Tnnt1 (troponin T1, slow skeletal type) - Rat Genome Database

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Gene: Tnnt1 (troponin T1, slow skeletal type) Rattus norvegicus
Analyze
Symbol: Tnnt1
Name: troponin T1, slow skeletal type
RGD ID: 621852
Description: Enables troponin T binding activity. Involved in slow-twitch skeletal muscle fiber contraction. Part of troponin complex. Human ortholog(s) of this gene implicated in nemaline myopathy 5A; nemaline myopathy 5B; and nemaline myopathy 5C. Orthologous to human TNNT1 (troponin T1, slow skeletal type); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fang2; slow skeletal muscle troponin T; sTnT; tnTs; troponin T type 1 (skeletal, slow); troponin T, slow skeletal muscle; troponin T1, skeletal, slow
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,349,035 - 78,359,394 (+)NCBIGRCr8
mRatBN7.2169,306,362 - 69,316,721 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,306,362 - 69,316,721 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx174,665,281 - 74,675,640 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0183,229,594 - 83,239,953 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0176,379,084 - 76,389,599 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0172,889,270 - 72,899,629 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl172,889,270 - 72,899,659 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0175,652,123 - 75,662,339 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4168,036,411 - 68,045,142 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1168,114,521 - 68,123,253 (+)NCBI
Celera167,811,420 - 67,821,558 (-)NCBICelera
Cytogenetic Map1q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
cannabidiol  (ISO)
Cannabidivarin  (ISO)
cantharidin  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
Cuprizon  (EXP)
daunorubicin  (ISO)
DDE  (ISO)
diethyl malate  (ISO)
diiodine  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
glyphosate  (EXP)
hydrogen peroxide  (ISO)
isoprenaline  (EXP)
ketamine  (ISO)
lead diacetate  (EXP)
lithium chloride  (ISO)
manganese(II) chloride  (EXP)
methylmercury chloride  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
naphthalene  (EXP)
oleuropein  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
pentanal  (ISO)
perfluorooctanoic acid  (EXP)
phenethyl caffeate  (EXP)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
pyrogallol  (ISO)
rac-lactic acid  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
spermine  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
thioacetamide  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
XL147  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
troponin complex  (IBA,IDA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Coupled expression of troponin T and troponin I isoforms in single skeletal muscle fibers correlates with contractility. Brotto MA, etal., Am J Physiol Cell Physiol. 2006 Feb;290(2):C567-76. Epub 2005 Sep 28.
2. Alternative splicing generates variants in important functional domains of human slow skeletal troponin T. Gahlmann R, etal., J Biol Chem 1987 Nov 25;262(33):16122-6.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. A novel nemaline myopathy in the Amish caused by a mutation in troponin T1. Johnston JJ, etal., Am J Hum Genet 2000 Oct;67(4):814-21. Epub 2000 Aug 21.
6. Expression and functional properties of four slow skeletal troponin T isoforms in rat muscles. Kischel P, etal., Am J Physiol Cell Physiol. 2005 Aug;289(2):C437-43. Epub 2005 Mar 23.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15665378   PMID:18032382   PMID:18978355  


Genomics

Comparative Map Data
Tnnt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,349,035 - 78,359,394 (+)NCBIGRCr8
mRatBN7.2169,306,362 - 69,316,721 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,306,362 - 69,316,721 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx174,665,281 - 74,675,640 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0183,229,594 - 83,239,953 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0176,379,084 - 76,389,599 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0172,889,270 - 72,899,629 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl172,889,270 - 72,899,659 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0175,652,123 - 75,662,339 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4168,036,411 - 68,045,142 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1168,114,521 - 68,123,253 (+)NCBI
Celera167,811,420 - 67,821,558 (-)NCBICelera
Cytogenetic Map1q12NCBI
TNNT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381955,132,698 - 55,149,206 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1955,132,698 - 55,149,206 (-)EnsemblGRCh38hg38GRCh38
GRCh371955,644,066 - 55,660,574 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361960,336,009 - 60,352,386 (-)NCBINCBI36Build 36hg18NCBI36
Build 341960,336,008 - 60,352,386NCBI
Celera1952,683,099 - 52,701,800 (-)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1951,967,104 - 51,981,532 (-)NCBIHuRef
CHM1_11955,637,767 - 55,654,167 (-)NCBICHM1_1
T2T-CHM13v2.01958,226,372 - 58,243,170 (-)NCBIT2T-CHM13v2.0
Tnnt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3974,507,568 - 4,518,974 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl74,507,569 - 4,519,381 (-)EnsemblGRCm39 Ensembl
GRCm3874,504,569 - 4,515,975 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl74,504,570 - 4,516,382 (-)EnsemblGRCm38mm10GRCm38
MGSCv3774,456,265 - 4,467,577 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3674,107,750 - 4,119,062 (-)NCBIMGSCv36mm8
Celera74,249,175 - 4,260,487 (-)NCBICelera
Cytogenetic Map7A1NCBI
cM Map72.6NCBI
Tnnt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555671,043,026 - 1,055,039 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555671,039,625 - 1,050,581 (+)NCBIChiLan1.0ChiLan1.0
TNNT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22061,268,613 - 61,282,914 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11962,997,739 - 63,012,038 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01952,173,523 - 52,190,577 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11960,868,241 - 60,885,197 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1960,868,330 - 60,882,005 (-)Ensemblpanpan1.1panPan2
TNNT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11102,479,617 - 102,490,776 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1102,366,801 - 102,491,147 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1102,536,670 - 102,547,827 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01103,133,191 - 103,144,315 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1102,973,590 - 103,144,307 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11102,770,115 - 102,781,270 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01102,481,708 - 102,492,858 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01103,245,737 - 103,256,895 (+)NCBIUU_Cfam_GSD_1.0
Tnnt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093492,124,674 - 2,133,897 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936886425,438 - 435,500 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936886425,331 - 434,546 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNNT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl659,347,582 - 59,365,284 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1659,351,445 - 59,365,584 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2654,300,086 - 54,314,541 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TNNT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1647,726,049 - 47,743,465 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl647,726,002 - 47,743,404 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045282,217 - 298,212 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tnnt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248322,094,903 - 2,100,560 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248322,093,852 - 2,100,647 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tnnt1
50 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:183
Count of miRNA genes:65
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000034957, ENSRNOT00000058843, ENSRNOT00000073491
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)15034351099980958Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat

Markers in Region
RH131706  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2169,311,353 - 69,311,570 (+)MAPPERmRatBN7.2
Rnor_6.0172,894,262 - 72,894,478NCBIRnor6.0
Rnor_5.0175,657,130 - 75,657,346UniSTSRnor5.0
RGSC_v3.4168,039,654 - 68,039,870UniSTSRGSC3.4
Celera167,816,350 - 67,816,566UniSTS
Cytogenetic Map1q12UniSTS
RH140454  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8178,356,648 - 78,357,441 (+)Marker Load Pipeline
mRatBN7.2169,313,975 - 69,314,768 (+)MAPPERmRatBN7.2
Rnor_6.0172,896,884 - 72,897,676NCBIRnor6.0
Rnor_5.0175,654,076 - 75,654,868UniSTSRnor5.0
RGSC_v3.4168,042,409 - 68,043,201UniSTSRGSC3.4
Celera167,813,373 - 67,814,165UniSTS
Cytogenetic Map1q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 217 97 93 44 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001277260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001277261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001277262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_134388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC141517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF399874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY334079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY334080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY334081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY334082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000034957   ⟹   ENSRNOP00000038327
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl169,306,362 - 69,316,721 (+)Ensembl
Rnor_6.0 Ensembl172,889,278 - 72,899,659 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000058843   ⟹   ENSRNOP00000055633
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl169,306,362 - 69,316,721 (+)Ensembl
Rnor_6.0 Ensembl172,889,270 - 72,899,629 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101852   ⟹   ENSRNOP00000076828
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl169,306,363 - 69,316,715 (+)Ensembl
RefSeq Acc Id: NM_001277260   ⟹   NP_001264189
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,349,035 - 78,359,394 (+)NCBI
mRatBN7.2169,306,362 - 69,316,721 (+)NCBI
Rnor_6.0172,889,270 - 72,899,629 (+)NCBI
Rnor_5.0175,652,123 - 75,662,339 (-)NCBI
Celera167,811,420 - 67,821,558 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001277261   ⟹   NP_001264190
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,349,035 - 78,359,394 (+)NCBI
mRatBN7.2169,306,362 - 69,316,721 (+)NCBI
Rnor_6.0172,889,270 - 72,899,629 (+)NCBI
Rnor_5.0175,652,123 - 75,662,339 (-)NCBI
Celera167,811,420 - 67,821,558 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001277262   ⟹   NP_001264191
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,349,035 - 78,359,394 (+)NCBI
mRatBN7.2169,306,362 - 69,316,721 (+)NCBI
Rnor_6.0172,889,270 - 72,899,629 (+)NCBI
Rnor_5.0175,652,123 - 75,662,339 (-)NCBI
Celera167,811,420 - 67,821,558 (-)NCBI
Sequence:
RefSeq Acc Id: NM_134388   ⟹   NP_599215
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,349,035 - 78,359,394 (+)NCBI
mRatBN7.2169,306,362 - 69,316,721 (+)NCBI
Rnor_6.0172,889,270 - 72,899,629 (+)NCBI
Rnor_5.0175,652,123 - 75,662,339 (-)NCBI
RGSC_v3.4168,036,411 - 68,045,142 (+)RGD
Celera167,811,420 - 67,821,558 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063276629   ⟹   XP_063132699
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,349,040 - 78,359,388 (+)NCBI
RefSeq Acc Id: XM_063276664   ⟹   XP_063132734
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,350,812 - 78,359,388 (+)NCBI
RefSeq Acc Id: XM_063276683   ⟹   XP_063132753
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,349,040 - 78,359,388 (+)NCBI
RefSeq Acc Id: XM_063276702   ⟹   XP_063132772
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,349,040 - 78,359,388 (+)NCBI
RefSeq Acc Id: XM_063276722   ⟹   XP_063132792
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,349,040 - 78,359,388 (+)NCBI
RefSeq Acc Id: XM_063276740   ⟹   XP_063132810
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,349,040 - 78,359,388 (+)NCBI
RefSeq Acc Id: XM_063276768   ⟹   XP_063132838
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,350,773 - 78,359,388 (+)NCBI
RefSeq Acc Id: XM_063276789   ⟹   XP_063132859
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,350,773 - 78,359,388 (+)NCBI
RefSeq Acc Id: XM_063276811   ⟹   XP_063132881
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,350,812 - 78,359,388 (+)NCBI
RefSeq Acc Id: XM_063276839   ⟹   XP_063132909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,350,812 - 78,359,388 (+)NCBI
RefSeq Acc Id: NP_599215   ⟸   NM_134388
- Peptide Label: isoform 1
- UniProtKB: Q7TNB2 (UniProtKB/Swiss-Prot),   Q7TNB1 (UniProtKB/Swiss-Prot),   Q7TNB0 (UniProtKB/Swiss-Prot),   Q7TNA9 (UniProtKB/Swiss-Prot),   Q923S7 (UniProtKB/Swiss-Prot),   A6KNL6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001264190   ⟸   NM_001277261
- Peptide Label: isoform 3
- UniProtKB: A6KNL6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001264191   ⟸   NM_001277262
- Peptide Label: isoform 4
- UniProtKB: A6KNL6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001264189   ⟸   NM_001277260
- Peptide Label: isoform 2
- UniProtKB: A6KNL6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000055633   ⟸   ENSRNOT00000058843
Ensembl Acc Id: ENSRNOP00000038327   ⟸   ENSRNOT00000034957
Ensembl Acc Id: ENSRNOP00000076828   ⟸   ENSRNOT00000101852
RefSeq Acc Id: XP_063132699   ⟸   XM_063276629
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063132792   ⟸   XM_063276722
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063132810   ⟸   XM_063276740
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063132753   ⟸   XM_063276683
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063132772   ⟸   XM_063276702
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063132838   ⟸   XM_063276768
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063132859   ⟸   XM_063276789
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063132881   ⟸   XM_063276811
- Peptide Label: isoform X9
- UniProtKB: A6KNL7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132734   ⟸   XM_063276664
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063132909   ⟸   XM_063276839
- Peptide Label: isoform X10
- UniProtKB: A6KNL7 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TNB2-F1-model_v2 AlphaFold Q7TNB2 1-261 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689706
Promoter ID:EPDNEW_R231
Type:single initiation site
Name:Tnnt1_1
Description:troponin T1, slow skeletal type
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0172,889,270 - 72,889,330EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621852 AgrOrtholog
BioCyc Gene G2FUF-60838 BioCyc
Ensembl Genes ENSRNOG00000028041 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000034957.7 UniProtKB/Swiss-Prot
  ENSRNOT00000058843.6 UniProtKB/Swiss-Prot
  ENSRNOT00000101852.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro TNNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Troponin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Troponin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171409 UniProtKB/Swiss-Prot
NCBI Gene 171409 ENTREZGENE
PANTHER PTHR11521 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TROPONIN T, SLOW SKELETAL MUSCLE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Troponin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tnnt1 PhenoGen
RatGTEx ENSRNOG00000028041 RatGTEx
  ENSRNOG00055015790 RatGTEx
  ENSRNOG00060027201 RatGTEx
  ENSRNOG00065032525 RatGTEx
Superfamily-SCOP SSF90250 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5YBH8_RAT UniProtKB/TrEMBL
  A6KNL6 ENTREZGENE, UniProtKB/TrEMBL
  A6KNL7 ENTREZGENE, UniProtKB/TrEMBL
  A6KNL8_RAT UniProtKB/TrEMBL
  Q7TNA9 ENTREZGENE
  Q7TNB0 ENTREZGENE
  Q7TNB1 ENTREZGENE
  Q7TNB2 ENTREZGENE
  Q923S7 ENTREZGENE
  TNNT1_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q7TNA9 UniProtKB/Swiss-Prot
  Q7TNB0 UniProtKB/Swiss-Prot
  Q7TNB1 UniProtKB/Swiss-Prot
  Q923S7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Tnnt1  troponin T1, slow skeletal type  Tnnt1  troponin T type 1 (skeletal, slow)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Tnnt1  troponin T type 1 (skeletal, slow)  Tnnt1  troponin T1, skeletal, slow  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Tnnt1  troponin T1, skeletal, slow      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Tnnt1  troponin T1, skeletal, slow      Symbol and Name status set to provisional 70820 PROVISIONAL