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Gene: Pfn2 (profilin 2) Rattus norvegicus

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Symbol:

Pfn2

Name:

profilin 2

RGD ID:

621826

Description:

Enables actin binding activity. Involved in regulation of actin filament polymerization. Predicted to be located in cytoskeleton. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynapse. Orthologous to human PFN2 (profilin 2); INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC100909840; profilin II; profilin-2; profilin-2-like

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PFN2 (profilin 2)	RGD	RGD
Mus musculus (house mouse):	Pfn2 (profilin 2)	RGD	RGD
Chinchilla lanigera (long-tailed chinchilla):	Pfn2 (profilin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PFN2 (profilin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PFN2 (profilin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	LOC101967251 (profilin-2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PFN2 (profilin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PFN2 (profilin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pfn2 (profilin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Pfn2 (profilin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	PFN1 (profilin 1)	HGNC	OrthoDB
Homo sapiens (human):	SFMBT1 (Scm like with four mbt domains 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	PFN2 (profilin 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Pfn2 (profilin 2)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pfn2a	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	pfn2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Candidate Gene For:

Bp367

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	144,217,100 - 144,222,936 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	144,205,636 - 144,222,936 (-)	Ensembl				GRCr8
mRatBN7.2	2	142,067,102 - 142,072,938 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	142,067,104 - 142,072,938 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	148,701,882 - 148,707,731 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	146,800,738 - 146,806,581 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	141,433,149 - 141,438,992 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	147,953,858 - 147,959,692 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	147,955,196 - 148,050,438 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	167,359,669 - 167,365,898 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	147,066,815 - 147,072,519 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	136,499,541 - 136,505,245 (-)	NCBI		Celera
RGSC_v3.1	2	147,016,780 - 147,022,482 (-)	NCBI
Cytogenetic Map	2	q26	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

hepatocellular carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane (EXP)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP,ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dimethoxyphenol (ISO)

2-methoxyethanol (EXP)

3',5'-cyclic AMP (EXP)

3,3',4,4',5-pentachlorobiphenyl (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

4-hydroxyphenyl retinamide (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

actinomycin D (ISO)

aflatoxin B1 (ISO)

amitrole (EXP)

ammonium chloride (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

beta-naphthoflavone (ISO)

bis(2-ethylhexyl) phthalate (EXP,ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

bisphenol F (EXP,ISO)

Brodifacoum (EXP)

butan-1-ol (ISO)

Butylbenzyl phthalate (ISO)

cadmium dichloride (ISO)

cadmium sulfate (ISO)

cannabidiol (ISO)

carbon nanotube (ISO)

chlordecone (ISO)

copper atom (ISO)

copper(0) (ISO)

corticosterone (EXP)

cyclosporin A (ISO)

decabromodiphenyl ether (EXP,ISO)

dexamethasone (EXP,ISO)

diallyl trisulfide (EXP)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP,ISO)

diethyl phthalate (ISO)

diisobutyl phthalate (ISO)

diisononyl phthalate (ISO)

doramapimod (ISO)

dorsomorphin (ISO)

endosulfan (EXP)

enzyme inhibitor (ISO)

epoxiconazole (ISO)

ethanol (ISO)

folic acid (ISO)

furan (EXP)

furfural (ISO)

genistein (EXP)

glyphosate (ISO)

hydrogen peroxide (ISO)

ivermectin (ISO)

lead(0) (ISO)

Mesaconitine (EXP)

methamphetamine (EXP)

methimazole (EXP)

methoxychlor (EXP)

methylazoxymethanol (ISO)

Methylazoxymethanol acetate (EXP)

microcystin-LR (ISO)

nickel atom (ISO)

nitrofen (EXP)

Nutlin-3 (ISO)

oxaliplatin (EXP)

paracetamol (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (EXP,ISO)

pirinixic acid (ISO)

progesterone (EXP)

propiconazole (ISO)

rotenone (EXP)

S-adenosyl-L-methioninate (ISO)

S-adenosyl-L-methionine (ISO)

sarin (EXP)

SB 431542 (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

sodium chloride (ISO)

sulfadimethoxine (EXP)

tamoxifen (ISO)

tert-butyl hydroperoxide (ISO)

testosterone (EXP,ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

trichostatin A (ISO)

triptonide (ISO)

tungsten (ISO)

tunicamycin (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin cytoskeleton organization (IEA,ISO)

modification of postsynaptic actin cytoskeleton (IEA,ISO)

modulation of chemical synaptic transmission (IEA,ISO)

negative regulation of actin filament polymerization (ISO)

negative regulation of epithelial cell migration (IEA,ISO)

negative regulation of ruffle assembly (IEA,ISO)

positive regulation of actin filament bundle assembly (IBA,IEA,ISO)

positive regulation of actin filament polymerization (IEA,ISO)

positive regulation of stress fiber assembly (IEA,ISO)

presynaptic actin cytoskeleton organization (IEA,ISO)

presynaptic modulation of chemical synaptic transmission (IEA,ISO)

protein stabilization (IEA,ISO)

regulation of actin filament organization (IEA)

regulation of actin filament polymerization (IBA,IDA,IEA)

regulation of synaptic vesicle exocytosis (ISO)

Cellular Component

cytoplasm (IBA)

cytoskeleton (IEA)

glutamatergic synapse (IEA,ISO)

postsynapse (IEA,ISO)

presynapse (IEA,ISO)

Schaffer collateral - CA1 synapse (IEA,ISO)

terminal bouton (ISO)

Molecular Function

actin binding (IBA,IDA,IEA)

actin monomer binding (IEA,ISO)

ATP hydrolysis activity (IEA,ISO)

phosphatidylinositol-4,5-bisphosphate binding (IEA,ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	RhoA/ROCK regulation of neuritogenesis via profilin IIa-mediated control of actin stability.	Da Silva JS, etal., J Cell Biol 2003 Sep 29;162(7):1267-79.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Profilin II is alternatively spliced, resulting in profilin isoforms that are differentially expressed and have distinct biochemical properties.	Lambrechts A, etal., Mol Cell Biol 2000 Nov;20(21):8209-19.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	GOA pipeline	RGD automated data pipeline
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Comprehensive Molecular Analyses of a Macrophage-Related Gene Signature With Regard to Prognosis, Immune Features, and Biomarkers for Immunotherapy in Hepatocellular Carcinoma Based on WGCNA and the LASSO Algorithm.	Wang T, etal., Front Immunol. 2022 May 27;13:843408. doi: 10.3389/fimmu.2022.843408. eCollection 2022.

Additional References at PubMed

PMID:7758455	PMID:12477932	PMID:12967995	PMID:15477377	PMID:15834419	PMID:17541406	PMID:17873296	PMID:18001770	PMID:18573880	PMID:19056867	PMID:19307711	PMID:23153535
PMID:23376485	PMID:26951674	PMID:28131823

Genomics

Comparative Map Data

Pfn2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	144,217,100 - 144,222,936 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	144,205,636 - 144,222,936 (-)	Ensembl				GRCr8
mRatBN7.2	2	142,067,102 - 142,072,938 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	142,067,104 - 142,072,938 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	148,701,882 - 148,707,731 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	146,800,738 - 146,806,581 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	141,433,149 - 141,438,992 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	147,953,858 - 147,959,692 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	147,955,196 - 148,050,438 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	167,359,669 - 167,365,898 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	147,066,815 - 147,072,519 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	136,499,541 - 136,505,245 (-)	NCBI		Celera
RGSC_v3.1	2	147,016,780 - 147,022,482 (-)	NCBI
Cytogenetic Map	2	q26	NCBI

PFN2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	149,964,904 - 149,970,895 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	149,964,904 - 150,050,788 (-)	Ensembl			hg38	GRCh38
GRCh37	3	149,682,691 - 149,688,682 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	151,165,381 - 151,171,431 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	3	151,165,391 - 151,171,355	NCBI
Celera	3	148,096,052 - 148,102,101 (-)	NCBI		Celera
Cytogenetic Map	3	q25.1	NCBI
HuRef	3	147,055,266 - 147,061,316 (-)	NCBI		HuRef
CHM1_1	3	149,645,850 - 149,651,900 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	152,716,278 - 152,722,269 (-)	NCBI		T2T-CHM13v2.0

Pfn2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	57,749,316 - 57,755,178 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	57,749,316 - 57,755,500 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	3	57,841,895 - 57,847,757 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	57,841,895 - 57,848,079 (-)	Ensembl			mm10	GRCm38
MGSCv37	3	57,645,817 - 57,651,679 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	3	57,929,824 - 57,935,466 (-)	NCBI		MGSCv36	mm8
Celera	3	57,533,511 - 57,539,335 (-)	NCBI		Celera
Cytogenetic Map	3	D	NCBI
cM Map	3	28.15	NCBI

Pfn2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955448	1,199,688 - 1,203,400 (-)	Ensembl
ChiLan1.0	NW_004955448	1,199,447 - 1,201,718 (-)	NCBI	ChiLan1.0	ChiLan1.0

PFN2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	147,857,672 - 147,864,214 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	147,862,403 - 147,868,701 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	146,986,364 - 146,992,558 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	154,562,118 - 154,586,486 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2

PFN2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	23	44,686,126 - 44,691,801 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	23	44,686,937 - 44,691,800 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	23	44,551,694 - 44,557,577 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	23	45,312,933 - 45,318,818 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	23	45,312,940 - 45,320,472 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	23	44,902,089 - 44,907,982 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	23	44,954,249 - 44,960,133 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	23	45,206,749 - 45,212,625 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

LOC101967251
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	35,568,047 - 35,568,588 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936727	1,992,508 - 1,993,271 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PFN2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	90,177,540 - 90,183,742 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	13	90,177,534 - 90,185,978 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	98,231,651 - 98,237,664 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PFN2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	40,718,892 - 40,726,731 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666041	13,555,020 - 13,561,412 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pfn2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	27,307,030 - 27,312,501 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624730	27,306,452 - 27,312,493 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Pfn2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	3	96,423,136 - 96,428,983 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Pfn2
24 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	910
Count of miRNA genes:	310
Interacting mature miRNAs:	402
Transcripts:	ENSRNOT00000023469, ENSRNOT00000063986, ENSRNOT00000064506
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2293671	Bss44	Bone structure and strength QTL 44	10.97	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	2	105628029	150628029	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	67845370	229470703	Rat
1358360	Sradr2	Stress Responsive Adrenal Weight QTL 2	10.24		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	2	124103798	154505346	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	83465462	229820014	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	20695736	231474293	Rat
1298076	Bp166	Blood pressure QTL 166		0.0009	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	138595962	205135428	Rat
1581576	Pur7	Proteinuria QTL 7		0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	2	80396178	220931218	Rat
152025245	Scl81	Serum cholesterol level QTL 81	3.49		blood cholesterol amount (VT:0000180)		2	124537199	209621565	Rat
631198	Cm22	Cardiac mass QTL 22	4.3	0.0008	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	78269809	208420281	Rat
1554319	Bmd2	Bone mineral density QTL 2	13.4	0.0001	lumbar vertebra area (VT:0010570)	lumbar vertebra cross-sectional area (CMO:0001689)	2	122597372	215234002	Rat
1302794	Stl27	Serum triglyceride level QTL 27	4.4	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	27148328	145807373	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	80396178	220931218	Rat
1358901	Cm38	Cardiac mass QTL 38	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	159440891	Rat
1359030	Bp277	Blood pressure QTL 277			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	143565208	188565208	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	4265106	205135428	Rat
1581502	Esta3	Estrogen-induced thymic atrophy QTL 3			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	2	139067258	192287892	Rat
1358899	Kidm23	Kidney mass QTL 23	3.88		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
1358908	Bw49	Body weight QTL 49	3.36		body mass (VT:0001259)	body weight (CMO:0000012)	2	27148557	159440760	Rat
1582257	Gluco21	Glucose level QTL 21	3.1	0.0035	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	120039407	159440891	Rat
1358910	Kidm27	Kidney mass QTL 27	5.77		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
1358911	Kidm28	Kidney mass QTL 28	5.42		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
1358904	Cm39	Cardiac mass QTL 39	2.26		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	159440891	Rat
1359035	Bp276	Blood pressure QTL 276			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	100807373	145807373	Rat
8662836	Vetf8	Vascular elastic tissue fragility QTL 8	0.66		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	106869825	151869825	Rat
1358887	Bw50	Body weight QTL 50	2.39		body mass (VT:0001259)	body weight (CMO:0000012)	2	27148557	159440760	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	67845182	205135428	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	83400752	223709938	Rat
5135226	Leukc2	Leukocyte quantity QTL 2			eosinophil quantity (VT:0002602)	blood eosinophil count (CMO:0000033)	2	120039407	151869825	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
2299162	Iddm32	Insulin dependent diabetes mellitus QTL 32	2.36		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	93602631	145807373	Rat
1358894	Kidm24	Kidney mass QTL 24	4.03		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
1359022	Ppulsi1	Prepulse inhibition QTL 1	3.63		prepulse inhibition trait (VT:0003088)	acoustic startle response measurement (CMO:0001519)	2	139067258	184067258	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	80396034	220931416	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	78269809	205135428	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	143344967	251712708	Rat
71113	Cari2	Carrageenan-induced inflammation QTL 2	2.7	0.009	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	2	143746578	205135428	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	143344967	251712708	Rat
634308	Sach6	Saccharin preference QTL 6	4.9		taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	2	114384617	215381366	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
1300165	Rf9	Renal function QTL 9	3.28		kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	2	113746222	205135428	Rat
7488933	Bp368	Blood pressure QTL 368		0.004	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	104957381	149957381	Rat
631507	Bp105	Blood pressure QTL 105		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	114384617	215381366	Rat
738007	Anxrr7	Anxiety related response QTL 7	4.4		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	2	120339555	165339555	Rat
9685068	Swd7	Spike wave discharge measurement QTL 7	3.2	0.01	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge rate (CMO:0001739)	2	143806628	149738646	Rat
1354609	Niddm62	Non-insulin dependent diabetes mellitus QTL 62	4.72	0.000006	insulin secretion trait (VT:0003564)	plasma insulin level (CMO:0000342)	2	117415288	205135428	Rat
2293835	Kiddil5	Kidney dilation QTL 5	3.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	44537979	159440891	Rat
1581552	Pur12	Proteinuria QTL 12	5.19	0.0009	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	2	114032149	150226270	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	83465462	225110681	Rat
1558653	Prcr1	Prostate cancer resistance QTL 1	5		prostate integrity trait (VT:0010571)	area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)	2	114440891	159440891	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	47856345	205135428	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	44537979	184731399	Rat
1354594	Despr10	Despair related QTL 10		2e-06	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	2	116804572	161804572	Rat
152025206	Hrtrt23	Heart rate QTL 23	5.98		heart pumping trait (VT:2000009)		2	30219200	171802126	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	76328396	209350714	Rat
152025204	Hrtrt22	Heart rate QTL 22	5.6		heart pumping trait (VT:2000009)		2	30219200	171802126	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
13	1	24	83	34	30	18	69	18	6	192	115	11	70	46	51	12	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_030873	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006232390	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF228736	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF228737	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY004289	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC087013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM077173	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ215807	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000023469 ⟹ ENSRNOP00000023469

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	144,217,100 - 144,222,936 (-)	Ensembl
mRatBN7.2 Ensembl	2	142,067,104 - 142,072,838 (-)	Ensembl
Rnor_6.0 Ensembl	2	147,955,196 - 148,050,438 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000063986 ⟹ ENSRNOP00000061388

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	144,205,636 - 144,222,936 (-)	Ensembl
mRatBN7.2 Ensembl	2	142,068,608 - 142,072,938 (-)	Ensembl
Rnor_6.0 Ensembl	2	147,955,367 - 147,959,567 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000064506 ⟹ ENSRNOP00000062782

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	2	148,046,223 - 148,050,423 (-)	Ensembl

RefSeq Acc Id:

NM_030873 ⟹ NP_110500

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	144,217,100 - 144,222,936 (-)	NCBI
mRatBN7.2	2	142,067,102 - 142,072,938 (-)	NCBI
Rnor_6.0	2	147,953,863 - 147,959,567 (-)	NCBI
Rnor_5.0	2	167,359,669 - 167,365,898 (-)	NCBI
RGSC_v3.4	2	147,066,815 - 147,072,519 (-)	RGD
Celera	2	136,499,541 - 136,505,245 (-)	RGD

Sequence:

show sequence

ATGGCCGGTTGGCAGAGCTACGTGGATAACCTGATGTGCGATGGCTGCTGCCAGGAGGCCGCCA
TTGTCGGCTACTGCGACGCCAAATACGTCTGGGCAGCCACGGCCGGGGGCGTCTTCCAGAGCAT
CACGCCAGCAGAAATAGATGTGATTATAGGAAAAGACCGGGAAGGTTTCTTTACCAATGGTTTG
ACTCTTGGAGGAAAGAAGTGCTCTGTGATCAGAGATAGCCTATACGTTGACTCGGACTGCACAA
TGGACATCCGGACAAAGAGTCAAGGTGGGGAGCCAACATACAACGTTGCTGTTGGCAGAGCTGG
GAGAGTCTTGGTCTTTGTAATGGGAAAAGAAGGGGTCCATGGAGGCGGATTGAATAAGAAGGCA
TACTCAATGGCAAAATACTTGAGAGACTCTTGGGTTCTAGCTGCTAGGCAGACTGTTAAGTATT
AGGGGAAATTGCTCTTAAATTTTCCTAGCTGTAAGCTTAAGTCTTAATTCTGGAAATTTTATTA
GCAATGCAGGGTGATGGGATATGAACCTGTGTCTCCTTTGTATCCCTCTGTTGGTGGGGAAAGG
TGTCTGTCTTTCTTCCCCTTCCCCTTAAATAATTCTGTTCATTTTTGGTTGTTTCCTTGTGTAC
TCCAGCATTGGTTATAGTTATGGGAAAGGAAGGTGTCCACACAGGCACAATTAACAAGAAAACA
TATGAACTCGCTTTATACCTGAAGAGGTCTGATGTATAAGCAGCCTCTCCCATCTACCTACCTA
TCAACTGTCTTCATCACCACCCTAATTATGGTCATAATGCTACCAGATTGTAGATGGTAGCTAG
TTTTTCCTTCCTTATTTTCTACTGTCATGATTCCCAAGGGTCATTTGTATGTTAGCCACTGTGT
GCCCAACCCTTATCTGGCATCGTGATCGCAGCACAATAATGATTTGCATGATATCTTGAGATTG
GGGGAAGGGGGCATGCCAAGTCGGGCATCACTTCGTCTTAGCAATTAGTGGAATACTGATTACT
AAAATAAGTTAATATTAAGCAAGGTGCCGGTGTACAATCTCTAATTTGATCAGTGTTTTCTCAG
CACTTTGAGCATTTACTTAGCTCATTTAGTCTTCCTTTTGTAGCGCATGGTTGGGAGGAAAAAG
TGCATGCATCTGTACTTCACACCTTTCTCATCCCCTCCCTTCGAACATGAGGCGTTTGGTTTGC
TTCCATTCTCTTTGTGTAGTGCCTGGTTTATTTAACCTAATCAATACCTCCTCGCTGAGCTGTG
AGAGTCGCAGTGATTTACTTTGATACAGTGATTGCACTTGGGACACACTGTTTGTAGTGTCAAT
AGCACGTGATGAGTGCAGCTGTGGAGAGAAAGGCACTTCCTCCCATGACCTTACTACAGTAACC
ATACCGATCAAATTCCCAGGGACATTCGATCATTGCAGTAGCTCAGACTTCTTGTCTTTTCTTT
GCACACCAGCTGTACTCTTGAGTAAAATTGTAAAAGGCTGCCATTATGGATATTAGGTAACCCA
ACATAACCATCTGGAGTGTGTCCAGTTTATTTTTCATAGGACCAATTTTTATTTGCAGCTTAGG
TTTTTATATGAAGTTGCATTATTGTGGACTTGGCTGTCTTGTGATGTATTTTTTTCATATGTAT
CCTGTGCCATACTATTGTTAAAATGAACTGTTGCTATTGTGAGATGGAATTTCTTTCGAATGGC
ACTACTTTAGGGACATTCTAGTATTTGCTTCTATTGTTTGGGCATTGTGGATAATGTACAGATT
TAAAAACAAATCTTGTTGCTGATTTGTCCATTTCTTTCCCTGCACTTTGTTACATCTGGGATAC
AGTCTAACTCATCTGATTTAATATGCATTTAAAAAAATGCCATAACTATTAAACACCTTGTTTA
CAGACAGATGAAATAAATTTATTCCAACCAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_110500	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAF86616	(Get FASTA)	NCBI Sequence Viewer
	AAG24947	(Get FASTA)	NCBI Sequence Viewer
	AAG24948	(Get FASTA)	NCBI Sequence Viewer
	EDM14873	(Get FASTA)	NCBI Sequence Viewer
	EDM14874	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000023469
	ENSRNOP00000023469.3
GenBank Protein	Q9EPC6	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_110500 ⟸ NM_030873
- UniProtKB:	Q9EPC6 (UniProtKB/Swiss-Prot), Q9JHU7 (UniProtKB/Swiss-Prot), A6JVH9 (UniProtKB/TrEMBL), D3ZDU5 (UniProtKB/TrEMBL), D4A9A4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAGWQSYVDNLMCDGCCQEAAIVGYCDAKYVWAATAGGVFQSITPAEIDVIIGKDREGFFTNGL TLGGKKCSVIRDSLYVDSDCTMDIRTKSQGGEPTYNVAVGRAGRVLVFVMGKEGVHGGGLNKKA YSMAKYLRDSWVLAARQTVKY hide sequence

Ensembl Acc Id:

ENSRNOP00000023469 ⟸ ENSRNOT00000023469

Ensembl Acc Id:

ENSRNOP00000061388 ⟸ ENSRNOT00000063986

Ensembl Acc Id:

ENSRNOP00000062782 ⟸ ENSRNOT00000064506

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9EPC6-F1-model_v2	AlphaFold	Q9EPC6	1-140	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691340

Promoter ID:

EPDNEW_R1865

Type:

multiple initiation site

Name:

LOC100909840_1

Description:

profilin-2-like

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	147,959,605 - 147,959,665	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621826	AgrOrtholog
BioCyc Gene	G2FUF-53017	BioCyc
Ensembl Genes	ENSRNOG00000017427	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000023469	ENTREZGENE
	ENSRNOT00000023469.8	UniProtKB/Swiss-Prot
Gene3D-CATH	Dynein light chain 2a, cytoplasmic	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7131700	IMAGE-MGC_LOAD
InterPro	PFN	UniProtKB/Swiss-Prot
	PFN	UniProtKB/Swiss-Prot
	PFN_sf	UniProtKB/Swiss-Prot
	Profilin1/2/3_vertebrate	UniProtKB/Swiss-Prot
	Profilin_CS	UniProtKB/Swiss-Prot
KEGG Report	rno:81531	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93397	IMAGE-MGC_LOAD
NCBI Gene	81531	ENTREZGENE
PANTHER	PROFILIN	UniProtKB/Swiss-Prot
	PTHR13936:SF15	UniProtKB/Swiss-Prot
Pfam	Profilin	UniProtKB/Swiss-Prot
PhenoGen	Pfn2	PhenoGen
PRINTS	PROFILIN	UniProtKB/Swiss-Prot
	PROFILINMAML	UniProtKB/Swiss-Prot
PROSITE	PROFILIN	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000017427	RatGTEx
SMART	PROF	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF55770	UniProtKB/Swiss-Prot
UniProt	A6JVH8_RAT	UniProtKB/TrEMBL
	A6JVH9	ENTREZGENE, UniProtKB/TrEMBL
	D3ZDU5	ENTREZGENE, UniProtKB/TrEMBL
	D4A9A4	ENTREZGENE
	PROF2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q9JHU7	ENTREZGENE
UniProt Secondary	Q9JHU7	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Pfn2	profilin 2	LOC100909840	profilin-2-like	Data merged from RGD:6501768	737654	PROVISIONAL
2012-07-05	LOC100909840	profilin-2-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2004-09-10	Pfn2	profilin 2		profilin II	Name updated	1299863	APPROVED
2002-08-07	Pfn2	profilin II			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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