Gimap4 (GTPase, IMAP family member 4)

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Gene: Gimap4 (GTPase, IMAP family member 4) Rattus norvegicus

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Symbol:

Gimap4

Name:

GTPase, IMAP family member 4

RGD ID:

628765

Description:

Predicted to enable GTP binding activity. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in cytosol. Orthologous to human GIMAP4 (GTPase, IMAP family member 4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; alpha-Zearalanol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

GTPase IMAP family member 4; IAN-1; Ian1; immune-associated nucleotide 1; immunity-associated nucleotide 1 protein; immunity-associated protein 4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GIMAP4 (GTPase, IMAP family member 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Gimap4 (GTPase, IMAP family member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GIMAP4 (GTPase, IMAP family member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GIMAP4 (GTPase, IMAP family member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	LOC101973529 (GTPase IMAP family member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GIMAP4 (GTPase, IMAP family member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GIMAP4 (GTPase, IMAP family member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gimap4 (GTPase, IMAP family member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ARV1 (ARV1 homolog, fatty acid homeostasis modulator)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	GIMAP4 (GTPase, IMAP family member 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gimap4 (GTPase, IMAP family member 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	zgc:194443	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Danio rerio (zebrafish):	si:dkey-73p2.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	zgc:101806	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Danio rerio (zebrafish):	zgc:172091	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Danio rerio (zebrafish):	si:ch211-254c8.3	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Danio rerio (zebrafish):	zgc:171452	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Danio rerio (zebrafish):	zgc:153642	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Danio rerio (zebrafish):	zgc:152658	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	si:ch211-113e8.5	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)

Candidate Gene For:

Iddm39

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	78,967,297 - 78,974,211 (+)	NCBI		GRCr8
mRatBN7.2	4	77,636,401 - 77,643,315 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	77,636,401 - 77,643,306 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	82,843,871 - 82,850,781 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	78,619,378 - 78,626,288 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	77,059,659 - 77,066,569 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	78,320,230 - 78,327,144 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	78,320,190 - 78,327,144 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	143,008,388 - 143,015,302 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	76,777,679 - 76,784,519 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	77,055,948 - 77,060,640 (+)	NCBI
Celera	4	72,573,763 - 72,580,677 (+)	NCBI		Celera
Cytogenetic Map	4	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

long QT syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4,6-tribromophenol (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

acetamide (EXP)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

antirheumatic drug (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

captan (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chloroprene (ISO)

cyclophosphamide (EXP)

decabromodiphenyl ether (ISO)

Dibutyl phosphate (ISO)

dioxygen (ISO)

doxorubicin (ISO)

folic acid (ISO)

folpet (ISO)

furan (EXP)

gentamycin (EXP)

lipopolysaccharide (ISO)

nickel atom (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pioglitazone (ISO)

pirinixic acid (ISO)

rotenone (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

sodium dichromate (ISO)

topotecan (EXP)

trichloroethene (EXP)

Triptolide (EXP)

tungsten (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

cytosol (IBA,IEA,ISO,ISS)

intracellular membrane-bounded organelle (IEA,ISO)

Molecular Function

GTP binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	The diabetes-prone BB rat carries a frameshift mutation in Ian4, a positional candidate of Iddm1.	Hornum L, etal., Diabetes 2002 Jun;51(6):1972-9.
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:16509771	PMID:17641045	PMID:23454188

Genomics

Comparative Map Data

Gimap4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	78,967,297 - 78,974,211 (+)	NCBI		GRCr8
mRatBN7.2	4	77,636,401 - 77,643,315 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	77,636,401 - 77,643,306 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	82,843,871 - 82,850,781 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	78,619,378 - 78,626,288 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	77,059,659 - 77,066,569 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	78,320,230 - 78,327,144 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	78,320,190 - 78,327,144 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	143,008,388 - 143,015,302 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	76,777,679 - 76,784,519 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	77,055,948 - 77,060,640 (+)	NCBI
Celera	4	72,573,763 - 72,580,677 (+)	NCBI		Celera
Cytogenetic Map	4	q24	NCBI

GIMAP4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	150,567,390 - 150,573,953 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	150,567,369 - 150,573,953 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	150,264,478 - 150,271,041 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	149,895,391 - 149,901,974 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	149,702,105 - 149,708,688	NCBI
Celera	7	144,821,534 - 144,828,117 (+)	NCBI		Celera
Cytogenetic Map	7	q36.1	NCBI
HuRef	7	144,080,319 - 144,086,687 (+)	NCBI		HuRef
CHM1_1	7	150,272,847 - 150,279,430 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	151,745,701 - 151,752,264 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	149,602,273 - 149,608,853 (+)	NCBI

Gimap4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	48,661,453 - 48,668,996 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	48,661,483 - 48,668,994 (+)	Ensembl		GRCm39 Ensembl
GRCm38	6	48,684,578 - 48,692,062 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	48,684,549 - 48,692,060 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	48,634,577 - 48,642,061 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	48,614,164 - 48,621,648 (+)	NCBI		MGSCv36	mm8
Celera	6	49,195,428 - 49,202,910 (+)	NCBI		Celera
Cytogenetic Map	6	B2.3	NCBI
cM Map	6	23.66	NCBI

GIMAP4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	187,009,270 - 187,015,878 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	39,019,539 - 39,026,142 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	142,176,170 - 142,182,797 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	154,329,572 - 154,336,257 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	154,329,572 - 154,336,257 (+)	Ensembl	panpan1.1		panPan2

GIMAP4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	14,811,421 - 14,832,880 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	14,811,416 - 14,832,019 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	15,419,773 - 15,440,681 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	16,526,715 - 16,547,633 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	16,526,781 - 16,547,622 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	14,906,140 - 14,927,048 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	15,487,435 - 15,508,340 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	15,537,710 - 15,558,644 (+)	NCBI		UU_Cfam_GSD_1.0

LOC101973529
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	6,747,059 - 6,747,499 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936527	6,155,923 - 6,156,367 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GIMAP4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	6,429,887 - 6,452,966 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	18	6,429,886 - 6,452,963 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	6,613,849 - 6,620,847 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GIMAP4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	118,758,814 - 118,765,237 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	118,761,379 - 118,765,296 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666072	14,725,693 - 14,732,174 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gimap4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624800	5,982,938 - 5,990,329 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624800	5,982,786 - 5,990,329 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Gimap4
44 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	55
Count of miRNA genes:	43
Interacting mature miRNAs:	55
Transcripts:	ENSRNOT00000032742
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358352	Srcrt3	Stress Responsive Cort QTL 3	2.29		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	38465774	146803430	Rat
1549843	Bw53	Body weight QTL 53		0.0001	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	61697658	103194791	Rat
61445	Strs3	Sensitivity to stroke QTL 3	3		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	4	40433388	85433388	Rat
6893678	Bw108	Body weight QTL 108	2.6	0.006	body mass (VT:0001259)	body weight (CMO:0000012)	4	43457976	88457976	Rat
10755501	Bp390	Blood pressure QTL 390	2.5		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	4	26775591	168368347	Rat
1357342	Bw40	Body weight QTL 40		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	4	76647384	117676292	Rat
1358363	Sradr3	Stress Responsive Adrenal Weight QTL 3	6.19		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	4	57486946	102486946	Rat
61330	Eau1	Experimental allergic uveoretinitis QTL 1		0.0003	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	4	70362013	132642728	Rat
70167	Bw22	Body weight QTL 22	3.1		body mass (VT:0001259)	body weight (CMO:0000012)	4	76647384	117676292	Rat
61336	Bp21	Blood pressure QTL 21	4.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	57114705	78881294	Rat
1549839	Bw52	Body weight QTL 52		0.0001	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	61697658	115089733	Rat
724522	Bp146	Blood pressure QTL 146	2.2	0.0021	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	73630210	118630210	Rat
8694439	Bw168	Body weight QTL 168	9.57	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	4	40433414	85433414	Rat
8655906	Rf60	Renal function QTL 60	3.8		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	4	29494195	81006281	Rat
1354660	Salc1	Saline consumption QTL 1	11.26		drinking behavior trait (VT:0001422)	saline drink intake rate (CMO:0001627)	4	44463908	148090542	Rat
2300179	Bmd50	Bone mineral density QTL 50	5.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	4	60928534	105928534	Rat
1298082	Stresp4	Stress response QTL 4			blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	50119848	146803430	Rat
70192	BpQTLcluster5	Blood pressure QTL cluster 5	4.183		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	4	62933508	114921294	Rat
1300139	Hrtrt6	Heart rate QTL 6	2.85		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	4	39524264	116179656	Rat
70200	Alc18	Alcohol consumption QTL 18	9.2		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	4	56647873	149491524	Rat
1578657	Bss12	Bone structure and strength QTL 12	8.9		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	4	60220938	105220938	Rat
1578658	Bss13	Bone structure and strength QTL 13	8		femur strength trait (VT:0010010)	femoral neck polar moment of inertia (CMO:0001670)	4	60220938	105220938	Rat
4889969	Bss96	Bone structure and strength QTL 96	4.9		tibia size trait (VT:0100001)	tibia cortical bone volume (CMO:0001725)	4	56647776	78882945	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	11320076	180699135	Rat
4889972	Bss97	Bone structure and strength QTL 97	5.6		tibia size trait (VT:0100001)	tibia total bone volume (CMO:0001724)	4	56647776	78882945	Rat
6478684	Anxrr30	Anxiety related response QTL 30		0.00087	defecation behavior trait (VT:0010462)	defecation rate (CMO:0000998)	4	62753847	107753847	Rat
2302051	Pia28	Pristane induced arthritis QTL 28	5.3	0.001	blood autoantibody amount (VT:0003725)	serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)	4	73630210	118630210	Rat
5685012	Bmd87	Bone mineral density QTL 87	5.1		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	4	56647776	78882945	Rat
5685009	Bmd86	Bone mineral density QTL 86	3.7		tibia mineral mass (VT:1000283)	bone mineral density (CMO:0001226)	4	56647776	78882945	Rat
8552782	Vie1	Viral induced encephalitis QTL 1	26.4		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	34430484	82490359	Rat
634311	Sach7	Saccharin preference QTL 7			taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	57114432	81266970	Rat
738009	Sach4	Saccharine consumption QTL 4	4.9	0.000016	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	59948935	154902892	Rat
2306545	Iddm39	Insulin dependent diabetes mellitus QTL 39			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	77356721	77687411	Rat
631261	Tcas3	Tongue tumor susceptibility QTL 3	6.88		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	4	10814170	91360527	Rat
2312567	Glom19	Glomerulus QTL 19	1.9	0.006	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	4	45456990	146803430	Rat
6478772	Anxrr49	Anxiety related response QTL 49		0.15488	defecation behavior trait (VT:0010462)	defecation rate (CMO:0000998)	4	62753847	107753847	Rat
631646	Stl4	Serum triglyceride level QTL 4	6.5	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	4	73169846	132642728	Rat
2312569	Pur19	Proteinuria QTL 19	3.4	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	4	65882107	96130297	Rat
8655961	Kidm43	Kidney mass QTL 43	18		kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	36303261	103194984	Rat
1354612	Foco1	Food consumption QTL 1	8.87		eating behavior trait (VT:0001431)	food intake rate (CMO:0000427)	4	44463908	148090542	Rat
634344	Hcar7	Hepatocarcinoma resistance QTL 7	7.8		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	4	70808386	115808386	Rat
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	5214602	146446691	Rat
8552801	Bw143	Body weight QTL 143	7.3		body mass (VT:0001259)	change in body weight to body weight ratio (CMO:0002216)	4	34430484	82490359	Rat
738031	Alc14	Alcohol consumption QTL 14	7.6	0.00003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	59948935	154902892	Rat
8552807	Vie4	Viral induced encephalitis QTL 4	7.3		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	62933508	82490359	Rat
619616	Bp79	Blood pressure QTL 79		0.0292	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	5214602	78882945	Rat
1576305	Emca6	Estrogen-induced mammary cancer QTL 6	5.8		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	4	44463720	155883716	Rat
61418	Pia5	Pristane induced arthritis QTL 5	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	62277855	128289560	Rat
631651	Bp124	Blood pressure QTL 124	3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	62879517	107879517	Rat
8552809	Vie5	Viral induced encephalitis QTL 5	25.3		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	34430484	82490359	Rat
738016	Alc16	Alcohol consumption QTL 16	3.6	0.00015	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	59948935	154902892	Rat
1558651	Swd3	Spike wave discharge measurement QTL 3	4.62	0.000024	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge frequency (CMO:0001742)	4	58432133	92991462	Rat
1641833	Alc21	Alcohol consumption QTL 21	8.6	0.0001	drinking behavior trait (VT:0001422)	ethanol drink intake rate (CMO:0001407)	4	56698790	126192555	Rat
631546	Bp86	Blood pressure QTL 86	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	57114432	91360801	Rat
631674	Iddm14	Insulin dependent diabetes mellitus QTL 14			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	4	64528739	157573521	Rat
6478743	Anxrr40	Anxiety related response QTL 40		0.83076	defecation behavior trait (VT:0010462)	defecation rate (CMO:0000998)	4	62753847	107753847	Rat
7394826	Bw126	Body weight QTL 126		0.002	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	62933269	87483707	Rat
12798520	Anxrr55	Anxiety related response QTL 55	4.45	0.01	locomotor behavior trait (VT:0001392)	number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)	4	32583980	114627242	Rat
631671	Iddm11	Insulin dependent diabetes mellitus QTL 11	3.6	0.0012	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	4	58635877	78886137	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_173153	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC099444	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AM285343	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AM285683	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY070268	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC070952	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CK479589	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ125339	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ125340	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000032742 ⟹ ENSRNOP00000038031

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	77,636,401 - 77,643,306 (+)	Ensembl
Rnor_6.0 Ensembl	4	78,320,190 - 78,327,144 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000091359 ⟹ ENSRNOP00000073865

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	4	78,320,241 - 78,327,026 (+)	Ensembl

RefSeq Acc Id:

NM_173153 ⟹ NP_775176

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	78,967,297 - 78,974,211 (+)	NCBI
mRatBN7.2	4	77,636,401 - 77,643,315 (+)	NCBI
Rnor_6.0	4	78,320,230 - 78,327,144 (+)	NCBI
Rnor_5.0	4	143,008,388 - 143,015,302 (+)	NCBI
RGSC_v3.4	4	76,777,679 - 76,784,519 (+)	RGD
Celera	4	72,573,763 - 72,580,677 (+)	RGD

Sequence:

show sequence

ATCAGAGAAGGCCACAGGACCCAGATTTTCAGGGATCTGAACTACAATGGAAGCCCAGTACAGT
GGTGTGGGGTCCATCCCGGAAAATTCAAGGAGCAGCCATGAGCTTGGAATACAAGATCAAGGAA
GTCCCCAACTGAGAATTGTCCTACTTGGAAAAACTGGAGCAGGAAAGAGTTCAACAGGGAACAG
CATCCTTGGAAGAAAAGCATTTCTTTCTGGCATTTGTGCAAAATCCATTACCAAGGTCTGTGAG
AAAGGAGTGAGCATCTGGGATGGGAAAGAGCTCGTTGTTGTGGATACACCTGGCATTTTCGACA
CTGAGGTACCAGATGCTGACACACAAAAGGAGATCACTCGCTGTGTTGCTCTGACCTCTCCAGG
GCCTCATGCTCTGCTTCTGGTCATCCCACTGGGGCGTTATACTGTGGAAGAACACAAGGCCACA
CGGAAACTTCTGAGCATGTTTGAAAAAAAGGCTAGAAGATTCATGATACTCTTGCTCACCAGGA
AGGATGACTTGGAAGACACAGATATCCATGAGTACTTAGAGACGGCTCCTGAAGTCCTTCAAGA
GTTGATCTATGAGTTCCGGAATCGCTACTGTTTGTTCAATAACAAAGCATCAGGAGCTGAACAG
GAAGAGCAGAAGAGGCAGCTGTTGACCTTAGTTCAGAGCATGGTGAGGGAAAATGGTGGAAAAT
ACTTTACTAACAAGATGTATGAAAGTGCTGAGGGTGTGATTCAGAAACAAACCTGGAAGAAGAA
AGAATTTTACAGAGAGGAACTGGAGAGAGAGAGAGCACGGATAAGACGGGAGTATGAAGCAGAG
ATTCAAGATCTGAGAGATGAGCTGGAAAGGGAAAGGAGAAGGGCACGTATGGAGAGGGAGTTCA
ATGAGAACGAGCTTATCTTTGCAGAGAGACAACAAAATGCTAGGAGGGAAGTTGAGAACACAAG
TATGATATACTTGAATTAATCATAAAAGCATGGGAGATTGCTTCCTTTATCTTCAACCAGTTTA
TGAGAGACTAGACTTCCTTGATAACATGCCGTACAGAGCTCACACCCATGACACACCCACTCCA
ACAGGGCTTTGCCTTCTAATGGTGCCACTCCCTGGGCTAAGTATATATGCCATAACAAACACCA
TGGCCAAAAGACACCTTGGAGAAGAAAGGGTTCATTTTTATCTTACAGCTTATAACCCATCCCA
GAGGAACAGCAACTCAAAGCAGGAACCTGGAGACAGGAACCGATGCAGAGGCCATGGAGGAGTG
CTTTACTTGCTTGGTGCCTATGACTTGCTTAGCTTTTTAAAACTTTTTTTTTTTTGTGAATTTT
ACATCATGCACACCAATCCCAATAATTTCCCTGTCCCTCCATATCCACCCTCTGCTGCTGCACC
TCCCCTCTAAAAGAAAACAAAATAAAATAAGACCAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_775176	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH70952	(Get FASTA)	NCBI Sequence Viewer
	AAL59007	(Get FASTA)	NCBI Sequence Viewer
	ABB03702	(Get FASTA)	NCBI Sequence Viewer
	ABB03703	(Get FASTA)	NCBI Sequence Viewer
	CAL00212	(Get FASTA)	NCBI Sequence Viewer
	CAL07463	(Get FASTA)	NCBI Sequence Viewer
	EDL88246	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000038031.5
GenBank Protein	Q8K3K9	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_775176 ⟸ NM_173153

- UniProtKB:

Q8K3K9 (UniProtKB/Swiss-Prot), Q6IRE3 (UniProtKB/TrEMBL), A6K0H2 (UniProtKB/TrEMBL), F7FBD4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEAQYSGVGSIPENSRSSHELGIQDQGSPQLRIVLLGKTGAGKSSTGNSILGRKAFLSGICAKS
ITKVCEKGVSIWDGKELVVVDTPGIFDTEVPDADTQKEITRCVALTSPGPHALLLVIPLGRYTV
EEHKATRKLLSMFEKKARRFMILLLTRKDDLEDTDIHEYLETAPEVLQELIYEFRNRYCLFNNK
ASGAEQEEQKRQLLTLVQSMVRENGGKYFTNKMYESAEGVIQKQTWKKKEFYREELERERARIR
REYEAEIQDLRDELERERRRARMEREFNENELIFAERQQNARREVENTSMIYLN

hide sequence

Ensembl Acc Id:

ENSRNOP00000038031 ⟸ ENSRNOT00000032742

Ensembl Acc Id:

ENSRNOP00000073865 ⟸ ENSRNOT00000091359

Protein Domains

AIG1-type G IQ

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8K3K9-F1-model_v2	AlphaFold	Q8K3K9	1-310	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693029

Promoter ID:

EPDNEW_R3552

Type:

multiple initiation site

Name:

Gimap4_1

Description:

GTPase, IMAP family member 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	4	78,320,216 - 78,320,276	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:628765	AgrOrtholog
BioCyc Gene	G2FUF-44945	BioCyc
Ensembl Genes	ENSRNOG00000008369	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000032742.7	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.300	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7100695	IMAGE-MGC_LOAD
InterPro	G_AIG1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GIMA/IAN/Toc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:286938	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:91425	IMAGE-MGC_LOAD
NCBI Gene	286938	ENTREZGENE
PANTHER	GTPASE IMAP FAMILY MEMBER 4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR10903	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	AIG1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Gimap4	PhenoGen
PROSITE	G_AIG1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000008369	RatGTEx
Superfamily-SCOP	SSF52540	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A6K0H2	ENTREZGENE
	F7FBD4	ENTREZGENE, UniProtKB/TrEMBL
	GIMA4_RAT	UniProtKB/Swiss-Prot
	Q0R3X4_RAT	UniProtKB/TrEMBL
	Q6IRE3	ENTREZGENE, UniProtKB/TrEMBL
	Q8K3K9	ENTREZGENE
UniProt Secondary	A6K0H2	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-01-20	Gimap4	GTPase, IMAP family member 4	Ian1	immune-associated nucleotide 1	Symbol and Name updated	1299863	APPROVED
2003-02-27	Ian1	immune-associated nucleotide 1			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in the thymus and the T-cell regions of the spleen	633092

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar