Fut11 (fucosyltransferase 11) - Rat Genome Database

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Gene: Fut11 (fucosyltransferase 11) Rattus norvegicus
Analyze
Symbol: Fut11
Name: fucosyltransferase 11
RGD ID: 628731
Description: Predicted to enable alpha-(1->3)-fucosyltransferase activity. Predicted to be involved in N-glycan fucosylation. Predicted to be located in Golgi cisterna membrane and Golgi membrane. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human FUT11 (fucosyltransferase 11); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: alpha-(1,3)-fucosyltransferase 11; alpha3-fucosyltransferase 11; fuc-TXI; fucosyltransferase 11 (alpha (1,3) fucosyltransferase); fucosyltransferase XI; fucT-XI; galactoside 3-L-fucosyltransferase 11; MGC94472
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8153,648,022 - 3,651,582 (-)NCBIGRCr8
mRatBN7.2153,598,768 - 3,602,328 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl153,598,758 - 3,602,356 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx153,608,959 - 3,612,519 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,995,435 - 4,998,995 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0153,607,768 - 3,611,328 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0154,031,504 - 4,035,064 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl154,031,504 - 4,035,064 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0158,132,722 - 8,136,282 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4153,824,218 - 3,827,778 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1153,824,207 - 3,827,806 (-)NCBI
Celera15991,857 - 995,417 (+)NCBICelera
Cytogenetic Map15p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Knockdown of FUT11 inhibits the progression of gastric cancer via the PI3K/AKT pathway. Cao W, etal., Heliyon. 2023 Jul 7;9(7):e17600. doi: 10.1016/j.heliyon.2023.e17600. eCollection 2023 Jul.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism. Roos C, etal., J Biol Chem 2002 Feb 1;277(5):3168-75. Epub 2001 Nov 6.
7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:19088067   PMID:23376485  


Genomics

Comparative Map Data
Fut11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8153,648,022 - 3,651,582 (-)NCBIGRCr8
mRatBN7.2153,598,768 - 3,602,328 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl153,598,758 - 3,602,356 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx153,608,959 - 3,612,519 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,995,435 - 4,998,995 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0153,607,768 - 3,611,328 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0154,031,504 - 4,035,064 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl154,031,504 - 4,035,064 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0158,132,722 - 8,136,282 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4153,824,218 - 3,827,778 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1153,824,207 - 3,827,806 (-)NCBI
Celera15991,857 - 995,417 (+)NCBICelera
Cytogenetic Map15p16NCBI
FUT11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381073,772,276 - 73,780,254 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1073,772,276 - 73,780,251 (+)EnsemblGRCh38hg38GRCh38
GRCh371075,532,034 - 75,535,977 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361075,202,055 - 75,205,983 (+)NCBINCBI36Build 36hg18NCBI36
Build 341075,202,054 - 75,205,980NCBI
Celera1068,815,227 - 68,819,145 (+)NCBICelera
Cytogenetic Map10q22.2NCBI
HuRef1069,527,224 - 69,531,120 (+)NCBIHuRef
CHM1_11075,813,820 - 75,817,752 (+)NCBICHM1_1
T2T-CHM13v2.01074,643,692 - 74,651,652 (+)NCBIT2T-CHM13v2.0
Fut11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391420,745,036 - 20,750,265 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1420,745,036 - 20,751,084 (+)EnsemblGRCm39 Ensembl
GRCm381420,694,968 - 20,700,197 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1420,694,968 - 20,701,016 (+)EnsemblGRCm38mm10GRCm38
MGSCv371421,514,190 - 21,519,419 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361419,483,520 - 19,488,749 (+)NCBIMGSCv36mm8
Celera1417,077,738 - 17,082,963 (+)NCBICelera
Cytogenetic Map14A3NCBI
cM Map1411.53NCBI
Fut11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543718,126,167 - 18,132,805 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543718,126,165 - 18,132,874 (-)NCBIChiLan1.0ChiLan1.0
FUT11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2885,923,086 - 85,931,133 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11085,928,410 - 85,936,457 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01070,295,122 - 70,301,897 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11072,967,970 - 72,974,517 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1072,968,025 - 72,972,030 (+)Ensemblpanpan1.1panPan2
FUT11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1424,209,235 - 24,213,192 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl424,209,271 - 24,212,515 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha424,346,846 - 24,352,467 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0424,489,372 - 24,495,211 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl424,489,388 - 24,492,854 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1424,386,557 - 24,392,344 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0424,587,177 - 24,592,794 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0424,942,244 - 24,947,858 (+)NCBIUU_Cfam_GSD_1.0
Fut11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721356,874,870 - 56,881,772 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365215,369,174 - 5,374,428 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365215,367,614 - 5,374,472 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FUT11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1476,498,827 - 76,505,767 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11476,497,894 - 76,505,776 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21482,625,856 - 82,629,556 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FUT11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1957,593,732 - 57,600,704 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl957,597,011 - 57,600,617 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604818,169,493 - 18,177,902 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fut11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247547,288,945 - 7,293,786 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247547,288,879 - 7,294,832 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fut11
5 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:85
Count of miRNA genes:73
Interacting mature miRNAs:77
Transcripts:ENSRNOT00000012300
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15226636822711984Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15105825014481294Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat

Markers in Region
RH128878  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2153,602,527 - 3,602,710 (+)MAPPERmRatBN7.2
Rnor_6.0154,035,264 - 4,035,446NCBIRnor6.0
Rnor_5.0158,136,482 - 8,136,664UniSTSRnor5.0
RGSC_v3.4153,827,978 - 3,828,160UniSTSRGSC3.4
Celera15991,475 - 991,657UniSTS
RH 3.4 Map1565.8UniSTS
Cytogenetic Map15p16UniSTS
RH139808  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2153,600,960 - 3,601,149 (+)MAPPERmRatBN7.2
Rnor_6.0154,033,697 - 4,033,885NCBIRnor6.0
Rnor_5.0158,134,915 - 8,135,103UniSTSRnor5.0
RGSC_v3.4153,826,411 - 3,826,599UniSTSRGSC3.4
Celera15993,036 - 993,224UniSTS
RH 3.4 Map1566.2UniSTS
Cytogenetic Map15p16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000012300   ⟹   ENSRNOP00000012300
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl153,598,758 - 3,602,356 (-)Ensembl
Rnor_6.0 Ensembl154,031,504 - 4,035,064 (-)Ensembl
RefSeq Acc Id: NM_173308   ⟹   NP_775430
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8153,648,022 - 3,651,582 (-)NCBI
mRatBN7.2153,598,768 - 3,602,328 (-)NCBI
Rnor_6.0154,031,504 - 4,035,064 (-)NCBI
Rnor_5.0158,132,722 - 8,136,282 (-)NCBI
RGSC_v3.4153,824,218 - 3,827,778 (-)RGD
Celera15991,857 - 995,417 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_775430 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH79316 (Get FASTA)   NCBI Sequence Viewer  
  CAD59737 (Get FASTA)   NCBI Sequence Viewer  
  EDL86242 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012300.1
  ENSRNOP00055026884
  ENSRNOP00060016931
  ENSRNOP00065012873
GenBank Protein Q68FV3 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_775430   ⟸   NM_173308
- Peptide Label: precursor
- UniProtKB: Q8CG40 (UniProtKB/Swiss-Prot),   Q68FV3 (UniProtKB/Swiss-Prot),   A6KKP8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012300   ⟸   ENSRNOT00000012300
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q68FV3-F1-model_v2 AlphaFold Q68FV3 1-494 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699561
Promoter ID:EPDNEW_R10084
Type:multiple initiation site
Name:Fut11_1
Description:fucosyltransferase 11
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0154,035,076 - 4,035,136EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628731 AgrOrtholog
BioCyc Gene G2FUF-14556 BioCyc
Ensembl Genes ENSRNOG00000009274 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055019429 UniProtKB/Swiss-Prot
  ENSRNOG00060012622 UniProtKB/Swiss-Prot
  ENSRNOG00065010402 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000012300.4 UniProtKB/Swiss-Prot
  ENSRNOT00055033167 UniProtKB/Swiss-Prot
  ENSRNOT00060021432 UniProtKB/Swiss-Prot
  ENSRNOT00065016832 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.11660 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7135022 IMAGE-MGC_LOAD
InterPro Alpha-1_3-FUT_met UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_tran_10_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_trans_10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GT10-like_C_sf UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
KEGG Report rno:286971 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:94472 IMAGE-MGC_LOAD
NCBI Gene 286971 ENTREZGENE
PANTHER ALPHA- 1,3 -FUCOSYLTRANSFERASE UniProtKB/TrEMBL
  ALPHA-(1,3)-FUCOSYLTRANSFERASE 11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11929 UniProtKB/Swiss-Prot
Pfam Glyco_tran_10_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_transf_10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fut11 PhenoGen
PIRSF Alpha1_3FUT_met UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009274 RatGTEx
  ENSRNOG00055019429 RatGTEx
  ENSRNOG00060012622 RatGTEx
  ENSRNOG00065010402 RatGTEx
Superfamily-SCOP UDP-Glycosyltransferase/glycogen phosphorylase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6KKP8 ENTREZGENE, UniProtKB/TrEMBL
  FUT11_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q8CG40 ENTREZGENE
UniProt Secondary Q8CG40 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Fut11  fucosyltransferase 11  Fut11  fucosyltransferase 11 (alpha (1,3) fucosyltransferase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-19 Fut11  fucosyltransferase 11 (alpha (1,3) fucosyltransferase)  Fut11  fucosyltransferase 11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Fut11  fucosyltransferase 11    alpha3-fucosyltransferase 11  Name updated 1299863 APPROVED
2003-02-27 Fut11  alpha3-fucosyltransferase 11      Symbol and Name status set to provisional 70820 PROVISIONAL