Tank (TRAF family member-associated NFKB activator) - Rat Genome Database

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Gene: Tank (TRAF family member-associated NFKB activator) Rattus norvegicus
Analyze
Symbol: Tank
Name: TRAF family member-associated NFKB activator
RGD ID: 628859
Description: Predicted to enable several functions, including deubiquitinase activator activity; molecular function inhibitor activity; and ubiquitin protein ligase binding activity. Predicted to contribute to cysteine-type deubiquitinase activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; negative regulation of signal transduction; and positive regulation of macromolecule metabolic process. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Orthologous to human TANK (TRAF family member associated NFKB activator); PARTICIPATES IN Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway; INTERACTS WITH 17beta-estradiol; 3-methylcholanthrene; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: TRAF family member-associated Nf-kappa B activator; TRAF family member-associated NF-kappa-B activator; TRAF interacting protein TANK
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8366,522,834 - 66,598,864 (+)NCBIGRCr8
mRatBN7.2346,114,230 - 46,190,270 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl346,114,274 - 46,190,264 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx349,452,587 - 49,528,949 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0358,036,094 - 58,112,454 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0355,824,243 - 55,901,927 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0347,439,007 - 47,515,706 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl347,439,076 - 47,515,700 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0354,111,767 - 54,188,472 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4343,396,247 - 43,475,491 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1343,329,797 - 43,371,197 (+)NCBI
Celera345,783,047 - 45,858,966 (+)NCBICelera
Cytogenetic Map3q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
diarsenic trioxide  (EXP)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diepoxybutane  (ISO)
diethylstilbestrol  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
epichlorohydrin  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
isoflurane  (EXP)
lipopolysaccharide  (ISO)
methyl methanesulfonate  (ISO)
N-acetyl-L-cysteine  (ISO)
oxaliplatin  (EXP)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
phenobarbital  (EXP)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
Tributyltin oxide  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases. Chariot A, etal., J Biol Chem 2002 Oct 4;277(40):37029-36. Epub 2002 Jul 19.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8710854   PMID:11279055   PMID:12477932   PMID:15882800   PMID:25861989  


Genomics

Comparative Map Data
Tank
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8366,522,834 - 66,598,864 (+)NCBIGRCr8
mRatBN7.2346,114,230 - 46,190,270 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl346,114,274 - 46,190,264 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx349,452,587 - 49,528,949 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0358,036,094 - 58,112,454 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0355,824,243 - 55,901,927 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0347,439,007 - 47,515,706 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl347,439,076 - 47,515,700 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0354,111,767 - 54,188,472 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4343,396,247 - 43,475,491 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1343,329,797 - 43,371,197 (+)NCBI
Celera345,783,047 - 45,858,966 (+)NCBICelera
Cytogenetic Map3q21NCBI
TANK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382161,136,963 - 161,236,230 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2161,136,908 - 161,236,230 (+)EnsemblGRCh38hg38GRCh38
GRCh372161,993,474 - 162,092,741 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362161,701,712 - 161,800,928 (+)NCBINCBI36Build 36hg18NCBI36
Build 342161,818,972 - 161,886,997NCBI
Celera2155,605,253 - 155,704,471 (+)NCBICelera
Cytogenetic Map2q24.2NCBI
HuRef2153,878,179 - 153,977,180 (+)NCBIHuRef
CHM1_12161,999,604 - 162,098,821 (+)NCBICHM1_1
T2T-CHM13v2.02161,595,211 - 161,694,538 (+)NCBIT2T-CHM13v2.0
Tank
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39261,408,901 - 61,484,515 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl261,408,929 - 61,484,515 (+)EnsemblGRCm39 Ensembl
GRCm38261,578,557 - 61,654,171 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl261,578,585 - 61,654,171 (+)EnsemblGRCm38mm10GRCm38
MGSCv37261,416,643 - 61,492,228 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36261,379,425 - 61,454,950 (+)NCBIMGSCv36mm8
Celera263,280,293 - 63,355,826 (+)NCBICelera
Cytogenetic Map2C1.3NCBI
cM Map235.56NCBI
Tank
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544912,470,085 - 12,561,370 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544912,470,203 - 12,561,364 (-)NCBIChiLan1.0ChiLan1.0
TANK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21363,847,693 - 63,923,533 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B63,839,226 - 63,938,505 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B48,426,036 - 48,525,265 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B165,797,247 - 165,896,438 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B165,820,833 - 165,896,438 (+)Ensemblpanpan1.1panPan2
TANK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1366,732,507 - 6,826,762 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl366,750,265 - 6,826,486 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha366,869,111 - 6,962,895 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0366,855,580 - 6,949,743 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl366,855,616 - 6,949,726 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1366,871,470 - 6,966,109 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0366,916,601 - 7,010,763 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0367,023,842 - 7,118,152 (+)NCBIUU_Cfam_GSD_1.0
Tank
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303123,862,875 - 123,952,061 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646917,665,593 - 17,742,422 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646917,665,604 - 17,754,845 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TANK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1567,952,173 - 68,048,963 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11567,970,972 - 68,048,681 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21575,433,203 - 75,529,766 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TANK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11046,527,795 - 46,632,133 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1046,556,614 - 46,632,186 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040152,907,321 - 153,010,811 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tank
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247324,220,963 - 4,300,861 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247324,221,294 - 4,325,199 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tank
469 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:285
Count of miRNA genes:195
Interacting mature miRNAs:221
Transcripts:ENSRNOT00000011794
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
10450816Scl75Serum cholesterol level QTL 754.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)33819223350749747Rat
2313093Bmd77Bone mineral density QTL 772.20.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)32749462150302886Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)31831145447233430Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)31831145447233430Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)31831145447233430Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)31831145447233430Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)31831145447233430Rat
2313101Bmd76Bone mineral density QTL 763.60.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)32749462150302886Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145447233430Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)31831145447233430Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
10450852Stl33Serum triglyceride level QTL 333.40.05blood LDL triglyceride amount (VT:0010699)blood lipoprotein triglyceride level (CMO:0002685)33819223350749747Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
4889975Bmd81Bone mineral density QTL 814.3tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)33871036550302886Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
634317Bw117Body weight QTL 1173.58abdominal fat pad mass (VT:1000711)abdominal fat pad weight to body weight ratio (CMO:0000095)33945463753296578Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
2313079Bss73Bone structure and strength QTL 731.5tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)32749462150302886Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
2313076Bss74Bone structure and strength QTL 7420.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)32749462150302886Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33370334761017857Rat
10450813Scl74Serum cholesterol level QTL 745.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)33819223350749747Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)33945463762951183Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
2313049Bss72Bone structure and strength QTL 722.60.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)32749462150302886Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat

Markers in Region
D3Chm10  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2346,174,894 - 46,175,108 (+)MAPPERmRatBN7.2
Rnor_6.0347,500,330 - 47,500,543NCBIRnor6.0
Rnor_5.0354,173,096 - 54,173,309UniSTSRnor5.0
RGSC_v3.4343,460,143 - 43,460,357RGDRGSC3.4
RGSC_v3.4343,460,144 - 43,460,357UniSTSRGSC3.4
Celera345,843,591 - 45,843,804UniSTS
Cytogenetic Map3q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001164073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_145788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010064568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_591517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AJ422211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC088854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC129086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EV776506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000011794   ⟹   ENSRNOP00000011794
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl346,128,652 - 46,190,264 (+)Ensembl
Rnor_6.0 Ensembl347,439,076 - 47,515,700 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081682   ⟹   ENSRNOP00000071679
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl346,128,652 - 46,190,264 (+)Ensembl
Rnor_6.0 Ensembl347,453,821 - 47,515,700 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116799   ⟹   ENSRNOP00000092979
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl346,114,274 - 46,190,193 (+)Ensembl
RefSeq Acc Id: NM_001164073   ⟹   NP_001157545
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8366,522,837 - 66,598,864 (+)NCBI
mRatBN7.2346,114,230 - 46,190,270 (+)NCBI
Rnor_6.0347,439,076 - 47,515,706 (+)NCBI
Rnor_5.0354,111,767 - 54,188,472 (+)NCBI
RGSC_v3.4343,396,247 - 43,475,491 (+)RGD
Celera345,783,047 - 45,858,966 (+)RGD
Sequence:
RefSeq Acc Id: NM_145788   ⟹   NP_665731
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8366,537,243 - 66,598,864 (+)NCBI
mRatBN7.2346,128,636 - 46,190,270 (+)NCBI
Rnor_6.0347,453,882 - 47,515,706 (+)NCBI
Rnor_5.0354,111,767 - 54,188,472 (+)NCBI
RGSC_v3.4343,396,247 - 43,475,491 (+)RGD
Celera345,797,400 - 45,858,966 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006234273   ⟹   XP_006234335
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8366,522,834 - 66,598,806 (+)NCBI
mRatBN7.2346,114,253 - 46,190,270 (+)NCBI
Rnor_6.0347,439,007 - 47,515,706 (+)NCBI
Rnor_5.0354,111,767 - 54,188,472 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006234274   ⟹   XP_006234336
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8366,537,193 - 66,598,806 (+)NCBI
mRatBN7.2346,128,589 - 46,190,270 (+)NCBI
Rnor_6.0347,453,831 - 47,515,706 (+)NCBI
Rnor_5.0354,111,767 - 54,188,472 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039104349   ⟹   XP_038960277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8366,584,120 - 66,598,806 (+)NCBI
mRatBN7.2346,175,527 - 46,190,270 (+)NCBI
RefSeq Acc Id: XM_039104353   ⟹   XP_038960281
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8366,537,192 - 66,598,806 (+)NCBI
mRatBN7.2346,128,589 - 46,190,270 (+)NCBI
RefSeq Acc Id: XM_039104354   ⟹   XP_038960282
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8366,537,265 - 66,598,806 (+)NCBI
mRatBN7.2346,128,589 - 46,190,270 (+)NCBI
RefSeq Acc Id: XM_039104355   ⟹   XP_038960283
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8366,537,192 - 66,598,806 (+)NCBI
mRatBN7.2346,128,589 - 46,190,270 (+)NCBI
RefSeq Acc Id: XM_039104356   ⟹   XP_038960284
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8366,537,192 - 66,598,806 (+)NCBI
mRatBN7.2346,128,589 - 46,190,270 (+)NCBI
RefSeq Acc Id: XM_039104358   ⟹   XP_038960286
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8366,537,192 - 66,575,187 (+)NCBI
mRatBN7.2346,128,589 - 46,166,591 (+)NCBI
RefSeq Acc Id: XM_063283148   ⟹   XP_063139218
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8366,573,417 - 66,598,806 (+)NCBI
RefSeq Acc Id: XR_010064568
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8366,537,289 - 66,589,082 (+)NCBI
RefSeq Acc Id: NP_665731   ⟸   NM_145788
- Peptide Label: isoform 1
- UniProtKB: Q8VDA2 (UniProtKB/TrEMBL),   A0A0G2K130 (UniProtKB/TrEMBL),   A6HLU4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001157545   ⟸   NM_001164073
- Peptide Label: isoform 2
- UniProtKB: A0A8J8YHZ3 (UniProtKB/TrEMBL),   Q8VDA2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234335   ⟸   XM_006234273
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K130 (UniProtKB/TrEMBL),   A6HLU4 (UniProtKB/TrEMBL),   Q8VDA2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234336   ⟸   XM_006234274
- Peptide Label: isoform X2
- UniProtKB: A0A8J8YHZ3 (UniProtKB/TrEMBL),   Q8VDA2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000011794   ⟸   ENSRNOT00000011794
Ensembl Acc Id: ENSRNOP00000071679   ⟸   ENSRNOT00000081682
RefSeq Acc Id: XP_038960281   ⟸   XM_039104353
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038960283   ⟸   XM_039104355
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038960282   ⟸   XM_039104354
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038960284   ⟸   XM_039104356
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038960286   ⟸   XM_039104358
- Peptide Label: isoform X8
- UniProtKB: A6HLU5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960277   ⟸   XM_039104349
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000092979   ⟸   ENSRNOT00000116799
RefSeq Acc Id: XP_063139218   ⟸   XM_063283148
- Peptide Label: isoform X4
Protein Domains
UBZ1-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M101-F1-model_v2 AlphaFold F1M101 1-413 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692096
Promoter ID:EPDNEW_R2620
Type:initiation region
Name:Tank_2
Description:TRAF family member-associated NFKB activator
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R2621  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0347,439,029 - 47,439,089EPDNEW
RGD ID:13692097
Promoter ID:EPDNEW_R2621
Type:initiation region
Name:Tank_1
Description:TRAF family member-associated NFKB activator
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R2620  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0347,453,910 - 47,453,970EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628859 AgrOrtholog
BioCyc Gene G2FUF-49601 BioCyc
Ensembl Genes ENSRNOG00000008859 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011794.7 UniProtKB/TrEMBL
  ENSRNOT00000081682.2 UniProtKB/TrEMBL
  ENSRNOT00000116799.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7317281 IMAGE-MGC_LOAD
  IMAGE:7365827 IMAGE-MGC_LOAD
InterPro CALCOCO1/2_Zn_UBZ1 UniProtKB/TrEMBL
  TANK UniProtKB/TrEMBL
  TBD UniProtKB/TrEMBL
KEGG Report rno:252961 UniProtKB/TrEMBL
MGC_CLONE MGC:105308 IMAGE-MGC_LOAD
  MGC:156587 IMAGE-MGC_LOAD
NCBI Gene 252961 ENTREZGENE
PANTHER PTHR15249 UniProtKB/TrEMBL
  TRAF FAMILY MEMBER-ASSOCIATED NF-KAPPA-B ACTIVATOR UniProtKB/TrEMBL
Pfam TBD UniProtKB/TrEMBL
PhenoGen Tank PhenoGen
PROSITE ZF_UBZ1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008859 RatGTEx
UniProt A0A0G2K130 ENTREZGENE, UniProtKB/TrEMBL
  A0A8J8YHZ3 ENTREZGENE, UniProtKB/TrEMBL
  A6HLU4 ENTREZGENE, UniProtKB/TrEMBL
  A6HLU5 ENTREZGENE, UniProtKB/TrEMBL
  F1M101_RAT UniProtKB/TrEMBL
  Q5HZX1_RAT UniProtKB/TrEMBL
  Q8VDA2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A1L1J0 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Tank  TRAF family member-associated NFKB activator  Tank  TRAF family member-associated Nf-kappa B activator  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Tank  TRAF family member-associated Nf-kappa B activator      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Tank  TRAF family member-associated Nf-kappa B activator      Symbol and Name status set to provisional 70820 PROVISIONAL