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Gene: Grin3b (glutamate ionotropic receptor NMDA type subunit 3B) Rattus norvegicus

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Symbol:

Grin3b

Name:

glutamate ionotropic receptor NMDA type subunit 3B

RGD ID:

621705

Description:

Enables glycine binding activity; monoatomic cation channel activity; and transmitter-gated monoatomic ion channel activity. Involved in cellular response to glycine; ionotropic glutamate receptor signaling pathway; and monoatomic cation transmembrane transport. Located in postsynaptic membrane and presynaptic membrane. Part of NMDA selective glutamate receptor complex. Is active in hippocampal mossy fiber to CA3 synapse; postsynaptic density membrane; and presynaptic active zone membrane. Orthologous to human GRIN3B (glutamate ionotropic receptor NMDA type subunit 3B); PARTICIPATES IN excitatory synaptic transmission pathway; glutamate signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

GluN3B; glutamate [NMDA] receptor subunit 3B; glutamate receptor ionotropic, NMDA 3B; glutamate receptor, ionotropic, N-methyl-D-aspartate 3B; glutamate receptor, ionotropic, NMDA3B; N-methyl-D-aspartate receptor subtype 3B; NMDAR3B; NR3B

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	10,381,495 - 10,387,817 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	10,381,496 - 10,387,817 (-)	Ensembl				GRCr8
mRatBN7.2	7	9,730,861 - 9,737,183 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	9,730,862 - 9,737,183 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	12,613,161 - 12,619,488 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	14,488,483 - 14,494,810 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	12,349,681 - 12,356,006 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	12,764,993 - 12,771,310 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	12,764,993 - 12,771,310 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	12,934,715 - 12,941,032 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	11,243,973 - 11,250,311 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	7,906,482 - 7,912,799 (-)	NCBI		Celera
RGSC_v3.1	7	11,243,973 - 11,250,304 (-)	NCBI
Cytogenetic Map	7	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Neurodevelopmental Disorders (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

actinomycin D (ISO)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

atrazine (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

Butylbenzyl phthalate (EXP)

cadmium dichloride (EXP)

camptothecin (ISO)

celecoxib (ISO)

chlorpyrifos (EXP)

cisplatin (ISO)

cocaine (EXP)

Cuprizon (EXP)

dexamethasone (EXP)

dieldrin (EXP)

dioxygen (ISO)

endosulfan (EXP)

ethanol (EXP)

fenvalerate (EXP)

gentamycin (EXP)

haloperidol (EXP)

iron dichloride (ISO)

kainic acid (ISO)

lead diacetate (EXP,ISO)

methotrexate (ISO)

Moniliformin (ISO)

mono(2-ethylhexyl) phthalate (ISO)

nickel atom (EXP)

Nutlin-3 (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

propanal (ISO)

rotenone (ISO)

sodium arsenite (ISO)

tamoxifen (ISO)

testosterone (EXP)

thioacetamide (EXP)

trichloroethene (EXP)

triphenyl phosphate (ISO)

triptonide (ISO)

trovafloxacin (ISO)

valproic acid (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

calcium ion transmembrane transport (IEA)

cellular response to glycine (IDA)

ionotropic glutamate receptor signaling pathway (IBA,IDA)

modulation of chemical synaptic transmission (IBA)

monoatomic cation transmembrane transport (IDA)

monoatomic ion transmembrane transport (IEA)

monoatomic ion transport (IEA)

protein insertion into membrane (IEA,ISO)

regulation of calcium ion transport (IEA,ISO)

regulation of postsynaptic membrane potential (IEA)

regulation of presynaptic membrane potential (IEA)

regulation of synaptic plasticity (IEA,ISO,ISS)

synaptic transmission, glutamatergic (IBA)

Cellular Component

endoplasmic reticulum membrane (IEA,TAS)

hippocampal mossy fiber to CA3 synapse (IDA)

membrane (IEA)

neuronal cell body (IEA,ISO)

neurotransmitter receptor complex (IEA,ISO)

NMDA selective glutamate receptor complex (IDA,IEA,ISO)

plasma membrane (IBA,IEA,TAS)

postsynaptic density membrane (IBA,IDA)

postsynaptic membrane (IDA,IEA)

presynaptic active zone membrane (IDA)

presynaptic membrane (IDA)

synapse (IEA)

Molecular Function

calcium channel activity (IEA,ISO)

glutamate receptor activity (IBA)

glycine binding (IDA,IEA)

ligand-gated monoatomic ion channel activity (IEA)

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (IEA,ISO)

monoatomic cation channel activity (IDA)

monoatomic ion channel activity (IEA)

neurotransmitter receptor activity (IDA)

NMDA glutamate receptor activity (IBA)

signaling receptor activity (IEA)

transmitter-gated monoatomic ion channel activity (IDA)

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

excitatory synaptic transmission pathway (IDA)

glutamate signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Pre- and postsynaptic localization of NMDA receptor subunits at hippocampal mossy fibre synapses.	Berg LK, etal., Neuroscience. 2013 Jan 29;230:139-50. doi: 10.1016/j.neuroscience.2012.10.061. Epub 2012 Nov 14.
2.	Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits.	Chatterton JE, etal., Nature 2002 Feb 14;415(6873):793-8.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	GOA pipeline	RGD automated data pipeline
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:11717388	PMID:11735224	PMID:14602821	PMID:18425811	PMID:19361480	PMID:20813147	PMID:20887777

Genomics

Comparative Map Data

Grin3b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	10,381,495 - 10,387,817 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	10,381,496 - 10,387,817 (-)	Ensembl				GRCr8
mRatBN7.2	7	9,730,861 - 9,737,183 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	9,730,862 - 9,737,183 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	12,613,161 - 12,619,488 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	14,488,483 - 14,494,810 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	12,349,681 - 12,356,006 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	12,764,993 - 12,771,310 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	12,764,993 - 12,771,310 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	12,934,715 - 12,941,032 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	11,243,973 - 11,250,311 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	7,906,482 - 7,912,799 (-)	NCBI		Celera
RGSC_v3.1	7	11,243,973 - 11,250,304 (-)	NCBI
Cytogenetic Map	7	q11	NCBI

GRIN3B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	1,000,419 - 1,009,732 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	1,000,419 - 1,009,732 (+)	Ensembl			hg38	GRCh38
GRCh37	19	1,000,418 - 1,009,731 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	951,437 - 960,723 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	19	932,775 - 942,061 (+)	NCBI		Celera
Cytogenetic Map	19	p13.3	NCBI
HuRef	19	773,711 - 783,359 (+)	NCBI		HuRef
CHM1_1	19	999,547 - 1,008,877 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	963,087 - 972,401 (+)	NCBI		T2T-CHM13v2.0

Grin3b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	79,806,227 - 79,813,024 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	79,806,549 - 79,813,024 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	10	79,970,397 - 79,977,190 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	79,970,715 - 79,977,190 (+)	Ensembl			mm10	GRCm38
MGSCv37	10	79,433,469 - 79,439,935 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	10	79,373,853 - 79,380,319 (+)	NCBI		MGSCv36	mm8
Celera	10	80,985,531 - 80,991,997 (+)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	39.72	NCBI

Grin3b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	6,859,909 - 6,866,306 (-)	Ensembl
ChiLan1.0	NW_004955495	6,859,909 - 6,866,297 (-)	NCBI	ChiLan1.0	ChiLan1.0

GRIN3B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	5,330,379 - 5,339,749 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	4,569,789 - 4,579,054 (+)	NCBI		NHGRI_mPanPan1
PanPan1.1 Ensembl	19	975,872 - 982,757 (+)	Ensembl			panPan2	panpan1.1

GRIN3B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	57,703,569 - 57,710,119 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	57,505,626 - 57,512,392 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	58,445,553 - 58,452,550 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	58,445,603 - 58,452,334 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	57,500,871 - 57,509,457 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	57,980,403 - 57,987,181 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	58,183,413 - 58,190,220 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Grin3b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	217,394,254 - 217,401,759 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936588	433,261 - 444,237 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936588	433,544 - 440,534 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GRIN3B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	77,401,368 - 77,412,136 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	77,402,191 - 77,411,878 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	77,585,744 - 77,595,456 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GRIN3B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	756,257 - 766,175 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	756,618 - 766,048 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666081	8,153,737 - 8,163,435 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Grin3b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624828	7,614,672 - 7,622,111 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624828	7,614,656 - 7,622,111 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Grin3b
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	154,899,190 - 154,905,499 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Grin3b
147 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	67
Count of miRNA genes:	60
Interacting mature miRNAs:	62
Transcripts:	ENSRNOT00000017064
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61410	Bw19	Body weight QTL 19	6.2	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	7	1669658	46669658	Rat
1300176	Hrtrt10	Heart rate QTL 10	3.19		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	7	1	23748937	Rat
9590102	Sffal5	Serum free fatty acids level QTL 5	8.62	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	7	7216097	52216097	Rat
1643004	Pain2	Pain QTL 2	1		mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	7	10112916	99900612	Rat
2290372	Gluco33	Glucose level QTL 33	2.71		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	1	31777942	Rat
1300149	Cm6	Cardiac mass QTL 6	4.09		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	7	1	104117804	Rat
631503	Bp102	Blood pressure QTL 102	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	1709527	46709527	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	1509236	116977875	Rat
9590142	Scort5	Serum corticosterone level QTL 5	24.4	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	1	32612984	Rat
1582260	Bw72	Body weight QTL 72	3.2	0.0043	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	39960528	Rat
1582261	Bw69	Body weight QTL 69	3.2	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	39960528	Rat
1582262	Bw75	Body weight QTL 75	3	0.0038	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	39960528	Rat
2298547	Neuinf5	Neuroinflammation QTL 5	3.7		nervous system integrity trait (VT:0010566)	spinal cord Cd74 protein level (CMO:0002131)	7	10112916	60150541	Rat
10059592	Kidm45	Kidney mass QTL 45	3.95	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	7	9460877	54460877	Rat
2298550	Neuinf6	Neuroinflammation QTL 6	3.3		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	7	1	29716167	Rat
724560	Plsm3	Polydactyly-luxate syndrome (PLS) morphotypes QTL 3		0.0003	tibia length (VT:0004357)	tibia length (CMO:0000450)	7	1	34650782	Rat
7411566	Bw136	Body weight QTL 136	10.4	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	1	32612984	Rat

Markers in Region

RH127486

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	9,712,644 - 9,712,846 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	12,763,622 - 12,763,823	NCBI	Rnor6.0
Rnor_5.0	7	12,933,344 - 12,933,545	UniSTS	Rnor5.0
RGSC_v3.4	7	11,225,323 - 11,225,524	UniSTS	RGSC3.4
Celera	7	7,888,321 - 7,888,522	UniSTS
RH 3.4 Map	7	25.2	UniSTS
Cytogenetic Map	7	q11	UniSTS

RH130604

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	9,730,674 - 9,730,885 (-)	MAPPER	mRatBN7.2
Rnor_6.0	7	12,771,286 - 12,771,496	NCBI	Rnor6.0
Rnor_5.0	7	12,941,008 - 12,941,218	UniSTS	Rnor5.0
RGSC_v3.4	7	11,243,787 - 11,243,997	UniSTS	RGSC3.4
Celera	7	7,906,296 - 7,906,506	UniSTS
RH 3.4 Map	7	49.1	UniSTS
Cytogenetic Map	7	q11	UniSTS

RH139166

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	9,713,029 - 9,713,169 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	12,764,007 - 12,764,146	NCBI	Rnor6.0
Rnor_5.0	7	12,933,729 - 12,933,868	UniSTS	Rnor5.0
RGSC_v3.4	7	11,225,708 - 11,225,847	UniSTS	RGSC3.4
Celera	7	7,888,706 - 7,888,845	UniSTS
Cytogenetic Map	7	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	11	41	121	55	54	23	90	23	6	285	163	9	100	75	84	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_133308	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF440691	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474029	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000017064 ⟹ ENSRNOP00000017064

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	10,381,496 - 10,387,817 (-)	Ensembl
mRatBN7.2 Ensembl	7	9,730,862 - 9,737,183 (-)	Ensembl
Rnor_6.0 Ensembl	7	12,764,993 - 12,771,309 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000093751

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	10,381,496 - 10,387,817 (-)	Ensembl
mRatBN7.2 Ensembl	7	9,730,862 - 9,737,183 (-)	Ensembl
Rnor_6.0 Ensembl	7	12,764,993 - 12,771,310 (+)	Ensembl

RefSeq Acc Id:

NM_133308 ⟹ NP_579842

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	10,381,495 - 10,387,817 (-)	NCBI
mRatBN7.2	7	9,730,861 - 9,737,183 (-)	NCBI
Rnor_6.0	7	12,764,993 - 12,771,310 (+)	NCBI
Rnor_5.0	7	12,934,715 - 12,941,032 (+)	NCBI
RGSC_v3.4	7	11,243,973 - 11,250,311 (-)	RGD
Celera	7	7,906,482 - 7,912,799 (-)	RGD

Sequence:

show sequence

GCACGAGGGGACAAGAGCGGGTCTGGCTGGGGTGTCTCCTTCCCTTCGCACAGCACAGTGGTAA
CTTCTTTCGGGATGGAGAGTGTGCGGACGCTGTGGCTCAGCGTGGCCCTGGCGCTGGCGGTGGG
GTCCCGAGTGGTGCGCGGTCACCCTCAGCCCTGCCGGGTTCCCACGCGCGCTGGGGCCTCCGTG
CGCCTGGCGGCGCTCCTGCCCCGGGCGCCCGCCGCCCGCGCCCGCGTCCTAGCTGCCCTGGCCA
CCCCTGCGCCGCGGCTGCCGCACAACCTGAGTCTGGAACTGGTGGCCGTCGCGTCCCCGACCCG
GGACCCCGCGTCGCTAGCTCGAGGTCTGTGCCAGGTTCTGGCACCGCCTGGCGTGGTGGCCTCT
ATAGCCTTTCCCGAGGCGCGGCCCGAGCTGCGGCTACTGCAGTTCCTGGCAGCCGCCACAGAGA
CCCCAGTGGTGAGCGTCCTGCGGAGGGAGGTGCGCACGGCCCTCGGAGCCCCGACTCCGTTCCA
TCTGCAGCTGGACTGGGCTAGTCCCCTGGAGACCATACTGGATGTGCTGGTGTCCCTGGTACGG
GCACATGCCTGGGAGGACATTGCTCTAGTACTCTGCCGTGTCCGGGACCCTGGCAGCCTGGTGA
CACTCTGGACTAACCATGCTAGCCAGGCTCCAAAGTTTGTGCTGGACCTGAGCCGGCTGGACAG
CAGGAATGACAGCCTTCGGGCTGGACTGGCCCTGTTGGGGGCGCTGGAAGGAGGGGGAACCCCA
GTGCCTGCAGCAGTCCTCCTAGGCTGCAGCACTGCCCGTGCACATGAGGTCCTAGAGGCTGCAC
CACCGGGTCCCCAGTGGTTGCTGGGCACACCATTGCCCGCTGAGGCACTGCCCACGACTGGTCT
GCCACCTGGCGTGCTGGCGCTGGGGGAAACCGAACAACACTCTCTGGAAGCTGTCGTCCACGAC
ATGGTGGAGCTTGTGGCTCAGGCACTCAGTAGCATGGCCCTTGTACACCCAGAGCGGGCACTGC
TTCCAGCTGTGGTGAACTGTGATGACCTGAAAACAGGCGGATCTGAGGCAACAGGGCGCACCTT
GGCTCGGTTTCTCGGCAACACCTCATTTCAGGGCCGAACAGGGGCCGTGTGGGTGACAGGCTCC
TCTCAGGTGCATGTGTCTCGGCATTTCAAGGTATGGAGCCTGCGCCGGGATCCGCTGGGTGCCC
CAGCCTGGGCAACCGTGGGCAGCTGGCAGGATGGACAGCTGGACTTCCAGCCAGGGGCAGCCGC
TCTCCGAGTCCCATCTCCGTCTGGCACCCAGGCCCGACCAAAGCTGCGTGTGGTAACCCTGGTG
GAACACCCGTTTGTGTTCACCAGGGAATCTGATGAAGACGGACAGTGCCCAGCTGGGCAGCTGT
GTCTGGACCCAGGCACCAATGACTCAGCCAGGCTGGATGCCCTCTTTGCTGCACTGGTGAATGG
CTCAGTACCTCGAACGCTGAGAAGATGCTGCTATGGCTACTGCATCGACCTGCTGGAGCGGCTG
GCCGAGGACCTGGCCTTTGACTTTGAGCTCTATATTGTGGGGGATGGCAAGTACGGGGCCCTGC
GTGATGGGCGCTGGACGGGCCTGGTGGGTGACCTGCTGGCTGGCCGGGCACACATGGCTGTGAC
CAGCTTCAGCATCAACTCAGCTCGCTCTCAGGTGGTGGATTTCACCAGCCCTTTCTTCTCCACC
AGCCTGGGGATTATGGTGCGCACGAGAGACACGGCCTCGCCCATCGGGGCTTTCATGTGGCCCC
TGCACTGGTCCATGTGGGTGGGCGTGTTTGCTGCTCTGCACCTCACAGCGCTCTTTCTCACCCT
GTACGAATGGCGAAGTCCCTACGGGCTCACGCCGCGCGGCCGCAACCGTGGCACTGTCTTCTCT
TACTCCTCCGCGCTCAACCTGTGCTATGCCATTCTCTTTGGACGCACTGTCTCCAGTAAGACGC
CCAAGTGCCCTACTGGACGCTTCCTCATGAACCTCTGGGCAATCTTCTGCCTGCTGGTGCTTTC
CAGTTACACGGCCAACCTGGCTGCTGTCATGGTTGGGGACAAAACCTTTGAGGAGCTGTCTGGA
ATCCATGATCCCAAGCTGCACCACCCTTCCCAAGGCTTTCGCTTTGGCACCGTATGGGAGAGCA
GCGCGGAGGCCTACATCAAGGCAAGCTTCCCTGAGATGCACGCACACATGCGTCGGCACAGCGC
ACCCACCACTCCACATGGGGTGGCCATGCTCACGAGCGACCCGCCCAAGCTCAACGCCTTCATC
ATGGATAAATCACTACTGGACTATGAGGTGTCCATAGATGCGGACTGCAAGCTGCTCACCGTTG
GCAAACCCTTTGCTATCGAGGGCTACGGCATAGGGCTACCCCAAAACTCGCCGCTCACCTCCAA
CCTGTCGGAGTTCATCAGTAGGTACAAGTCTTCAGGCTTCATTGATCTGCTCCATGACAAGTGG
TACAAGATGGTGCCTTGCGGGAAGCGGGTGTTCGCCGTGACGGAGACGCTGCAGATGGGGGTCT
ACCACTTCTCAGGATTGTTTGTCCTGCTGTGCCTCGGGCTGGGCAGCGCGCTTCTCACCTCTCT
GGGTGAGCATGTCTTCTACCGCCTGGTGCTGCCGCGCATCCGCAGGGGTAATAAGCTGCAGTAT
TGGCTTCACACGAGCCAGAAGATCCACCGAGCCCTCAATACAGGACCACCCGAGGGGCAACAGG
AGAGGGCAGAGCAGGAGCGCAGCGGCCCCAAGGACGAGCTGCCTGCCACCGATGGTGCAGGGCG
CTGGAGGCGGGTGCGCCGGGCTGTGGAACGGGAGCGACGCGTGCGTTTCCTGCTGGAACCTGGG
GAGGCTGGCGGAGACCGCCCGTGGCTCTGCTCCAACGGGCCCGGGCTGCAAGCGGAGCTGCGGG
AGCTGGAGCTGCGCATTGAGGCTGCACGGGAGCGGCTGCGCAGTGCGCTGTTGCGGCGCGGGGA
GCTGCGGGCCCTGCTTGGGGATGGCACCCGGCTCAGGCCACTGCGCCTGTTGCATGCGGCGCCT
GCTGAGAGCTGAGGAACCACAAGGCCGCACTGTCCACGACAGTTTATTCTATATACAAACACGA
CTCTGTACACTGCAATTAAATAGCGTGGAACGTGAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_579842	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAL69893	(Get FASTA)	NCBI Sequence Viewer
	EDL89361	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000017064
GenBank Protein	Q8VHN2	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_579842 ⟸ NM_133308
- Peptide Label:	precursor
- UniProtKB:	Q8VHN2 (UniProtKB/Swiss-Prot), F1LPZ6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MESVRTLWLSVALALAVGSRVVRGHPQPCRVPTRAGASVRLAALLPRAPAARARVLAALATPAP RLPHNLSLELVAVASPTRDPASLARGLCQVLAPPGVVASIAFPEARPELRLLQFLAAATETPVV SVLRREVRTALGAPTPFHLQLDWASPLETILDVLVSLVRAHAWEDIALVLCRVRDPGSLVTLWT NHASQAPKFVLDLSRLDSRNDSLRAGLALLGALEGGGTPVPAAVLLGCSTARAHEVLEAAPPGP QWLLGTPLPAEALPTTGLPPGVLALGETEQHSLEAVVHDMVELVAQALSSMALVHPERALLPAV VNCDDLKTGGSEATGRTLARFLGNTSFQGRTGAVWVTGSSQVHVSRHFKVWSLRRDPLGAPAWA TVGSWQDGQLDFQPGAAALRVPSPSGTQARPKLRVVTLVEHPFVFTRESDEDGQCPAGQLCLDP GTNDSARLDALFAALVNGSVPRTLRRCCYGYCIDLLERLAEDLAFDFELYIVGDGKYGALRDGR WTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRTRDTASPIGAFMWPLHWS MWVGVFAALHLTALFLTLYEWRSPYGLTPRGRNRGTVFSYSSALNLCYAILFGRTVSSKTPKCP TGRFLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPSQGFRFGTVWESSAEA YIKASFPEMHAHMRRHSAPTTPHGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKLLTVGKPF AIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVFAVTETLQMGVYHFS GLFVLLCLGLGSALLTSLGEHVFYRLVLPRIRRGNKLQYWLHTSQKIHRALNTGPPEGQQERAE QERSGPKDELPATDGAGRWRRVRRAVERERRVRFLLEPGEAGGDRPWLCSNGPGLQAELRELEL RIEAARERLRSALLRRGELRALLGDGTRLRPLRLLHAAPAES hide sequence

Ensembl Acc Id:

ENSRNOP00000017064 ⟸ ENSRNOT00000017064

Protein Domains

Ionotropic glutamate receptor C-terminal Ionotropic glutamate receptor L-glutamate and

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8VHN2-F1-model_v2	AlphaFold	Q8VHN2	1-1002	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621705	AgrOrtholog
BioCyc Gene	G2FUF-34904	BioCyc
Ensembl Genes	ENSRNOG00000012562	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000017064	ENTREZGENE
Gene3D-CATH	3.40.50.2300	UniProtKB/Swiss-Prot
	Periplasmic binding protein-like II	UniProtKB/Swiss-Prot
InterPro	Glu/Gly-bd	UniProtKB/Swiss-Prot
	Iono_rcpt_met	UniProtKB/Swiss-Prot
	Ionotropic_Glu_rcpt	UniProtKB/Swiss-Prot
	Iontro_rcpt	UniProtKB/Swiss-Prot
	Peripla_BP_I	UniProtKB/Swiss-Prot
KEGG Report	rno:170796	UniProtKB/Swiss-Prot
NCBI Gene	170796	ENTREZGENE
PANTHER	IONOTROPIC GLUTAMATE RECEPTOR	UniProtKB/Swiss-Prot
Pfam	Lig_chan	UniProtKB/Swiss-Prot
	Lig_chan-Glu_bd	UniProtKB/Swiss-Prot
PhenoGen	Grin3b	PhenoGen
PRINTS	NMDARECEPTOR	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000012562	RatGTEx
SMART	Lig_chan-Glu_bd	UniProtKB/Swiss-Prot
	PBPe	UniProtKB/Swiss-Prot
Superfamily-SCOP	Periplasmic binding protein-like II	UniProtKB/Swiss-Prot
	SSF53822	UniProtKB/Swiss-Prot
UniProt	A0A8I5YBD4_RAT	UniProtKB/TrEMBL
	A6K8U1_RAT	UniProtKB/TrEMBL
	F1LPZ6	ENTREZGENE, UniProtKB/TrEMBL
	NMD3B_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-11	Grin3b	glutamate ionotropic receptor NMDA type subunit 3B	Grin3b	glutamate receptor, ionotropic, N-methyl-D-aspartate 3B	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	Grin3b	glutamate receptor, ionotropic, N-methyl-D-aspartate 3B		glutamate receptor, ionotropic, NMDA3B	Name updated	1299863	APPROVED
2002-08-07	Grin3b	glutamate receptor, ionotropic, NMDA3B			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed predominantly in motor neurons	632842

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)