Wap (whey acidic protein) - Rat Genome Database

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Gene: Wap (whey acidic protein) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Wap
Name: whey acidic protein
RGD ID: 621851
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in antibacterial humoral response and innate immune response. Predicted to be located in extracellular region. Predicted to be active in extracellular space; INTERACTS WITH 17beta-estradiol; 3-methylcholanthrene; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: whey phosphoprotein
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81485,717,038 - 85,719,159 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1485,717,038 - 85,719,159 (-)EnsemblGRCr8
mRatBN7.21481,503,123 - 81,505,244 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1481,503,123 - 81,505,219 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1485,904,418 - 85,906,510 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01487,144,223 - 87,146,315 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01483,593,818 - 83,595,910 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01486,897,948 - 86,900,417 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1486,897,948 - 86,900,042 (-)Ensemblrn6Rnor6.0
Rnor_5.01480,531,392 - 80,533,484 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41487,392,577 - 87,394,669 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1480,384,678 - 80,386,770 (-)NCBICelera
RGSC_v3.11487,411,722 - 87,413,814 (-)NCBI
Cytogenetic Map14q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Complete sequence analysis of cDNA clones encoding rat whey phosphoprotein: homology to a protease inhibitor. Dandekar AM, etal., Proc Natl Acad Sci U S A 1982 Jul;79(13):3987-91.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Comparative sequence analysis of the mRNAs coding for mouse and rat whey protein. Hennighausen LG, etal., Nucleic Acids Res 1982 Jun 25;10(12):3733-44.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:6095207   PMID:15652158  


Genomics

Variants

.
Variants in Wap
17 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:93
Count of miRNA genes:80
Interacting mature miRNAs:84
Transcripts:ENSRNOT00000010744
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631213Bw60Body weight QTL604.51retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)1484164970100078267Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1459848686104848686Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1477914838104348525Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)147297021087582095Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1433424686102238540Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1474255551109089856Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147764007196755654Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1462398852107398852Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1477640071100078267Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1460854936105854936Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1474255551109089856Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147764007196755654Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1459848686104848686Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144261625899224555Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)146592028399224555Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143941117087582095Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
ectoderm
endocrine system
endoderm
hemolymphoid system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
1 1 14 4 4 5 1 9 5 13 2 28 4 3 3

Sequence


Ensembl Acc Id: ENSRNOT00000091193   ⟹   ENSRNOP00000073381
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1485,717,038 - 85,719,159 (-)Ensembl
mRatBN7.2 Ensembl1481,503,123 - 81,505,219 (-)Ensembl
Rnor_6.0 Ensembl1486,897,948 - 86,900,042 (-)Ensembl
RefSeq Acc Id: NM_053751   ⟹   NP_446203
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81485,717,038 - 85,719,159 (-)NCBI
mRatBN7.21481,503,123 - 81,505,244 (-)NCBI
Rnor_6.01486,897,948 - 86,900,040 (-)NCBI
Rnor_5.01480,531,392 - 80,533,484 (-)NCBI
RGSC_v3.41487,392,577 - 87,394,669 (-)RGD
Celera1480,384,678 - 80,386,770 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446203 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42346 (Get FASTA)   NCBI Sequence Viewer  
  AAA42347 (Get FASTA)   NCBI Sequence Viewer  
  CAA25600 (Get FASTA)   NCBI Sequence Viewer  
  EDM00373 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000073381
GenBank Protein P01174 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446203   ⟸   NM_053751
- Peptide Label: precursor
- UniProtKB: P01174 (UniProtKB/Swiss-Prot),   G3V718 (UniProtKB/TrEMBL),   A6IKV9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073381   ⟸   ENSRNOT00000091193
Protein Domains
WAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01174-F1-model_v2 AlphaFold P01174 1-137 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:6849606
Promoter ID:EP14040
Type:single initiation site
Name:RN_WAP
Description:Whey acidic protein, WAP gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 26; Rodent whey acidic protein
Experiment Methods:Sequencing of a full-length cDNA; experiments performed with; closely related gene
Regulation:mammary glands; (induced by or strongly expressed in) PRL, (induced by or strongly expressed in) glucocorticoid
Position:
Rat AssemblyChrPosition (strand)Source
RGSC_v3.41487,394,702 - 87,394,762EPD

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621851 AgrOrtholog
BioCyc Gene G2FUF-15065 BioCyc
Ensembl Genes ENSRNOG00000055684 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000091193 ENTREZGENE
Gene3D-CATH 4.10.75.10 UniProtKB/Swiss-Prot
InterPro Elafin-like_sf UniProtKB/Swiss-Prot
  WAP_dom UniProtKB/Swiss-Prot
  WAP_four-disulfide_core UniProtKB/Swiss-Prot
KEGG Report rno:114596 UniProtKB/Swiss-Prot
NCBI Gene 114596 ENTREZGENE
PANTHER WHEY ACDIC PROTEIN WAP UniProtKB/Swiss-Prot
  WHEY ACIDIC PROTEIN UniProtKB/Swiss-Prot
Pfam WAP UniProtKB/Swiss-Prot
PhenoGen Wap PhenoGen
PRINTS 4DISULPHCORE UniProtKB/Swiss-Prot
PROSITE WAP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000055684 RatGTEx
SMART WAP UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57256 UniProtKB/Swiss-Prot
UniProt A6IKV9 ENTREZGENE, UniProtKB/TrEMBL
  G3V718 ENTREZGENE, UniProtKB/TrEMBL
  P01174 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-07-08 Wap  whey acidic protein      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Wap  whey acidic protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA detected in mammary gland during midpregnancy and lactation 730110
gene_protein putative protein contains 137 aa residues 729985