Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Sorbs3 | Rat | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of SORBS3 mRNA] | CTD | PMID:31150632 | Sorbs3 | Rat | 17alpha-ethynylestradiol | increases expression | ISO | Sorbs3 (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of SORBS3 mRNA | CTD | PMID:17942748 | Sorbs3 | Rat | 17alpha-ethynylestradiol | multiple interactions | ISO | Sorbs3 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SORBS3 mRNA | CTD | PMID:17942748 | Sorbs3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Sorbs3 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SORBS3 mRNA | CTD | PMID:17942748 | Sorbs3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SORBS3 mRNA | CTD | PMID:33387578 | Sorbs3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Sorbs3 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of SORBS3 mRNA | CTD | PMID:21570461 | Sorbs3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of SORBS3 mRNA | CTD | PMID:22298810 | Sorbs3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SORBS3 mRNA | CTD | PMID:21215274 | Sorbs3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Sorbs3 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SORBS3 mRNA | CTD | PMID:19770486 and PMID:19933214 | Sorbs3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Sorbs3 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SORBS3 mRNA | CTD | PMID:17942748 | Sorbs3 | Rat | 2-palmitoylglycerol | increases expression | ISO | SORBS3 (Homo sapiens) | 6480464 | 2-palmitoylglycerol results in increased expression of SORBS3 mRNA | CTD | PMID:37199045 | Sorbs3 | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | SORBS3 (Homo sapiens) | 6480464 | bisphenol S results in increased expression of SORBS3 protein | CTD | PMID:34186270 | Sorbs3 | Rat | 5-aza-2'-deoxycytidine | affects expression | ISO | SORBS3 (Homo sapiens) | 6480464 | Decitabine affects the expression of SORBS3 mRNA | CTD | PMID:23300844 | Sorbs3 | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of SORBS3 mRNA | CTD | PMID:36843608 | Sorbs3 | Rat | aflatoxin B1 | decreases methylation | ISO | SORBS3 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of SORBS3 gene | CTD | PMID:27153756 | Sorbs3 | Rat | aldrin | decreases expression | ISO | Sorbs3 (Mus musculus) | 6480464 | Aldrin results in decreased expression of SORBS3 mRNA | CTD | PMID:18579281 | Sorbs3 | Rat | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of SORBS3 mRNA | CTD | PMID:16483693 | Sorbs3 | Rat | anthra[1,9-cd]pyrazol-6(2H)-one | multiple interactions | ISO | Sorbs3 (Mus musculus) | 6480464 | pyrazolanthrone inhibits the reaction [sodium arsenite promotes the reaction [CPEB4 protein binds to SORBS3 protein]] | CTD | PMID:25237887 | Sorbs3 | Rat | antirheumatic drug | multiple interactions | ISO | SORBS3 (Homo sapiens) | 6480464 | [Antirheumatic Agents co-treated with Methotrexate] results in decreased expression of SORBS3 mRNA | CTD | PMID:16817978 | Sorbs3 | Rat | benzo[a]pyrene | decreases expression | ISO | SORBS3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of SORBS3 mRNA | CTD | PMID:20106945 | Sorbs3 | Rat | benzo[a]pyrene | increases methylation | ISO | SORBS3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of SORBS3 promoter | CTD | PMID:27901495 | Sorbs3 | Rat | benzo[a]pyrene | affects methylation | ISO | SORBS3 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of SORBS3 5' UTR | CTD | PMID:27901495 | Sorbs3 | Rat | benzo[a]pyrene | increases expression | ISO | Sorbs3 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of SORBS3 mRNA | CTD | PMID:21569818 | Sorbs3 | Rat | benzo[a]pyrene | decreases expression | ISO | Sorbs3 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of SORBS3 mRNA | CTD | PMID:19770486 | Sorbs3 | Rat | Benzo[k]fluoranthene | decreases expression | ISO | Sorbs3 (Mus musculus) | 6480464 | benzo(k)fluoranthene results in decreased expression of SORBS3 mRNA | CTD | PMID:26377693 | Sorbs3 | Rat | bis(2-ethylhexyl) phthalate | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of SORBS3 promoter | CTD | PMID:23359474 | Sorbs3 | Rat | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of SORBS3 promoter | CTD | PMID:23359474 | Sorbs3 | Rat | bisphenol A | increases expression | ISO | Sorbs3 (Mus musculus) | 6480464 | bisphenol A results in increased expression of SORBS3 mRNA | CTD | PMID:32156529 and PMID:34585602 | Sorbs3 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of SORBS3 mRNA | CTD | PMID:32145629 | Sorbs3 | Rat | bisphenol A | affects expression | ISO | SORBS3 (Homo sapiens) | 6480464 | bisphenol A affects the expression of SORBS3 mRNA | CTD | PMID:30903817 | Sorbs3 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of SORBS3 mRNA | CTD | PMID:25181051 | Sorbs3 | Rat | Bisphenol B | increases expression | ISO | SORBS3 (Homo sapiens) | 6480464 | bisphenol B results in increased expression of SORBS3 protein | CTD | PMID:34186270 | Sorbs3 | Rat | bisphenol F | decreases expression | ISO | Sorbs3 (Mus musculus) | 6480464 | bisphenol F results in decreased expression of SORBS3 mRNA | CTD | PMID:38685157 | Sorbs3 | Rat | bisphenol F | increases expression | ISO | SORBS3 (Homo sapiens) | 6480464 | bisphenol F results in increased expression of SORBS3 protein | CTD | PMID:34186270 | Sorbs3 | Rat | cadmium dichloride | decreases expression | EXP | | 6480464 | Cadmium Chloride results in decreased expression of SORBS3 mRNA | CTD | PMID:33453195 | Sorbs3 | Rat | caffeine | affects phosphorylation | ISO | SORBS3 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of SORBS3 protein | CTD | PMID:35688186 | Sorbs3 | Rat | carbon nanotube | affects expression | ISO | Sorbs3 (Mus musculus) | 6480464 | Nanotubes and Carbon affects the expression of SORBS3 protein | CTD | PMID:21135415 | Sorbs3 | Rat | carbon nanotube | increases expression | ISO | Sorbs3 (Mus musculus) | 6480464 | Nanotubes and Carbon results in increased expression of SORBS3 mRNA | CTD | PMID:25554681 | Sorbs3 | Rat | carbon nanotube | decreases expression | ISO | Sorbs3 (Mus musculus) | 6480464 | Nanotubes and Carbon analog results in decreased expression of SORBS3 mRNA | CTD | PMID:25554681 | Sorbs3 | Rat | CGP 52608 | multiple interactions | ISO | SORBS3 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to SORBS3 gene] | CTD | PMID:28238834 | Sorbs3 | Rat | chloroethene | decreases expression | ISO | Sorbs3 (Mus musculus) | 6480464 | Vinyl Chloride results in decreased expression of SORBS3 mRNA | CTD | PMID:18579281 | Sorbs3 | Rat | chlorpyrifos | increases expression | ISO | Sorbs3 (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of SORBS3 mRNA | CTD | PMID:37019170 | Sorbs3 | Rat | choline | multiple interactions | ISO | Sorbs3 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SORBS3 gene | CTD | PMID:20938992 | Sorbs3 | Rat | cisplatin | affects expression | ISO | SORBS3 (Homo sapiens) | 6480464 | Cisplatin affects the expression of SORBS3 mRNA | CTD | PMID:23300844 | Sorbs3 | Rat | cisplatin | decreases expression | ISO | SORBS3 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of SORBS3 mRNA | CTD | PMID:27392435 | Sorbs3 | Rat | copper(II) sulfate | decreases expression | ISO | SORBS3 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of SORBS3 mRNA | CTD | PMID:19549813 | Sorbs3 | Rat | copper(II) sulfate | decreases expression | ISO | Sorbs3 (Mus musculus) | 6480464 | Copper Sulfate results in decreased expression of SORBS3 mRNA | CTD | PMID:18579281 | Sorbs3 | Rat | coumarin | increases phosphorylation | ISO | SORBS3 (Homo sapiens) | 6480464 | coumarin results in increased phosphorylation of SORBS3 protein | CTD | PMID:35688186 | Sorbs3 | Rat | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of SORBS3 mRNA | CTD | PMID:26577399 | Sorbs3 | Rat | cyclosporin A | decreases expression | ISO | SORBS3 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of SORBS3 mRNA | CTD | PMID:25562108 | Sorbs3 | Rat | dibenz[a,h]anthracene | increases expression | ISO | Sorbs3 (Mus musculus) | 6480464 | 1 more ... | CTD | PMID:26377693 | Sorbs3 | Rat | dibutyl phthalate | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of SORBS3 promoter | CTD | PMID:23359474 | Sorbs3 | Rat | dicrotophos | increases expression | ISO | SORBS3 (Homo sapiens) | 6480464 | dicrotophos results in increased expression of SORBS3 mRNA | CTD | PMID:28302478 | Sorbs3 | Rat | diethylstilbestrol | increases expression | ISO | SORBS3 (Homo sapiens) | 6480464 | Diethylstilbestrol results in increased expression of SORBS3 mRNA | CTD | PMID:36621641 | Sorbs3 | Rat | disodium selenite | increases expression | ISO | SORBS3 (Homo sapiens) | 6480464 | Sodium Selenite results in increased expression of SORBS3 mRNA | CTD | PMID:18175754 | Sorbs3 | Rat | elemental selenium | increases expression | ISO | SORBS3 (Homo sapiens) | 6480464 | Selenium results in increased expression of SORBS3 mRNA | CTD | PMID:19244175 | Sorbs3 | Rat | endosulfan | increases expression | EXP | | 6480464 | Endosulfan results in increased expression of SORBS3 mRNA | CTD | PMID:29391264 | Sorbs3 | Rat | enzyme inhibitor | multiple interactions | ISO | SORBS3 (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SORBS3 protein | CTD | PMID:23301498 | Sorbs3 | Rat | ethanol | increases expression | ISO | Sorbs3 (Mus musculus) | 6480464 | Ethanol results in increased expression of SORBS3 mRNA | CTD | PMID:30319688 | Sorbs3 | Rat | fenamidone | increases expression | ISO | Sorbs3 (Mus musculus) | 6480464 | fenamidone results in increased expression of SORBS3 mRNA | CTD | PMID:27029645 | Sorbs3 | Rat | fenvalerate | increases expression | EXP | | 6480464 | fenvalerate results in increased expression of SORBS3 mRNA | CTD | PMID:30307764 | Sorbs3 | Rat | fluoranthene | multiple interactions | ISO | Sorbs3 (Mus musculus) | 6480464 | [1-methylanthracene co-treated with fluoranthene] results in decreased expression of SORBS3 mRNA | CTD | PMID:28329830 | Sorbs3 | Rat | fluoranthene | decreases expression | ISO | Sorbs3 (Mus musculus) | 6480464 | fluoranthene results in decreased expression of SORBS3 mRNA | CTD | PMID:28329830 | Sorbs3 | Rat | folic acid | multiple interactions | ISO | Sorbs3 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SORBS3 gene | CTD | PMID:20938992 | Sorbs3 | Rat | FR900359 | increases phosphorylation | ISO | SORBS3 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of SORBS3 protein | CTD | PMID:37730182 | Sorbs3 | Rat | furan | decreases expression | ISO | Sorbs3 (Mus musculus) | 6480464 | furan results in decreased expression of SORBS3 mRNA | CTD | PMID:24183702 | Sorbs3 | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of SORBS3 mRNA | CTD | PMID:33387578 | Sorbs3 | Rat | isoprenaline | increases expression | ISO | Sorbs3 (Mus musculus) | 6480464 | Isoproterenol results in increased expression of SORBS3 mRNA | CTD | PMID:20003209 | Sorbs3 | Rat | ivermectin | decreases expression | ISO | SORBS3 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of SORBS3 protein | CTD | PMID:32959892 | Sorbs3 | Rat | L-methionine | multiple interactions | ISO | Sorbs3 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SORBS3 gene | CTD | PMID:20938992 | Sorbs3 | Rat | methotrexate | multiple interactions | ISO | SORBS3 (Homo sapiens) | 6480464 | [Antirheumatic Agents co-treated with Methotrexate] results in decreased expression of SORBS3 mRNA | CTD | PMID:16817978 | Sorbs3 | Rat | methoxychlor | affects expression | ISO | Sorbs3 (Mus musculus) | 6480464 | Methoxychlor affects the expression of SORBS3 mRNA | CTD | PMID:20829426 | Sorbs3 | Rat | ozone | increases expression | EXP | | 6480464 | Ozone results in increased expression of SORBS3 protein | CTD | PMID:33146391 | Sorbs3 | Rat | paracetamol | affects expression | ISO | Sorbs3 (Mus musculus) | 6480464 | Acetaminophen affects the expression of SORBS3 mRNA | CTD | PMID:17562736 | Sorbs3 | Rat | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of SORBS3 mRNA | CTD | PMID:33387578 | Sorbs3 | Rat | paracetamol | decreases expression | ISO | SORBS3 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of SORBS3 mRNA | CTD | PMID:29067470 | Sorbs3 | Rat | pirinixic acid | multiple interactions | ISO | SORBS3 (Homo sapiens) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SORBS3 mRNA | CTD | PMID:19710929 | Sorbs3 | Rat | pirinixic acid | multiple interactions | ISO | Sorbs3 (Mus musculus) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SORBS3 mRNA | CTD | PMID:19710929 | Sorbs3 | Rat | quinolin-8-ol | increases expression | ISO | SORBS3 (Homo sapiens) | 6480464 | Oxyquinoline results in increased expression of SORBS3 mRNA | CTD | PMID:21632981 | Sorbs3 | Rat | resveratrol | multiple interactions | ISO | SORBS3 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of SORBS3 mRNA | CTD | PMID:23557933 | Sorbs3 | Rat | selenium atom | increases expression | ISO | SORBS3 (Homo sapiens) | 6480464 | Selenium results in increased expression of SORBS3 mRNA | CTD | PMID:19244175 | Sorbs3 | Rat | sodium arsenite | multiple interactions | ISO | SORBS3 (Homo sapiens) | 6480464 | sodium arsenite inhibits the reaction [VCL protein binds to SORBS3 protein] | CTD | PMID:25237887 | Sorbs3 | Rat | sodium arsenite | multiple interactions | ISO | Sorbs3 (Mus musculus) | 6480464 | [MAPK8 protein mutant form results in decreased phosphorylation of and results in decreased activity of MAPK8 protein] inhibits the reaction [sodium arsenite promotes the reaction [CPEB4 protein binds to SORBS3 protein]] more ... | CTD | PMID:25237887 | Sorbs3 | Rat | sodium arsenite | affects response to substance | ISO | SORBS3 (Homo sapiens) | 6480464 | SORBS3 protein affects the susceptibility to sodium arsenite | CTD | PMID:25237887 | Sorbs3 | Rat | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of SORBS3 mRNA | CTD | PMID:31150632 | Sorbs3 | Rat | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of SORBS3 mRNA] | CTD | PMID:31150632 | Sorbs3 | Rat | thimerosal | decreases expression | ISO | SORBS3 (Homo sapiens) | 6480464 | Thimerosal results in decreased expression of SORBS3 mRNA | CTD | PMID:27188386 | Sorbs3 | Rat | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of SORBS3 mRNA | CTD | PMID:34492290 | Sorbs3 | Rat | titanium dioxide | decreases methylation | ISO | Sorbs3 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of SORBS3 gene | CTD | PMID:35295148 | Sorbs3 | Rat | titanium dioxide | increases methylation | ISO | Sorbs3 (Mus musculus) | 6480464 | titanium dioxide results in increased methylation of SORBS3 gene | CTD | PMID:35295148 | Sorbs3 | Rat | tremolite asbestos | decreases expression | ISO | Sorbs3 (Mus musculus) | 6480464 | tremolite results in decreased expression of SORBS3 mRNA | CTD | PMID:29279043 | Sorbs3 | Rat | trimellitic anhydride | decreases expression | ISO | Sorbs3 (Mus musculus) | 6480464 | trimellitic anhydride results in decreased expression of SORBS3 mRNA | CTD | PMID:16141432 | Sorbs3 | Rat | trovafloxacin | decreases expression | ISO | Sorbs3 (Mus musculus) | 6480464 | trovafloxacin results in decreased expression of SORBS3 mRNA | CTD | PMID:35537566 | Sorbs3 | Rat | urethane | decreases expression | ISO | SORBS3 (Homo sapiens) | 6480464 | Urethane results in decreased expression of SORBS3 mRNA | CTD | PMID:28818685 | |