Slc2a13 (solute carrier family 2 member 13) - Rat Genome Database

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Pathways
Gene: Slc2a13 (solute carrier family 2 member 13) Rattus norvegicus
Analyze
Symbol: Slc2a13
Name: solute carrier family 2 member 13
RGD ID: 621814
Description: Enables myo-inositol transmembrane transporter activity. Involved in myo-inositol transport. Located in several cellular components, including astrocyte end-foot; cell body; and growth cone. Orthologous to human SLC2A13 (solute carrier family 2 member 13); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: h(+)-myo-inositol cotransporter; h(+)-myo-inositol symporter; Hmit; proton myo-inositol cotransporter; proton myo-inositol symporter; solute carrier family 2 (facilitated glucose transporter), member 13
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87124,278,881 - 124,606,146 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7124,278,882 - 124,606,146 (-)EnsemblGRCr8
mRatBN7.27122,399,329 - 122,726,605 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7122,399,330 - 122,726,605 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7124,190,797 - 124,509,651 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07126,416,678 - 126,735,509 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07126,344,095 - 126,663,650 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07132,430,852 - 132,757,558 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7132,430,853 - 132,757,558 (-)Ensemblrn6Rnor6.0
Rnor_5.07132,104,400 - 132,430,525 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47129,682,782 - 130,005,752 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7118,849,289 - 119,165,027 (-)NCBICelera
RGSC_v3.17129,718,778 - 130,078,763 (-)NCBI
Cytogenetic Map7q35NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
apical plasma membrane  (IBA)
astrocyte end-foot  (IDA)
cell body  (IDA,IEA,ISO)
cell periphery  (IDA,IEA,ISO)
cell projection  (IDA,IEA,ISO)
cytoplasm  (IDA)
early endosome  (ISO)
Golgi apparatus  (IDA)
growth cone  (IDA)
lysosome  (ISO)
membrane  (IDA,IEA)
organelle membrane  (IEA,ISO)
plasma membrane  (IDA,IMP,ISO)
synaptic vesicle  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Evaluation of expression and function of the H+/myo-inositol transporter HMIT. Di Daniel E, etal., BMC Cell Biol. 2009 Jul 16;10:54. doi: 10.1186/1471-2121-10-54.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Identification of a mammalian H(+)-myo-inositol symporter expressed predominantly in the brain. Uldry M, etal., EMBO J 2001 Aug 15;20(16):4467-77.
8. Regulated exocytosis of an H+/myo-inositol symporter at synapses and growth cones. Uldry M, etal., EMBO J. 2004 Feb 11;23(3):531-40. doi: 10.1038/sj.emboj.7600072. Epub 2004 Jan 29.
Additional References at PubMed
PMID:26094765   PMID:29551423  


Genomics

Comparative Map Data
Slc2a13
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87124,278,881 - 124,606,146 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7124,278,882 - 124,606,146 (-)EnsemblGRCr8
mRatBN7.27122,399,329 - 122,726,605 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7122,399,330 - 122,726,605 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7124,190,797 - 124,509,651 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07126,416,678 - 126,735,509 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07126,344,095 - 126,663,650 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07132,430,852 - 132,757,558 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7132,430,853 - 132,757,558 (-)Ensemblrn6Rnor6.0
Rnor_5.07132,104,400 - 132,430,525 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47129,682,782 - 130,005,752 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7118,849,289 - 119,165,027 (-)NCBICelera
RGSC_v3.17129,718,778 - 130,078,763 (-)NCBI
Cytogenetic Map7q35NCBI
SLC2A13
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381239,755,025 - 40,106,081 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1239,755,025 - 40,106,089 (-)Ensemblhg38GRCh38
GRCh371240,148,827 - 40,499,883 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361238,435,090 - 38,785,928 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341238,438,830 - 38,785,928NCBI
Celera1238,952,820 - 39,302,877 (-)NCBICelera
Cytogenetic Map12q12NCBI
HuRef1237,175,523 - 37,526,463 (-)NCBIHuRef
CHM1_11240,114,744 - 40,465,453 (-)NCBICHM1_1
T2T-CHM13v2.01239,704,874 - 40,055,977 (-)NCBIT2T-CHM13v2.0
Slc2a13
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391591,151,894 - 91,457,467 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1591,151,899 - 91,457,464 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381591,267,691 - 91,573,261 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1591,267,696 - 91,573,261 (-)Ensemblmm10GRCm38
MGSCv371591,098,122 - 91,403,692 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361591,095,464 - 91,401,028 (-)NCBIMGSCv36mm8
Celera1593,375,071 - 93,685,498 (-)NCBICelera
Cytogenetic Map15E3NCBI
cM Map1546.05NCBI
Slc2a13
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955505396,744 - 662,738 (+)Ensembl
ChiLan1.0NW_004955505395,380 - 664,272 (+)NCBIChiLan1.0ChiLan1.0
SLC2A13
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21054,052,206 - 54,391,929 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11254,049,005 - 54,388,665 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01248,609,170 - 48,948,828 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11249,467,356 - 49,808,114 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1249,469,306 - 49,803,110 (+)EnsemblpanPan2panpan1.1
SLC2A13
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12713,535,997 - 13,898,154 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2713,536,054 - 13,905,483 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2732,543,604 - 32,917,842 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02713,709,817 - 14,065,777 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2713,709,841 - 14,073,029 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12713,502,093 - 13,875,296 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02713,557,171 - 13,912,943 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02732,688,067 - 33,043,995 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc2a13
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494574,074,941 - 74,352,727 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936607909,677 - 1,186,922 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936607909,691 - 1,185,550 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC2A13
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl571,295,008 - 71,673,785 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1571,294,999 - 71,673,853 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2573,929,840 - 74,234,744 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC2A13
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11136,007,521 - 36,372,605 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1136,007,533 - 36,372,744 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037210,404,423 - 210,782,983 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc2a13
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624778396,503 - 726,262 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624778396,414 - 728,278 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc2a13
2220 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:193
Count of miRNA genes:130
Interacting mature miRNAs:144
Transcripts:ENSRNOT00000021153
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7121393075137014596Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7119280025135560836Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)7116269196132020414Rat
1582240Sffal1Serum free fatty acids level QTL 13.40.0021blood free fatty acid amount (VT:0001553)serum free fatty acids level (CMO:0000547)7118556868125929417Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 82 59 6 346 182 11 139 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000021153   ⟹   ENSRNOP00000021153
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7124,278,882 - 124,606,146 (-)Ensembl
mRatBN7.2 Ensembl7122,399,330 - 122,726,605 (-)Ensembl
Rnor_6.0 Ensembl7132,430,853 - 132,757,558 (-)Ensembl
RefSeq Acc Id: NM_133611   ⟹   NP_598295
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87124,278,881 - 124,606,146 (-)NCBI
mRatBN7.27122,399,329 - 122,726,605 (-)NCBI
Rnor_6.07132,430,852 - 132,757,558 (-)NCBI
Rnor_5.07132,104,400 - 132,430,525 (-)NCBI
RGSC_v3.47129,682,782 - 130,005,752 (-)RGD
Celera7118,849,289 - 119,165,027 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_598295 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAC51117 (Get FASTA)   NCBI Sequence Viewer  
  CBN63430 (Get FASTA)   NCBI Sequence Viewer  
  EDL76599 (Get FASTA)   NCBI Sequence Viewer  
  EDL76600 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000021153
  ENSRNOP00000021153.2
GenBank Protein Q921A2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_598295   ⟸   NM_133611
- UniProtKB: Q921A2 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021153   ⟸   ENSRNOT00000021153
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q921A2-F1-model_v2 AlphaFold Q921A2 1-637 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695598
Promoter ID:EPDNEW_R6122
Type:initiation region
Name:Slc2a13_1
Description:solute carrier family 2 member 13
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07132,757,597 - 132,757,657EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621814 AgrOrtholog
BioCyc Gene G2FUF-32401 BioCyc
Ensembl Genes ENSRNOG00000015741 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000021153 ENTREZGENE
  ENSRNOT00000021153.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot
InterPro MFS_dom UniProtKB/Swiss-Prot
  MFS_sugar_transport-like UniProtKB/Swiss-Prot
  MFS_trans_sf UniProtKB/Swiss-Prot
  Myo-inositol_Transporter UniProtKB/Swiss-Prot
  Sugar/inositol_transpt UniProtKB/Swiss-Prot
  Sugar_transporter_CS UniProtKB/Swiss-Prot
KEGG Report rno:171147 UniProtKB/Swiss-Prot
NCBI Gene 171147 ENTREZGENE
PANTHER PROTON MYO-INOSITOL COTRANSPORTER UniProtKB/Swiss-Prot
  PROTON MYO-INOSITOL COTRANSPORTER UniProtKB/Swiss-Prot
Pfam Sugar_tr UniProtKB/Swiss-Prot
PhenoGen Slc2a13 PhenoGen
PRINTS SUGRTRNSPORT UniProtKB/Swiss-Prot
PROSITE MFS UniProtKB/Swiss-Prot
  SUGAR_TRANSPORT_1 UniProtKB/Swiss-Prot
  SUGAR_TRANSPORT_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015741 RatGTEx
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot
UniProt A6K7Q6_RAT UniProtKB/TrEMBL
  A6K7Q7_RAT UniProtKB/TrEMBL
  MYCT_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Slc2a13  solute carrier family 2 member 13  Slc2a13  solute carrier family 2 (facilitated glucose transporter), member 13  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc2a13  solute carrier family 2 (facilitated glucose transporter), member 13      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Slc2a13  solute carrier family 2 (facilitated glucose transporter), member 13      Symbol and Name status set to provisional 70820 PROVISIONAL