Gzmf (granzyme F) - Rat Genome Database

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Gene: Gzmf (granzyme F) Rattus norvegicus
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Symbol: Gzmf
Name: granzyme F
RGD ID: 628603
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein maturation. Predicted to be located in cytolytic granule. Predicted to be active in extracellular space. Orthologous to human GZMH (granzyme H); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: granzyme G; granzyme G-like; granzyme H; Gzmg; LOC100910060; natural killer cell protease 7; Rnkp7
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,975,543 - 33,997,505 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1533,977,505 - 33,997,572 (-)EnsemblGRCr8
mRatBN7.21530,005,361 - 30,018,649 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1530,007,267 - 30,018,649 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1531,853,246 - 31,864,626 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01533,000,449 - 33,011,831 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01531,258,585 - 31,269,969 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01535,182,405 - 35,195,725 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1535,184,364 - 35,195,725 (-)Ensemblrn6Rnor6.0
Rnor_5.01539,071,306 - 39,082,672 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41534,696,237 - 34,707,618 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1529,581,398 - 29,592,512 (-)NCBICelera
RGSC_v3.11534,711,937 - 34,723,318 (-)NCBI
Cytogenetic Map15p12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. P-4 and RNKP-7, new granzyme-like serine proteases expressed in activated rat lymphocytes. Ewoldt GR, etal., J Immunol 1997 May 15;158(10):4574-83.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Gzmf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,975,543 - 33,997,505 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1533,977,505 - 33,997,572 (-)EnsemblGRCr8
mRatBN7.21530,005,361 - 30,018,649 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1530,007,267 - 30,018,649 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1531,853,246 - 31,864,626 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01533,000,449 - 33,011,831 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01531,258,585 - 31,269,969 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01535,182,405 - 35,195,725 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1535,184,364 - 35,195,725 (-)Ensemblrn6Rnor6.0
Rnor_5.01539,071,306 - 39,082,672 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41534,696,237 - 34,707,618 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1529,581,398 - 29,592,512 (-)NCBICelera
RGSC_v3.11534,711,937 - 34,723,318 (-)NCBI
Cytogenetic Map15p12NCBI
GZMH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381424,606,480 - 24,609,685 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1424,606,480 - 24,609,821 (-)Ensemblhg38GRCh38
GRCh371425,075,686 - 25,078,891 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361424,145,533 - 24,148,704 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341424,145,532 - 24,148,704NCBI
Celera144,940,483 - 4,943,654 (-)NCBICelera
Cytogenetic Map14q12NCBI
HuRef145,190,499 - 5,193,739 (-)NCBIHuRef
CHM1_11425,074,581 - 25,077,821 (-)NCBICHM1_1
T2T-CHM13v2.01418,805,362 - 18,808,567 (-)NCBIT2T-CHM13v2.0
Gzmf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391456,442,720 - 56,448,864 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1456,442,720 - 56,448,874 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381456,205,263 - 56,211,407 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1456,205,263 - 56,211,417 (-)Ensemblmm10GRCm38
MGSCv371456,824,100 - 56,830,244 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361455,159,328 - 55,188,724 (-)NCBIMGSCv36mm8
Celera1454,002,389 - 54,008,533 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI

Variants

.
Variants in Gzmf
192 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:70
Count of miRNA genes:66
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000044840
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 8 18 36 40 27 39 27 6 102 50 2 9 9 39 13 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000044840   ⟹   ENSRNOP00000040372
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1533,977,505 - 33,988,887 (-)Ensembl
mRatBN7.2 Ensembl1530,007,267 - 30,018,649 (-)Ensembl
Rnor_6.0 Ensembl1535,184,364 - 35,195,725 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000073741   ⟹   ENSRNOP00000065966
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1530,007,267 - 30,010,137 (-)Ensembl
Rnor_6.0 Ensembl1535,263,718 - 35,264,841 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000121003   ⟹   ENSRNOP00000098561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1533,977,505 - 33,997,572 (-)Ensembl
RefSeq Acc Id: NM_153466   ⟹   NP_703196
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,977,505 - 33,988,887 (-)NCBI
mRatBN7.21530,007,265 - 30,018,649 (-)NCBI
Rnor_6.01535,184,359 - 35,195,725 (-)NCBI
Rnor_5.01539,071,306 - 39,082,672 (-)NCBI
RGSC_v3.41534,696,237 - 34,707,618 (-)RGD
Celera1529,581,398 - 29,592,512 (-)RGD
Sequence:
RefSeq Acc Id: XM_063274035   ⟹   XP_063130105
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,975,543 - 33,997,505 (-)NCBI
Protein Sequences
Protein RefSeqs NP_703196 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130105 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB05241 (Get FASTA)   NCBI Sequence Viewer  
  EDM14319 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000040372
  ENSRNOP00000040372.3
  ENSRNOP00000098560.1
  ENSRNOP00000098561
  ENSRNOP00000098561.2
RefSeq Acc Id: NP_703196   ⟸   NM_153466
- Peptide Label: precursor
- UniProtKB: F7FBB5 (UniProtKB/TrEMBL),   A6KH90 (UniProtKB/TrEMBL),   Q63637 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000040372   ⟸   ENSRNOT00000044840
Ensembl Acc Id: ENSRNOP00000065966   ⟸   ENSRNOT00000073741
RefSeq Acc Id: XP_063130105   ⟸   XM_063274035
- Peptide Label: isoform X1
- UniProtKB: Q63637 (UniProtKB/TrEMBL),   A6KH90 (UniProtKB/TrEMBL),   F7FBB5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000098561   ⟸   ENSRNOT00000121003
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R906-F1-model_v2 AlphaFold M0R906 1-180 view protein structure
AF-Q63637-F1-model_v2 AlphaFold Q63637 1-241 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628603 AgrOrtholog
BioCyc Gene G2FUF-13658 BioCyc
Ensembl Genes ENSRNOG00000028810 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000048542 Ensembl
  ENSRNOG00000071307 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000044840 ENTREZGENE
  ENSRNOT00000044840.5 UniProtKB/TrEMBL
  ENSRNOT00000121002.2 UniProtKB/TrEMBL
  ENSRNOT00000121003 ENTREZGENE
  ENSRNOT00000121003.2 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
InterPro Peptidase_S1/S6_AS UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1_S6 UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Ser/Cys_Pept_Trypsin-like UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
KEGG Report rno:266704 UniProtKB/TrEMBL
NCBI Gene 266704 ENTREZGENE
PANTHER GRANZYME H UniProtKB/TrEMBL
  KALLIKREIN-RELATED UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/TrEMBL
PhenoGen Gzmf PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028810 RatGTEx
  ENSRNOG00000048542 RatGTEx
  ENSRNOG00000071307 RatGTEx
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP Pept_Ser_Cys UniProtKB/TrEMBL
UniProt A0ABK0LBG7_RAT UniProtKB/TrEMBL
  A6KH90 ENTREZGENE, UniProtKB/TrEMBL
  F7FBB5 ENTREZGENE, UniProtKB/TrEMBL
  Q63637 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Gzmf  granzyme F  LOC100910060  granzyme G-like  Data merged from RGD:6500474 737654 PROVISIONAL
2012-07-05 LOC100910060  granzyme G-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-02-25 Gzmf  granzyme F  Gzmg  granzyme G  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Gzmg  granzyme G  Rnkp7  natural killer cell protease 7  Symbol and Name updated 1299863 APPROVED
2003-02-27 Rnkp7  natural killer cell protease 7      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in activated lymphocytes 632834