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Gene: Akr7a3 (aldo-keto reductase family 7 member A3) Rattus norvegicus

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Symbol:

Akr7a3

Name:

aldo-keto reductase family 7 member A3

RGD ID:

628635

Description:

Enables NADP+ binding activity; alcohol dehydrogenase (NAD+) activity; and alcohol dehydrogenase (NADP+) activity. Involved in aflatoxin catabolic process. Located in Golgi apparatus and cytosol. Orthologous to several human genes including AKR7A3 (aldo-keto reductase family 7 member A3); INTERACTS WITH 1,3-dinitrobenzene; 1-nitropropane; 17alpha-ethynylestradiol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Afar; AFB1-AR; aflatoxin B1 aldehyde reductase; aflatoxin B1 aldehyde reductase member 1; aflatoxin B1 aldehyde reductase member 3; Akr7a1; aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase); rAFAR1

RGD Orthologs

Human

Bonobo

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	AKR7A3 (aldo-keto reductase family 7 member A3)	HGNC	HomoloGene, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Pan paniscus (bonobo/pygmy chimpanzee):	AKR7A3 (aldo-keto reductase family 7 member A3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	AKR7L (aldo-keto reductase family 7 like (gene/pseudogene))	HGNC	Inparanoid, Panther
Homo sapiens (human):	AKR7A2 (aldo-keto reductase family 7 member A2)	HGNC	OrthoDB, Treefam
Homo sapiens (human):	KLK3 (kallikrein related peptidase 3)	HGNC	OMA
Homo sapiens (human):	KLK2 (kallikrein related peptidase 2)	HGNC	OMA
Homo sapiens (human):	KLK1 (kallikrein 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	AKR7A3 (aldo-keto reductase family 7 member A3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	AKR7L (aldo-keto reductase family 7 like (gene/pseudogene))	Alliance	DIOPT (InParanoid\|OrthoFinder\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	akr7a3 (aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase))	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	AAD10	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector)
Saccharomyces cerevisiae (baker's yeast):	AAD10	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	AAD14	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector)
Saccharomyces cerevisiae (baker's yeast):	AAD14	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	akr7a2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	akr7a2	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	AAD3	Alliance	DIOPT (Ensembl Compara\|InParanoid\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	AAD4	Alliance	DIOPT (Ensembl Compara\|InParanoid\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	156,876,721 - 156,884,599 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	156,874,086 - 156,885,153 (+)	Ensembl				GRCr8
mRatBN7.2	5	151,590,968 - 151,601,394 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	151,584,479 - 151,601,394 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	154,292,151 - 154,300,047 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	156,066,511 - 156,074,407 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	156,047,478 - 156,055,349 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	157,801,120 - 157,813,756 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	157,801,163 - 157,813,756 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	161,540,977 - 161,553,468 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	158,139,986 - 158,147,516 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	149,973,124 - 149,980,999 (+)	NCBI		Celera
RGSC_v3.1	5	158,150,024 - 158,157,553 (+)	NCBI
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

Hepatomegaly (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,3-dinitrobenzene (EXP)

1-nitropropane (EXP)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4,6-trinitrotoluene (EXP)

2,4-diaminotoluene (EXP)

2,4-dinitrotoluene (EXP)

2,6-di-tert-butyl-4-methylphenol (EXP)

2,6-diaminotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one (EXP)

2-acetamidofluorene (EXP)

2-amino-4,6-dinitrotoluene (EXP)

2-nitro-p-phenylenediamine (EXP)

2-nitrofluorene (EXP)

2-nitropropane (EXP)

2-palmitoylglycerol (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3-chloropropane-1,2-diol (EXP)

3H-1,2-dithiole-3-thione (EXP)

4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one (EXP)

4-acetylaminofluorene (EXP)

4-amino-2,6-dinitrotoluene (EXP)

4-nitro-1,2-phenylenediamine (EXP)

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole (EXP)

6-propyl-2-thiouracil (EXP)

9,10-phenanthroquinone (EXP,ISO)

acetamide (EXP)

acrolein (EXP)

aflatoxin B1 (EXP,ISO)

amiodarone (EXP)

ammonium chloride (EXP)

antirheumatic drug (ISO)

aristolochic acid A (EXP,ISO)

Aroclor 1254 (EXP)

arsenous acid (ISO)

atazanavir sulfate (ISO)

atrazine (EXP)

benzbromarone (EXP)

benzene (EXP)

benzo[a]pyrene (ISO)

benzo[a]pyrene-7,8-dione (ISO)

beta-naphthoflavone (EXP)

bisphenol A (EXP,ISO)

bromobenzene (EXP)

buspirone (EXP)

butylated hydroxyanisole (EXP)

cadmium atom (EXP)

cadmium dichloride (EXP)

cafestol (EXP)

capsaicin (EXP)

carbamazepine (EXP)

chenodeoxycholic acid (ISO)

chloroform (EXP)

chlorohydrocarbon (EXP)

cisplatin (EXP)

clofibrate (EXP)

cobalt dichloride (EXP)

cocaine (EXP)

copper(II) sulfate (ISO)

coumarin (EXP)

Cuprizon (EXP)

cyclosporin A (ISO)

deoxycholic acid (ISO)

Diallyl sulfide (EXP)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP)

dichlorvos (EXP)

diuron (EXP)

emodin (ISO)

endosulfan (EXP)

ethanol (ISO)

ethoxyquin (EXP)

etofenprox (EXP)

felbamate (EXP)

finasteride (EXP)

fipronil (EXP)

fluconazole (EXP)

flutamide (EXP)

furan (EXP)

gabapentin (EXP)

gamma-hexachlorocyclohexane (EXP)

gemfibrozil (EXP)

gentamycin (EXP)

glafenine (EXP)

glutathione (EXP)

glycochenodeoxycholic acid (ISO)

glycocholic acid (ISO)

glycodeoxycholic acid (ISO)

indole-3-methanol (EXP)

kahweol (EXP)

L-ethionine (EXP)

lead diacetate (EXP)

melatonin (EXP)

mercury atom (EXP)

mercury dichloride (EXP)

mercury(0) (EXP)

methapyrilene (EXP)

methimazole (EXP)

methylmercury chloride (EXP)

N-nitrosodiethylamine (EXP)

N-nitrosodimethylamine (EXP)

N-nitrosomorpholine (EXP)

NADP zwitterion (ISO)

NADP(+) (ISO)

naphthalene (EXP)

naphthalenes (ISO)

nefazodone (EXP,ISO)

nimesulide (EXP)

O-methyleugenol (ISO)

ochratoxin A (EXP)

okadaic acid (ISO)

oltipraz (EXP)

omeprazole (EXP)

orphenadrine (EXP)

oxaliplatin (EXP)

oxfendazole (EXP)

p-toluidine (EXP)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (EXP)

phenethyl isothiocyanate (EXP)

phenobarbital (EXP)

phenytoin (EXP)

piperonyl butoxide (EXP)

pirinixic acid (EXP)

pregnenolone 16alpha-carbonitrile (EXP)

propiconazole (EXP)

pyrazinecarboxamide (EXP)

quercetin (EXP)

quercetin 3-O-beta-D-glucofuranoside (EXP)

quercetin 3-O-beta-D-glucopyranoside (EXP)

S-nitrosoglutathione (ISO)

sinigrin (EXP)

sodium arsenite (ISO)

sodium dichromate (EXP)

streptozocin (EXP)

succinic semialdehyde (EXP)

Sunset Yellow FCF (ISO)

tartrazine (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

toluene (EXP)

topotecan (EXP)

triadimefon (EXP)

trichloroethene (EXP)

triclosan (ISO)

triphenyl phosphate (EXP,ISO)

trovafloxacin (EXP)

umbelliferone (ISO)

valdecoxib (EXP)

valproic acid (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

aflatoxin catabolic process (IDA,IEA,IMP,ISO)

aflatoxin metabolic process (IDA)

response to toxic substance (IEA)

Cellular Component

cytoplasm (IBA,IDA,IEA)

cytosol (IDA,IEA,ISO)

Golgi apparatus (IDA)

Molecular Function

alcohol dehydrogenase (NAD+) activity (IDA)

alcohol dehydrogenase (NADP+) activity (IBA,IDA,IEA,ISO)

identical protein binding (IEA,ISO)

NADP+ binding (IDA)

nucleotide binding (IEA)

oxidoreductase activity (IEA)

oxidoreductase activity, acting on CH-OH group of donors (IDA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Characterization of the rat aflatoxin B1 aldehyde reductase gene, AKR7A1. Structure and chromosomal localization of AKR7A1 as well as identification of antioxidant response elements in the gene promoter.	Ellis EM, etal., Carcinogenesis 2003 Apr;24(4):727-37.
2.	An ethoxyquin-inducible aldehyde reductase from rat liver that metabolizes aflatoxin B1 defines a subfamily of aldo-keto reductases.	Ellis EM, etal., Proc Natl Acad Sci U S A 1993 Nov 1;90(21):10350-4.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteins.	Kelly VP, etal., Biochem J 2002 Sep 15;366(Pt 3):847-61.
6.	cDNA cloning, expression and activity of a second human aflatoxin B1-metabolizing member of the aldo-keto reductase superfamily, AKR7A3.	Knight LP, etal., Carcinogenesis. 1999 Jul;20(7):1215-23. doi: 10.1093/carcin/20.7.1215.
7.	The crystal structure of rat liver AKR7A1. A dimeric member of the aldo-keto reductase superfamily.	Kozma E, etal., J Biol Chem 2002 May 3;277(18):16285-93. Epub 2002 Feb 11.
8.	GOA pipeline	RGD automated data pipeline
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8395332	PMID:12477932	PMID:16189514	PMID:19056867	PMID:23376485	PMID:23533145	PMID:25416956	PMID:29383608	PMID:31515488

Genomics

Comparative Map Data

Akr7a3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	156,876,721 - 156,884,599 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	156,874,086 - 156,885,153 (+)	Ensembl				GRCr8
mRatBN7.2	5	151,590,968 - 151,601,394 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	151,584,479 - 151,601,394 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	154,292,151 - 154,300,047 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	156,066,511 - 156,074,407 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	156,047,478 - 156,055,349 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	157,801,120 - 157,813,756 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	157,801,163 - 157,813,756 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	161,540,977 - 161,553,468 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	158,139,986 - 158,147,516 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	149,973,124 - 149,980,999 (+)	NCBI		Celera
RGSC_v3.1	5	158,150,024 - 158,157,553 (+)	NCBI
Cytogenetic Map	5	q36	NCBI

AKR7A3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	19,274,229 - 19,288,770 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	19,282,496 - 19,288,823 (-)	Ensembl			hg38	GRCh38
GRCh37	1	19,609,067 - 19,615,264 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	19,481,644 - 19,487,867 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	19,354,362 - 19,360,586	NCBI
Celera	1	17,936,048 - 17,942,271 (-)	NCBI		Celera
Cytogenetic Map	1	p36.13	NCBI
HuRef	1	17,855,438 - 17,861,662 (-)	NCBI		HuRef
CHM1_1	1	19,718,377 - 19,724,602 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	19,097,755 - 19,112,298 (-)	NCBI		T2T-CHM13v2.0

AKR7A3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	207,826,569 - 207,832,727 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	206,941,860 - 206,949,514 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	18,241,298 - 18,248,142 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	19,287,926 - 19,294,576 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	19,288,100 - 19,294,041 (-)	Ensembl			panPan2	panpan1.1

Variants

Variants in Akr7a3
38 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	45
Count of miRNA genes:	40
Interacting mature miRNAs:	43
Transcripts:	ENSRNOT00000024160
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	130249266	172190305	Rat
8552960	Pigfal15	Plasma insulin-like growth factor 1 level QTL 15			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	116702075	161702075	Rat
1354583	Despr3	Despair related QTL3	4.98	0.0002	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	5	132930505	172190305	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	141212838	172190305	Rat
1300119	Bp180	Blood pressure QTL 180	3.82		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	149642129	171146538	Rat
61452	Ciaa5	CIA Autoantibody QTL 5	3.5		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	5	99905133	172190305	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	133789363	172190305	Rat
1331803	Rf32	Renal function QTL 32	2.798		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	134369199	172190305	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	65089051	166764498	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	136631198	172190305	Rat
7207486	Bss109	Bone structure and strength QTL 109			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	5	112142946	157142946	Rat
1354631	Swd2	Spike wave discharge measurement QTL 2	3.64	0.0002	brain electrophysiology trait (VT:0010557)	brain total spike-and-wave discharge duration (CMO:0001740)	5	156396728	172190305	Rat
7207481	Bss106	Bone structure and strength QTL 106	7.9		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	112142946	157142946	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	133081618	172190305	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	51657967	166600247	Rat
631263	Cm24	Cardiac mass QTL 24	3.5		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	149805999	162987697	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	138002522	170842766	Rat
1549838	Bss4	Bone structure and strength QTL 4	9.2		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	5	112142946	157142946	Rat
1581505	Rf54	Renal function QTL 54			kidney physiology trait (VT:0002136)	kidney 20-HETE level (CMO:0001854)	5	133270647	172190305	Rat
2317753	Glom24	Glomerulus QTL 24	3.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	5	141764300	172190305	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	133789363	172190305	Rat
1331721	Bp210	Blood pressure QTL 210	3.413		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	148093485	172129029	Rat
1581510	Cm54	Cardiac mass QTL 54	3.4	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	125969677	172190305	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55124766	172190305	Rat
631272	Lanf1	Left ventricular atrial natriuretic factor QTL 1	12		heart left ventricle natriuretic peptide A amount (VT:0010596)	heart left ventricle natriuretic peptide A level (CMO:0002165)	5	156396728	167181764	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	131708216	172190305	Rat
1598847	Cm62	Cardiac mass QTL 62	3.4		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	114131300	159131300	Rat
2313096	Bmd78	Bone mineral density QTL 78	3.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	5	149661912	166600247	Rat
7207488	Bss110	Bone structure and strength QTL 1	8.4		femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	5	112142946	157142946	Rat
8694441	Bw169	Body weight QTL 169	17.61	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	5	116702075	161702075	Rat
7207491	Bss112	Bone structure and strength QTL 112	7		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	5	112142946	157142946	Rat
8694389	Bw160	Body weight QTL 160	6.17	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	5	116702075	161702075	Rat
8694198	Abfw3	Abdominal fat weight QTL 3	16.13	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	5	116702075	161702075	Rat
1298090	Bp155	Blood pressure QTL 155	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	156289283	171137955	Rat
1298089	Scl14	Serum cholesterol level QTL 14	5.8	0.0004	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	114131300	159131300	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	133081618	172190305	Rat

Markers in Region

BI275071

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	151,601,823 - 151,602,057 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	157,814,186 - 157,814,419	NCBI	Rnor6.0
Rnor_6.0	5	157,807,608 - 157,807,841	NCBI	Rnor6.0
Rnor_5.0	5	161,553,898 - 161,554,131	UniSTS	Rnor5.0
Rnor_5.0	5	161,547,422 - 161,547,655	UniSTS	Rnor5.0
RGSC_v3.4	5	158,147,946 - 158,148,179	UniSTS	RGSC3.4
Celera	5	149,981,429 - 149,981,662	UniSTS
RH 3.4 Map	5	1044.7	UniSTS
Cytogenetic Map	5	q36	UniSTS

AA891811

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	151,601,235 - 151,601,336 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	157,813,598 - 157,813,698	NCBI	Rnor6.0
Rnor_6.0	5	157,807,020 - 157,807,120	NCBI	Rnor6.0
Rnor_5.0	5	161,553,310 - 161,553,410	UniSTS	Rnor5.0
Rnor_5.0	5	161,546,834 - 161,546,934	UniSTS	Rnor5.0
RGSC_v3.4	5	158,147,358 - 158,147,458	UniSTS	RGSC3.4
Celera	5	149,980,841 - 149,980,941	UniSTS
RH 3.4 Map	5	1047.0	UniSTS
Cytogenetic Map	5	q36	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	11	66	141	91	90	59	92	59	6	354	190	11	120	81	92	31	12	12

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_013215	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017593183	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109345	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF045464	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC078872	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC089811	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X74673	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000024160 ⟹ ENSRNOP00000024160

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	156,874,086 - 156,885,153 (+)	Ensembl
mRatBN7.2 Ensembl	5	151,584,479 - 151,601,394 (+)	Ensembl
Rnor_6.0 Ensembl	5	157,801,163 - 157,813,756 (+)	Ensembl

RefSeq Acc Id:

NM_013215 ⟹ NP_037347

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	156,876,721 - 156,884,599 (+)	NCBI
mRatBN7.2	5	151,593,516 - 151,601,394 (+)	NCBI
Rnor_6.0	5	157,801,163 - 157,813,756 (+)	NCBI
Rnor_5.0	5	161,540,977 - 161,553,468 (+)	NCBI
RGSC_v3.4	5	158,139,986 - 158,147,516 (+)	RGD
Celera	5	149,973,124 - 149,980,999 (+)	RGD

Sequence:

show sequence

GAATTCGACTGCTGGAACCAACGTCCTCTCTTACCCTCCACCTTCTTCTGCCACCTCTACCACG
GTCACCATGTCGCAAGCCCGGCCTGCCACTGTGCTGGGTGCCATGGAGATGGGTCGCCGCATGG
ATGTGACCTCCAGCTCCGCGTCGGTGCGCGCCTTCCTGCAGCGCGGCCACACGGAGATAGACAC
CGCCTTCGTGTATGCGAACGGTCAGTCTGAGACCATCCTAGGAGACCTGGGGCTCGGACTGGGC
CGCAGCGGCTGCAAAGTAAAAATTGCCACCAAGGCTGCCCCAATGTTTGGGAAGACACTGAAGC
CAGCCGATGTTCGGTTCCAGCTGGAGACGTCACTGAAGAGGCTGCAGTGTCCCCGGGTGGACCT
CTTCTATTTACACTTTCCAGACCACGGCACTCCTATAGAGGAGACCCTGCAGGCCTGCCACCAG
CTGCATCAGGAGGGCAAGTTTGTGGAGCTTGGTCTGTCCAACTATGTCTCCTGGGAAGTGGCTG
AGATTTGTACCCTCTGCAAGAAAAATGGCTGGATCATGCCAACTGTGTACCAGGGCATGTACAA
CGCCATCACCAGGCAGGTGGAGACTGAGCTCTTCCCCTGCCTCAGACACTTCGGACTAAGGTTC
TACGCCTTCAACCCTTTGGCTGGGGGCCTGCTGACTGGCAGATATAAATACCAGGATAAGGATG
GGAAGAATCCTGAGAGCCGCTTCTTTGGGAATCCATTTTCTCAACTGTACATGGACCGCTACTG
GAAGGAGGAACACTTCAATGGCATCGCCTTGGTGGAGAAGGCTCTGAAGACTACCTATGGCCCC
ACTGCCCCCAGTATGATCTCAGCTGCCGTACGGTGGATGTACCATCACTCACAGCTCAAGGGCA
CCCAAGGGGATGCAGTCATTCTGGGCATGTCCAGTCTGGAACAACTGGAGCAGAACTTGGCCTT
GGTCGAGGAAGGGCCTCTGGAGCCAGCTGTTGTGGATGCCTTTGACCAAGCCTGGAACCTAGTT
GCCCACGAGTGTCCCAACTATTTCCGCTAAGATACATCTGCCTTGGGGATGGCGCAGCTTACTG
CCTGCCCCGCCTTGTCCTGGGCTCGATCTGATCTGGTTCTTTCCTTTTTAGACAGGTCACTGTC
TTTTTCTTCCCTGCTTTCTATACAGCCAGTTGCTTTCAAAGTGAGAGCTGGCTGAGCCCCAATA
CCTCCTGCTGAATAAAACTGTTCCCTGTCACAGCCTGGGCTACAACTGGCGGCCGA

hide sequence

RefSeq Acc Id:

XM_039109345 ⟹ XP_038965273

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	156,876,850 - 156,884,598 (+)	NCBI
mRatBN7.2	5	151,593,662 - 151,601,393 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_037347	(Get FASTA)	NCBI Sequence Viewer
	XP_038965273	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAD02413	(Get FASTA)	NCBI Sequence Viewer
	AAH78872	(Get FASTA)	NCBI Sequence Viewer
	AAH89811	(Get FASTA)	NCBI Sequence Viewer
	CAA52740	(Get FASTA)	NCBI Sequence Viewer
	EDL80916	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000024160
GenBank Protein	P38918	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_037347 ⟸ NM_013215

- UniProtKB:

Q68FZ3 (UniProtKB/Swiss-Prot), Q5EBB7 (UniProtKB/Swiss-Prot), Q9QX16 (UniProtKB/Swiss-Prot), P38918 (UniProtKB/Swiss-Prot), A6ITL5 (UniProtKB/TrEMBL), A0A8L2QCW7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSQARPATVLGAMEMGRRMDVTSSSASVRAFLQRGHTEIDTAFVYANGQSETILGDLGLGLGRS
GCKVKIATKAAPMFGKTLKPADVRFQLETSLKRLQCPRVDLFYLHFPDHGTPIEETLQACHQLH
QEGKFVELGLSNYVSWEVAEICTLCKKNGWIMPTVYQGMYNAITRQVETELFPCLRHFGLRFYA
FNPLAGGLLTGRYKYQDKDGKNPESRFFGNPFSQLYMDRYWKEEHFNGIALVEKALKTTYGPTA
PSMISAAVRWMYHHSQLKGTQGDAVILGMSSLEQLEQNLALVEEGPLEPAVVDAFDQAWNLVAH
ECPNYFR

hide sequence

Ensembl Acc Id:

ENSRNOP00000024160 ⟸ ENSRNOT00000024160

RefSeq Acc Id:	XP_038965273 ⟸ XM_039109345
- Peptide Label:	isoform X1

Protein Domains

NADP-dependent oxidoreductase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P38918-F1-model_v2	AlphaFold	P38918	1-327	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694205

Promoter ID:

EPDNEW_R4729

Type:

multiple initiation site

Name:

Akr7a3_1

Description:

aldo-keto reductase family 7 member A3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	157,801,154 - 157,801,214	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:628635	AgrOrtholog
BioCyc Gene	G2FUF-39416	BioCyc
Ensembl Genes	ENSRNOG00000017899	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000024160	ENTREZGENE
Gene3D-CATH	3.20.20.100	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7126881	IMAGE-MGC_LOAD
	IMAGE:7127297	IMAGE-MGC_LOAD
InterPro	AKR_Detox_Biosynth	UniProtKB/Swiss-Prot
	Aldo/keto_reductase	UniProtKB/Swiss-Prot
	NADP_OxRdtase_dom	UniProtKB/Swiss-Prot
	NADP_OxRdtase_dom_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:26760	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:108733	IMAGE-MGC_LOAD
	MGC:93546	IMAGE-MGC_LOAD
NCBI Gene	26760	ENTREZGENE
PANTHER	NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN	UniProtKB/Swiss-Prot
	NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED	UniProtKB/Swiss-Prot
Pfam	Aldo_ket_red	UniProtKB/Swiss-Prot
PhenoGen	Akr7a3	PhenoGen
PRINTS	ALDKETRDTASE	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000017899	RatGTEx
Superfamily-SCOP	SSF51430	UniProtKB/Swiss-Prot
UniProt	A0A8L2QCW7	ENTREZGENE, UniProtKB/TrEMBL
	A6ITL5	ENTREZGENE, UniProtKB/TrEMBL
	ARK73_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q5EBB7	ENTREZGENE
	Q68FZ3	ENTREZGENE
	Q9QX16	ENTREZGENE
UniProt Secondary	Q5EBB7	UniProtKB/Swiss-Prot
	Q68FZ3	UniProtKB/Swiss-Prot
	Q9QX16	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-06-08	Akr7a3	aldo-keto reductase family 7 member A3	Akr7a3	aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Akr7a3	aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)	Afar	aflatoxin B1 aldehyde reductase	Symbol and Name updated	1299863	APPROVED
2003-02-27	Afar	aflatoxin B1 aldehyde reductase			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in liver	632009
gene_product	belongs to the subfamily of aldo-keto reductases	632009

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD