Slc35a4 (solute carrier family 35, member A4)

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Gene: Slc35a4 (solute carrier family 35, member A4) Rattus norvegicus

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Symbol:

Slc35a4

Name:

solute carrier family 35, member A4

RGD ID:

628792

Description:

Predicted to enable transmembrane transporter activity. Predicted to be involved in positive regulation of cellular respiration; positive regulation of translation in response to stress; and transmembrane transport. Located in Golgi apparatus. Orthologous to human SLC35A4 (solute carrier family 35 member A4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

complex leucine repeat protein; MGC93140; MGC93141; Plrr-4; PLRR-4 polymorphic leucine-rich repeat protein; Plrr4; probable UDP-sugar transporter protein SLC35A4; solute carrier family 35 member A4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	28,555,471 - 28,558,639 (+)	NCBI		GRCr8
mRatBN7.2	18	28,280,483 - 28,284,610 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	28,279,750 - 28,284,725 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	28,408,579 - 28,411,747 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	29,170,670 - 29,173,838 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	28,505,908 - 28,509,076 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	29,505,239 - 29,509,304 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	29,506,128 - 29,509,296 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	29,210,348 - 29,214,377 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	29,318,679 - 29,321,847 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	29,345,324 - 29,348,493 (+)	NCBI
Celera	18	28,008,608 - 28,011,776 (+)	NCBI		Celera
Cytogenetic Map	18	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant intellectual developmental disorder 31 (ISO)

familial adenomatous polyposis 1 (ISO)

Hereditary Neoplastic Syndromes (ISO)

Neurodevelopmental Disorders (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

14-Deoxy-11,12-didehydroandrographolide (ISO)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-methylcholine (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

ammonium chloride (EXP)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

corosolic acid (ISO)

Dibutyl phosphate (ISO)

dicrotophos (ISO)

diuron (ISO)

epoxiconazole (ISO)

fenthion (ISO)

folic acid (ISO)

gentamycin (EXP)

ivermectin (ISO)

lead(0) (ISO)

methimazole (EXP)

methotrexate (ISO)

N(4)-hydroxycytidine (ISO)

nickel atom (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

sunitinib (ISO)

tamoxifen (ISO)

testosterone (ISO)

thiram (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

valproic acid (ISO)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

positive regulation of cellular respiration (ISO)

positive regulation of translation in response to stress (ISO)

pyrimidine nucleotide-sugar transmembrane transport (IEA)

transmembrane transport (IBA)

Cellular Component

Golgi apparatus (IDA)

Golgi membrane (IBA,ISO,ISS)

mitochondrial inner membrane (ISO)

mitochondrion (ISO)

Molecular Function

protein binding (ISO)

pyrimidine nucleotide-sugar transmembrane transporter activity (IEA)

transmembrane transporter activity (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	Cloning of the cDNA and mRNA expression of CLRP, a complex leucine repeat protein of the Golgi apparatus expressed by specific neurons of the rat brain.	Perez-Marquez J, etal., J Neurobiol 2002 Aug;52(2):166-73.
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:25621764	PMID:34800366

Genomics

Comparative Map Data

Slc35a4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	28,555,471 - 28,558,639 (+)	NCBI		GRCr8
mRatBN7.2	18	28,280,483 - 28,284,610 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	28,279,750 - 28,284,725 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	28,408,579 - 28,411,747 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	29,170,670 - 29,173,838 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	28,505,908 - 28,509,076 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	29,505,239 - 29,509,304 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	29,506,128 - 29,509,296 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	29,210,348 - 29,214,377 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	29,318,679 - 29,321,847 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	29,345,324 - 29,348,493 (+)	NCBI
Celera	18	28,008,608 - 28,011,776 (+)	NCBI		Celera
Cytogenetic Map	18	p11	NCBI

SLC35A4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	140,564,828 - 140,569,100 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	140,564,819 - 140,569,100 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	139,944,413 - 139,948,685 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	139,924,604 - 139,928,867 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	139,924,603 - 139,928,867	NCBI
Celera	5	136,021,170 - 136,025,433 (+)	NCBI		Celera
Cytogenetic Map	5	q31.3	NCBI
HuRef	5	135,089,755 - 135,094,018 (+)	NCBI		HuRef
CHM1_1	5	139,377,668 - 139,381,931 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	141,090,259 - 141,094,531 (+)	NCBI		T2T-CHM13v2.0

Slc35a4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	36,812,268 - 36,816,915 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	36,812,632 - 36,816,911 (+)	Ensembl		GRCm39 Ensembl
GRCm38	18	36,679,215 - 36,683,862 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	36,679,215 - 36,683,861 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	36,838,869 - 36,843,516 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	36,805,566 - 36,809,831 (+)	NCBI		MGSCv36	mm8
Celera	18	37,128,348 - 37,133,004 (+)	NCBI		Celera
Cytogenetic Map	18	B2	NCBI
cM Map	18	19.46	NCBI

Slc35a4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955418	115,895 - 116,863 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955418	114,916 - 116,878 (-)	NCBI	ChiLan1.0	ChiLan1.0

LOC100975969
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	135,822,260 - 135,826,637 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	133,961,807 - 133,966,188 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	135,928,922 - 135,933,498 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	142,046,118 - 142,050,655 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

SLC35A4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	35,761,589 - 35,763,511 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	35,761,626 - 35,762,600 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	32,799,834 - 32,801,744 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	36,216,233 - 36,218,143 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	36,213,562 - 36,218,143 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	33,269,104 - 33,271,014 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	34,136,642 - 34,138,551 (+)	NCBI		UNSW_CanFamBas_1.0

LOC101976450
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	152,077,342 - 152,079,579 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936531	9,534,340 - 9,535,308 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936531	9,531,885 - 9,536,254 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC35A4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	142,323,341 - 142,325,335 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	142,320,884 - 142,342,939 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	148,267,140 - 148,288,847 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC35A4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	43,209,396 - 43,213,621 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	43,211,716 - 43,212,690 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	34,670,796 - 34,675,128 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc35a4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624743	33,331,326 - 33,332,300 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624743	33,331,276 - 33,333,192 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Slc35a4
8 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	110
Count of miRNA genes:	82
Interacting mature miRNAs:	104
Transcripts:	ENSRNOT00000003878
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331733	Bp233	Blood pressure QTL 233	3.97196		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	24796977	79788953	Rat
1358358	Sradr6	Stress Responsive Adrenal Weight QTL 6	2.49		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	18	11944299	59330563	Rat
1331735	Rf44	Renal function QTL 44	2.981		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	18	18234564	31359530	Rat
61382	Bp46	Blood pressure QTL 46	18.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11941791	31393320	Rat
2301413	Bp318	Blood pressure QTL 318		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	26548082	46969551	Rat
1331741	Bp232	Blood pressure QTL 232	3.59112		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	21372893	83213037	Rat
61388	Bp2	Blood pressure QTL 2	3.23		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	1	35374722	Rat
6903359	Bp355	Blood pressure QTL 355	3.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11944544	59796478	Rat
12904668	Bw188	Body weight QTL 188		0.03	body mass (VT:0001259)	body weight (CMO:0000012)	18	26548082	46969551	Rat
2313082	Bss85	Bone structure and strength QTL 85	0.8	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	18	14951337	59951337	Rat
12904669	Cm125	Cardiac mass QTL 125		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	26548082	46969551	Rat
1641923	Colcr8	Colorectal carcinoma resistance QTL 8	3.1	0.0014	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	18	22066242	52293055	Rat
12904670	Cm126	Cardiac mass QTL 126		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	26548082	46969551	Rat
2312568	Glom21	Glomerulus QTL 21	2	0.005	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	18	5185858	40503530	Rat
12904677	Kidm72	Kidney mass QTL 72		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	26548082	46969551	Rat
1331766	Bp236	Blood pressure QTL 236	3.022		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	11944299	31359530	Rat
1358193	Emca2	Estrogen-induced mammary cancer QTL 2	1.6		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	18	18007599	63571040	Rat
12904673	Cm127	Cardiac mass QTL 127		0.005	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	26548082	46969551	Rat
12904675	Am19	Aortic mass QTL 19		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	26548082	46969551	Rat
631264	Scl22	Serum cholesterol level QTL 22	6.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	18	11941791	31393320	Rat
1331775	Bp235	Blood pressure QTL 235	3.201		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	18234564	31359530	Rat
2325839	Bp348	Blood pressure QTL 348		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	25570985	70570985	Rat
1600373	Mamtr6	Mammary tumor resistance QTL 6			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	18	19278901	83218561	Rat
2293708	Bss46	Bone structure and strength QTL 46	8.8	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	18	11791518	63636873	Rat
9589153	Insul31	Insulin level QTL 31	7.15	0.05	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	18	1	42547119	Rat
1578667	Bss21	Bone structure and strength QTL 21	3.5		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	18	11791518	83218561	Rat
2312598	Bp340	Blood pressure QTL 340		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	1	30558703	Rat
2300180	Bmd67	Bone mineral density QTL 67	4.8	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	18	1	34291613	Rat
2299160	Iddm35	Insulin dependent diabetes mellitus QTL 35	2.79		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	18	4207941	60377792	Rat
1578661	Bss20	Bone structure and strength QTL 20	3.7		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	18	11791518	83218561	Rat
1331753	Bp231	Blood pressure QTL 231	3.643		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11944299	52293055	Rat
2293661	Bss50	Bone structure and strength QTL 50	4.64	0.0003	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	18	1	34291613	Rat
61375	Bp41	Blood pressure QTL 41	2.4		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	18	11944299	41122201	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001432747	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001432748	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_147140	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006254528	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC097756	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF406814	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF406815	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC085695	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473974	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000003878 ⟹ ENSRNOP00000003878

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	28,280,577 - 28,284,685 (+)	Ensembl
Rnor_6.0 Ensembl	18	29,506,128 - 29,509,296 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000100525 ⟹ ENSRNOP00000096880

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	28,279,750 - 28,284,725 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000109501 ⟹ ENSRNOP00000079324

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	28,280,628 - 28,284,616 (+)	Ensembl

RefSeq Acc Id:

NM_147140 ⟹ NP_671481

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	28,555,471 - 28,558,639 (+)	NCBI
mRatBN7.2	18	28,281,435 - 28,284,603 (+)	NCBI
Rnor_6.0	18	29,506,128 - 29,509,296 (+)	NCBI
Rnor_5.0	18	29,210,348 - 29,214,377 (+)	NCBI
RGSC_v3.4	18	29,318,679 - 29,321,847 (+)	RGD
Celera	18	28,008,608 - 28,011,776 (+)	RGD

Sequence:

show sequence

TTGAGCAGGGCATGGGACTGGGTCAAGTCTGCTGGAGCCAGCCTCTCCCTTGTCCTAGGATTCT
CTGCCCAAGCTTAAGGACTTGACATTTCTCAAGAAGCAGCTGGAGCGCCTACAGCAGCGTGTGG
AAGATGAAGTCAACAGTGGCGTAGGCCAGGATGGCTCGCTCTTGTCCTCCCCGTTCTTCAAGGG
ATTCCTGGCAGGATACATGGTGGCCAAACTGAGGGCATCTGCAGTATTGGGCTTTGCAGTGGGC
ACTTGCACTGGCATCTACGCGGCTCAGGCATACGCTGTACCCAACGTGGAGAAGACACTGAAGA
ACTACTTTAGGTCACTACGAAAGGGGCCTGACTAGCCCCTGTGGAGAAGGCAGGATGAGCATGT
TGGGCCTGCAGGTAGAGACCTTCCTGTCACAGCCACTCTGCCTGGCTCCCTCTGCTGTTCATGT
GCTAACCCCACCCCTCCTGCCTCTTTCCTCCCTGCCTTTCTTCCTGCAGAGAGTGGACAATGCA
TTGTCAGCCTGCACCCTACACTCCTTCCCTCCCTAGTTCCATGGGACTGACCCCAAAACTACGG
GTCATGAACCCCCTCTTCAAGACCTAACTGGAATGTGCAGCTGTCTCTGATCCTCAGTATTCTC
TCTGGTGATGTACCACAGTTCTATACTCAATTTCCTACAACTGTGTCCCAGTCCCTCTGTCCCT
TGCTAGCTACCCAGGACACCCAGGATCTGGTGTGGGCCATGAGTGTAGAAGATGGGGGTATGCC
AGGCCTAGCCCGGCCAAAACAGGCTCGCTGGACCCTGATGCTGTTCCTGTCCACTGCCATGTAT
GGTGCCCATGCGCCATTCTTAGCACTGTGCCATGTGGATGGCCGAGTGCCCTTCCGGCCCTCCT
CAGCTGTGTTACTCACTGAACTGACCAAGCTCCTGTTGTGCGCCTTCTCCCTCCTGGTAGGCTG
GCAAACATGGCCCCAGGGCACGCCACCCTGGCGCCAGGCCGCACCTTTCGCACTATCAGCTCTG
CTCTATGGCGCCAACAACAACCTGGTGATTTATCTGCAGCGCTACATGGACCCCAGCACCTATC
AGGTGCTGAGCAATCTCAAGATTGGAAGCACAGCTCTGTTGTATTGCCTCTGCCTTGGACATCG
CCTCTCTGCGCGCCAGGGGTTGGCGCTGCTGCTGCTGATGGCTGCGGGAGCCTGCTATGCCTCA
GGTGGCTTTCAGGAACCTGGGAACACCCTTCCGGGGCCCCGGTCAGCAGCTGGAGCCCGTCCCA
TGCCCTTGCATATCACTCCACTGGGACTTCTGCTCCTCATCCTATACTGCCTCATCTCCGGCTT
GTCCTCCGTGTACACAGAGTTGATCATGAAGCGACAGCGGTTGCCCTTGGCTCTTCAGAACCTC
TTCCTCTACACTTTTGGGGTAATCCTGAACCTTGGACTGTACGCTGGCAGTGGCCCGGGCCCAG
GCTTCCTAGAGGGTTTCTCTGGATGGGCAGTGCTGGTGGTGCTGAACCAGGCAGTAAATGGACT
GCTCATGTCAGCCGTCATGAAGCATGGCAGCAGCATCACACGCCTCTTCATCGTGTCCTGCTCG
CTAGTGGTCAATGCTGTGCTGTCAGCAGTGCTGCTACAGCTGCAGCTCACAGCCACCTTCTTCC
TGGCCGCACTGCTCATTGGTCTGGCTGTGTGCTTGTACTATGGTAGCCCCTAAGTCATTGACCA
CCTGCACTCACTTGTGGCTGCGTAGATTAGATGCAACCACCAGAGTCACCTCCCAGGCCTCTGT
GATCCCTCTAACAAGTGCCTTGTAAGAAAAGCTAAGGTGTCCAGGTTAGCCTTTGCATGTTCAG
TGGGAGAGTTAGCCCTAGGAGCAGAGTGGGCTTGGTTAAGGAAACACCTAACTGCACTCTCTGT
GTTCCCTCATCTAAAGAACTGGGAGCCCAAAACCCAGGCCTGGGCAGCCTGTCCTTGAAGCACC
CTGCCTTGTCCTGCATGTACATGGCTGCTTCAAGTGAAGTTTCAGTCTTCTCACCTGCTGCGGT
CACTCCTGAAGACTTTGTTTCCAAGCTTGGTGCTGGCTGCTCCAGCCCAGCATGACTTCTGCAG
AAGAGATGCTTAGTTTGCCCCCTCTACAGTGCTGTTCCCCTTTCCCATCCATTATTCTGGAAAG
GTCAGAGGGAGCTGGGGCTTGACTCATCTCAGGGAACATTGCCCCTGGGCCCTGGCTTAAGCCT
ACACTCCTGACCCCTGTGCTAACCCGAGAGCCCTGTTGAAGCCCACGTTACCTCTGAAGCACTT
AGGAGGGACTGTTCTTCCCACTCTTCAGAGGTGTCCTAAGTTCCAACAACTTGGGAGGGTTCTG
CAGAGTAACCAGGGACCAGGTCCAGAAAACATTTATAGCCAATCAGTGTCAAACTACTTCAGCA
ATAAGGTCTTAATAAAGTGTCCTGGCTGTAGGTGCTTCCTACAACCATTAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001419676	(Get FASTA)	NCBI Sequence Viewer
	NP_001419677	(Get FASTA)	NCBI Sequence Viewer
	NP_671481	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH85695	(Get FASTA)	NCBI Sequence Viewer
	AAK96221	(Get FASTA)	NCBI Sequence Viewer
	AAK96222	(Get FASTA)	NCBI Sequence Viewer
	EDL76305	(Get FASTA)	NCBI Sequence Viewer
	EDL76306	(Get FASTA)	NCBI Sequence Viewer
	EDL76307	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000003878.4
	ENSRNOP00000079324.1
	ENSRNOP00000096880.1
	ENSRNOP00055032328
	ENSRNOP00055032332
	ENSRNOP00055032335
	ENSRNOP00060029538
	ENSRNOP00060029567
	ENSRNOP00060029608
	ENSRNOP00065016656
	ENSRNOP00065016663
	ENSRNOP00065016672
GenBank Protein	Q91ZR7	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_671481 ⟸ NM_147140

- UniProtKB:

Q5RKL6 (UniProtKB/Swiss-Prot), Q91ZR7 (UniProtKB/Swiss-Prot), A6J325 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSVEDGGMPGLARPKQARWTLMLFLSTAMYGAHAPFLALCHVDGRVPFRPSSAVLLTELTKLLL
CAFSLLVGWQTWPQGTPPWRQAAPFALSALLYGANNNLVIYLQRYMDPSTYQVLSNLKIGSTAL
LYCLCLGHRLSARQGLALLLLMAAGACYASGGFQEPGNTLPGPRSAAGARPMPLHITPLGLLLL
ILYCLISGLSSVYTELIMKRQRLPLALQNLFLYTFGVILNLGLYAGSGPGPGFLEGFSGWAVLV
VLNQAVNGLLMSAVMKHGSSITRLFIVSCSLVVNAVLSAVLLQLQLTATFFLAALLIGLAVCLY
YGSP

hide sequence

Ensembl Acc Id:

ENSRNOP00000003878 ⟸ ENSRNOT00000003878

Ensembl Acc Id:

ENSRNOP00000079324 ⟸ ENSRNOT00000109501

Ensembl Acc Id:

ENSRNOP00000096880 ⟸ ENSRNOT00000100525

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q91ZR7-F1-model_v2	AlphaFold	Q91ZR7	1-324	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700724

Promoter ID:

EPDNEW_R11248

Type:

single initiation site

Name:

Slc35a4_1

Description:

solute carrier family 35, member A4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	18	29,507,217 - 29,507,277	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:628792	AgrOrtholog
BioCyc Gene	G2FUF-7869	BioCyc
Ensembl Genes	ENSRNOG00000002908	Ensembl, UniProtKB/Swiss-Prot
	ENSRNOG00055023180	UniProtKB/Swiss-Prot
	ENSRNOG00060020729	UniProtKB/Swiss-Prot
	ENSRNOG00065013117	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000003878.5	UniProtKB/Swiss-Prot
	ENSRNOT00000100525.1	UniProtKB/Swiss-Prot
	ENSRNOT00000109501.1	UniProtKB/Swiss-Prot
	ENSRNOT00055039827	UniProtKB/Swiss-Prot
	ENSRNOT00055039834	UniProtKB/Swiss-Prot
	ENSRNOT00055039847	UniProtKB/Swiss-Prot
	ENSRNOT00060035896	UniProtKB/Swiss-Prot
	ENSRNOT00060035934	UniProtKB/Swiss-Prot
	ENSRNOT00060035981	UniProtKB/Swiss-Prot
	ENSRNOT00065021506	UniProtKB/Swiss-Prot
	ENSRNOT00065021513	UniProtKB/Swiss-Prot
	ENSRNOT00065021523	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7191954	IMAGE-MGC_LOAD
	IMAGE:7192444	IMAGE-MGC_LOAD
InterPro	Nuc_sug_transpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:257647	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:93140	IMAGE-MGC_LOAD
	MGC:93141	IMAGE-MGC_LOAD
NCBI Gene	257647	ENTREZGENE
PANTHER	NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
	UDP-SUGAR TRANSPORTER PROTEIN SLC35A4-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Nuc_sug_transp	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Slc35a4	PhenoGen
PIRSF	UDP-gal_transpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000002908	RatGTEx
	ENSRNOG00055023180	RatGTEx
	ENSRNOG00060020729	RatGTEx
	ENSRNOG00065013117	RatGTEx
Superfamily-SCOP	Multidrug resistance efflux transporter EmrE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A6J325	ENTREZGENE, UniProtKB/TrEMBL
	Q5RKL6	ENTREZGENE
	Q91ZR7	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	Q5RKL6	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Slc35a4	solute carrier family 35, member A4		PLRR-4 polymorphic leucine-rich repeat protein	Name updated	1299863	APPROVED
2004-09-10	Slc35a4	PLRR-4 polymorphic leucine-rich repeat protein	Plrr4		Symbol and Name updated	1299863	APPROVED
2003-02-27	Plrr4	PLRR-4 polymorphic leucine-rich repeat protein			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in the brain, kidney, lung, testis, and prostate	633719
gene_homology	homologous to galactose, N-acetylglucosamine, and sialic acid transporters	633719

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar