Bmf (Bcl2 modifying factor) - Rat Genome Database

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Gene: Bmf (Bcl2 modifying factor) Rattus norvegicus
Analyze
Symbol: Bmf
Name: Bcl2 modifying factor
RGD ID: 628658
Description: Predicted to be involved in several processes, including cellular response to UV; negative regulation of autophagic cell death; and positive regulation of cellular component organization. Predicted to act upstream of or within anoikis; negative regulation of apoptotic signaling pathway; and positive regulation of apoptotic signaling pathway. Located in acrosomal vesicle. Orthologous to human BMF (Bcl2 modifying factor); PARTICIPATES IN intrinsic apoptotic pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Bcl-2 modifying factor; bcl-2-modifying factor; Bmf-pending
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83125,953,466 - 125,974,087 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3125,953,466 - 125,974,258 (-)EnsemblGRCr8
mRatBN7.23105,499,534 - 105,520,159 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3105,499,538 - 105,520,145 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3109,173,179 - 109,193,801 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03117,768,734 - 117,789,356 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03115,429,111 - 115,449,729 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03110,303,515 - 110,324,125 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3110,306,067 - 110,324,084 (-)Ensemblrn6Rnor6.0
Rnor_5.03116,849,170 - 116,869,775 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43104,966,652 - 104,984,752 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3104,419,059 - 104,437,108 (-)NCBICelera
RGSC_v3.13104,863,079 - 104,881,180 (-)NCBI
Cytogenetic Map3q35NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-alpha-phellandrene  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-aminopyridine  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antimycin A  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chloroacetaldehyde  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
DDT  (EXP)
deguelin  (ISO)
depsipeptide  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dichloroacetic acid  (ISO)
diethyl maleate  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
epoxiconazole  (ISO)
estriol  (ISO)
fenofibrate  (EXP,ISO)
fenpyroximate  (ISO)
FR900359  (ISO)
furan  (EXP,ISO)
genistein  (ISO)
gentamycin  (EXP)
inulin  (ISO)
iron dichloride  (ISO)
isoprenaline  (EXP)
L-ethionine  (EXP)
leflunomide  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
metformin  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (ISO)
nickel dichloride  (EXP)
niclosamide  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
omeprazole  (EXP)
ozone  (ISO)
p-menthan-3-ol  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
picoxystrobin  (ISO)
pinostrobin  (ISO)
pirinixic acid  (EXP,ISO)
potassium bromate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
propionic acid  (ISO)
pyrazinecarboxamide  (EXP)
resveratrol  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tebufenpyrad  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zearalenone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Bcl-2-related protein family gene expression during oligodendroglial differentiation. Itoh T, etal., J Neurochem 2003 Jun;85(6):1500-12.
3. BH3-only proteins in apoptosis and beyond: an overview. Lomonosova E and Chinnadurai G, Oncogene. 2008 Dec;27 Suppl 1:S2-19.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. Testicular expression and distribution of the rat bcl2 modifying factor in response to reduced intratesticular testosterone. Show MD, etal., Biol Reprod. 2004 Apr;70(4):1153-61. Epub 2003 Dec 10.
Additional References at PubMed
PMID:11546872   PMID:18222916   PMID:19671867   PMID:20841353   PMID:21041309   PMID:23629966   PMID:27539959   PMID:31200256   PMID:36315357  


Genomics

Comparative Map Data
Bmf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83125,953,466 - 125,974,087 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3125,953,466 - 125,974,258 (-)EnsemblGRCr8
mRatBN7.23105,499,534 - 105,520,159 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3105,499,538 - 105,520,145 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3109,173,179 - 109,193,801 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03117,768,734 - 117,789,356 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03115,429,111 - 115,449,729 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03110,303,515 - 110,324,125 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3110,306,067 - 110,324,084 (-)Ensemblrn6Rnor6.0
Rnor_5.03116,849,170 - 116,869,775 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43104,966,652 - 104,984,752 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3104,419,059 - 104,437,108 (-)NCBICelera
RGSC_v3.13104,863,079 - 104,881,180 (-)NCBI
Cytogenetic Map3q35NCBI
BMF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381540,087,890 - 40,108,879 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1540,087,889 - 40,108,928 (-)Ensemblhg38GRCh38
GRCh371540,380,091 - 40,401,080 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361538,167,383 - 38,188,367 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341538,167,385 - 38,185,931NCBI
Celera1517,145,999 - 17,167,002 (-)NCBICelera
Cytogenetic Map15q15.1NCBI
HuRef1517,223,445 - 17,244,440 (-)NCBIHuRef
CHM1_11540,499,972 - 40,520,967 (-)NCBICHM1_1
T2T-CHM13v2.01537,894,726 - 37,915,713 (-)NCBIT2T-CHM13v2.0
Bmf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392118,359,238 - 118,385,240 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2118,359,238 - 118,380,168 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382118,528,757 - 118,549,686 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2118,528,757 - 118,549,687 (-)Ensemblmm10GRCm38
MGSCv372118,354,493 - 118,375,414 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362118,220,198 - 118,241,119 (-)NCBIMGSCv36mm8
Celera2119,683,712 - 119,704,619 (-)NCBICelera
Cytogenetic Map2E5NCBI
cM Map259.4NCBI
Bmf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554167,052,290 - 7,068,910 (-)Ensembl
ChiLan1.0NW_0049554167,048,654 - 7,068,917 (-)NCBIChiLan1.0ChiLan1.0
BMF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21629,326,014 - 29,346,967 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11533,477,360 - 33,498,321 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01519,026,053 - 19,047,008 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11537,281,655 - 37,302,365 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1537,281,655 - 37,302,075 (-)EnsemblpanPan2panpan1.1
BMF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1307,301,000 - 7,321,949 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl307,274,174 - 7,322,034 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha307,355,731 - 7,376,675 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0307,429,431 - 7,450,406 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl307,402,587 - 7,450,406 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1307,351,934 - 7,372,873 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0307,458,286 - 7,479,257 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0307,586,431 - 7,607,394 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Bmf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864085,725,364 - 85,746,902 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364713,577,221 - 3,594,981 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364713,573,437 - 3,594,438 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BMF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1131,178,315 - 131,200,393 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11131,178,021 - 131,199,668 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
BMF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12642,893,997 - 42,915,062 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2642,894,460 - 42,915,062 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604898,040,714 - 98,061,923 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bmf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248047,423,547 - 7,440,014 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248047,420,003 - 7,440,012 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Bmf
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1596,681,539 - 96,702,154 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Bmf
85 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:212
Count of miRNA genes:133
Interacting mature miRNAs:160
Transcripts:ENSRNOT00000010381
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3122654702136118980Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)3116582412136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3101255536134750886Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)381541464126563126Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)3125814931139636791Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
D15S214  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23105,519,233 - 105,519,547 (+)MAPPERmRatBN7.2
Rnor_6.03110,323,212 - 110,323,527NCBIRnor6.0
Rnor_5.03116,868,867 - 116,869,182UniSTSRnor5.0
RGSC_v3.43104,983,880 - 104,984,195UniSTSRGSC3.4
Celera3104,436,198 - 104,436,551UniSTS
Cytogenetic Map3q35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 91 59 6 355 191 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000010381   ⟹   ENSRNOP00000010381
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3125,953,466 - 125,974,064 (-)Ensembl
mRatBN7.2 Ensembl3105,499,538 - 105,520,145 (-)Ensembl
Rnor_6.0 Ensembl3110,306,067 - 110,324,084 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105313   ⟹   ENSRNOP00000096398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3125,953,466 - 125,971,728 (-)Ensembl
mRatBN7.2 Ensembl3105,499,538 - 105,517,800 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000150084   ⟹   ENSRNOP00000111477
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3125,956,077 - 125,974,258 (-)Ensembl
RefSeq Acc Id: NM_001401791   ⟹   NP_001388720
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83125,953,466 - 125,974,064 (-)NCBI
mRatBN7.23105,499,534 - 105,520,134 (-)NCBI
RefSeq Acc Id: NM_139258   ⟹   NP_640351
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83125,953,466 - 125,974,064 (-)NCBI
mRatBN7.23105,499,534 - 105,520,134 (-)NCBI
Rnor_6.03110,306,067 - 110,324,084 (-)NCBI
Rnor_5.03116,849,170 - 116,869,775 (-)NCBI
RGSC_v3.43104,966,652 - 104,984,752 (-)RGD
Celera3104,419,059 - 104,437,108 (-)RGD
Sequence:
RefSeq Acc Id: XM_006234724   ⟹   XP_006234786
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83125,953,467 - 125,974,087 (-)NCBI
mRatBN7.23105,503,224 - 105,520,159 (-)NCBI
Rnor_6.03110,307,259 - 110,324,125 (-)NCBI
Rnor_5.03116,849,170 - 116,869,775 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008762079   ⟹   XP_008760301
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83125,953,467 - 125,974,086 (-)NCBI
mRatBN7.23105,499,534 - 105,520,159 (-)NCBI
Rnor_6.03110,303,515 - 110,324,122 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063283080   ⟹   XP_063139150
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83125,953,467 - 125,973,891 (-)NCBI
RefSeq Acc Id: XR_005501773
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83125,969,477 - 125,974,086 (-)NCBI
mRatBN7.23105,515,550 - 105,520,159 (-)NCBI
RefSeq Acc Id: NP_640351   ⟸   NM_139258
- Peptide Label: isoform 1
- UniProtKB: A0A8L2Q4K3 (UniProtKB/TrEMBL),   A6HPB4 (UniProtKB/TrEMBL),   A6HPB3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234786   ⟸   XM_006234724
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008760301   ⟸   XM_008762079
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000010381   ⟸   ENSRNOT00000010381
Ensembl Acc Id: ENSRNOP00000096398   ⟸   ENSRNOT00000105313
RefSeq Acc Id: NP_001388720   ⟸   NM_001401791
- Peptide Label: isoform 2
- UniProtKB: Q8K589 (UniProtKB/Swiss-Prot),   A0A8I6GLK7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139150   ⟸   XM_063283080
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000111477   ⟸   ENSRNOT00000150084

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K589-F1-model_v2 AlphaFold Q8K589 1-185 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692310
Promoter ID:EPDNEW_R2834
Type:multiple initiation site
Name:Bmf_1
Description:Bcl2 modifying factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03110,324,078 - 110,324,138EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628658 AgrOrtholog
BioCyc Gene G2FUF-48249 BioCyc
Ensembl Genes ENSRNOG00000007529 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000010381 ENTREZGENE
  ENSRNOT00000105313 ENTREZGENE
  ENSRNOT00000150084 ENTREZGENE
InterPro BMF UniProtKB/Swiss-Prot
KEGG Report rno:246142 UniProtKB/Swiss-Prot
NCBI Gene 246142 ENTREZGENE
PANTHER BCL-2-MODIFYING FACTOR UniProtKB/Swiss-Prot
  PTHR32014 UniProtKB/Swiss-Prot
Pfam BMF UniProtKB/Swiss-Prot
PhenoGen Bmf PhenoGen
RatGTEx ENSRNOG00000007529 RatGTEx
UniProt A0A8I6GLK7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q4K3 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LYH6_RAT UniProtKB/TrEMBL
  A6HPB3 ENTREZGENE, UniProtKB/TrEMBL
  A6HPB4 ENTREZGENE, UniProtKB/TrEMBL
  BMF_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Bmf  Bcl2 modifying factor    Bcl-2 modifying factor  Name updated 1299863 APPROVED
2003-02-27 Bmf  Bcl-2 modifying factor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a BH3 domain 631874