Fev (FEV transcription factor, ETS family member) - Rat Genome Database

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Gene: Fev (FEV transcription factor, ETS family member) Rattus norvegicus
Analyze
Symbol: Fev
Name: FEV transcription factor, ETS family member
RGD ID: 628860
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nuclear speck. Predicted to be active in nucleus. Orthologous to human FEV (FEV transcription factor, ETS family member); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; acrylamide; alpha-hexachlorocyclohexane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ETS domain transcription factor Pet-1; FEV (ETS oncogene family); FEV, ETS transcription factor; PC12 ETS domain-containing transcription factor 1; PC12 ETS factor 1; pet-1; Pet1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8983,887,844 - 83,891,718 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl983,887,844 - 83,891,737 (-)EnsemblGRCr8
mRatBN7.2976,439,164 - 76,443,603 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl976,439,172 - 76,443,065 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx984,884,303 - 84,888,174 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0990,013,255 - 90,017,126 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0988,399,404 - 88,403,275 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0982,142,981 - 82,146,855 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl982,142,981 - 82,146,874 (-)Ensemblrn6Rnor6.0
Rnor_5.0981,911,561 - 81,915,435 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4974,214,764 - 74,218,638 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera974,010,770 - 74,014,644 (-)NCBICelera
RGSC_v3.1974,361,745 - 74,365,639 (-)NCBI
Cytogenetic Map9q33NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nuclear speck  (IEA,ISO)
nucleus  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Pet-1, a novel ETS domain factor that can activate neuronal nAchR gene transcription. Fyodorov D, etal., J Neurobiol 1998 Feb 5;34(2):151-63.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11875656   PMID:19168037   PMID:20818386  


Genomics

Comparative Map Data
Fev
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8983,887,844 - 83,891,718 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl983,887,844 - 83,891,737 (-)EnsemblGRCr8
mRatBN7.2976,439,164 - 76,443,603 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl976,439,172 - 76,443,065 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx984,884,303 - 84,888,174 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0990,013,255 - 90,017,126 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0988,399,404 - 88,403,275 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0982,142,981 - 82,146,855 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl982,142,981 - 82,146,874 (-)Ensemblrn6Rnor6.0
Rnor_5.0981,911,561 - 81,915,435 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4974,214,764 - 74,218,638 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera974,010,770 - 74,014,644 (-)NCBICelera
RGSC_v3.1974,361,745 - 74,365,639 (-)NCBI
Cytogenetic Map9q33NCBI
FEV
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382218,981,087 - 218,985,184 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2218,981,087 - 218,985,184 (-)Ensemblhg38GRCh38
GRCh372219,845,809 - 219,849,906 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,554,053 - 219,558,623 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342219,671,313 - 219,675,884NCBI
Celera2213,615,522 - 213,620,092 (-)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2211,699,837 - 211,704,406 (-)NCBIHuRef
CHM1_12219,853,266 - 219,857,836 (-)NCBICHM1_1
T2T-CHM13v2.02219,469,462 - 219,473,559 (-)NCBIT2T-CHM13v2.0
Fev
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39174,920,660 - 74,924,632 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl174,920,668 - 74,924,578 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38174,881,501 - 74,885,473 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl174,881,509 - 74,885,419 (-)Ensemblmm10GRCm38
MGSCv37174,928,083 - 74,931,982 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36174,814,716 - 74,818,626 (-)NCBIMGSCv36mm8
Celera175,436,582 - 75,440,470 (-)NCBICelera
Cytogenetic Map1C4NCBI
Fev
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545314,449,352 - 14,452,663 (+)Ensembl
ChiLan1.0NW_00495545314,449,352 - 14,453,145 (+)NCBIChiLan1.0ChiLan1.0
FEV
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213121,611,786 - 121,616,374 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B121,626,750 - 121,631,339 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B106,238,933 - 106,243,499 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B224,832,403 - 224,838,813 (-)NCBIPanPan1.1PanPan1.1panPan2
FEV
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13725,548,578 - 25,552,092 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3726,367,854 - 26,372,353 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03725,563,091 - 25,567,596 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3725,563,099 - 25,568,000 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13725,467,675 - 25,472,180 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03725,402,725 - 25,407,296 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03725,423,527 - 25,428,026 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fev
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303175,059,167 - 175,062,546 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365691,402,513 - 1,406,067 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365691,402,513 - 1,408,699 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FEV
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15121,004,665 - 121,009,014 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115121,005,279 - 121,008,748 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FEV
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110104,879,790 - 104,886,722 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10104,880,347 - 104,883,916 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604094,509,000 - 94,513,765 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fev
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248236,032,352 - 6,036,211 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248236,032,188 - 6,036,211 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Fev
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14148,302,275 - 148,306,206 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fev
15 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:79
Count of miRNA genes:62
Interacting mature miRNAs:68
Transcripts:ENSRNOT00000024190
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)98216882386720295Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 18 57 70 54 47 2 47 122 34 1 43 25 34 7 3 3

Sequence


Ensembl Acc Id: ENSRNOT00000024190   ⟹   ENSRNOP00000024190
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl983,887,844 - 83,891,737 (-)Ensembl
mRatBN7.2 Ensembl976,439,172 - 76,443,065 (-)Ensembl
Rnor_6.0 Ensembl982,142,981 - 82,146,874 (-)Ensembl
RefSeq Acc Id: NM_144753   ⟹   NP_653354
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,887,844 - 83,891,718 (-)NCBI
mRatBN7.2976,439,172 - 76,443,046 (-)NCBI
Rnor_6.0982,142,981 - 82,146,855 (-)NCBI
Rnor_5.0981,911,561 - 81,915,435 (-)NCBI
RGSC_v3.4974,214,764 - 74,218,638 (-)RGD
Celera974,010,770 - 74,014,644 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_653354 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL75373 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000024190
  ENSRNOP00000024190.5
GenBank Protein O70132 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_653354   ⟸   NM_144753
- UniProtKB: O70132 (UniProtKB/Swiss-Prot),   A6JVW5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024190   ⟸   ENSRNOT00000024190
Protein Domains
ETS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70132-F1-model_v2 AlphaFold O70132 1-237 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628860 AgrOrtholog
BioCyc Gene G2FUF-27112 BioCyc
Ensembl Genes ENSRNOG00000017856 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024190 ENTREZGENE
  ENSRNOT00000024190.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot
InterPro Ets_dom UniProtKB/Swiss-Prot
  ETS_fam UniProtKB/Swiss-Prot
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot
  WH_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report rno:246271 UniProtKB/Swiss-Prot
NCBI Gene 246271 ENTREZGENE
PANTHER PROTEIN FEV UniProtKB/Swiss-Prot
  PTHR11849 UniProtKB/Swiss-Prot
Pfam Ets UniProtKB/Swiss-Prot
PhenoGen Fev PhenoGen
PRINTS ETSDOMAIN UniProtKB/Swiss-Prot
PROSITE ETS_DOMAIN_1 UniProtKB/Swiss-Prot
  ETS_DOMAIN_2 UniProtKB/Swiss-Prot
  ETS_DOMAIN_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017856 RatGTEx
SMART ETS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot
UniProt A0A0H2UHP3_RAT UniProtKB/TrEMBL
  A6JVW5 ENTREZGENE, UniProtKB/TrEMBL
  FEV_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-10 Fev  FEV transcription factor, ETS family member  Fev  FEV, ETS transcription factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-01 Fev  FEV, ETS transcription factor  Fev  FEV (ETS oncogene family)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Fev  FEV (ETS oncogene family)  Pet1  ETS domain transcription factor Pet-1  Symbol and Name updated 1299863 APPROVED
2003-02-27 Pet1  ETS domain transcription factor Pet-1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains an ETS DNA-binding domain 633697
gene_expression enriched in adrenal gland; present in brain, intestine, and eye 633697
gene_protein 340 amino acids; 35.4 kD 633697