031 - 9,811,631 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3639,774,031 - 9,786,661 (-)NCBINCBI36Build 36hg18NCBI36
Build 3439,774,031 - 9,786,661NCBI
Celera39,733,733 - 9,746,362 (-)NCBICelera
Cytogenetic Map3p25.3NCBI
HuRef39,735,376 - 9,748,016 (-)NCBIHuRef
CHM1_139,749,224 - 9,761,863 (-)NCBICHM1_1
T2T-CHM13v2.039,749,303 - 9,761,902 (-)NCBIT2T-CHM13v2.0
Camk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396113,311,085 - 113,320,883 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6113,311,085 - 113,320,945 (-)EnsemblGRCm39 Ensembl
GRCm386113,334,124 - 113,343,922 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6113,334,124 - 113,343,984 (-)EnsemblGRCm38mm10GRCm38
MGSCv376113,284,118 - 113,293,916 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366113,299,901 - 113,309,699 (-)NCBIMGSCv36mm8
Celera6115,161,124 - 115,170,917 (-)NCBICelera
Cytogenetic Map6E3NCBI
cM Map652.75NCBI
Camk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555611,282,970 - 1,294,972 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555611,282,970 - 1,292,710 (-)NCBIChiLan1.0ChiLan1.0
CAMK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v229,768,303 - 9,780,976 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan139,773,061 - 9,785,734 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v039,708,782 - 9,721,433 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.139,947,275 - 9,959,560 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl39,945,609 - 9,959,560 (-)Ensemblpanpan1.1panPan2
CAMK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1208,475,902 - 8,486,214 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl208,475,716 - 8,486,214 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha208,508,977 - 8,519,292 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0208,505,194 - 8,515,504 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl208,505,011 - 8,517,090 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1208,227,664 - 8,237,979 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0208,572,188 - 8,582,503 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0208,545,805 - 8,556,117 (+)NCBIUU_Cfam_GSD_1.0
Camk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494215,496,367 - 15,507,235 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366023,401,005 - 3,414,935 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366023,402,559 - 3,413,323 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAMK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1366,044,720 - 66,055,295 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11366,044,713 - 66,055,290 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21373,092,176 - 73,102,714 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CAMK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12245,763,799 - 45,776,792 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2245,762,499 - 45,774,597 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041120,790,539 - 120,803,686 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Camk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247314,383,927 - 4,399,369 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247314,388,373 - 4,399,762 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Camk1
16 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:35
Interacting mature miRNAs:36
Transcripts:ENSRNOT00000029728
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4116179486151161268Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
12798527Anxrr58Anxiety related response QTL 584.110.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4119463257147278687Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4120260281147278687Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4120926564148090731Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat

Markers in Region
RH128087  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24146,480,937 - 146,481,139 (+)MAPPERmRatBN7.2
Rnor_6.04145,289,042 - 145,289,243NCBIRnor6.0
Rnor_5.04208,586,192 - 208,586,392UniSTSRnor5.0
Celera4135,038,254 - 135,038,455UniSTS
RH 3.4 Map4937.4UniSTS
Cytogenetic Map4q42UniSTS
AI505105  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24146,481,267 - 146,481,394 (+)MAPPERmRatBN7.2
Rnor_6.04145,289,372 - 145,289,498NCBIRnor6.0
Rnor_5.04208,586,521 - 208,586,647UniSTSRnor5.0
Celera4135,038,584 - 135,038,710UniSTS
Cytogenetic Map4q42UniSTS
D6Ertd263e  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24146,481,234 - 146,481,453 (+)MAPPERmRatBN7.2
Rnor_6.04145,289,339 - 145,289,557NCBIRnor6.0
Rnor_5.04208,586,488 - 208,586,706UniSTSRnor5.0
Celera4135,038,551 - 135,038,769UniSTS
Cytogenetic Map4q42UniSTS
RH136941  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24146,481,737 - 146,481,926 (+)MAPPERmRatBN7.2
Rnor_6.04145,289,842 - 145,290,030NCBIRnor6.0
Rnor_5.04208,586,991 - 208,587,179UniSTSRnor5.0
Celera4135,039,054 - 135,039,242UniSTS
RH 3.4 Map4937.5UniSTS
Cytogenetic Map4q42UniSTS
RH137514  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24146,481,260 - 146,481,393 (+)MAPPERmRatBN7.2
Rnor_6.04145,289,365 - 145,289,497NCBIRnor6.0
Rnor_5.04208,586,514 - 208,586,646UniSTSRnor5.0
Celera4135,038,577 - 135,038,709UniSTS
Cytogenetic Map4q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 37 27 13 27 1 74 35 34 11
Low 20 14 6 14 8 10 7 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000029728   ⟹   ENSRNOP00000033456
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4146,481,196 - 146,492,081 (-)Ensembl
Rnor_6.0 Ensembl4145,288,996 - 145,300,177 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093950   ⟹   ENSRNOP00000091265
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4146,481,199 - 146,491,517 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000106794   ⟹   ENSRNOP00000096413
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4146,481,196 - 146,488,887 (-)Ensembl
RefSeq Acc Id: NM_134468   ⟹   NP_604463
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84148,036,843 - 148,047,145 (-)NCBI
mRatBN7.24146,481,196 - 146,491,498 (-)NCBI
Rnor_6.04145,289,300 - 145,299,602 (-)NCBI
Rnor_5.04208,586,449 - 208,597,283 (-)NCBI
RGSC_v3.44149,220,661 - 149,229,168 (-)RGD
Celera4135,038,512 - 135,048,763 (-)RGD
Sequence:
RefSeq Acc Id: XM_006237001   ⟹   XP_006237063
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84148,036,848 - 148,047,673 (-)NCBI
mRatBN7.24146,481,201 - 146,492,038 (-)NCBI
Rnor_6.04145,289,305 - 145,300,146 (-)NCBI
Rnor_5.04208,586,449 - 208,597,283 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039106984   ⟹   XP_038962912
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84148,036,848 - 148,047,674 (-)NCBI
mRatBN7.24146,481,201 - 146,492,039 (-)NCBI
RefSeq Acc Id: XM_039106985   ⟹   XP_038962913
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84148,036,848 - 148,047,669 (-)NCBI
mRatBN7.24146,481,201 - 146,492,034 (-)NCBI
RefSeq Acc Id: XM_063285458   ⟹   XP_063141528
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84148,036,848 - 148,047,675 (-)NCBI
RefSeq Acc Id: XM_063285459   ⟹   XP_063141529
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84148,036,848 - 148,047,669 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_604463   ⟸   NM_134468
- UniProtKB: Q63084 (UniProtKB/Swiss-Prot),   Q63450 (UniProtKB/Swiss-Prot),   A6IBQ6 (UniProtKB/TrEMBL),   A0A8I6B458 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237063   ⟸   XM_006237001
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AEY2 (UniProtKB/TrEMBL),   A0A8I6B458 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000033456   ⟸   ENSRNOT00000029728
RefSeq Acc Id: XP_038962912   ⟸   XM_039106984
- Peptide Label: isoform X1
- UniProtKB: A0A8I6B458 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962913   ⟸   XM_039106985
- Peptide Label: isoform X3
- UniProtKB: A0A8L2UL04 (UniProtKB/TrEMBL),   A0A8I6B458 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000091265   ⟸   ENSRNOT00000093950
RefSeq Acc Id: ENSRNOP00000096413   ⟸   ENSRNOT00000106794
RefSeq Acc Id: XP_063141528   ⟸   XM_063285458
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063141529   ⟸   XM_063285459
- Peptide Label: isoform X3
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63450-F1-model_v2 AlphaFold Q63450 1-374 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693296
Promoter ID:EPDNEW_R3820
Type:initiation region
Name:Camk1_1
Description:calcium/calmodulin-dependent protein kinase I
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04145,299,642 - 145,299,702EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:629473 AgrOrtholog
BioCyc Gene G2FUF-43394 BioCyc
Ensembl Genes ENSRNOG00000021781 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055007856 UniProtKB/Swiss-Prot
  ENSRNOG00060013595 UniProtKB/Swiss-Prot
  ENSRNOG00065027661 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000029728.6 UniProtKB/TrEMBL
  ENSRNOT00000093950.1 UniProtKB/TrEMBL
  ENSRNOT00000106794 ENTREZGENE
  ENSRNOT00000106794.1 UniProtKB/TrEMBL
  ENSRNOT00055013194 UniProtKB/Swiss-Prot
  ENSRNOT00060023204 UniProtKB/Swiss-Prot
  ENSRNOT00065047693 UniProtKB/Swiss-Prot
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7098592 IMAGE-MGC_LOAD
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171503 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:91494 IMAGE-MGC_LOAD
NCBI Gene 171503 ENTREZGENE
PANTHER CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Camk1 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021781 RatGTEx
  ENSRNOG00055007856 RatGTEx
  ENSRNOG00060013595 RatGTEx
  ENSRNOG00065027661 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AEY2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6B458 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UL04 ENTREZGENE, UniProtKB/TrEMBL
  A6IBQ6 ENTREZGENE, UniProtKB/TrEMBL
  KCC1A_RAT UniProtKB/Swiss-Prot
  Q63084 ENTREZGENE
  Q63450 ENTREZGENE
UniProt Secondary Q63084 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Camk1  calcium/calmodulin-dependent protein kinase I    regulator of G-protein signalling 19  Name updated 1299863 APPROVED
2003-04-06 Camk1  regulator of G-protein signalling 19      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in hippocampal neurons 625618