Fads1 (fatty acid desaturase 1) - Rat Genome Database

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Gene: Fads1 (fatty acid desaturase 1) Rattus norvegicus
Analyze
Symbol: Fads1
Name: fatty acid desaturase 1
RGD ID: 621678
Description: Enables acyl-CoA (8-3)-desaturase activity. Involved in several processes, including response to fenofibrate; response to vitamin A; and unsaturated fatty acid metabolic process. Predicted to be located in endoplasmic reticulum membrane and mitochondrion. Predicted to be active in membrane. Biomarker of congestive heart failure; hypertension; and obesity. Orthologous to human FADS1 (fatty acid desaturase 1); PARTICIPATES IN alpha-linolenic acid metabolic pathway; linoleic acid metabolic pathway; unsaturated fatty acid biosynthetic pathway; INTERACTS WITH (+)-schisandrin B; (+)-sesamin; 1-(3-(trifluoromethyl)phenyl)piperazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: acyl-CoA (8-3)-desaturase; D5D; delta(5) desaturase; delta(5) fatty acid desaturase; delta-5 desaturase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81216,252,605 - 216,267,618 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1216,252,602 - 216,267,615 (+)EnsemblGRCr8
mRatBN7.21206,827,724 - 206,842,734 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1206,827,765 - 206,842,734 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1215,206,218 - 215,221,144 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01222,261,434 - 222,276,337 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01214,956,433 - 214,971,336 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01226,234,034 - 226,249,118 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1226,234,074 - 226,249,138 (+)Ensemblrn6Rnor6.0
Rnor_5.01233,178,735 - 233,193,802 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41212,670,792 - 212,685,718 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1204,324,218 - 204,339,144 (+)NCBICelera
RGSC_v3.11212,829,200 - 212,844,142 (+)NCBI
Cytogenetic Map1q43NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(+)-sesamin  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-(3-(trifluoromethyl)phenyl)piperazine  (EXP)
1-benzylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
25-hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
alpha-linolenic acid  (ISO)
amiodarone  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
arachidonic acid  (ISO)
aristolochic acid A  (EXP,ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP,ISO)
bezafibrate  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (EXP,ISO)
bromobenzene  (EXP)
buspirone  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chloroform  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (EXP)
coumestrol  (ISO)
curcumin  (EXP,ISO)
cyanocob(III)alamin  (EXP)
cyclosporin A  (EXP,ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dibromoacetic acid  (EXP)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
diethylstilbestrol  (EXP)
dorsomorphin  (ISO)
endosulfan  (EXP)
erythromycin estolate  (EXP)
ethanol  (ISO)
fenofibrate  (ISO)
flutamide  (EXP)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
gemfibrozil  (EXP)
gentamycin  (EXP)
geraniol  (ISO)
glafenine  (EXP)
GSK-J4  (ISO)
indometacin  (ISO)
isotretinoin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lithocholic acid  (ISO)
mercury dichloride  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
miconazole  (ISO)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
naled  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phytosterols  (ISO)
pirinixic acid  (EXP,ISO)
probenecid  (EXP)
progesterone  (ISO)
propiconazole  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
streptozocin  (EXP)
sulfadimethoxine  (EXP)
tamoxifen  (EXP,ISO)
tauroursodeoxycholic acid  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thapsigargin  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
troglitazone  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Desaturase activities in rat model of insulin resistance induced by a sucrose-rich diet. Brenner RR, etal., Lipids. 2003 Jul;38(7):733-42.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Effect of simvastatin on desaturase activities in liver from lean and obese Zucker rats. Georges B, etal., Lipids. 1993 Jan;28(1):63-5.
4. Delta 5 desaturase activity in rat kidney microsomes. Irazu CE, etal., Mol Cell Biochem. 1993 Dec 8;129(1):31-7.
5. Age-related changes in delta 6 and delta 5 desaturase activities in rat liver microsomes. Maniongui C, etal., Lipids. 1993 Apr;28(4):291-7.
6. Psychosocial stress, catecholamines, and essential fatty acid metabolism in rats. Mills DE, etal., Proc Soc Exp Biol Med. 1994 Jan;205(1):56-61.
7. Effects of fenofibrate and insulin on the biosynthesis of unsaturated fatty acids in streptozotocin diabetic rats. Montanaro MA, etal., Prostaglandins Leukot Essent Fatty Acids. 2005 Nov;73(5):369-78.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Long-term melatonin administration reduces hyperinsulinemia and improves the altered fatty-acid compositions in type 2 diabetic rats via the restoration of Delta-5 desaturase activity. Nishida S, etal., J Pineal Res. 2002 Jan;32(1):26-33.
10. L-Carnitine prevents the development of ventricular fibrosis and heart failure with preserved ejection fraction in hypertensive heart disease. Omori Y, etal., J Hypertens. 2012 Sep;30(9):1834-44. doi: 10.1097/HJH.0b013e3283569c5a.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Trans-vaccenate is Δ13-desaturated by FADS3 in rodents. Rioux V, etal., J Lipid Res. 2013 Dec;54(12):3438-52. doi: 10.1194/jlr.M042572. Epub 2013 Sep 25.
16. Synthesis of long-chain polyunsaturated fatty acids in lactating mammary gland: role of Delta5 and Delta6 desaturases, SREBP-1, PPARalpha, and PGC-1. Rodriguez-Cruz M, etal., J Lipid Res. 2006 Mar;47(3):553-60. Epub 2005 Dec 6.
17. Desaturase activities are depleted before and after weaning in liver microsomes of spontaneously hypertensive rats. Savelli JL, etal., Prostaglandins Leukot Essent Fatty Acids. 2002 May-Jun;66(5-6):541-7.
18. Fatty acid delta 5 desaturation in rat liver cell nuclei. Ves-Losada A and Brenner RR, Mol Cell Biochem. 1995 Jan 26;142(2):163-70.
19. Fatty acid delta(5)-desaturase mRNA is regulated by dietary vitamin A and exogenous retinoic acid in liver of adult rats. Zolfaghari R, etal., Arch Biochem Biophys 2001 Jul 1;391(1):8-15.
Additional References at PubMed
PMID:10601301   PMID:16846730   PMID:19157821   PMID:19946888   PMID:22133376  


Genomics

Comparative Map Data
Fads1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81216,252,605 - 216,267,618 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1216,252,602 - 216,267,615 (+)EnsemblGRCr8
mRatBN7.21206,827,724 - 206,842,734 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1206,827,765 - 206,842,734 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1215,206,218 - 215,221,144 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01222,261,434 - 222,276,337 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01214,956,433 - 214,971,336 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01226,234,034 - 226,249,118 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1226,234,074 - 226,249,138 (+)Ensemblrn6Rnor6.0
Rnor_5.01233,178,735 - 233,193,802 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41212,670,792 - 212,685,718 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1204,324,218 - 204,339,144 (+)NCBICelera
RGSC_v3.11212,829,200 - 212,844,142 (+)NCBI
Cytogenetic Map1q43NCBI
FADS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,799,627 - 61,817,003 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,799,624 - 61,829,318 (-)Ensemblhg38GRCh38
GRCh371161,567,099 - 61,584,475 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361161,323,679 - 61,340,886 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341161,323,674 - 61,340,886NCBI
Celera1158,902,499 - 58,919,931 (-)NCBICelera
Cytogenetic Map11q12.2NCBI
HuRef1157,895,333 - 57,912,766 (-)NCBIHuRef
CHM1_11161,450,312 - 61,467,744 (-)NCBICHM1_1
T2T-CHM13v2.01161,788,544 - 61,805,920 (-)NCBIT2T-CHM13v2.0
Fads1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391910,160,245 - 10,174,238 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1910,160,252 - 10,174,241 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381910,182,877 - 10,196,874 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1910,182,888 - 10,196,877 (+)Ensemblmm10GRCm38
MGSCv371910,257,378 - 10,271,364 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361910,250,018 - 10,263,922 (+)NCBIMGSCv36mm8
Celera1910,878,803 - 10,892,791 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map196.54NCBI
Fads1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555115,907,726 - 5,915,764 (+)Ensembl
ChiLan1.0NW_0049555115,908,394 - 5,915,764 (+)NCBIChiLan1.0ChiLan1.0
FADS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2962,967,955 - 62,987,259 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11164,012,583 - 64,028,644 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01157,101,553 - 57,116,243 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11160,462,420 - 60,476,798 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1160,462,420 - 60,476,798 (-)EnsemblpanPan2panpan1.1
FADS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11854,659,406 - 54,672,803 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1854,659,406 - 54,670,623 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1853,240,872 - 53,254,256 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01855,712,876 - 55,726,262 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1855,712,831 - 55,724,132 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11854,773,452 - 54,786,834 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01854,394,906 - 54,406,186 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01855,262,070 - 55,273,351 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fads1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494711,198,378 - 11,213,211 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365811,312,183 - 1,327,998 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365811,312,199 - 1,327,046 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FADS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl29,735,322 - 9,750,506 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.129,735,425 - 9,747,405 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.229,250,849 - 9,262,860 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FADS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1112,037,173 - 12,051,907 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl112,037,513 - 12,055,159 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038109,411,319 - 109,425,855 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fads1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624926598,922 - 606,611 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624926594,421 - 607,654 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Fads1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v129,660,162 - 9,674,713 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fads1
120 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:263
Count of miRNA genes:165
Interacting mature miRNAs:208
Transcripts:ENSRNOT00000027834
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1207243873252243873Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1207243873252243873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1209203273254203273Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1207243873252243873Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1203300512229359342Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1191190115223964326Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1212738576257738576Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1208798288253798288Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1197807365233480676Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1202851915223964440Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1207099883252099883Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat

Markers in Region
BF396356  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21206,833,139 - 206,833,334 (+)MAPPERmRatBN7.2
Rnor_6.01226,239,524 - 226,239,718NCBIRnor6.0
Rnor_5.01233,184,208 - 233,184,402UniSTSRnor5.0
RGSC_v3.41212,676,124 - 212,676,318UniSTSRGSC3.4
Celera1204,329,550 - 204,329,744UniSTS
RH 3.4 Map19127.6UniSTS
Cytogenetic Map1q43UniSTS
RH137120  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21206,842,472 - 206,842,691 (+)MAPPERmRatBN7.2
Rnor_6.01226,248,857 - 226,249,075NCBIRnor6.0
Rnor_5.01233,193,541 - 233,193,759UniSTSRnor5.0
RGSC_v3.41212,685,457 - 212,685,675UniSTSRGSC3.4
Celera1204,338,883 - 204,339,101UniSTS
RH 3.4 Map11519.7UniSTS
Cytogenetic Map1q43UniSTS
RH70629  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21206,833,215 - 206,834,427 (+)MAPPERmRatBN7.2
Rnor_6.01226,239,600 - 226,240,811NCBIRnor6.0
Rnor_5.01233,184,284 - 233,185,495UniSTSRnor5.0
RGSC_v3.41212,676,200 - 212,677,411UniSTSRGSC3.4
Celera1204,329,626 - 204,330,837UniSTS
Cytogenetic Map1q43UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 88 59 6 352 188 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000027834   ⟹   ENSRNOP00000027834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1216,252,629 - 216,267,615 (+)Ensembl
mRatBN7.2 Ensembl1206,827,765 - 206,842,730 (+)Ensembl
Rnor_6.0 Ensembl1226,234,074 - 226,249,138 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112242   ⟹   ENSRNOP00000083085
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1216,252,602 - 216,267,614 (+)Ensembl
mRatBN7.2 Ensembl1206,827,776 - 206,842,734 (+)Ensembl
RefSeq Acc Id: NM_053445   ⟹   NP_445897
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,252,692 - 216,267,618 (+)NCBI
mRatBN7.21206,827,808 - 206,842,734 (+)NCBI
Rnor_6.01226,234,113 - 226,249,118 (+)NCBI
Rnor_5.01233,178,735 - 233,193,802 (+)NCBI
RGSC_v3.41212,670,792 - 212,685,718 (+)RGD
Celera1204,324,218 - 204,339,144 (+)RGD
Sequence:
RefSeq Acc Id: XM_006231075   ⟹   XP_006231137
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,252,605 - 216,267,618 (+)NCBI
mRatBN7.21206,827,724 - 206,842,734 (+)NCBI
Rnor_6.01226,234,034 - 226,249,118 (+)NCBI
Rnor_5.01233,178,735 - 233,193,802 (+)NCBI
Sequence:
RefSeq Acc Id: NP_445897   ⟸   NM_053445
- UniProtKB: Q9EPV4 (UniProtKB/Swiss-Prot),   Q920R3 (UniProtKB/Swiss-Prot),   A6I010 (UniProtKB/TrEMBL),   H2BF30 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231137   ⟸   XM_006231075
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZYM0 (UniProtKB/TrEMBL),   H2BF30 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027834   ⟸   ENSRNOT00000027834
Ensembl Acc Id: ENSRNOP00000083085   ⟸   ENSRNOT00000112242
Protein Domains
Cytochrome b5 heme-binding   Fatty acid desaturase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q920R3-F1-model_v2 AlphaFold Q920R3 1-447 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690766
Promoter ID:EPDNEW_R1291
Type:initiation region
Name:Fads1_1
Description:fatty acid desaturase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01226,234,070 - 226,234,130EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621678 AgrOrtholog
BioCyc Gene G2FUF-56440 BioCyc
BioCyc Pathway PWY-7049 [icosapentaenoate biosynthesis II (6-desaturase, mammals)] BioCyc
  PWY-7592 [arachidonate biosynthesis III (6-desaturase, mammals)] BioCyc
BioCyc Pathway Image PWY-7049 BioCyc
  PWY-7592 BioCyc
Ensembl Genes ENSRNOG00000020480 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000027834 ENTREZGENE
  ENSRNOT00000112242 ENTREZGENE
Gene3D-CATH 3.10.120.10 UniProtKB/Swiss-Prot
InterPro Cyt_B5-like_heme/steroid-bd UniProtKB/Swiss-Prot
  Cyt_B5-like_heme/steroid_sf UniProtKB/Swiss-Prot
  FA_desaturase_dom UniProtKB/Swiss-Prot
  Fatty_acid_desaturase UniProtKB/Swiss-Prot
KEGG Report rno:84575 UniProtKB/Swiss-Prot
NCBI Gene 84575 ENTREZGENE
PANTHER ACYL-COA (8-3)-DESATURASE UniProtKB/Swiss-Prot
  PTHR19353 UniProtKB/Swiss-Prot
Pfam Cyt-b5 UniProtKB/Swiss-Prot
  FA_desaturase UniProtKB/Swiss-Prot
PhenoGen Fads1 PhenoGen
PIRSF FA_sphinglp_des UniProtKB/Swiss-Prot
PRINTS CYTOCHROMEB5 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_B5_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020480 RatGTEx
SMART Cyt-b5 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55856 UniProtKB/Swiss-Prot
UniProt A0A8I5ZYM0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UKH4_RAT UniProtKB/TrEMBL
  A6I010 ENTREZGENE, UniProtKB/TrEMBL
  A6I011_RAT UniProtKB/TrEMBL
  FADS1_RAT UniProtKB/Swiss-Prot
  H2BF30 ENTREZGENE, UniProtKB/TrEMBL
  Q920R3 ENTREZGENE
  Q9EPV4 ENTREZGENE
UniProt Secondary Q9EPV4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Fads1  fatty acid desaturase 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Fads1  fatty acid desaturase 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression abundant in adrenal gland and mammary tissue; expressed in liver, kidney, lung, spleen, thymus, brain, and eye 632758