Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-catechin | multiple interactions | ISO | GPR176 (Homo sapiens) | 6480464 | [Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of GPR176 mRNA | CTD | PMID:24763279 | 1,2-dichloroethane | decreases expression | ISO | Gpr176 (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of GPR176 mRNA | CTD | PMID:28960355 | 1-naphthyl isothiocyanate | increases expression | EXP | | 6480464 | 1-Naphthylisothiocyanate results in increased expression of GPR176 mRNA | CTD | PMID:30723492 | 17beta-estradiol | multiple interactions | ISO | GPR176 (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in increased expression of GPR176 mRNA and ESR1 protein affects the reaction [Estradiol results in increased expression of GPR176 mRNA] | CTD | PMID:14699072 and PMID:30165855 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of GPR176 mRNA | CTD | PMID:32741896 | 17beta-estradiol | affects expression | ISO | GPR176 (Homo sapiens) | 6480464 | Estradiol affects the expression of GPR176 mRNA | CTD | PMID:14699072 | 17beta-estradiol 3-benzoate | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of GPR176 mRNA | CTD | PMID:32741896 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Gpr176 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of GPR176 mRNA | CTD | PMID:21570461 | 4,4'-sulfonyldiphenol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of GPR176 mRNA | CTD | PMID:36041667 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of GPR176 mRNA | CTD | PMID:30047161 | aflatoxin B1 | decreases methylation | ISO | GPR176 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of GPR176 gene | CTD | PMID:27153756 | Aflatoxin B2 alpha | increases methylation | ISO | GPR176 (Homo sapiens) | 6480464 | aflatoxin B2 results in increased methylation of GPR176 intron | CTD | PMID:30157460 | amitrole | increases expression | EXP | | 6480464 | Amitrole results in increased expression of GPR176 mRNA | CTD | PMID:30047161 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of GPR176 mRNA | CTD | PMID:16483693 | amphetamine | decreases expression | EXP | | 6480464 | Amphetamine results in decreased expression of GPR176 mRNA | CTD | PMID:30779732 | benzo[a]pyrene | increases expression | ISO | GPR176 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of GPR176 mRNA | CTD | PMID:17879257 | benzo[a]pyrene | decreases methylation | ISO | GPR176 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of GPR176 exon | CTD | PMID:27901495 | benzo[a]pyrene | increases methylation | ISO | GPR176 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of GPR176 3' UTR and Benzo(a)pyrene results in increased methylation of GPR176 5' UTR | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | ISO | Gpr176 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of GPR176 mRNA | CTD | PMID:22228805 | bis(2-ethylhexyl) phthalate | increases expression | ISO | Gpr176 (Mus musculus) | 6480464 | Diethylhexyl Phthalate results in increased expression of GPR176 mRNA | CTD | PMID:35716406 | bisphenol A | decreases expression | ISO | GPR176 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of GPR176 mRNA | CTD | PMID:31715268 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of GPR176 mRNA | CTD | PMID:36041667 | bisphenol A | decreases methylation | ISO | GPR176 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of GPR176 gene | CTD | PMID:31601247 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of GPR176 mRNA | CTD | PMID:34947998 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of GPR176 mRNA | CTD | PMID:30816183 and PMID:32528016 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of GPR176 mRNA | CTD | PMID:25181051 | bisphenol F | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of GPR176 mRNA | CTD | PMID:36041667 | capsaicin | decreases expression | EXP | | 6480464 | Capsaicin results in decreased expression of GPR176 mRNA | CTD | PMID:16278290 | carbon nanotube | increases expression | ISO | Gpr176 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | GPR176 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to GPR176 gene] | CTD | PMID:28238834 | choline | multiple interactions | ISO | Gpr176 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GPR176 mRNA | CTD | PMID:20938992 | cisplatin | decreases expression | EXP | | 6480464 | Cisplatin results in decreased expression of GPR176 mRNA | CTD | PMID:22023808 | cisplatin | multiple interactions | ISO | GPR176 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of GPR176 mRNA | CTD | PMID:27392435 | dexamethasone | increases expression | ISO | Gpr176 (Mus musculus) | 6480464 | Dexamethasone results in increased expression of GPR176 mRNA | CTD | PMID:22733784 | dextran sulfate | multiple interactions | ISO | Gpr176 (Mus musculus) | 6480464 | [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of GPR176 mRNA | CTD | PMID:29950665 | diclofenac | decreases expression | ISO | Gpr176 (Mus musculus) | 6480464 | Diclofenac results in decreased expression of GPR176 mRNA | CTD | PMID:35537566 | dioxygen | multiple interactions | ISO | Gpr176 (Mus musculus) | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of GPR176 mRNA | CTD | PMID:30529165 | dorsomorphin | multiple interactions | ISO | GPR176 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GPR176 mRNA | CTD | PMID:27188386 | doxorubicin | affects response to substance | ISO | GPR176 (Homo sapiens) | 6480464 | GPR176 protein affects the susceptibility to Doxorubicin | CTD | PMID:16217747 | entinostat | increases expression | ISO | GPR176 (Homo sapiens) | 6480464 | entinostat results in increased expression of GPR176 mRNA | CTD | PMID:27188386 | fenvalerate | increases expression | EXP | | 6480464 | fenvalerate results in increased expression of GPR176 mRNA | CTD | PMID:30307764 | ferroheme b | increases expression | ISO | Gpr176 (Mus musculus) | 6480464 | Heme metabolite results in increased expression of GPR176 mRNA | CTD | PMID:19191707 | folic acid | multiple interactions | ISO | Gpr176 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GPR176 mRNA | CTD | PMID:20938992 | furan | decreases methylation | EXP | | 6480464 | furan results in decreased methylation of GPR176 gene | CTD | PMID:27387713 | furan | increases expression | EXP | | 6480464 | furan results in increased expression of GPR176 mRNA | CTD | PMID:27387713 | genistein | increases expression | ISO | Gpr176 (Mus musculus) | 6480464 | Genistein results in increased expression of GPR176 mRNA | CTD | PMID:32186404 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of GPR176 mRNA | CTD | PMID:22061828 | heme b | increases expression | ISO | Gpr176 (Mus musculus) | 6480464 | Heme metabolite results in increased expression of GPR176 mRNA | CTD | PMID:19191707 | L-methionine | multiple interactions | ISO | Gpr176 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GPR176 mRNA | CTD | PMID:20938992 | methimazole | increases expression | EXP | | 6480464 | Methimazole results in increased expression of GPR176 mRNA | CTD | PMID:30047161 | methylmercury chloride | decreases expression | ISO | GPR176 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of GPR176 mRNA | CTD | PMID:28001369 | N-methyl-4-phenylpyridinium | increases expression | EXP | | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of GPR176 mRNA | CTD | PMID:28801915 | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of GPR176 mRNA | CTD | PMID:25729387 | oxaliplatin | increases expression | EXP | | 6480464 | oxaliplatin results in increased expression of GPR176 mRNA | CTD | PMID:25729387 | ozone | multiple interactions | ISO | Gpr176 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which results in increased expression of GPR176 mRNA | CTD | PMID:27106289 | paraquat | increases expression | EXP | | 6480464 | Paraquat results in increased expression of GPR176 mRNA | CTD | PMID:32680482 | perfluorohexanesulfonic acid | increases expression | ISO | Gpr176 (Mus musculus) | 6480464 | perfluorohexanesulfonic acid results in increased expression of GPR176 mRNA | CTD | PMID:37995155 | phenylmercury acetate | decreases expression | ISO | GPR176 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of GPR176 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | GPR176 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GPR176 mRNA | CTD | PMID:27188386 | potassium chromate | decreases expression | ISO | GPR176 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of GPR176 mRNA | CTD | PMID:22714537 | SB 431542 | multiple interactions | ISO | GPR176 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GPR176 mRNA | CTD | PMID:27188386 | silicon dioxide | increases expression | ISO | Gpr176 (Mus musculus) | 6480464 | Silicon Dioxide results in increased expression of GPR176 mRNA | CTD | PMID:29203145 and PMID:29341224 | sodium arsenite | decreases expression | ISO | Gpr176 (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of GPR176 mRNA | CTD | PMID:37682722 | testosterone | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of GPR176 mRNA | CTD | PMID:32741896 | tetrachloromethane | affects expression | ISO | Gpr176 (Mus musculus) | 6480464 | Carbon Tetrachloride affects the expression of GPR176 mRNA | CTD | PMID:17484886 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of GPR176 mRNA | CTD | PMID:34492290 | titanium dioxide | increases expression | ISO | Gpr176 (Mus musculus) | 6480464 | titanium dioxide results in increased expression of GPR176 mRNA | CTD | PMID:23557971 | titanium dioxide | multiple interactions | ISO | Gpr176 (Mus musculus) | 6480464 | [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of GPR176 mRNA | CTD | PMID:29950665 | titanium dioxide | decreases expression | ISO | Gpr176 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of GPR176 mRNA | CTD | PMID:29264374 | topotecan | increases expression | EXP | | 6480464 | Topotecan results in increased expression of GPR176 mRNA | CTD | PMID:25729387 | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of GPR176 mRNA | CTD | PMID:25729387 | trichloroethene | decreases expression | EXP | | 6480464 | Trichloroethylene results in decreased expression of GPR176 mRNA | CTD | PMID:33387578 | triclosan | decreases expression | ISO | GPR176 (Homo sapiens) | 6480464 | Triclosan results in decreased expression of GPR176 mRNA | CTD | PMID:30510588 | trovafloxacin | decreases expression | ISO | Gpr176 (Mus musculus) | 6480464 | trovafloxacin results in decreased expression of GPR176 mRNA | CTD | PMID:35537566 | valproic acid | increases expression | ISO | GPR176 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of GPR176 mRNA | CTD | PMID:23179753 and PMID:27188386 | vincaleukoblastine | affects response to substance | ISO | GPR176 (Homo sapiens) | 6480464 | GPR176 protein affects the susceptibility to Vinblastine | CTD | PMID:16217747 | vinclozolin | decreases methylation | EXP | | 6480464 | vinclozolin results in decreased methylation of GPR176 gene | CTD | PMID:31079544 | vorinostat | increases expression | ISO | GPR176 (Homo sapiens) | 6480464 | vorinostat results in increased expression of GPR176 mRNA | CTD | PMID:27188386 | |