Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Pou2f2 | Rat | 1,2-dimethylhydrazine | increases expression | ISO | Pou2f2 (Mus musculus) | 6480464 | 1,2-Dimethylhydrazine results in increased expression of POU2F2 mRNA | CTD | PMID:22206623 | Pou2f2 | Rat | 17beta-estradiol | multiple interactions | ISO | POU2F2 (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in increased expression of POU2F2 mRNA | CTD | PMID:30165855 | Pou2f2 | Rat | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of POU2F2 mRNA | CTD | PMID:32741896 | Pou2f2 | Rat | 17beta-estradiol 3-benzoate | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of POU2F2 mRNA | CTD | PMID:32741896 | Pou2f2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Pou2f2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of POU2F2 mRNA | CTD | PMID:24058054|PMID:24680724 | Pou2f2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of POU2F2 mRNA | CTD | PMID:34747641 | Pou2f2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Pou2f2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of POU2F2 mRNA | CTD | PMID:37172768 | Pou2f2 | Rat | 4,4'-sulfonyldiphenol | decreases expression | ISO | Pou2f2 (Mus musculus) | 6480464 | bisphenol S results in decreased expression of POU2F2 mRNA | CTD | PMID:30951980 | Pou2f2 | Rat | 4,4'-sulfonyldiphenol | affects methylation | ISO | Pou2f2 (Mus musculus) | 6480464 | bisphenol S affects the methylation of POU2F2 gene | CTD | PMID:31683443 | Pou2f2 | Rat | 4,4'-sulfonyldiphenol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of more ... | CTD | PMID:36041667 | Pou2f2 | Rat | 4,4'-sulfonyldiphenol | decreases methylation | ISO | POU2F2 (Homo sapiens) | 6480464 | bisphenol S results in decreased methylation of POU2F2 gene | CTD | PMID:31601247 | Pou2f2 | Rat | 4,4'-sulfonyldiphenol | decreases methylation | ISO | Pou2f2 (Mus musculus) | 6480464 | bisphenol S results in decreased methylation of POU2F2 exon | CTD | PMID:33297965 | Pou2f2 | Rat | 4-hydroxynon-2-enal | decreases expression | ISO | Pou2f2 (Mus musculus) | 6480464 | 4-hydroxy-2-nonenal results in decreased expression of POU2F2 mRNA | CTD | PMID:19191707 | Pou2f2 | Rat | 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole | multiple interactions | ISO | POU2F2 (Homo sapiens) | 6480464 | Omeprazole inhibits the reaction [Cisplatin results in increased expression of POU2F2 protein] | CTD | PMID:30452898 | Pou2f2 | Rat | 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole | multiple interactions | EXP | | 6480464 | Omeprazole inhibits the reaction [Cisplatin results in increased expression of POU2F2 protein] | CTD | PMID:30452898 | Pou2f2 | Rat | 6-propyl-2-thiouracil | affects expression | EXP | | 6480464 | Propylthiouracil affects the expression of POU2F2 mRNA | CTD | PMID:24780913 | Pou2f2 | Rat | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of POU2F2 mRNA | CTD | PMID:31881176 | Pou2f2 | Rat | alpha-Zearalanol | increases expression | EXP | | 6480464 | Zeranol results in increased expression of POU2F2 mRNA | CTD | PMID:35163327 | Pou2f2 | Rat | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of POU2F2 mRNA | CTD | PMID:16483693 | Pou2f2 | Rat | amosite asbestos | decreases methylation | ISO | POU2F2 (Homo sapiens) | 6480464 | Asbestos, Amosite results in decreased methylation of POU2F2 promoter | CTD | PMID:29626692 | Pou2f2 | Rat | amphetamine | decreases expression | EXP | | 6480464 | Amphetamine results in decreased expression of POU2F2 mRNA | CTD | PMID:30779732 | Pou2f2 | Rat | antirheumatic drug | decreases expression | ISO | POU2F2 (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of POU2F2 mRNA | CTD | PMID:24449571 | Pou2f2 | Rat | aripiprazole | multiple interactions | ISO | POU2F2 (Homo sapiens) | 6480464 | [Aripiprazole co-treated with Ozone] results in increased expression of POU2F2 mRNA | CTD | PMID:31476115 | Pou2f2 | Rat | Aroclor 1254 | increases expression | EXP | | 6480464 | Chlorodiphenyl (54% Chlorine) results in increased expression of POU2F2 mRNA | CTD | PMID:34858468 | Pou2f2 | Rat | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of POU2F2 gene | CTD | PMID:28931070 | Pou2f2 | Rat | atrazine | decreases expression | EXP | | 6480464 | Atrazine results in decreased expression of POU2F2 mRNA | CTD | PMID:36841081 | Pou2f2 | Rat | benzo[a]pyrene | affects methylation | ISO | POU2F2 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of POU2F2 3' UTR; Benzo(a)pyrene affects the methylation of POU2F2 promoter | CTD | PMID:27901495 | Pou2f2 | Rat | benzo[a]pyrene | increases expression | ISO | POU2F2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of POU2F2 mRNA | CTD | PMID:35870112 | Pou2f2 | Rat | benzo[a]pyrene | increases methylation | ISO | POU2F2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of POU2F2 5' UTR | CTD | PMID:27901495 | Pou2f2 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of POU2F2 mRNA | CTD | PMID:25181051|PMID:34947998 | Pou2f2 | Rat | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of more ... | CTD | PMID:36041667 | Pou2f2 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of POU2F2 mRNA | CTD | PMID:34858468 | Pou2f2 | Rat | bisphenol A | affects methylation | ISO | Pou2f2 (Mus musculus) | 6480464 | bisphenol A affects the methylation of POU2F2 promoter | CTD | PMID:27334623 | Pou2f2 | Rat | bisphenol F | multiple interactions | ISO | POU2F2 (Homo sapiens) | 6480464 | [bisphenol F co-treated with Fulvestrant] results in increased methylation of POU2F2 gene | CTD | PMID:31601247 | Pou2f2 | Rat | bisphenol F | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of more ... | CTD | PMID:36041667 | Pou2f2 | Rat | buta-1,3-diene | decreases expression | ISO | Pou2f2 (Mus musculus) | 6480464 | 1,3-butadiene results in decreased expression of POU2F2 mRNA | CTD | PMID:29038090 | Pou2f2 | Rat | cadmium dichloride | decreases expression | EXP | | 6480464 | Cadmium Chloride results in decreased expression of POU2F2 mRNA | CTD | PMID:33453195 | Pou2f2 | Rat | cadmium dichloride | increases expression | ISO | POU2F2 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of POU2F2 mRNA | CTD | PMID:38568856 | Pou2f2 | Rat | carbon nanotube | decreases expression | ISO | Pou2f2 (Mus musculus) | 6480464 | Nanotubes, Carbon analog results in decreased expression of POU2F2 mRNA; Nanotubes, Carbon results in decreased more ... | CTD | PMID:25554681 | Pou2f2 | Rat | chlorpyrifos | increases expression | EXP | | 6480464 | Chlorpyrifos results in increased expression of POU2F2 mRNA | CTD | PMID:34858468 | Pou2f2 | Rat | choline | multiple interactions | ISO | Pou2f2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation more ... | CTD | PMID:20938992 | Pou2f2 | Rat | cisplatin | multiple interactions | ISO | POU2F2 (Homo sapiens) | 6480464 | Omeprazole inhibits the reaction [Cisplatin results in increased expression of POU2F2 protein] | CTD | PMID:30452898 | Pou2f2 | Rat | cisplatin | increases expression | EXP | | 6480464 | Cisplatin results in increased expression of POU2F2 protein | CTD | PMID:30452898 | Pou2f2 | Rat | cisplatin | increases expression | ISO | POU2F2 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of POU2F2 protein | CTD | PMID:30452898 | Pou2f2 | Rat | cisplatin | multiple interactions | EXP | | 6480464 | Omeprazole inhibits the reaction [Cisplatin results in increased expression of POU2F2 protein] | CTD | PMID:30452898 | Pou2f2 | Rat | crocidolite asbestos | decreases methylation | ISO | POU2F2 (Homo sapiens) | 6480464 | Asbestos, Crocidolite results in decreased methylation of POU2F2 promoter | CTD | PMID:29626692 | Pou2f2 | Rat | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of POU2F2 mRNA | CTD | PMID:26577399 | Pou2f2 | Rat | diazinon | increases methylation | ISO | POU2F2 (Homo sapiens) | 6480464 | Diazinon results in increased methylation of POU2F2 gene | CTD | PMID:22964155 | Pou2f2 | Rat | diclofenac | increases expression | ISO | Pou2f2 (Mus musculus) | 6480464 | Diclofenac results in increased expression of POU2F2 mRNA | CTD | PMID:26934552 | Pou2f2 | Rat | dimethylarsinic acid | multiple interactions | ISO | Pou2f2 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results more ... | CTD | PMID:34876320 | Pou2f2 | Rat | doxorubicin | decreases expression | ISO | POU2F2 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of POU2F2 mRNA | CTD | PMID:29803840 | Pou2f2 | Rat | ethanol | increases expression | ISO | Pou2f2 (Mus musculus) | 6480464 | Ethanol results in increased expression of POU2F2 mRNA | CTD | PMID:30319688 | Pou2f2 | Rat | ethyl methanesulfonate | increases expression | ISO | POU2F2 (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in increased expression of POU2F2 mRNA | CTD | PMID:23649840 | Pou2f2 | Rat | folic acid | multiple interactions | ISO | Pou2f2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation more ... | CTD | PMID:20938992 | Pou2f2 | Rat | formaldehyde | increases expression | ISO | POU2F2 (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of POU2F2 mRNA | CTD | PMID:23649840 | Pou2f2 | Rat | formaldehyde | decreases expression | ISO | POU2F2 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of POU2F2 mRNA | CTD | PMID:28937961 | Pou2f2 | Rat | fulvestrant | multiple interactions | ISO | POU2F2 (Homo sapiens) | 6480464 | [bisphenol F co-treated with Fulvestrant] results in increased methylation of POU2F2 gene | CTD | PMID:31601247 | Pou2f2 | Rat | GSK-J4 | decreases expression | ISO | POU2F2 (Homo sapiens) | 6480464 | GSK-J4 results in decreased expression of POU2F2 mRNA | CTD | PMID:29301935 | Pou2f2 | Rat | ionomycin | multiple interactions | ISO | POU2F2 (Homo sapiens) | 6480464 | [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of POU2F2 mRNA; pyrrolidine dithiocarbamic acid more ... | CTD | PMID:15477007 | Pou2f2 | Rat | L-methionine | multiple interactions | ISO | Pou2f2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation more ... | CTD | PMID:20938992 | Pou2f2 | Rat | lead diacetate | increases activity | EXP | | 6480464 | lead acetate results in increased activity of POU2F2 protein | CTD | PMID:17093203 | Pou2f2 | Rat | lead diacetate | increases expression | EXP | | 6480464 | lead acetate results in increased expression of POU2F2 mRNA; lead acetate results in increased expression more ... | CTD | PMID:17093203 | Pou2f2 | Rat | lead(0) | increases expression | EXP | | 6480464 | Lead results in increased expression of POU2F2 mRNA; Lead results in increased expression of POU2F2 more ... | CTD | PMID:17093203 | Pou2f2 | Rat | lead(0) | increases activity | EXP | | 6480464 | Lead results in increased activity of POU2F2 protein | CTD | PMID:17093203 | Pou2f2 | Rat | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of POU2F2 gene | CTD | PMID:35440735 | Pou2f2 | Rat | methylarsonic acid | multiple interactions | ISO | Pou2f2 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results more ... | CTD | PMID:34876320 | Pou2f2 | Rat | N,N-diethyl-m-toluamide | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in decreased methylation of POU2F2 gene | CTD | PMID:33148267 | Pou2f2 | Rat | N-nitrosodiethylamine | multiple interactions | ISO | Pou2f2 (Mus musculus) | 6480464 | [Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of POU2F2 gene | CTD | PMID:23968726 | Pou2f2 | Rat | nickel atom | increases expression | ISO | POU2F2 (Homo sapiens) | 6480464 | Nickel results in increased expression of POU2F2 mRNA | CTD | PMID:25583101 | Pou2f2 | Rat | nitrates | multiple interactions | ISO | Pou2f2 (Mus musculus) | 6480464 | [Particulate Matter results in increased abundance of Nitrates] which results in increased expression of POU2F2 more ... | CTD | PMID:35964746 | Pou2f2 | Rat | okadaic acid | increases expression | ISO | POU2F2 (Homo sapiens) | 6480464 | Okadaic Acid results in increased expression of POU2F2 mRNA | CTD | PMID:38832940 | Pou2f2 | Rat | omeprazole | multiple interactions | ISO | POU2F2 (Homo sapiens) | 6480464 | Omeprazole inhibits the reaction [Cisplatin results in increased expression of POU2F2 protein] | CTD | PMID:30452898 | Pou2f2 | Rat | omeprazole | multiple interactions | EXP | | 6480464 | Omeprazole inhibits the reaction [Cisplatin results in increased expression of POU2F2 protein] | CTD | PMID:30452898 | Pou2f2 | Rat | ozone | multiple interactions | ISO | POU2F2 (Homo sapiens) | 6480464 | [Aripiprazole co-treated with Ozone] results in increased expression of POU2F2 mRNA | CTD | PMID:31476115 | Pou2f2 | Rat | ozone | multiple interactions | ISO | Pou2f2 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased more ... | CTD | PMID:34911549 | Pou2f2 | Rat | ozone | increases expression | ISO | POU2F2 (Homo sapiens) | 6480464 | Ozone results in increased expression of POU2F2 mRNA | CTD | PMID:31476115 | Pou2f2 | Rat | perfluorohexanesulfonic acid | increases expression | ISO | Pou2f2 (Mus musculus) | 6480464 | perfluorohexanesulfonic acid results in increased expression of POU2F2 mRNA | CTD | PMID:37315490 | Pou2f2 | Rat | permethrin | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in decreased methylation of POU2F2 gene | CTD | PMID:33148267 | Pou2f2 | Rat | phorbol 13-acetate 12-myristate | multiple interactions | ISO | POU2F2 (Homo sapiens) | 6480464 | [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of POU2F2 mRNA; pyrrolidine dithiocarbamic acid more ... | CTD | PMID:15477007 | Pou2f2 | Rat | piperonyl butoxide | multiple interactions | ISO | Pou2f2 (Mus musculus) | 6480464 | [Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of POU2F2 gene | CTD | PMID:23968726 | Pou2f2 | Rat | pyrrolidine dithiocarbamate | multiple interactions | ISO | POU2F2 (Homo sapiens) | 6480464 | pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression more ... | CTD | PMID:15477007 | Pou2f2 | Rat | serpentine asbestos | decreases methylation | ISO | POU2F2 (Homo sapiens) | 6480464 | Asbestos, Serpentine results in decreased methylation of POU2F2 promoter | CTD | PMID:29626692 | Pou2f2 | Rat | silicon dioxide | increases expression | ISO | POU2F2 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in increased expression of POU2F2 mRNA | CTD | PMID:23806026 | Pou2f2 | Rat | sodium arsenate | multiple interactions | ISO | Pou2f2 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results more ... | CTD | PMID:34876320 | Pou2f2 | Rat | sodium arsenate | increases expression | ISO | Pou2f2 (Mus musculus) | 6480464 | sodium arsenate results in increased expression of POU2F2 mRNA | CTD | PMID:39847705 | Pou2f2 | Rat | sodium arsenite | increases expression | ISO | POU2F2 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of POU2F2 mRNA | CTD | PMID:12377979 | Pou2f2 | Rat | sodium arsenite | multiple interactions | ISO | Pou2f2 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results more ... | CTD | PMID:34876320 | Pou2f2 | Rat | sotorasib | multiple interactions | ISO | POU2F2 (Homo sapiens) | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of POU2F2 mRNA | CTD | PMID:36139627 | Pou2f2 | Rat | succimer | multiple interactions | ISO | Pou2f2 (Mus musculus) | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in increased expression of POU2F2 mRNA | CTD | PMID:21641980 | Pou2f2 | Rat | testosterone | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of POU2F2 mRNA | CTD | PMID:32741896 | Pou2f2 | Rat | thiram | increases expression | ISO | POU2F2 (Homo sapiens) | 6480464 | Thiram results in increased expression of POU2F2 mRNA | CTD | PMID:38568856 | Pou2f2 | Rat | trametinib | multiple interactions | ISO | POU2F2 (Homo sapiens) | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of POU2F2 mRNA | CTD | PMID:36139627 | Pou2f2 | Rat | trimellitic anhydride | increases expression | ISO | Pou2f2 (Mus musculus) | 6480464 | trimellitic anhydride results in increased expression of POU2F2 mRNA | CTD | PMID:19042947 | Pou2f2 | Rat | valproic acid | increases expression | ISO | Pou2f2 (Mus musculus) | 6480464 | Valproic Acid results in increased expression of POU2F2 mRNA | CTD | PMID:21427059 | Pou2f2 | Rat | valproic acid | increases methylation | ISO | POU2F2 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of POU2F2 gene | CTD | PMID:29154799 | Pou2f2 | Rat | vinclozolin | increases methylation | EXP | | 6480464 | vinclozolin results in increased methylation of POU2F2 gene | CTD | PMID:31079544 | Pou2f2 | Rat | vorinostat | decreases expression | ISO | POU2F2 (Homo sapiens) | 6480464 | vorinostat results in decreased expression of POU2F2 mRNA | CTD | PMID:27188386 | Pou2f2 | Rat | zinc atom | multiple interactions | ISO | POU2F2 (Homo sapiens) | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of POU2F2 mRNA | CTD | PMID:18593933 | Pou2f2 | Rat | zinc(0) | multiple interactions | ISO | POU2F2 (Homo sapiens) | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of POU2F2 mRNA | CTD | PMID:18593933 | |






















