Gjb6 (gap junction protein, beta 6) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Gjb6 (gap junction protein, beta 6) Rattus norvegicus
Analyze
Symbol: Gjb6
Name: gap junction protein, beta 6
RGD ID: 621830
Description: Predicted to enable cytoskeletal protein binding activity and gap junction channel activity involved in cell communication by electrical coupling. Involved in several processes, including cellular response to glucose stimulus; response to electrical stimulus; and response to lipopolysaccharide. Located in apical plasma membrane and gap junction. Biomarker of borna disease; status epilepticus; transient cerebral ischemia; and ureteral obstruction. Human ortholog(s) of this gene implicated in Clouston syndrome; autosomal dominant nonsyndromic deafness 3B; autosomal recessive nonsyndromic deafness 1A; autosomal recessive nonsyndromic deafness 1B; and ectodermal dysplasia. Orthologous to human GJB6 (gap junction protein beta 6); INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol 3-benzoate; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: connexin f; Cx30; Cxnf; gap junction beta-6 protein; gap junction membrane channel protein beta 6; gap junction protein, beta 6 (connexin 30)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81535,400,147 - 35,410,649 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1535,398,770 - 35,410,849 (-)EnsemblGRCr8
mRatBN7.21531,284,561 - 31,294,552 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1531,284,419 - 31,294,582 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1533,275,886 - 33,285,877 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01534,426,541 - 34,436,532 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01532,684,670 - 32,694,661 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01537,400,888 - 37,411,656 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1537,400,889 - 37,410,848 (-)Ensemblrn6Rnor6.0
Rnor_5.01541,248,072 - 41,258,522 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41536,177,736 - 36,186,513 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1530,996,679 - 31,005,456 (-)NCBICelera
RGSC_v3.11536,193,435 - 36,202,213 (-)NCBI
Cytogenetic Map15p12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Upregulation of connexins 30 and 32 gap junctions in rat hippocampus at transcription level by chronic central injection of lipopolysaccharide. Abbasian M, etal., Iran Biomed J. 2012;16(3):127-32. doi: 10.6091/ibj.1099.2012.
2. Expression of connexin 30 and connexin 32 in hippocampus of rat during epileptogenesis in a kindling model of epilepsy. Akbarpour B, etal., Neurosci Bull. 2012 Dec;28(6):729-36. doi: 10.1007/s12264-012-1279-6. Epub 2012 Nov 12.
3. Reduced gap junctional communication among astrocytes in experimental diabetes: contributions of altered connexin protein levels and oxidative-nitrosative modifications. Ball KK, etal., J Neurosci Res. 2011 Dec;89(12):2052-67. doi: 10.1002/jnr.22663. Epub 2011 May 2.
4. Absence of GJB6 mutations in Indian patients with non-syndromic hearing loss. Bhalla S, etal., Int J Pediatr Otorhinolaryngol. 2011 Mar;75(3):356-9. doi: 10.1016/j.ijporl.2010.12.003. Epub 2011 Jan 11.
5. Hearing loss features in GJB2 biallelic mutations and GJB2/GJB6 digenic inheritance in a large Italian cohort. Cama E, etal., Int J Audiol. 2009 Jan;48(1):12-7. doi: 10.1080/14992020802400654.
6. Prevalence of GJB6 mutations in Chinese patients with non-syndromic hearing loss. Chen P, etal., Int J Pediatr Otorhinolaryngol. 2012 Feb;76(2):265-7. doi: 10.1016/j.ijporl.2011.11.018. Epub 2011 Dec 18.
7. Connexin-30 mRNA is up-regulated in astrocytes and expressed in apoptotic neuronal cells of rat brain following kainate-induced seizures. Condorelli DF, etal., Mol Cell Neurosci 2002 Sep;21(1):94-113.
8. Expression of multiple connexins in the rat epididymis indicates a complex regulation of gap junctional communication. Dufresne J, etal., Am J Physiol Cell Physiol 2003 Jan;284(1):C33-43.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Prevalence of DFNB1 mutations in Argentinean children with non-syndromic deafness. Report of a novel mutation in GJB2. Gravina LP, etal., Int J Pediatr Otorhinolaryngol. 2010 Mar;74(3):250-4. doi: 10.1016/j.ijporl.2009.11.014. Epub 2009 Dec 22.
11. Hydrogen supplemented air inhalation reduces changes of prooxidant enzyme and gap junction protein levels after transient global cerebral ischemia in the rat hippocampus. Hugyecz M, etal., Brain Res. 2011 Aug 2;1404:31-8. Epub 2011 Jun 12.
12. Layer specific changes of astroglial gap junctions in the rat cerebellar cortex by persistent Borna Disease Virus infection. Koster-Patzlaff C, etal., Brain Res. 2008 Jul 11;1219:143-58. doi: 10.1016/j.brainres.2008.04.062. Epub 2008 Apr 30.
13. Mutations in GJB6 cause hidrotic ectodermal dysplasia. Lamartine J, etal., Nat Genet. 2000 Oct;26(2):142-4.
14. Developmental expression patterns of connexin26 and -30 in the rat cochlea. Lautermann J, etal., Dev Genet. 1999;25(4):306-11.
15. Molecular screening of patients with nonsyndromic hearing loss from Nanjing city of China. Lu Y, etal., J Biomed Res. 2011 Sep;25(5):309-18. doi: 10.1016/S1674-8301(11)60042-0.
16. High glucose-induced downregulation of connexin 30.2 promotes retinal vascular lesions: implications for diabetic retinopathy. Manasson J, etal., Invest Ophthalmol Vis Sci. 2013 Mar 28;54(3):2361-6. doi: 10.1167/iovs.12-10815.
17. Connexin 30 expression and frequency of connexin heterogeneity in astrocyte gap junction plaques increase with age in the rat retina. Mansour H, etal., PLoS One. 2013;8(3):e57038. doi: 10.1371/journal.pone.0057038. Epub 2013 Mar 14.
18. Spectrum and frequency of GJB2 mutations in a cohort of 264 Portuguese nonsyndromic sensorineural hearing loss patients. Matos TD, etal., Int J Audiol. 2013 Jul;52(7):466-71. doi: 10.3109/14992027.2013.783719. Epub 2013 May 13.
19. Localization of connexin 30 in the luminal membrane of cells in the distal nephron. McCulloch F, etal., Am J Physiol Renal Physiol. 2005 Dec;289(6):F1304-12. Epub 2005 Aug 2.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Connexin30 in rodent, cat and human brain: selective expression in gray matter astrocytes, co-localization with connexin43 at gap junctions and late developmental appearance. Nagy JI, etal., Neuroscience. 1999 Jan;88(2):447-68.
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
24. Rat gap junction connexin-30 inhibits proliferation of glioma cell lines. Princen F, etal., Carcinogenesis. 2001 Mar;22(3):507-13.
25. Identification of cells expressing Cx43, Cx30, Cx26, Cx32 and Cx36 in gap junctions of rat brain and spinal cord. Rash JE, etal., Cell Commun Adhes 2001;8(4-6):315-20.
26. GOA pipeline RGD automated data pipeline
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. Comprehensive gene review and curation RGD comprehensive gene curation
30. The human deafness-associated connexin 30 T5M mutation causes mild hearing loss and reduces biochemical coupling among cochlear non-sensory cells in knock-in mice. Schutz M, etal., Hum Mol Genet. 2010 Dec 15;19(24):4759-73. doi: 10.1093/hmg/ddq402. Epub 2010 Sep 21.
31. Expression of connexins in the normal and obstructed developing kidney. Silverstein DM, etal., Pediatr Nephrol. 2003 Mar;18(3):216-24. Epub 2003 Feb 7.
32. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
33. Connexin30 (Gjb6)-deficiency causes severe hearing impairment and lack of endocochlear potential. Teubner B, etal., Hum Mol Genet. 2003 Jan 1;12(1):13-21.
34. Differential expression of hippocampal connexins after acute hypoxia in the developing brain. Zeinieh MP, etal., Brain Dev. 2010 Nov;32(10):810-7. doi: 10.1016/j.braindev.2009.11.003. Epub 2010 Jan 19.
Additional References at PubMed
PMID:12767933   PMID:14595769   PMID:19285977   PMID:20089884   PMID:22871113   PMID:24301293   PMID:24590285   PMID:27130897   PMID:28875331   PMID:32462383  


Genomics

Comparative Map Data
Gjb6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81535,400,147 - 35,410,649 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1535,398,770 - 35,410,849 (-)EnsemblGRCr8
mRatBN7.21531,284,561 - 31,294,552 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1531,284,419 - 31,294,582 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1533,275,886 - 33,285,877 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01534,426,541 - 34,436,532 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01532,684,670 - 32,694,661 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01537,400,888 - 37,411,656 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1537,400,889 - 37,410,848 (-)Ensemblrn6Rnor6.0
Rnor_5.01541,248,072 - 41,258,522 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41536,177,736 - 36,186,513 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1530,996,679 - 31,005,456 (-)NCBICelera
RGSC_v3.11536,193,435 - 36,202,213 (-)NCBI
Cytogenetic Map15p12NCBI
GJB6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381320,221,962 - 20,232,319 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1320,221,962 - 20,232,450 (-)Ensemblhg38GRCh38
GRCh371320,796,101 - 20,806,458 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361319,694,101 - 19,703,067 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341319,694,101 - 19,703,067NCBI
Celera131,857,920 - 1,868,353 (-)NCBICelera
Cytogenetic Map13q12.11NCBI
HuRef131,601,586 - 1,612,019 (-)NCBIHuRef
CHM1_11320,764,612 - 20,775,034 (-)NCBICHM1_1
T2T-CHM13v2.01319,418,446 - 19,428,785 (-)NCBIT2T-CHM13v2.0
Gjb6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391457,360,760 - 57,370,764 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1457,360,760 - 57,371,068 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381457,123,301 - 57,133,611 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1457,123,303 - 57,133,611 (-)Ensemblmm10GRCm38
MGSCv371457,742,140 - 57,752,414 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361456,077,413 - 56,087,687 (-)NCBIMGSCv36mm8
Celera1454,913,863 - 54,924,132 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1430.1NCBI
Gjb6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554971,018,610 - 1,027,360 (-)Ensembl
ChiLan1.0NW_0049554971,018,610 - 1,027,593 (-)NCBIChiLan1.0ChiLan1.0
GJB6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21419,852,221 - 19,862,541 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11310,964,567 - 10,974,876 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0131,549,089 - 1,559,452 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11319,864,208 - 19,874,385 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1319,864,939 - 19,865,724 (-)EnsemblpanPan2panpan1.1
GJB6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12517,912,036 - 17,922,310 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2517,911,262 - 17,921,605 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2517,942,707 - 17,952,942 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02518,049,941 - 18,060,202 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2518,049,939 - 18,062,858 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12517,916,508 - 17,926,768 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02517,928,188 - 17,938,444 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02517,984,771 - 17,995,017 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gjb6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945119,938,223 - 119,947,042 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367201,493,733 - 1,494,518 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367201,485,895 - 1,494,673 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GJB6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl11793,280 - 800,046 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.111793,276 - 800,109 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GJB6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.13775,410 - 783,770 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl3782,251 - 783,036 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605743,801,650 - 43,810,335 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gjb6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477617,477,966 - 17,487,303 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477617,477,947 - 17,487,304 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Gjb6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11267,679,952 - 67,690,237 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gjb6
128 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:141
Count of miRNA genes:102
Interacting mature miRNAs:114
Transcripts:ENSRNOT00000011742
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat

Markers in Region
RH131114  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21531,284,567 - 31,284,749 (+)MAPPERmRatBN7.2
Rnor_6.01537,400,894 - 37,401,075NCBIRnor6.0
Rnor_5.01541,248,078 - 41,248,259UniSTSRnor5.0
RGSC_v3.41536,177,739 - 36,177,920UniSTSRGSC3.4
Celera1530,996,682 - 30,996,863UniSTS
RH 3.4 Map15260.89UniSTS
Cytogenetic Map15p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
5 9 34 136 55 59 29 23 29 6 180 76 10 113 62 84 30 3 3

Sequence


Ensembl Acc Id: ENSRNOT00000011742   ⟹   ENSRNOP00000011828
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1535,399,940 - 35,410,799 (-)Ensembl
mRatBN7.2 Ensembl1531,284,419 - 31,293,653 (-)Ensembl
Rnor_6.0 Ensembl1537,400,889 - 37,409,668 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081757   ⟹   ENSRNOP00000071038
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1535,398,770 - 35,410,849 (-)Ensembl
mRatBN7.2 Ensembl1531,284,419 - 31,294,582 (-)Ensembl
Rnor_6.0 Ensembl1537,400,889 - 37,410,848 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094969   ⟹   ENSRNOP00000097059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1531,284,566 - 31,293,255 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099568   ⟹   ENSRNOP00000086326
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1535,399,940 - 35,408,766 (-)Ensembl
mRatBN7.2 Ensembl1531,284,566 - 31,293,255 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000139621   ⟹   ENSRNOP00000108582
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1535,398,770 - 35,409,821 (-)Ensembl
RefSeq Acc Id: NM_001393806   ⟹   NP_001380735
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81535,400,147 - 35,410,138 (-)NCBI
mRatBN7.21531,284,561 - 31,294,552 (-)NCBI
RefSeq Acc Id: NM_053388   ⟹   NP_445840
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81535,400,148 - 35,408,962 (-)NCBI
mRatBN7.21531,284,562 - 31,293,376 (-)NCBI
Rnor_6.01537,400,891 - 37,409,668 (-)NCBI
Rnor_5.01541,248,072 - 41,258,522 (-)NCBI
RGSC_v3.41536,177,736 - 36,186,513 (-)RGD
Celera1530,996,679 - 31,005,456 (-)RGD
Sequence:
RefSeq Acc Id: XM_006252080   ⟹   XP_006252142
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81535,400,148 - 35,409,140 (-)NCBI
mRatBN7.21531,284,562 - 31,293,481 (-)NCBI
Rnor_6.01537,400,888 - 37,410,546 (-)NCBI
Rnor_5.01541,248,072 - 41,258,522 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063274731   ⟹   XP_063130801
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81535,400,148 - 35,410,649 (-)NCBI
RefSeq Acc Id: NP_445840   ⟸   NM_053388
- UniProtKB: Q6AZ42 (UniProtKB/TrEMBL),   A6KHB3 (UniProtKB/TrEMBL),   Q9R140 (UniProtKB/TrEMBL),   A6KHB2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252142   ⟸   XM_006252080
- Peptide Label: isoform X1
- UniProtKB: Q6AZ42 (UniProtKB/TrEMBL),   A6KHB3 (UniProtKB/TrEMBL),   Q9R140 (UniProtKB/TrEMBL),   A6KHB2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000011828   ⟸   ENSRNOT00000011742
Ensembl Acc Id: ENSRNOP00000071038   ⟸   ENSRNOT00000081757
Ensembl Acc Id: ENSRNOP00000097059   ⟸   ENSRNOT00000094969
Ensembl Acc Id: ENSRNOP00000086326   ⟸   ENSRNOT00000099568
RefSeq Acc Id: NP_001380735   ⟸   NM_001393806
- UniProtKB: Q6AZ42 (UniProtKB/TrEMBL),   A6KHB3 (UniProtKB/TrEMBL),   Q9R140 (UniProtKB/TrEMBL),   A6KHB2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130801   ⟸   XM_063274731
- Peptide Label: isoform X1
- UniProtKB: A6KHB2 (UniProtKB/TrEMBL),   A6KHB3 (UniProtKB/TrEMBL),   Q6AZ42 (UniProtKB/TrEMBL),   Q9R140 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000108582   ⟸   ENSRNOT00000139621
Protein Domains
Connexin N-terminal   Gap junction protein cysteine-rich

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AZ42-F1-model_v2 AlphaFold Q6AZ42 1-261 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621830 AgrOrtholog
BioCyc Gene G2FUF-13608 BioCyc
Ensembl Genes ENSRNOG00000022116 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011742.5 UniProtKB/TrEMBL
  ENSRNOT00000081757 ENTREZGENE
  ENSRNOT00000081757.3 UniProtKB/TrEMBL
  ENSRNOT00000099568.2 UniProtKB/TrEMBL
  ENSRNOT00000139621 ENTREZGENE
  ENSRNOT00000139621.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1440.80 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7132296 IMAGE-MGC_LOAD
InterPro Connexin UniProtKB/TrEMBL
  Connexin_CCC UniProtKB/TrEMBL
  Connexin_CS UniProtKB/TrEMBL
  Connexin_N UniProtKB/TrEMBL
  Connexin_N_sf UniProtKB/TrEMBL
MGC_CLONE MGC:93246 IMAGE-MGC_LOAD
NCBI Gene 84403 ENTREZGENE
PANTHER Connexin UniProtKB/TrEMBL
  GAP JUNCTION BETA-6 PROTEIN UniProtKB/TrEMBL
Pfam Connexin UniProtKB/TrEMBL
PhenoGen Gjb6 PhenoGen
PRINTS CONNEXIN UniProtKB/TrEMBL
PROSITE CONNEXINS_1 UniProtKB/TrEMBL
  CONNEXINS_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022116 RatGTEx
SMART CNX UniProtKB/TrEMBL
  Connexin_CCC UniProtKB/TrEMBL
UniProt A6KHB2 ENTREZGENE, UniProtKB/TrEMBL
  A6KHB3 ENTREZGENE
  Q6AZ42 ENTREZGENE, UniProtKB/TrEMBL
  Q9R140 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A6KHB3 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-20 Gjb6  gap junction protein, beta 6  Gjb6  gap junction membrane channel protein beta 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Gjb6  gap junction membrane channel protein beta 6    gap junction protein, beta 6 (connexin 30)  Name updated 1299863 APPROVED
2002-08-07 Gjb6  gap junction protein, beta 6 (connexin 30)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in grey matter astrocytes of the brain 632751
gene_expression expressed in adult epididymis 628541
gene_regulation enhanced expression in neuronal cells undergoing cell death by kainate-induced seizures 632751