Ndrg2 (NDRG family member 2) - Rat Genome Database

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Gene: Ndrg2 (NDRG family member 2) Rattus norvegicus
Analyze
Symbol: Ndrg2
Name: NDRG family member 2
RGD ID: 621874
Description: Predicted to be involved in signal transduction and substantia nigra development. Predicted to act upstream of or within negative regulation of ERK1 and ERK2 cascade; negative regulation of vascular associated smooth muscle cell proliferation; and regulation of cytokine production. Predicted to be located in Golgi apparatus and nucleus. Predicted to be active in cytoplasm. Orthologous to human NDRG2 (NDRG family member 2); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: antidepressant-related protein ADRG123; N-myc downstream regulated gene 2; N-myc downstream-regulated gene 2; NDRG1-related protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81527,074,481 - 27,087,376 (-)NCBIGRCr8
mRatBN7.21524,600,981 - 24,609,621 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,600,982 - 24,609,626 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1527,372,005 - 27,380,671 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,327,768 - 28,336,407 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,580,712 - 26,589,351 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01528,305,820 - 28,314,459 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,305,821 - 28,314,459 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01532,118,799 - 32,127,439 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41527,338,552 - 27,347,196 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11527,354,251 - 27,362,896 (-)NCBI
Celera1524,906,439 - 24,915,078 (-)NCBICelera
Cytogenetic Map15p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-alpha-phellandrene  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-phellandrene  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
antimony(0)  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
caffeine  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
cobalt dichloride  (EXP)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
D-glucose  (EXP,ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP)
genistein  (EXP,ISO)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (EXP,ISO)
glyphosate  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
L-ascorbic acid  (EXP)
L-ethionine  (EXP)
manganese(II) chloride  (EXP)
mechlorethamine  (ISO)
methapyrilene  (EXP)
methoxyacetic acid  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP,ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nimesulide  (EXP)
omeprazole  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
PhIP  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP,ISO)
propiconazole  (ISO)
Propiverine  (EXP)
quercetin  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
succimer  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thioacetamide  (EXP)
tipifarnib  (EXP)
titanium dioxide  (EXP,ISO)
topotecan  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
trimellitic anhydride  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
Golgi apparatus  (IEA,ISO)
growth cone  (IEA)
nucleus  (IEA,ISO)
perinuclear region of cytoplasm  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Characterization of Rat NDRG2 (N-Myc Downstream Regulated Gene 2), a Novel Early Mineralocorticoid-specific Induced Gene. Boulkroun S, etal., J Biol Chem 2002 Aug 30;277(35):31506-15.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 Uncovers their roles in dendrite arborization and spine development. Ultanir SK, etal., Neuron. 2012 Mar 22;73(6):1127-42. doi: 10.1016/j.neuron.2012.01.019. Epub 2012 Mar 21.
Additional References at PubMed
PMID:14985363   PMID:14993068   PMID:15769300   PMID:16039777   PMID:16396499   PMID:16520977   PMID:17652085   PMID:19199708   PMID:19471968   PMID:19815093   PMID:20840522   PMID:21241684  
PMID:22110735   PMID:22610521   PMID:22871113   PMID:22926577   PMID:23376485   PMID:23463182   PMID:23540409   PMID:24343104   PMID:26414218   PMID:26631961   PMID:28670853   PMID:29476059  
PMID:32196570   PMID:32329820   PMID:32357304   PMID:32688030   PMID:32990844   PMID:33583230   PMID:38411782  


Genomics

Comparative Map Data
Ndrg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81527,074,481 - 27,087,376 (-)NCBIGRCr8
mRatBN7.21524,600,981 - 24,609,621 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,600,982 - 24,609,626 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1527,372,005 - 27,380,671 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,327,768 - 28,336,407 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,580,712 - 26,589,351 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01528,305,820 - 28,314,459 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,305,821 - 28,314,459 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01532,118,799 - 32,127,439 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41527,338,552 - 27,347,196 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11527,354,251 - 27,362,896 (-)NCBI
Celera1524,906,439 - 24,915,078 (-)NCBICelera
Cytogenetic Map15p14NCBI
NDRG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381421,016,763 - 21,070,872 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1421,016,763 - 21,070,872 (-)EnsemblGRCh38hg38GRCh38
GRCh371421,484,922 - 21,539,031 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361420,554,762 - 20,563,775 (-)NCBINCBI36Build 36hg18NCBI36
Build 341420,554,762 - 20,563,104NCBI
Celera141,345,785 - 1,354,798 (-)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef141,606,057 - 1,614,869 (-)NCBIHuRef
CHM1_11421,487,031 - 21,496,044 (-)NCBICHM1_1
T2T-CHM13v2.01415,214,166 - 15,268,302 (-)NCBIT2T-CHM13v2.0
Ndrg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391452,142,738 - 52,151,463 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1452,142,728 - 52,151,615 (-)EnsemblGRCm39 Ensembl
GRCm381451,905,271 - 51,914,004 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1451,905,271 - 51,914,158 (-)EnsemblGRCm38mm10GRCm38
MGSCv371452,524,946 - 52,533,163 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361450,827,232 - 50,835,302 (-)NCBIMGSCv36mm8
Celera1448,890,602 - 48,898,821 (-)NCBICelera
Cytogenetic Map14C2NCBI
cM Map1426.72NCBI
Ndrg2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555501,767,911 - 1,780,635 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555501,771,514 - 1,778,693 (-)NCBIChiLan1.0ChiLan1.0
NDRG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21522,468,347 - 22,477,409 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11421,684,834 - 21,693,890 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0141,831,764 - 1,840,819 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11419,913,665 - 19,922,753 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1419,913,674 - 19,967,470 (-)Ensemblpanpan1.1panPan2
NDRG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11518,106,651 - 18,115,026 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1518,106,654 - 18,113,970 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1518,592,191 - 18,609,584 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01518,367,496 - 18,384,905 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1518,367,498 - 18,421,013 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11518,048,851 - 18,058,146 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01518,104,845 - 18,122,209 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01518,233,466 - 18,241,162 (-)NCBIUU_Cfam_GSD_1.0
Ndrg2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864032,309,751 - 32,318,531 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936880219,102 - 228,246 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936880219,131 - 227,856 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NDRG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl778,112,536 - 78,121,215 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1778,111,736 - 78,121,216 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NDRG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12921,490,219 - 21,499,194 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2921,488,808 - 21,496,757 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605924,936,647 - 24,945,655 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ndrg2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248257,008,475 - 7,017,676 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248257,008,475 - 7,017,422 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ndrg2
7 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:411
Count of miRNA genes:169
Interacting mature miRNAs:199
Transcripts:ENSRNOT00000040540, ENSRNOT00000042055
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152024860037896129Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat

Markers in Region
RH129362  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21524,601,242 - 24,601,438 (+)MAPPERmRatBN7.2
Rnor_6.01528,306,081 - 28,306,276NCBIRnor6.0
Rnor_5.01532,119,061 - 32,119,256UniSTSRnor5.0
RGSC_v3.41527,338,813 - 27,339,008UniSTSRGSC3.4
Celera1524,906,700 - 24,906,895UniSTS
Cytogenetic Map15p14UniSTS
RH130102  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21524,601,012 - 24,601,173 (+)MAPPERmRatBN7.2
Rnor_6.01528,305,851 - 28,306,011NCBIRnor6.0
Rnor_5.01532,118,831 - 32,118,991UniSTSRnor5.0
RGSC_v3.41527,338,583 - 27,338,743UniSTSRGSC3.4
Celera1524,906,470 - 24,906,630UniSTS
Cytogenetic Map15p14UniSTS
RH140915  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81527,074,517 - 27,074,761 (+)Marker Load Pipeline
mRatBN7.21524,601,018 - 24,601,262 (+)MAPPERmRatBN7.2
Rnor_6.01528,305,857 - 28,306,100NCBIRnor6.0
Rnor_5.01532,118,837 - 32,119,080UniSTSRnor5.0
RGSC_v3.41527,338,589 - 27,338,832UniSTSRGSC3.4
Celera1524,906,476 - 24,906,719UniSTS
Cytogenetic Map15p14UniSTS
Ndrg2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21524,601,010 - 24,601,842 (+)MAPPERmRatBN7.2
Rnor_6.01528,305,849 - 28,306,680NCBIRnor6.0
Rnor_5.01532,118,829 - 32,119,660UniSTSRnor5.0
RGSC_v3.41527,338,581 - 27,339,412UniSTSRGSC3.4
Celera1524,906,468 - 24,907,299UniSTS
Cytogenetic Map15p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001270862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_133583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC094516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF334105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF334106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ426424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ426425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ426426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ426427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM045410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM057759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000040540   ⟹   ENSRNOP00000039619
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1524,600,982 - 24,608,684 (-)Ensembl
Rnor_6.0 Ensembl1528,305,821 - 28,314,459 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000042055   ⟹   ENSRNOP00000042949
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1524,600,982 - 24,609,626 (-)Ensembl
Rnor_6.0 Ensembl1528,305,821 - 28,314,459 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085897   ⟹   ENSRNOP00000072772
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1524,600,982 - 24,608,213 (-)Ensembl
Rnor_6.0 Ensembl1528,305,821 - 28,313,841 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094910   ⟹   ENSRNOP00000081522
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1524,600,982 - 24,608,213 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099063   ⟹   ENSRNOP00000089946
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1524,601,819 - 24,609,626 (-)Ensembl
RefSeq Acc Id: NM_001270862   ⟹   NP_001257791
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,074,481 - 27,083,120 (-)NCBI
mRatBN7.21524,600,982 - 24,609,621 (-)NCBI
Rnor_6.01528,305,820 - 28,314,459 (-)NCBI
Rnor_5.01532,118,799 - 32,127,439 (-)NCBI
Celera1524,906,439 - 24,915,078 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001270863   ⟹   NP_001257792
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,074,481 - 27,082,502 (-)NCBI
mRatBN7.21524,600,982 - 24,609,003 (-)NCBI
Rnor_6.01528,305,820 - 28,313,841 (-)NCBI
Rnor_5.01532,118,799 - 32,127,439 (-)NCBI
Celera1524,906,439 - 24,914,460 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001270864   ⟹   NP_001257793
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,074,481 - 27,082,502 (-)NCBI
mRatBN7.21524,600,982 - 24,609,003 (-)NCBI
Rnor_6.01528,305,820 - 28,313,841 (-)NCBI
Rnor_5.01532,118,799 - 32,127,439 (-)NCBI
Celera1524,906,439 - 24,914,460 (-)NCBI
Sequence:
RefSeq Acc Id: NM_133583   ⟹   NP_598267
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,074,481 - 27,083,120 (-)NCBI
mRatBN7.21524,600,982 - 24,609,621 (-)NCBI
Rnor_6.01528,305,820 - 28,314,459 (-)NCBI
Rnor_5.01532,118,799 - 32,127,439 (-)NCBI
RGSC_v3.41527,338,552 - 27,347,196 (-)RGD
Celera1524,906,439 - 24,915,078 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039092969   ⟹   XP_038948897
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,074,481 - 27,082,240 (-)NCBI
mRatBN7.21524,600,981 - 24,608,628 (-)NCBI
RefSeq Acc Id: XM_063273926   ⟹   XP_063129996
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,074,481 - 27,081,478 (-)NCBI
RefSeq Acc Id: XM_063273927   ⟹   XP_063129997
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,074,481 - 27,082,459 (-)NCBI
RefSeq Acc Id: XM_063273928   ⟹   XP_063129998
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,074,481 - 27,081,478 (-)NCBI
RefSeq Acc Id: XM_063273929   ⟹   XP_063129999
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,074,481 - 27,081,478 (-)NCBI
RefSeq Acc Id: XM_063273930   ⟹   XP_063130000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,074,481 - 27,081,478 (-)NCBI
RefSeq Acc Id: XM_063273931   ⟹   XP_063130001
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,074,481 - 27,087,376 (-)NCBI
RefSeq Acc Id: NP_598267   ⟸   NM_133583
- Peptide Label: isoform b
- UniProtKB: Q8VI01 (UniProtKB/Swiss-Prot),   Q8VI00 (UniProtKB/Swiss-Prot),   Q8VBW2 (UniProtKB/Swiss-Prot),   Q8VBU2 (UniProtKB/Swiss-Prot),   A6KEE4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257791   ⟸   NM_001270862
- Peptide Label: isoform a
- UniProtKB: Q8VI01 (UniProtKB/Swiss-Prot),   Q8VI00 (UniProtKB/Swiss-Prot),   Q8VBW2 (UniProtKB/Swiss-Prot),   Q8VBU2 (UniProtKB/Swiss-Prot),   A0A0G2JSV0 (UniProtKB/TrEMBL),   A6KEE6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257793   ⟸   NM_001270864
- Peptide Label: isoform b
- UniProtKB: Q8VI01 (UniProtKB/Swiss-Prot),   Q8VI00 (UniProtKB/Swiss-Prot),   Q8VBW2 (UniProtKB/Swiss-Prot),   Q8VBU2 (UniProtKB/Swiss-Prot),   A6KEE4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257792   ⟸   NM_001270863
- Peptide Label: isoform a
- UniProtKB: Q8VI01 (UniProtKB/Swiss-Prot),   Q8VI00 (UniProtKB/Swiss-Prot),   Q8VBW2 (UniProtKB/Swiss-Prot),   Q8VBU2 (UniProtKB/Swiss-Prot),   A0A0G2JSV0 (UniProtKB/TrEMBL),   A6KEE6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000042949   ⟸   ENSRNOT00000042055
Ensembl Acc Id: ENSRNOP00000072772   ⟸   ENSRNOT00000085897
Ensembl Acc Id: ENSRNOP00000039619   ⟸   ENSRNOT00000040540
RefSeq Acc Id: XP_038948897   ⟸   XM_039092969
- Peptide Label: isoform X5
- UniProtKB: Q8VI01 (UniProtKB/Swiss-Prot),   Q8VI00 (UniProtKB/Swiss-Prot),   Q8VBW2 (UniProtKB/Swiss-Prot),   Q8VBU2 (UniProtKB/Swiss-Prot),   A0A0G2JSU4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000089946   ⟸   ENSRNOT00000099063
Ensembl Acc Id: ENSRNOP00000081522   ⟸   ENSRNOT00000094910
RefSeq Acc Id: XP_063130001   ⟸   XM_063273931
- Peptide Label: isoform X6
- UniProtKB: Q8VI01 (UniProtKB/Swiss-Prot),   Q8VI00 (UniProtKB/Swiss-Prot),   Q8VBW2 (UniProtKB/Swiss-Prot),   Q8VBU2 (UniProtKB/Swiss-Prot),   A6KEE4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129997   ⟸   XM_063273927
- Peptide Label: isoform X2
- UniProtKB: Q8VI01 (UniProtKB/Swiss-Prot),   Q8VI00 (UniProtKB/Swiss-Prot),   Q8VBW2 (UniProtKB/Swiss-Prot),   Q8VBU2 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063130000   ⟸   XM_063273930
- Peptide Label: isoform X6
- UniProtKB: Q8VI01 (UniProtKB/Swiss-Prot),   Q8VI00 (UniProtKB/Swiss-Prot),   Q8VBW2 (UniProtKB/Swiss-Prot),   Q8VBU2 (UniProtKB/Swiss-Prot),   A6KEE4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129999   ⟸   XM_063273929
- Peptide Label: isoform X4
- UniProtKB: Q8VI01 (UniProtKB/Swiss-Prot),   Q8VI00 (UniProtKB/Swiss-Prot),   Q8VBW2 (UniProtKB/Swiss-Prot),   Q8VBU2 (UniProtKB/Swiss-Prot),   A0A0G2JSV0 (UniProtKB/TrEMBL),   A6KEE6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129998   ⟸   XM_063273928
- Peptide Label: isoform X3
- UniProtKB: Q8VI01 (UniProtKB/Swiss-Prot),   Q8VI00 (UniProtKB/Swiss-Prot),   Q8VBW2 (UniProtKB/Swiss-Prot),   Q8VBU2 (UniProtKB/Swiss-Prot),   A0A8I5ZS65 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129996   ⟸   XM_063273926
- Peptide Label: isoform X1
- UniProtKB: Q8VI01 (UniProtKB/Swiss-Prot),   Q8VI00 (UniProtKB/Swiss-Prot),   Q8VBW2 (UniProtKB/Swiss-Prot),   Q8VBU2 (UniProtKB/Swiss-Prot),   A0A0G2K3T7 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VBU2-F1-model_v2 AlphaFold Q8VBU2 1-371 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699632
Promoter ID:EPDNEW_R10156
Type:multiple initiation site
Name:Ndrg2_1
Description:NDRG family member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10157  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01528,313,827 - 28,313,887EPDNEW
RGD ID:13699633
Promoter ID:EPDNEW_R10157
Type:initiation region
Name:Ndrg2_2
Description:NDRG family member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10156  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01528,314,467 - 28,314,527EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621874 AgrOrtholog
BioCyc Gene G2FUF-14002 BioCyc
Ensembl Genes ENSRNOG00000010389 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000040540.3 UniProtKB/TrEMBL
  ENSRNOT00000042055.4 UniProtKB/TrEMBL
  ENSRNOT00000085897.2 UniProtKB/TrEMBL
  ENSRNOT00000094910.1 UniProtKB/TrEMBL
  ENSRNOT00000099063.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NDRG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171114 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 171114 ENTREZGENE
PANTHER PTHR11034 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11034:SF17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ndr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ndrg2 PhenoGen
RatGTEx ENSRNOG00000010389 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JSU4 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2JSV0 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K3T7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZS65 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ACP0_RAT UniProtKB/TrEMBL
  A6KEE4 ENTREZGENE, UniProtKB/TrEMBL
  A6KEE6 ENTREZGENE, UniProtKB/TrEMBL
  A6KEE7_RAT UniProtKB/TrEMBL
  NDRG2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q8VBW2 ENTREZGENE
  Q8VI00 ENTREZGENE
  Q8VI01 ENTREZGENE
UniProt Secondary Q8VBW2 UniProtKB/Swiss-Prot
  Q8VI00 UniProtKB/Swiss-Prot
  Q8VI01 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Ndrg2  NDRG family member 2  Ndrg2  N-myc downstream regulated gene 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-07-29 Ndrg2  N-myc downstream regulated gene 2  Ndrg2  NDRG family member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-01-22 Ndrg2  NDRG family member 2  Ndrg2  N-myc downstream regulated gene 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-12-15 Ndrg2  N-myc downstream regulated gene 2  Ndrg2  NDRG family member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Ndrg2  NDRG family member 2  Ndrg2  N-myc downstream regulated gene 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Ndrg2  N-myc downstream regulated gene 2  Ndrg2  N-myc downstream-regulated gene 2  Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_product member of the family of differentiation-related genes 625480