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Gene: Tmprss5 (transmembrane serine protease 5) Rattus norvegicus

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Symbol:

Tmprss5

Name:

transmembrane serine protease 5

RGD ID:

628625

Description:

Predicted to enable serine-type peptidase activity. Predicted to be involved in proteolysis. Predicted to be located in neuronal cell body. Predicted to be active in plasma membrane. Orthologous to human TMPRSS5 (transmembrane serine protease 5); INTERACTS WITH 6-propyl-2-thiouracil; acetamide; ammonium chloride.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

adrenal mitochondrial protease; Amp; transmembrane protease serine 5; transmembrane protease, serine 5; transmembrane protease, serine 5 (spinesin)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TMPRSS5 (transmembrane serine protease 5)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Tmprss5 (transmembrane protease, serine 5 (spinesin))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tmprss5 (transmembrane serine protease 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TMPRSS5 (transmembrane serine protease 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TMPRSS5 (transmembrane serine protease 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tmprss5 (transmembrane serine protease 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TMPRSS5 (transmembrane serine protease 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TMPRSS5 (transmembrane serine protease 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tmprss5 (transmembrane serine protease 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Tmprss5 (transmembrane serine protease 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	CHUK (component of inhibitor of nuclear factor kappa B kinase complex)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	TMPRSS5 (transmembrane serine protease 5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Tmprss5 (transmembrane protease, serine 5 (spinesin))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tmprss5 (transmembrane serine protease 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG11836	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector)
Caenorhabditis elegans (roundworm):	try-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder)
Caenorhabditis elegans (roundworm):	try-1	Alliance	DIOPT (InParanoid\|PANTHER)
Drosophila melanogaster (fruit fly):	CG18735	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector)
Drosophila melanogaster (fruit fly):	CG31954	Alliance	DIOPT (InParanoid\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG3355	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector)
Drosophila melanogaster (fruit fly):	CG4386	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector)
Drosophila melanogaster (fruit fly):	CG4613	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector)
Drosophila melanogaster (fruit fly):	CG4914	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector)
Drosophila melanogaster (fruit fly):	CG9294	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector)
Xenopus tropicalis (tropical clawed frog):	LOC100491119	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	58,338,455 - 58,357,886 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	58,338,397 - 58,357,881 (+)	Ensembl				GRCr8
mRatBN7.2	8	49,437,321 - 49,461,395 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	49,441,984 - 49,460,071 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	54,947,848 - 54,965,958 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	53,226,715 - 53,244,819 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	51,090,973 - 51,109,077 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	53,411,259 - 53,430,744 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	53,411,316 - 53,429,420 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	52,026,465 - 52,049,795 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	52,361,394 - 52,379,599 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	48,998,835 - 49,016,935 (+)	NCBI		Celera
RGSC_v3.1	8	52,380,447 - 52,398,653 (+)	NCBI
Cytogenetic Map	8	q23	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3,7,8-tetrachlorodibenzodioxine (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

ammonium chloride (EXP)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

CGP 52608 (ISO)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

fulvestrant (ISO)

glyphosate (EXP)

lipopolysaccharide (ISO)

mono(2-ethylhexyl) phthalate (ISO)

paracetamol (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

sodium arsenite (ISO)

titanium dioxide (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

protein processing (IBA)

proteolysis (IEA,ISO)

Cellular Component

membrane (IEA)

neuronal cell body (IEA,ISO)

plasma membrane (IBA,IEA,ISO)

Molecular Function

hydrolase activity (IEA)

peptidase activity (IEA,ISO)

serine-type endopeptidase activity (IEA)

serine-type peptidase activity (IBA,IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	Identification of two alternate splice variants of a novel serine protease expressed in steroidogenic tissues.	Omer S, etal., Endocr Res 2002 Nov;28(4):339-48.
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:17918732

Genomics

Comparative Map Data

Tmprss5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	58,338,455 - 58,357,886 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	58,338,397 - 58,357,881 (+)	Ensembl				GRCr8
mRatBN7.2	8	49,437,321 - 49,461,395 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	49,441,984 - 49,460,071 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	54,947,848 - 54,965,958 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	53,226,715 - 53,244,819 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	51,090,973 - 51,109,077 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	53,411,259 - 53,430,744 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	53,411,316 - 53,429,420 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	52,026,465 - 52,049,795 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	52,361,394 - 52,379,599 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	48,998,835 - 49,016,935 (+)	NCBI		Celera
RGSC_v3.1	8	52,380,447 - 52,398,653 (+)	NCBI
Cytogenetic Map	8	q23	NCBI

TMPRSS5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	113,687,550 - 113,706,308 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	113,687,543 - 113,706,382 (-)	Ensembl			hg38	GRCh38
GRCh37	11	113,558,272 - 113,577,030 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	113,063,483 - 113,082,305 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	11	113,063,482 - 113,082,305	NCBI
Celera	11	110,711,188 - 110,729,987 (-)	NCBI		Celera
Cytogenetic Map	11	q23.2	NCBI
HuRef	11	109,486,617 - 109,505,613 (-)	NCBI		HuRef
CHM1_1	11	113,441,156 - 113,460,349 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	113,697,893 - 113,722,789 (-)	NCBI		T2T-CHM13v2.0

Tmprss5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	49,013,994 - 49,028,891 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	48,992,560 - 49,028,887 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	9	49,079,274 - 49,117,591 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	49,081,260 - 49,117,587 (+)	Ensembl			mm10	GRCm38
MGSCv37	9	48,910,884 - 48,925,692 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	9	48,854,711 - 48,869,517 (+)	NCBI		MGSCv36	mm8
Celera	9	46,399,833 - 46,414,637 (+)	NCBI		Celera
Cytogenetic Map	9	A5.3	NCBI
cM Map	9	26.59	NCBI

Tmprss5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955412	15,319,400 - 15,333,224 (-)	Ensembl
ChiLan1.0	NW_004955412	15,319,945 - 15,333,161 (-)	NCBI	ChiLan1.0	ChiLan1.0

TMPRSS5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	114,430,466 - 114,449,433 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	115,524,764 - 115,543,769 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	108,566,007 - 108,585,002 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	112,408,976 - 112,421,633 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	112,408,976 - 112,427,704 (-)	Ensembl			panPan2	panpan1.1

TMPRSS5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	19,536,038 - 19,560,829 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	19,547,992 - 19,560,708 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	19,459,227 - 19,484,018 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	19,556,950 - 19,581,768 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	19,525,195 - 19,581,737 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	19,620,557 - 19,645,353 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	19,521,535 - 19,548,997 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	19,569,647 - 19,594,463 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Tmprss5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	95,809,808 - 95,825,978 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936612	881,236 - 896,646 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936612	881,293 - 895,801 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TMPRSS5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	9	41,326,225 - 41,337,834 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	46,145,805 - 46,159,698 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TMPRSS5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	105,053,145 - 105,079,242 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	105,060,036 - 105,071,835 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666043	20,935,130 - 20,957,297 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tmprss5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624784	9,170,558 - 9,184,133 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Tmprss5
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	8	43,592,542 - 43,603,631 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Tmprss5
124 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	314
Count of miRNA genes:	189
Interacting mature miRNAs:	223
Transcripts:	ENSRNOT00000011107
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2313057	Bss76	Bone structure and strength QTL 76	3	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	8	39106258	91341052	Rat
1298065	Scl16	Serum cholesterol level QTL 16	3.8		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	39752803	84752803	Rat
1549908	Neudeg1	Neurodegradation QTL 1	5.5	0	nervous system integrity trait (VT:0010566)	logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)	8	58337123	103337123	Rat
2317030	Wbc5	White blood cell count QTL 5	3.21	0.005	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	8	16994642	61994642	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	49849908	118871671	Rat
2313067	Bss77	Bone structure and strength QTL 77	3.1	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	8	39106258	91341052	Rat
1578769	Uae31	Urinary albumin excretion QTL 31	3.3	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	39106363	103375781	Rat
2301416	Bp315	Blood pressure QTL 315		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	15952279	60952279	Rat
1298079	Activ2	Activity QTL 2	9.5	0.000001	voluntary movement trait (VT:0003491)	rearing measurement (CMO:0001515)	8	50763951	95763951	Rat
11556286	Cm81	Cardiac mass QTL 81		0.01	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	39106258	84106258	Rat
70161	Bp62	Blood pressure QTL 62	2.9	0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	51589699	99045312	Rat
1578765	Klgr1	Kidney lesion grade QTL 1	3.3	0.0001	kidney morphology trait (VT:0002135)	organ lesion measurement (CMO:0000677)	8	39106363	103375781	Rat
5684993	Bmd84	Bone mineral density QTL 84	4.1		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	8	51589699	58991895	Rat
2317051	Aia18	Adjuvant induced arthritis QTL 18	2.42		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	8	16994642	61994642	Rat
61464	Niddm11	Non-insulin dependent diabetes mellitus QTL 11	3.1	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	44477926	89477926	Rat
1578755	Pur5	Proteinuria QTL 5	3.3	0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	8	39106258	103375958	Rat
2313088	Bss75	Bone structure and strength QTL 75	3.1	0.0001	body length (VT:0001256)	body length, nose to rump (CMO:0000079)	8	39106258	91341052	Rat
1358896	Bp262	Blood pressure QTL 262	2.89		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	35464071	107982864	Rat
2302278	Gluco36	Glucose level QTL 36	4.2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	8	37760859	58991895	Rat
731182	Uae24	Urinary albumin excretion QTL 24	6.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	47541419	92541419	Rat
631648	Stl5	Serum triglyceride level QTL 5	4	0.0003	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	35464071	71842899	Rat
724514	Uae15	Urinary albumin excretion QTL 15	2.9		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	37760859	61459705	Rat
61353	Bp35	Blood pressure QTL 35		0.001	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	8	39106258	84106258	Rat
1331837	Bw23	Body weight QTL 23	4.19	0.00007	body mass (VT:0001259)	body weight (CMO:0000012)	8	55428416	107963099	Rat
631842	Inf1	Infertility severity QTL 1	4.1	0.001	seminal gland mass (VT:0010524)	seminal vesicle wet weight (CMO:0001603)	8	31543661	76543661	Rat
737824	Hcar10	Hepatocarcinoma resistance QTL 10	2.9		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	8	49610204	68373388	Rat
1359033	Bp273	Blood pressure QTL 273			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	39106258	84106258	Rat
1331769	Rf39	Renal function QTL 39	3.871		urine output (VT:0003620)	timed urine volume (CMO:0000260)	8	50763951	107970527	Rat
61358	Bp39	Blood pressure QTL 39	2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	44447837	89447837	Rat
1358906	Bp253	Blood pressure QTL 253	4	0.0004	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	49610204	94610204	Rat
1358907	Cm40	Cardiac mass QTL 40	1.89		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	35464071	107982864	Rat
1598824	Memor4	Memory QTL 4	2.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	8	17993862	62252873	Rat
1331744	Bp217	Blood pressure QTL 217	3.398		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	39106258	67378345	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	55428333	127966348	Rat
2313046	Bss78	Bone structure and strength QTL 78	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	8	39106258	91341052	Rat
2316950	Scl66	Serum cholesterol level QTL 66	4.1		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	39106363	114525825	Rat
1582254	Kidm31	Kidney mass QTL 31	3		kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	8	49245178	94245178	Rat
724540	Uae8	Urinary albumin excretion QTL 8	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	8	39106258	103375958	Rat
1358892	Kidm26	Kidney mass QTL 26	3.69		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	35464071	107982864	Rat
631216	Stl9	Serum triglyceride level QTL 9	4.71	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	8	50763951	67219641	Rat
1582243	Bw66	Body weight QTL 66	3.4	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	8	49245178	94245178	Rat
61373	Mcs4	Mammary carcinoma susceptibility QTL 4	1.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	8	44475043	89475043	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
13	12	66	164	87	86	55	79	55	6	330	178	11	143	76	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_153311	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008766194	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017595489	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080928	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080929	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063264990	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063264991	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063264992	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC132524	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF537098	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF537099	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473975	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000011107 ⟹ ENSRNOP00000011107

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	58,338,397 - 58,357,881 (+)	Ensembl
mRatBN7.2 Ensembl	8	49,441,984 - 49,460,071 (+)	Ensembl
Rnor_6.0 Ensembl	8	53,411,316 - 53,429,420 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000086957 ⟹ ENSRNOP00000068548

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	58,338,455 - 58,356,561 (+)	Ensembl
mRatBN7.2 Ensembl	8	49,441,984 - 49,460,071 (+)	Ensembl
Rnor_6.0 Ensembl	8	53,411,316 - 53,429,420 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000103114 ⟹ ENSRNOP00000085861

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	49,441,984 - 49,460,071 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000104156 ⟹ ENSRNOP00000096991

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	49,441,984 - 49,457,831 (+)	Ensembl

RefSeq Acc Id:

NM_153311 ⟹ NP_695223

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	58,338,455 - 58,356,561 (+)	NCBI
mRatBN7.2	8	49,441,984 - 49,460,071 (+)	NCBI
Rnor_6.0	8	53,411,316 - 53,429,420 (+)	NCBI
Rnor_5.0	8	52,026,465 - 52,049,795 (+)	NCBI
RGSC_v3.4	8	52,361,394 - 52,379,599 (+)	RGD
Celera	8	48,998,835 - 49,016,935 (+)	RGD

Sequence:

show sequence

CTGACATGAGGACAGGCGCCACACCCTGCCCAGCAGACCTTACTGCCTTACATCAGTGCAACTG
ACTCACCTGAGTTCAACATTGGATGACCAATGCCCAATGGAGATCCGGTGCACAGAAGAGGGTC
CTGGGCCTGGGATCTTCAGAGCAGAGTTGGGAGACCAGCAGCAACCCATCTCTCAGTCCCAGCG
TTGGTGCTGCCTGCAACGTGGCTGTGTAATACTGGGAGCCCTGGGGCTGCTGGCTGGAGCAGGT
GTTGGTTCCTGGCTCTTAGTGTTGTATCTCTGGCCGGCTGCCTCTCCACCCGTCTCGGTGACGT
TGCAGGAGGAGGAGGTAACGCTGAGCTGCCCAGGAGTGAGCAGTGAGGAAAAACTCCTTCCATC
TCTTCCCAAAGCAGTATCTTTCAGAATAAATGGTGAGGATCTTCTGCTTGAAGTGCAAGTAAGG
GCTCGGCCAGACTGGCTCCTGGTCTGCCATGAGGGCTGGAACCCTGCCCTGGGGATGCACATCT
GCCAGAGTCTTGGATATTTCAGGCTCACTCAACACAAGGCAGTGAATCTGTCTGACATCAAGCT
CAACAGATCCCAGGAGTTTGCTCAGCTCTCTGCTAGACCGGGAAGCCTTGTAGAGGAGGCATGG
CAGCCCAGCACTAACTGTCCTTCTGGCCGAATTGTTTCTCTCAAATGTTCTGAGTGTGGGGCAA
GACCTCTGGCTTCTCGAATAGTTGGCGGTCAAGCTGTGGCTTCTGGGCGCTGGCCGTGGCAAGC
TAGTGTGATGCTCGGCTCCCGACACACATGTGGGGGCTCTGTGCTGGCACCCTACTGGGTAGTG
ACTGCCGCCCACTGCATGTACAGTTTCAGGCTGTCCCGTCTATCCAGCTGGCGGGTTCATGCAG
GGCTGGTCAGCCACAGTGCTGTCCGACAACACCAGGGAACTATGGTGGAGAAGATCATTCCCCA
CCCTTTGTACAGCGCCCAGAACCATGACTATGATGTGGCTCTGCTGCAGCTCCGTACACCAATC
AACTTCTCAGACACTGTGAGCGCTGTGTGTTTGCCGGCCAAGGAGCAGCACTTTCCACAAGGGT
CGCAGTGCTGGGTGTCTGGCTGGGGCCACACCGACCCCAGCCATACTCATAGCTCAGATACACT
GCAGGACACAATGGTACCCCTGCTTAGCACCGATCTCTGCAACAGCTCATGCATGTACAGTGGG
GCACTCACACACCGCATGCTGTGTGCCGGCTACCTGGATGGAAGGGCAGATGCGTGCCAGGGAG
ACAGTGGGGGACCCCTGGTGTGTCCCAGTGGTGACACGTGGCACCTTGTAGGGGTGGTCAGCTG
GGGTCGTGGCTGTGCAGAGCCCAATCGCCCAGGTGTCTATGCCAAAGTAGCAGAGTTCCTGGAC
TGGATCCATGACACTGTGCAGGTCCGCTAGCTGAAGAAGAAGCAGCTGCTGCCTGCGACACAGA
ACTGTGGATCTCCCATGGATCATCCCAGACTGAGGACTAGCATCTGGGTCACTGGGCCTTTCCC
CAAAGGCTCTGACTTCTAGTTTGTCTTTCTCATCTGAGAACCTCCACAACAGAGAAGAGTCTGG
GGCTGGGTTGGGAATGATGATGAGAGGAAGGGATAAGAAGACAGAGGAGACAGAAGAGGCTTCT
GGAAGCATCTGGGAGACTGCCCTCTGCTCTCCACACACCCCATGTGCATCCACTGGGAGGATGC
TGGAGGTGCCCCAGCCCTGTTTTCTTCTGAGGCCAGGGAAGGCCTAAGTTCAACTTTAGAAGAT
GCCCTGTCTCAAGGGTCTTAGGCAGATAATGTTAAGGTTGGACCAGCTCAGGTAAAGGCATCGA
AATCAAGATCCCCCCCATGCTGGTCCTGTTTTGAGGTAACTCTAAGTAGCCCTCCGTGAAGCAG
AGGTCTACAAGGTAAGAAGGATGGAGTTGGGTTAGGATGCTGTTTTTCACACGACAGTTCTGTA
AATTGCTTGATATTAAGTGGAGATTATATATAATCTTGGTTGAGGTCCTCCCTCTCTGTATTAG
CTAATGTGATGAAACACACGGTCAAGAGAACTTACTTTGGCTCAGAGACAAAAGATCCAGTCTA
CTGTGCTGAGGAATGTGAGGTGCTACTCTGTCAGGAAGCAGGGAGAGGAGGTGCTGGGGCTTTG
GTCCGGCCATTGCTTAGAGGCCCTAACATACAGGGCAAGTCTCAGTTACACCTCTCAGGAAAGT
CCCTCACAGATGTACTTAGAGGTGTGTCTCCCAGGTGATTCAAAATCCAGCATACTTGTCAGCA
AAGACTAGCCATCACTGTCACACGTGTTACTGAATAGAAATACAAATTTCCTCCCAAAAAAAAA
AAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039080928 ⟹ XP_038936856

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	58,341,249 - 58,357,886 (+)	NCBI
mRatBN7.2	8	49,441,949 - 49,461,395 (+)	NCBI

RefSeq Acc Id:

XM_039080929 ⟹ XP_038936857

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	58,341,251 - 58,357,886 (+)	NCBI
mRatBN7.2	8	49,446,110 - 49,461,395 (+)	NCBI

RefSeq Acc Id:

XM_063264990 ⟹ XP_063121060

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	58,341,228 - 58,357,886 (+)	NCBI

RefSeq Acc Id:

XM_063264991 ⟹ XP_063121061

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	58,341,244 - 58,357,886 (+)	NCBI

RefSeq Acc Id:

XM_063264992 ⟹ XP_063121062

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	58,341,232 - 58,353,691 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_695223	(Get FASTA)	NCBI Sequence Viewer
	XP_038936856	(Get FASTA)	NCBI Sequence Viewer
	XP_038936857	(Get FASTA)	NCBI Sequence Viewer
	XP_063121060	(Get FASTA)	NCBI Sequence Viewer
	XP_063121061	(Get FASTA)	NCBI Sequence Viewer
	XP_063121062	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAN06757	(Get FASTA)	NCBI Sequence Viewer
	AAN06758	(Get FASTA)	NCBI Sequence Viewer
	EDL95435	(Get FASTA)	NCBI Sequence Viewer
	EDL95436	(Get FASTA)	NCBI Sequence Viewer
	EDL95437	(Get FASTA)	NCBI Sequence Viewer
	EDL95438	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000011107
	ENSRNOP00000011107.7
	ENSRNOP00000068548.2

RefSeq Acc Id:

NP_695223 ⟸ NM_153311

- UniProtKB:

A6J4B2 (UniProtKB/TrEMBL), Q8CJ17 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEIRCTEEGPGPGIFRAELGDQQQPISQSQRWCCLQRGCVILGALGLLAGAGVGSWLLVLYLWP
AASPPVSVTLQEEEVTLSCPGVSSEEKLLPSLPKAVSFRINGEDLLLEVQVRARPDWLLVCHEG
WNPALGMHICQSLGYFRLTQHKAVNLSDIKLNRSQEFAQLSARPGSLVEEAWQPSTNCPSGRIV
SLKCSECGARPLASRIVGGQAVASGRWPWQASVMLGSRHTCGGSVLAPYWVVTAAHCMYSFRLS
RLSSWRVHAGLVSHSAVRQHQGTMVEKIIPHPLYSAQNHDYDVALLQLRTPINFSDTVSAVCLP
AKEQHFPQGSQCWVSGWGHTDPSHTHSSDTLQDTMVPLLSTDLCNSSCMYSGALTHRMLCAGYL
DGRADACQGDSGGPLVCPSGDTWHLVGVVSWGRGCAEPNRPGVYAKVAEFLDWIHDTVQVR

hide sequence

Ensembl Acc Id:

ENSRNOP00000068548 ⟸ ENSRNOT00000086957

Ensembl Acc Id:

ENSRNOP00000011107 ⟸ ENSRNOT00000011107

RefSeq Acc Id:	XP_038936856 ⟸ XM_039080928
- Peptide Label:	isoform X3
- UniProtKB:	A6J4B4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038936857 ⟸ XM_039080929
- Peptide Label:	isoform X5
- UniProtKB:	A6J4B4 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000096991 ⟸ ENSRNOT00000104156

Ensembl Acc Id:

ENSRNOP00000085861 ⟸ ENSRNOT00000103114

RefSeq Acc Id:	XP_063121060 ⟸ XM_063264990
- Peptide Label:	isoform X1
- UniProtKB:	Q8CJ17 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063121062 ⟸ XM_063264992
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_063121061 ⟸ XM_063264991
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I6A2F3 (UniProtKB/TrEMBL), A6J4B4 (UniProtKB/TrEMBL)

Protein Domains

Peptidase S1 SRCR

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1LSP0-F1-model_v2	AlphaFold	F1LSP0	1-445	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:628625	AgrOrtholog
BioCyc Gene	G2FUF-30586	BioCyc
Ensembl Genes	ENSRNOG00000008058	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000011107	ENTREZGENE
	ENSRNOT00000011107.9	UniProtKB/TrEMBL
	ENSRNOT00000086957.3	UniProtKB/TrEMBL
Gene3D-CATH	2.40.10.10	UniProtKB/TrEMBL
	3.10.250.10	UniProtKB/TrEMBL
InterPro	Pept_cys/ser_Trypsin-like	UniProtKB/TrEMBL
	Peptidase_S1/S6_AS	UniProtKB/TrEMBL
	Peptidase_S1_PA_chymotrypsin	UniProtKB/TrEMBL
	Peptidase_S1_S6	UniProtKB/TrEMBL
	Peptidase_S1A	UniProtKB/TrEMBL
	SRCR-like_dom_sf	UniProtKB/TrEMBL
	Srcr_rcpt	UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/TrEMBL
KEGG Report	rno:266681	UniProtKB/TrEMBL
NCBI Gene	266681	ENTREZGENE
PANTHER	ACROSIN-RELATED	UniProtKB/TrEMBL
	SUPPRESSOR OF TUMORIGENICITY 14 PROTEIN HOMOLOG-RELATED	UniProtKB/TrEMBL
Pfam	SRCR_2	UniProtKB/TrEMBL
	Trypsin	UniProtKB/TrEMBL
PhenoGen	Tmprss5	PhenoGen
PRINTS	CHYMOTRYPSIN	UniProtKB/TrEMBL
PROSITE	SRCR_1	UniProtKB/TrEMBL
	SRCR_2	UniProtKB/TrEMBL
	TRYPSIN_DOM	UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000008058	RatGTEx
SMART	Tryp_SPc	UniProtKB/TrEMBL
Superfamily-SCOP	Pept_Ser_Cys	UniProtKB/TrEMBL
	Srcr_receptor	UniProtKB/TrEMBL
UniProt	A0A0G2JT29_RAT	UniProtKB/TrEMBL
	A0A8I6A2F3	ENTREZGENE
	A6J4B2	ENTREZGENE, UniProtKB/TrEMBL
	A6J4B4	ENTREZGENE, UniProtKB/TrEMBL
	A6J4B5_RAT	UniProtKB/TrEMBL
	F1LSP0_RAT	UniProtKB/TrEMBL
	Q8CJ17	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-01-26	Tmprss5	transmembrane serine protease 5	Tmprss5	transmembrane protease, serine 5	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-11-20	Tmprss5	transmembrane protease, serine 5	Tmprss5	transmembrane protease, serine 5 (spinesin)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Tmprss5	transmembrane protease, serine 5 (spinesin)		adrenal mitochondrial protease	Name updated	1299863	APPROVED
2004-09-10	Tmprss5	adrenal mitochondrial protease	Amp		Symbol and Name updated	1299863	APPROVED
2003-02-27	Amp	adrenal mitochondrial protease			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in brain, testis, ovarian follicles and adrenal cortex	634547

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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