Pkig (cAMP-dependent protein kinase inhibitor gamma)

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Gene: Pkig (cAMP-dependent protein kinase inhibitor gamma) Rattus norvegicus

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Symbol:

Pkig

Name:

cAMP-dependent protein kinase inhibitor gamma

RGD ID:

628775

Description:

Enables cAMP-dependent protein kinase inhibitor activity. Predicted to act upstream of or within negative regulation of protein import into nucleus; negative regulation of protein kinase activity; and negative regulation of transcription by RNA polymerase II. Predicted to be active in cytoplasm and nucleus. Orthologous to human PKIG (cAMP-dependent protein kinase inhibitor gamma); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; dibutyl phthalate.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

MGC108574; protein kinase (cAMP-dependent, catalytic) inhibitor gamma; protein kinase inhibitor, gamma

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	172,749,871 - 172,817,514 (+)	NCBI		GRCr8
mRatBN7.2	3	152,330,477 - 152,398,085 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	152,366,041 - 152,398,082 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	156,137,960 - 156,205,545 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	164,636,891 - 164,704,478 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	162,380,926 - 162,448,601 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	160,047,257 - 160,115,180 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	160,047,296 - 160,115,177 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	166,238,121 - 166,305,341 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	154,568,485 - 154,635,867 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	154,474,520 - 154,541,903 (+)	NCBI
Celera	3	150,983,346 - 151,050,377 (+)	NCBI		Celera
Cytogenetic Map	3	q42	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adenosine deaminase deficiency (ISO)

focal epilepsy (ISO)

T-Cell Immunodeficiency, Recurrent Infections, and Autoimmunity with or without Cardiac Malformations (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (ISO)

5-aza-2'-deoxycytidine (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

arsenite(3-) (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

benzo[e]pyrene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

carbon nanotube (ISO)

choline (ISO)

chrysene (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dibenz[a,h]anthracene (ISO)

dibutyl phthalate (EXP)

doxorubicin (ISO)

epoxiconazole (ISO)

folic acid (ISO)

formaldehyde (ISO)

isoflurane (ISO)

L-methionine (ISO)

lipopolysaccharide (ISO)

methapyrilene (ISO)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

O-methyleugenol (ISO)

oxaliplatin (ISO)

paracetamol (ISO)

PCB138 (EXP)

pyrogallol (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silicon dioxide (ISO)

sulforaphane (ISO)

sunitinib (ISO)

T-2 toxin (EXP)

tetrachloromethane (ISO)

tetraphene (ISO)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

valproic acid (ISO)

vincristine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of protein import into nucleus (ISO)

negative regulation of protein kinase activity (ISO)

negative regulation of transcription by RNA polymerase II (ISO)

Cellular Component

cytoplasm (IBA)

nucleus (IBA)

Molecular Function

cAMP-dependent protein kinase inhibitor activity (IBA,IMP,ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Endogenous protein kinase inhibitor gamma terminates immediate-early gene expression induced by cAMP-dependent protein kinase (PKA) signaling: termination depends on PKA inactivation rather than PKA export from the nucleus.	Chen X, etal., J Biol Chem 2005 Jan 28;280(4):2700-7. Epub 2004 Nov 19.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9218452	PMID:12477932

Genomics

Comparative Map Data

Pkig
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	172,749,871 - 172,817,514 (+)	NCBI		GRCr8
mRatBN7.2	3	152,330,477 - 152,398,085 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	152,366,041 - 152,398,082 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	156,137,960 - 156,205,545 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	164,636,891 - 164,704,478 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	162,380,926 - 162,448,601 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	160,047,257 - 160,115,180 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	160,047,296 - 160,115,177 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	166,238,121 - 166,305,341 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	154,568,485 - 154,635,867 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	154,474,520 - 154,541,903 (+)	NCBI
Celera	3	150,983,346 - 151,050,377 (+)	NCBI		Celera
Cytogenetic Map	3	q42	NCBI

PKIG
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	44,531,875 - 44,619,037 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	44,531,785 - 44,624,247 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	43,160,516 - 43,247,678 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	42,593,850 - 42,681,092 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	42,593,849 - 42,681,091	NCBI
Celera	20	39,869,083 - 39,956,320 (+)	NCBI		Celera
Cytogenetic Map	20	q13.12	NCBI
HuRef	20	39,901,964 - 39,989,219 (+)	NCBI		HuRef
CHM1_1	20	43,063,548 - 43,150,794 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	46,267,641 - 46,354,809 (+)	NCBI		T2T-CHM13v2.0

Pkig
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	163,500,306 - 163,568,078 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	163,500,306 - 163,568,078 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	163,658,211 - 163,726,158 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	163,658,386 - 163,726,158 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	163,484,122 - 163,551,894 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	163,349,892 - 163,417,599 (+)	NCBI		MGSCv36	mm8
Celera	2	169,601,971 - 169,669,883 (+)	NCBI		Celera
Cytogenetic Map	2	H3	NCBI
cM Map	2	84.4	NCBI

Pkig
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955445	12,717,962 - 12,818,734 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955445	12,717,962 - 12,818,734 (-)	NCBI	ChiLan1.0	ChiLan1.0

PKIG
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	50,264,249 - 50,352,262 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	50,257,358 - 50,345,365 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	40,861,694 - 40,949,756 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	41,955,938 - 42,044,131 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	42,039,676 - 42,049,064 (+)	Ensembl	panpan1.1		panPan2

PKIG
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	31,983,131 - 32,083,307 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	32,050,242 - 32,082,919 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	31,624,520 - 31,724,671 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	32,689,751 - 32,790,237 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	32,696,491 - 32,790,234 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	31,952,297 - 32,051,932 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	32,066,281 - 32,166,638 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	32,607,496 - 32,707,896 (+)	NCBI		UU_Cfam_GSD_1.0

Pkig
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	180,979,965 - 181,081,729 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936530	2,224,496 - 2,262,653 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936530	2,224,492 - 2,326,287 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PKIG
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	47,008,035 - 47,044,049 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	46,933,418 - 47,044,044 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	52,419,567 - 52,501,664 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PKIG
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	19,200,718 - 19,289,649 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	19,201,221 - 19,237,497 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	67,869,101 - 67,958,344 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pkig
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624790	9,829,686 - 9,871,564 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624790	9,829,686 - 9,936,336 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Pkig
254 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	362
Count of miRNA genes:	191
Interacting mature miRNAs:	220
Transcripts:	ENSRNOT00000051590
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2301411	Bp320	Blood pressure QTL 320		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	145925360	166177555	Rat
12879876	Bw182	Body weight QTL 182		0.003	body mass (VT:0001259)	body weight (CMO:0000012)	3	145925360	166177555	Rat
2312673	Scl63	Serum cholesterol level QTL 63		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	98535255	168026850	Rat
1300113	Bp176	Blood pressure QTL 176	3.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	145956084	157309487	Rat
12879872	Cm97	Cardiac mass QTL 97		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	145925360	166177555	Rat
1578653	Vnigr3	Vascular neointimal growth QTL 3	3.1		artery morphology trait (VT:0002191)	artery neointimal hyperplastic lesion area (CMO:0001414)	3	130656562	169034231	Rat
1598877	Bp285	Blood pressure QTL 285	1.5	0.03	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	120538241	165538241	Rat
12879873	Cm96	Cardiac mass QTL 96		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	3	145925360	166177555	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	98535386	161695835	Rat
12879874	Cm98	Cardiac mass QTL 98		0.005	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	3	145925360	166177555	Rat
1298068	Bp167	Blood pressure QTL 167		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	141074471	169034231	Rat
12879875	Kidm64	Kidney mass QTL 64		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	145925360	166177555	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
2298477	Eau4	Experimental allergic uveoretinitis QTL 4		0.0011	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	3	137398739	169034231	Rat
8552791	Vie2	Viral induced encephalitis QTL 2	4.1		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	3	145956084	169034231	Rat
61335	Bp20	Blood pressure QTL 20	3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	141339236	155617360	Rat
2317883	Alcrsp26	Alcohol response QTL 26	1.8	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	3	145526770	169034231	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
1331726	Bp208	Blood pressure QTL 208	3.129		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	141339013	162184794	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	112681431	157681431	Rat
1598854	Memor10	Memory QTL 10	2		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	3	145956084	161299569	Rat
9589106	Insul23	Insulin level QTL 23	13.86	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	3	131635904	169034231	Rat
10755461	Coatc16	Coat color QTL 16			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	3	122438700	167438700	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	59242096	157323038	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
2303620	Vencon4	Ventilatory control QTL 4	3.9		respiration trait (VT:0001943)	tidal volume (CMO:0000222)	3	127162703	168026850	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	94856903	159898684	Rat
1576306	Schws3	Schwannoma susceptibility QTL 3		0.001	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	3	118839124	163839124	Rat
619618	Rf3	Renal disease susceptibility QTL 3	6.5	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate to body weight ratio (CMO:0001270)	3	107693393	152693393	Rat
1300159	Kidm4	Kidney mass QTL 4	3.83		kidney mass (VT:0002707)	right kidney wet weight to body weight ratio (CMO:0001953)	3	121056165	157309487	Rat
631673	Iddm13	Insulin dependent diabetes mellitus QTL 13	1.3	0.663	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	3	130193298	161695983	Rat
2312659	Slep7	Serum leptin concentration QTL 7		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	3	98535255	168026850	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
1578666	Vnigr1	Vascular neointimal growth QTL 1	4.6		artery morphology trait (VT:0002191)	artery lumen area (CMO:0001409)	3	149040888	168026850	Rat
1578656	Vnigr2	Vascular neointimal growth QTL 2	4.2		artery morphology trait (VT:0002191)	lesioned artery residual lumen area (CMO:0001417)	3	130656562	169034231	Rat
8552952	Pigfal13	Plasma insulin-like growth factor 1 level QTL 13			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	3	138799500	169034231	Rat
12879871	Am7	Aortic mass QTL 7		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	3	145925360	166177555	Rat
631541	Bp81	Blood pressure QTL 81	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	124122556	169034231	Rat
2312670	Bw94	Body weight QTL 94		0.01	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	3	98535255	168026850	Rat

Markers in Region

RH131830

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	152,397,761 - 152,397,972 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	160,114,857 - 160,115,067	NCBI	Rnor6.0
Rnor_5.0	3	166,305,018 - 166,305,228	UniSTS	Rnor5.0
RGSC_v3.4	3	154,635,547 - 154,635,757	UniSTS	RGSC3.4
Celera	3	151,050,057 - 151,050,267	UniSTS
Cytogenetic Map	3	q42	UniSTS

BF410183

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	152,385,476 - 152,385,706 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	160,102,572 - 160,102,801	NCBI	Rnor6.0
Rnor_5.0	3	166,292,733 - 166,292,962	UniSTS	Rnor5.0
RGSC_v3.4	3	154,623,263 - 154,623,492	UniSTS	RGSC3.4
Celera	3	151,037,770 - 151,037,999	UniSTS
RH 3.4 Map	3	1376.5	UniSTS
Cytogenetic Map	3	q42	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001401793	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001401794	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001401795	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001401796	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001401797	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_153469	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008762470	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063283174	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063283175	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY150308	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC088108	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ218619	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000051590 ⟹ ENSRNOP00000044753

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	152,366,041 - 152,398,082 (+)	Ensembl
Rnor_6.0 Ensembl	3	160,047,296 - 160,115,177 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000080707 ⟹ ENSRNOP00000071633

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	3	160,092,975 - 160,114,554 (+)	Ensembl

RefSeq Acc Id:

NM_001401793 ⟹ NP_001388722

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	172,749,915 - 172,817,514 (+)	NCBI
mRatBN7.2	3	152,330,477 - 152,398,085 (+)	NCBI

RefSeq Acc Id:

NM_001401794 ⟹ NP_001388723

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	172,750,132 - 172,817,514 (+)	NCBI
mRatBN7.2	3	152,330,694 - 152,398,085 (+)	NCBI

RefSeq Acc Id:

NM_001401795 ⟹ NP_001388724

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	172,750,132 - 172,817,514 (+)	NCBI
mRatBN7.2	3	152,330,694 - 152,398,085 (+)	NCBI

RefSeq Acc Id:

NM_001401796 ⟹ NP_001388725

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	172,786,275 - 172,817,514 (+)	NCBI
mRatBN7.2	3	152,366,847 - 152,398,085 (+)	NCBI

RefSeq Acc Id:

NM_001401797 ⟹ NP_001388726

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	172,786,275 - 172,817,514 (+)	NCBI
mRatBN7.2	3	152,366,847 - 152,398,085 (+)	NCBI

RefSeq Acc Id:

NM_153469 ⟹ NP_703199

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	172,749,915 - 172,817,514 (+)	NCBI
mRatBN7.2	3	152,330,477 - 152,398,085 (+)	NCBI
Rnor_6.0	3	160,047,296 - 160,115,177 (+)	NCBI
Rnor_5.0	3	166,238,121 - 166,305,341 (+)	NCBI
RGSC_v3.4	3	154,568,485 - 154,635,867 (+)	RGD
Celera	3	150,983,346 - 151,050,377 (+)	RGD

Sequence:

show sequence

CGCTCGCGCCGTCGGCCCGGGCTCCGCGAGGCGACGAGGCGGCAGGCCTGAGGAGCGATGCGAC
AGGCATGATGGAAGTCGAGTCCTCCTACTCGGACTTCATCTCCTGTGACCGGACAGGCCGTCGG
AATGCAGTCCCTGACATCCAGGGTGACTCGGAGGCCGTGAGCGTGCGGAAGCTAGCTGGAGACA
TGGGCGAGCTCGCACTTGAGGGGGCAGAAGGACAGGCAGAGGGAAGTACCCCAGACAAGGAAGC
CAGCAGCCAGCCGGAGAGCAGTGACGCGAACACCTCATCCTGAGTCTGCCTGTGGTCCTCACAG
GCTGAGAGAGACCTGCTGTCCCTCCTGCACTGGAGCCCTGGCCAGCCAGGCTGACTGAGAGCCT
CATGGAGTCCTCTGTGGCCCCTGCTCCAGTAAAGTCCTCCACTCACACCACAGGCTCCTCTTTC
CCACCTCCCACGGTGCCCACGGTGCCCAGGGTGCCCAGGCGCACTTCAGAGACACGAGCACCAT
GAGGTGTTATCTCTTCAGCTGGGCGGGGCTCGAGCCAGGCCCTGCCCCTAGGTGAGCGGCTGTC
ACCTGGACAGGGATGTCCGGCCACCACTCACCCCTCCAGCCAGCCCCCTCTAGCCAGCCATCCG
TTGAGAAGATCTTCCTAGCCCTTTTTTAAAGCCTCTTTTACATTTTTTAAAAACATAACTTTTT
CAGAGAGAGAGAGGGGAGCGGACAATCACTTTTTTTCTGTTTTGGTTTTTGGTTGGTTTTTTTT
CTTTTTTTGAAAGACATTTTAAGCTCAGTTCTGATGATCTATGCAGCTCTAAGTTCCCTCACAG
AGCCTCACAGATCCAGTTTTGGGAAAGGATTTGGACTCAAAACTAACTGACCAATTCTTTGCCC
TTTGTACCAAGAGACTGATACTTAGACCTAGGAAATAAATGCTGGTGATTTGTGAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_008762470 ⟹ XP_008760692

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	172,754,966 - 172,817,511 (+)	NCBI
mRatBN7.2	3	152,335,545 - 152,398,085 (+)	NCBI
Rnor_6.0	3	160,052,372 - 160,115,180 (+)	NCBI

Sequence:

show sequence

ACTATGTAGACCAGGCTGGTCTTGAACTCAGAGAGCCACTTACCTCTGCTTCTGGAATACTGTG
GTTAAAGGCCTGAGGAGCGATGCGACAGGCATGATGGAAGTCGAGTCCTCCTACTCGGACTTCA
TCTCCTGTGACCGGACAGGCCGTCGGAATGCAGTCCCTGACATCCAGGGTGACTCGGAGGCCGT
GAGCGTGCGGAAGCTAGCTGGAGACATGGGCGAGCTCGCACTTGAGGGGGCAGAAGGACAGGCA
GAGGGAAGTACCCCAGACAAGGAAGCCAGCAGCCAGCCGGAGAGCAGTGACGCGAACACCTCAT
CCTGAGTCTGCCTGTGGTCCTCACAGGCTGAGAGAGACCTGCTGTCCCTCCTGCACTGGAGCCC
TGGCCAGCCAGGCTGACTGAGAGCCTCATGGAGTCCTCTGTGGCCCCTGCTCCAGTAAAGTCCT
CCACTCACACCACAGGCTCCTCTTTCCCACCTCCCACGGTGCCCACGGTGCCCAGGGTGCCCAG
GCGCACTTCAGAGACACGAGCACCATGAGGTGTTATCTCTTCAGCTGGGCGGGGCTCGAGCCAG
GCCCTGCCCCTAGGTGAGCGGCTGTCACCTGGACAGGGATGTCCGGCCACCACTCACCCCTCCA
GCCAGCCCCCTCTAGCCAGCCATCCGTTGAGAAGATCTTCCTAGCCCTTTTTTAAAGCCTCTTT
TACATTTTTTAAAAACATAACTTTTTCAGAGAGAGAGAGGGGAGCGGACAATCACTTTTTTTCT
GTTTTGGTTTTTGGTTGGTTTTTTTTCTTTTTTTGAAAGACATTTTAAGCTCAGTTCTGATGAT
CTATGCAGCTCTAAGTTCCCTCACAGAGCCTCACAGATCCAGTTTTGGGAAAGGATTTGGACTC
AAAACTAACTGACCAATTCTTTGCCCTTTGTACCAAGAGACTGATACTTAGACCTAGGAAATAA
ATGCTGGTGATTTGTGTGA

hide sequence

RefSeq Acc Id:

XM_063283174 ⟹ XP_063139244

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	172,776,632 - 172,814,026 (+)	NCBI

RefSeq Acc Id:

XM_063283175 ⟹ XP_063139245

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	172,749,871 - 172,814,026 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001388722	(Get FASTA)	NCBI Sequence Viewer
	NP_001388723	(Get FASTA)	NCBI Sequence Viewer
	NP_001388724	(Get FASTA)	NCBI Sequence Viewer
	NP_001388725	(Get FASTA)	NCBI Sequence Viewer
	NP_001388726	(Get FASTA)	NCBI Sequence Viewer
	NP_703199	(Get FASTA)	NCBI Sequence Viewer
	XP_008760692	(Get FASTA)	NCBI Sequence Viewer
	XP_063139244	(Get FASTA)	NCBI Sequence Viewer
	XP_063139245	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH88108	(Get FASTA)	NCBI Sequence Viewer
	AAN15275	(Get FASTA)	NCBI Sequence Viewer
	EDL96563	(Get FASTA)	NCBI Sequence Viewer
	EDL96564	(Get FASTA)	NCBI Sequence Viewer
	EDL96565	(Get FASTA)	NCBI Sequence Viewer
	EDL96566	(Get FASTA)	NCBI Sequence Viewer
	EDL96567	(Get FASTA)	NCBI Sequence Viewer
	EDL96568	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000044753.2

RefSeq Acc Id:	NP_703199 ⟸ NM_153469
- UniProtKB:	Q6YH22 (UniProtKB/TrEMBL), A6JX44 (UniProtKB/TrEMBL), A6JX43 (UniProtKB/TrEMBL)
- Sequence:	show sequence MMEVESSYSDFISCDRTGRRNAVPDIQGDSEAVSVRKLAGDMGELALEGAEGQAEGSTPDKEAS SQPESSDANTSS hide sequence

RefSeq Acc Id:	XP_008760692 ⟸ XM_008762470
- Peptide Label:	isoform X2
- UniProtKB:	Q6YH22 (UniProtKB/TrEMBL), A6JX44 (UniProtKB/TrEMBL), A6JX43 (UniProtKB/TrEMBL)
- Sequence:	show sequence MMEVESSYSDFISCDRTGRRNAVPDIQGDSEAVSVRKLAGDMGELALEGAEGQAEGSTPDKEAS SQPESSDANTSS hide sequence

Ensembl Acc Id:

ENSRNOP00000071633 ⟸ ENSRNOT00000080707

Ensembl Acc Id:

ENSRNOP00000044753 ⟸ ENSRNOT00000051590

RefSeq Acc Id:	NP_001388722 ⟸ NM_001401793
- UniProtKB:	Q6YH22 (UniProtKB/TrEMBL), A6JX44 (UniProtKB/TrEMBL), A6JX43 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001388724 ⟸ NM_001401795
- UniProtKB:	Q6YH22 (UniProtKB/TrEMBL), A6JX44 (UniProtKB/TrEMBL), A6JX43 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001388723 ⟸ NM_001401794
- UniProtKB:	Q6YH22 (UniProtKB/TrEMBL), A6JX44 (UniProtKB/TrEMBL), A6JX43 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001388726 ⟸ NM_001401797
- UniProtKB:	Q6YH22 (UniProtKB/TrEMBL), A6JX44 (UniProtKB/TrEMBL), A6JX43 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001388725 ⟸ NM_001401796
- UniProtKB:	Q6YH22 (UniProtKB/TrEMBL), A6JX44 (UniProtKB/TrEMBL), A6JX43 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063139245 ⟸ XM_063283175
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_063139244 ⟸ XM_063283174
- Peptide Label:	isoform X1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6YH22-F1-model_v2	AlphaFold	Q6YH22	1-76	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692640

Promoter ID:

EPDNEW_R3163

Type:

initiation region

Name:

Pkig_1

Description:

cAMP-dependent protein kinase inhibitor gamma

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	160,047,247 - 160,047,307	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:628775	AgrOrtholog
BioCyc Gene	G2FUF-46897	BioCyc
Ensembl Genes	ENSRNOG00000010235	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000051590.3	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7368431	IMAGE-MGC_LOAD
InterPro	cAMP_dep_PKI	UniProtKB/TrEMBL
MGC_CLONE	MGC:108574	IMAGE-MGC_LOAD
NCBI Gene	266709	ENTREZGENE
PANTHER	CAMP-DEPENDENT PROTEIN KINASE INHIBITOR GAMMA	UniProtKB/TrEMBL
	PTHR15416	UniProtKB/TrEMBL
Pfam	PKI	UniProtKB/TrEMBL
PhenoGen	Pkig	PhenoGen
PIRSF	PKI	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000010235	RatGTEx
UniProt	A6JX43	ENTREZGENE, UniProtKB/TrEMBL
	A6JX44	ENTREZGENE, UniProtKB/TrEMBL
	F7F4X2_RAT	UniProtKB/TrEMBL
	Q6YH22	ENTREZGENE
UniProt Secondary	Q6YH22	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-01-03	Pkig	cAMP-dependent protein kinase inhibitor gamma	Pkig	protein kinase (cAMP-dependent, catalytic) inhibitor gamma	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2014-03-13	Pkig	protein kinase (cAMP-dependent, catalytic) inhibitor gamma	Pkig	protein kinase inhibitor, gamma	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-12-15	Pkig	protein kinase inhibitor, gamma	Pkig	protein kinase (cAMP-dependent, catalytic) inhibitor gamma	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-09	Pkig	protein kinase (cAMP-dependent, catalytic) inhibitor gamma	Pkig	protein kinase inhibitor, gamma	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-12-14	Pkig	protein kinase inhibitor, gamma			Symbol and Name status set to approved	1299863	APPROVED
2003-02-27	Pkig	protein kinase inhibitor, gamma			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	localized to the nucleus and cytoplasm	1359036

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar