Srek1 (splicing regulatory glutamic acid and lysine rich protein 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Srek1 (splicing regulatory glutamic acid and lysine rich protein 1) Rattus norvegicus
Analyze
Symbol: Srek1
Name: splicing regulatory glutamic acid and lysine rich protein 1
RGD ID: 621696
Description: Predicted to enable RNA binding activity. Predicted to be involved in RNA splicing and mRNA processing. Predicted to be located in nucleus. Predicted to be part of spliceosomal complex. Orthologous to human SREK1 (splicing regulatory glutamic acid and lysine rich protein 1); INTERACTS WITH 17beta-estradiol; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: serine-arginine-rich splicing regulatory protein 86; serine-arginine-rich-splicing regulatory protein 86; serine/arginine-rich splicing factor 12; serine/arginine-rich-splicing regulatory protein 86; Sfrs12; splicing factor, arginine/serine-rich 12; splicing regulatory glutamic acid/lysine-rich protein 1; splicing regulatory glutamine/lysine-rich protein 1; SR-related protein of 86 kDa; Srrp86; Srsf12
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8236,583,412 - 36,618,978 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl236,583,412 - 36,619,001 (-)EnsemblGRCr8
mRatBN7.2234,849,548 - 34,885,120 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl234,852,458 - 34,884,972 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx241,974,185 - 41,993,119 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0240,032,876 - 40,051,810 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0234,874,333 - 34,893,277 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0233,806,035 - 33,841,594 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl233,809,807 - 33,841,499 (-)Ensemblrn6Rnor6.0
Rnor_5.0252,935,275 - 52,970,575 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4234,690,996 - 34,710,132 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera230,833,959 - 30,852,836 (-)NCBICelera
RGSC_v3.1234,611,364 - 34,630,501 (+)NCBI
Cytogenetic Map2q13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
clofibric acid  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dorsomorphin  (ISO)
enzyme inhibitor  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
miconazole  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
ozone  (ISO)
perfluorodecanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
potassium dichromate  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
titanium dioxide  (ISO)
torcetrapib  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
triticonazole  (EXP)
tungsten  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification and characterization of a novel serine-arginine-rich splicing regulatory protein. Barnard DC and Patton JG, Mol Cell Biol 2000 May;20(9):3049-57.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Regulation of alternative splicing by SRrp86 and its interacting proteins. Li J, etal., Mol Cell Biol. 2003 Nov;23(21):7437-47.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11991645   PMID:22681889  


Genomics

Comparative Map Data
Srek1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8236,583,412 - 36,618,978 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl236,583,412 - 36,619,001 (-)EnsemblGRCr8
mRatBN7.2234,849,548 - 34,885,120 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl234,852,458 - 34,884,972 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx241,974,185 - 41,993,119 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0240,032,876 - 40,051,810 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0234,874,333 - 34,893,277 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0233,806,035 - 33,841,594 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl233,809,807 - 33,841,499 (-)Ensemblrn6Rnor6.0
Rnor_5.0252,935,275 - 52,970,575 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4234,690,996 - 34,710,132 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera230,833,959 - 30,852,836 (-)NCBICelera
RGSC_v3.1234,611,364 - 34,630,501 (+)NCBI
Cytogenetic Map2q13NCBI
SREK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38566,144,300 - 66,183,615 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl566,139,971 - 66,183,615 (+)Ensemblhg38GRCh38
GRCh37565,440,128 - 65,479,443 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36565,475,841 - 65,512,472 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34565,489,710 - 65,512,395NCBI
Celera562,438,135 - 62,474,766 (+)NCBICelera
Cytogenetic Map5q12.3NCBI
HuRef562,397,593 - 62,436,975 (+)NCBIHuRef
CHM1_1565,440,155 - 65,479,577 (+)NCBICHM1_1
T2T-CHM13v2.0566,965,512 - 67,004,823 (+)NCBIT2T-CHM13v2.0
Srek1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913103,873,291 - 103,911,379 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13103,875,856 - 103,911,116 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3813103,738,565 - 103,774,616 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13103,739,348 - 103,774,608 (-)Ensemblmm10GRCm38
MGSCv3713104,531,695 - 104,554,662 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3613104,861,997 - 104,884,964 (-)NCBIMGSCv36mm8
Celera13108,143,950 - 108,166,676 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1356.16NCBI
Srek1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554462,908,587 - 2,947,312 (-)Ensembl
ChiLan1.0NW_0049554462,908,587 - 2,946,966 (-)NCBIChiLan1.0ChiLan1.0
SREK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2447,745,359 - 47,783,734 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1545,899,214 - 45,937,361 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0547,808,086 - 47,866,971 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1549,382,815 - 49,420,912 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl549,382,798 - 49,420,912 (-)EnsemblpanPan2panpan1.1
SREK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1251,761,727 - 51,807,124 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl251,761,763 - 51,802,694 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha248,716,220 - 48,761,604 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0252,253,007 - 52,298,423 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl252,252,970 - 52,296,028 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1249,317,712 - 49,363,064 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0250,100,815 - 50,146,240 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0250,993,761 - 51,039,212 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Srek1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213194,110,789 - 194,153,448 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364803,050,063 - 3,090,116 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364803,050,063 - 3,089,947 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SREK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1644,578,783 - 44,620,094 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11644,578,531 - 44,621,898 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21647,921,725 - 47,956,625 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SREK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1462,338,417 - 62,376,960 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604910,988,753 - 11,027,660 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Srek1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248153,645,968 - 3,682,836 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248153,646,520 - 3,682,844 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Srek1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13193,581,483 - 193,616,921 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Srek1
359 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:45
Count of miRNA genes:40
Interacting mature miRNAs:45
Transcripts:ENSRNOT00000040533
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21332504158325041Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22411781369117813Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2142977529Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
9590080Insglur4Insulin/glucose ratio QTL 428.70.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)2615276751152767Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)23561408353462005Rat
1579916Bp270Blood pressure QTL 2700.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21605188361051883Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22203804467038044Rat
731166Mamtr2Mammary tumor resistance QTL 20.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2962358154623581Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22888999173889991Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21436870759368707Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2962358144538110Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266683465677Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)2573632550736325Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21822713763227137Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
1582246Cm60Cardiac mass QTL 605.8heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)23326999678269996Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266673652666Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000040533   ⟹   ENSRNOP00000049050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl236,583,412 - 36,618,878 (-)Ensembl
mRatBN7.2 Ensembl234,853,084 - 34,884,972 (-)Ensembl
Rnor_6.0 Ensembl233,809,807 - 33,841,499 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097103   ⟹   ENSRNOP00000097810
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl234,852,458 - 34,884,946 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098044   ⟹   ENSRNOP00000093834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl236,583,412 - 36,618,878 (-)Ensembl
mRatBN7.2 Ensembl234,852,458 - 34,884,946 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102302   ⟹   ENSRNOP00000085824
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl236,583,412 - 36,619,001 (-)Ensembl
mRatBN7.2 Ensembl234,852,458 - 34,884,946 (-)Ensembl
RefSeq Acc Id: NM_001412515   ⟹   NP_001399444
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8236,583,412 - 36,618,878 (-)NCBI
mRatBN7.2234,849,548 - 34,885,015 (-)NCBI
RefSeq Acc Id: NM_020092   ⟹   NP_064477
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8236,583,412 - 36,606,846 (-)NCBI
mRatBN7.2234,849,548 - 34,872,983 (-)NCBI
Rnor_6.0233,810,005 - 33,828,921 (-)NCBI
Rnor_5.0252,935,275 - 52,970,575 (-)NCBI
RGSC_v3.4234,690,996 - 34,710,132 (+)RGD
Celera230,833,959 - 30,852,836 (-)RGD
Sequence:
RefSeq Acc Id: XM_039102993   ⟹   XP_038958921
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8236,585,430 - 36,618,978 (-)NCBI
mRatBN7.2234,849,552 - 34,885,108 (-)NCBI
RefSeq Acc Id: XM_039102994   ⟹   XP_038958922
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8236,585,430 - 36,610,286 (-)NCBI
mRatBN7.2234,849,552 - 34,877,664 (-)NCBI
RefSeq Acc Id: XM_063282421   ⟹   XP_063138491
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8236,585,430 - 36,610,286 (-)NCBI
RefSeq Acc Id: XM_063282422   ⟹   XP_063138492
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8236,600,673 - 36,618,978 (-)NCBI
RefSeq Acc Id: NP_064477   ⟸   NM_020092
- Peptide Label: isoform 2
- UniProtKB: Q9JKL7 (UniProtKB/Swiss-Prot),   A6I5E4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000049050   ⟸   ENSRNOT00000040533
RefSeq Acc Id: XP_038958921   ⟸   XM_039102993
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AGJ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038958922   ⟸   XM_039102994
- Peptide Label: isoform X3
- UniProtKB: Q9JKL7 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000093834   ⟸   ENSRNOT00000098044
Ensembl Acc Id: ENSRNOP00000085824   ⟸   ENSRNOT00000102302
Ensembl Acc Id: ENSRNOP00000097810   ⟸   ENSRNOT00000097103
RefSeq Acc Id: NP_001399444   ⟸   NM_001412515
- Peptide Label: isoform 1
- UniProtKB: A0A8I6A4G5 (UniProtKB/TrEMBL),   A6I5E3 (UniProtKB/TrEMBL),   A0A8I6AGJ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138491   ⟸   XM_063282421
- Peptide Label: isoform X2
- UniProtKB: Q9JKL7 (UniProtKB/Swiss-Prot),   A6I5E4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138492   ⟸   XM_063282422
- Peptide Label: isoform X4
Protein Domains
RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JKL7-F1-model_v2 AlphaFold Q9JKL7 1-494 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691118
Promoter ID:EPDNEW_R1643
Type:initiation region
Name:Srek1_1
Description:splicing regulatory glutamic acid and lysine rich protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0233,841,501 - 33,841,561EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621696 AgrOrtholog
BioCyc Gene G2FUF-54563 BioCyc
Ensembl Genes ENSRNOG00000032735 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000098044 ENTREZGENE
  ENSRNOT00000102302 ENTREZGENE
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot
  RBD_domain_sf UniProtKB/Swiss-Prot
  RRM_dom UniProtKB/Swiss-Prot
  SREK1_RRM2 UniProtKB/Swiss-Prot
KEGG Report rno:56763 UniProtKB/Swiss-Prot
NCBI Gene 56763 ENTREZGENE
PANTHER SERINE/ARGININE-RICH SPLICING FACTOR UniProtKB/Swiss-Prot
  SPLICING REGULATORY GLUTAMINE/LYSINE-RICH PROTEIN 1 UniProtKB/Swiss-Prot
Pfam RRM_1 UniProtKB/Swiss-Prot
PhenoGen Srek1 PhenoGen
PROSITE RRM UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000032735 RatGTEx
SMART RRM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot
UniProt A0A8I6A4G5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AGJ5 ENTREZGENE, UniProtKB/TrEMBL
  A6I5E3 ENTREZGENE, UniProtKB/TrEMBL
  A6I5E4 ENTREZGENE, UniProtKB/TrEMBL
  G3V9I9_RAT UniProtKB/TrEMBL
  Q9JKL7 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-15 Srek1  splicing regulatory glutamic acid and lysine rich protein 1  Srek1  splicing regulatory glutamic acid/lysine-rich protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-01-13 Srek1  splicing regulatory glutamic acid/lysine-rich protein 1  Srek1  splicing regulatory glutamine/lysine-rich protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-01 Srek1  splicing regulatory glutamine/lysine-rich protein 1  Sfrs12  splicing factor, arginine/serine-rich 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-07-22 Sfrs12  splicing factor, arginine/serine-rich 12  Srek1  splicing regulatory glutamine/lysine-rich protein 1   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-07-13 Srek1  splicing regulatory glutamine/lysine-rich protein 1   Sfrs12  splicing factor, arginine/serine-rich 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-09-20 Sfrs12  splicing factor, arginine/serine-rich 12  Srsf12  serine/arginine-rich splicing factor 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-09-14 Srsf12  serine/arginine-rich splicing factor 12  Sfrs12  splicing factor, arginine/serine-rich 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Sfrs12  splicing factor, arginine/serine-rich 12  Srrp86  serine-arginine-rich splicing regulatory protein 86  Symbol and Name updated 1299863 APPROVED
2002-08-07 Srrp86  serine-arginine-rich splicing regulatory protein 86      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process inhibits the ability of purified SR proteins to activate splicing and activates splicing in the presence of SRp20 634220
gene_product member of the SR protein family 634220
gene_protein precipitates in high magnesium concentrations 634220