Obp1f (odorant binding protein I f) - Rat Genome Database

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Gene: Obp1f (odorant binding protein I f) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Obp1f
Name: odorant binding protein I f
RGD ID: 621639
Description: Enables odorant binding activity. Predicted to be involved in sensory perception of smell. Predicted to be located in extracellular region. Predicted to be active in extracellular space; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC103690319; OBP; Obp-1f; odorant-binding protein; odorant-binding protein 1F
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X45,833,861 - 45,839,070 (+)NCBIGRCr8
mRatBN7.2X41,955,618 - 41,960,681 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX41,955,618 - 41,960,681 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX43,258,991 - 43,264,064 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X46,726,331 - 46,731,404 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X44,391,061 - 44,396,138 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X83,847,944 - 83,864,150 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX45,282,187 - 45,284,341 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X83,742,999 - 83,746,062 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0X45,505,140 - 45,506,321 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X63,689,823 - 63,696,729 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X63,743,291 - 63,750,198 (-)NCBI
CeleraX42,669,718 - 42,676,625 (-)NCBICelera
Cytogenetic MapXq21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 14 of 14 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Obp1fRat17beta-estradiol multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in decreased expression of OBP1F mRNACTDPMID:32741896
Obp1fRat17beta-estradiol 3-benzoate multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in decreased expression of OBP1F mRNACTDPMID:32741896
Obp1fRat4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases expressionEXP 64804644-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of OBP1F mRNACTDPMID:22484513
Obp1fRatammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of OBP1F mRNACTDPMID:16483693
Obp1fRatbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of OBP1F mRNACTDPMID:25181051
Obp1fRatflavonoids increases expressionEXP 6480464Flavonoids results in increased expression of OBP1F mRNACTDPMID:18035473
Obp1fRatindole-3-methanol affects expressionEXP 6480464indole-3-carbinol affects the expression of OBP1F mRNACTDPMID:21396975
Obp1fRatMuraglitazar increases expressionEXP 6480464muraglitazar results in increased expression of OBP1F mRNACTDPMID:21515302
Obp1fRatN-nitrosomorpholine increases expressionEXP 6480464N-nitrosomorpholine results in increased expression of OBP1F mRNACTDPMID:19716841
Obp1fRatperfluorooctanoic acid increases expressionEXP 6480464perfluorooctanoic acid results in increased expression of OBP1F mRNACTDPMID:16221955 and PMID:19162173
Obp1fRatTesaglitazar increases expressionEXP 6480464tesaglitazar results in increased expression of OBP1F mRNACTDPMID:21515302
Obp1fRattestosterone multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in decreased expression of OBP1F mRNACTDPMID:32741896
Obp1fRatthioacetamide decreases expressionEXP 6480464Thioacetamide results in decreased expression of OBP1F mRNACTDPMID:34492290
Obp1fRattroglitazone increases expressionEXP 6480464troglitazone results in increased expression of OBP1F mRNACTDPMID:21515302

1 to 14 of 14 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Obp1fRatsensory perception of smell involved_inIEAUniProtKB-KW:KW-05521600115GO_REF:0000043UniProtGO_REF:0000043

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Obp1fRatextracellular region located_inIEAUniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
Obp1fRatextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
Obp1fRatextracellular space is_active_inIBAMGI:2387617 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Obp1fRatodorant binding enablesIBAMGI:1277949 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Obp1fRatodorant binding  IDA 633371 RGD 
Obp1fRatsmall molecule binding enablesIEAInterPro:IPR0023451600115GO_REF:0000002InterProGO_REF:0000002


#
Reference Title
Reference Citation
1. Ligand-binding properties and structural characterization of a novel rat odorant-binding protein variant. Briand L, etal., Eur J Biochem 2000 May;267(10):3079-89.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. Molecular cloning of odorant-binding protein: member of a ligand carrier family. Pevsner J, etal., Science 1988 Jul 15;241(4863):336-9.
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:15047593   PMID:16849331   PMID:17584948   PMID:19390145   PMID:19688223   PMID:20932975  



.

.
Variants in Obp1f
14 total Variants

Predicted Target Of
Summary Value
Count of predictions:128
Count of miRNA genes:111
Interacting mature miRNAs:115
Transcripts:ENSRNOT00000045436, ENSRNOT00000073734
Prediction methods:Microtar, Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat




alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
2 9 43 64 49 34 5 34 2 99 30 26 33 44 15



Ensembl Acc Id: ENSRNOT00000045436   ⟹   ENSRNOP00000039557
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX45,282,187 - 45,284,341 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000088538   ⟹   ENSRNOP00000071673
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX41,955,618 - 41,960,681 (+)Ensembl
Rnor_6.0 EnsemblX45,213,228 - 45,217,455 (+)Ensembl
RefSeq Acc Id: NM_138903   ⟹   NP_620258
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X45,834,006 - 45,839,069 (+)NCBI
mRatBN7.2X41,955,618 - 41,960,681 (+)NCBI
Rnor_6.0X83,847,944 - 83,864,150 (-)NCBI
Rnor_5.0X45,505,140 - 45,506,321 (-)NCBI
Rnor_5.0X83,742,999 - 83,746,062 (+)NCBI
RGSC_v3.4X63,689,823 - 63,696,729 (-)RGD
CeleraX42,669,718 - 42,676,625 (-)RGD
Sequence:
RefSeq Acc Id: XM_063279774   ⟹   XP_063135844
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X45,833,861 - 45,839,070 (+)NCBI
Protein RefSeqs NP_620258 (Get FASTA)   NCBI Sequence Viewer  
  XP_063135844 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAB61693 (Get FASTA)   NCBI Sequence Viewer  
  EDL96077 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064887
GenBank Protein P08937 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_620258   ⟸   NM_138903
- Peptide Label: precursor
- UniProtKB: Q9QYU9 (UniProtKB/TrEMBL),   A6IPT6 (UniProtKB/TrEMBL),   A6IPT5 (UniProtKB/TrEMBL),   A0A0G2K124 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000039557   ⟸   ENSRNOT00000045436
Ensembl Acc Id: ENSRNOP00000071673   ⟸   ENSRNOT00000088538
RefSeq Acc Id: XP_063135844   ⟸   XM_063279774
- Peptide Label: isoform X1
Lipocalin/cytosolic fatty-acid binding

Name Modeler Protein Id AA Range Protein Structure
AF-P08937-F1-model_v2 AlphaFold P08937 1-172 view protein structure
AF-Q9QYU9-F1-model_v2 AlphaFold Q9QYU9 1-173 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 31 of 31 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-2409 BioCyc
Ensembl Genes ENSRNOG00000045757 Ensembl
  ENSRNOG00000058697 Ensembl
  ENSRNOG00000063224 Ensembl
  ENSRNOG00000086793 ENTREZGENE
Ensembl Transcript ENSRNOT00000073734 ENTREZGENE
Gene3D-CATH 2.40.128.20 UniProtKB/Swiss-Prot
InterPro Calycin UniProtKB/Swiss-Prot
  Lipocalin UniProtKB/Swiss-Prot
  Lipocalin_CS UniProtKB/Swiss-Prot
  Lipocln_cytosolic_FA-bd_dom UniProtKB/Swiss-Prot
  OBP-like UniProtKB/Swiss-Prot
KEGG Report rno:192267 UniProtKB/Swiss-Prot
NCBI Gene 192267 ENTREZGENE
PANTHER ODORANT-BINDING PROTEIN 1A-RELATED UniProtKB/Swiss-Prot
  PTHR11430 UniProtKB/Swiss-Prot
Pfam Lipocalin UniProtKB/Swiss-Prot
PhenoGen Obp1f PhenoGen
PRINTS ODORANTBNDNG UniProtKB/Swiss-Prot
PROSITE LIPOCALIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000045757 RatGTEx
  ENSRNOG00000058697 RatGTEx
  ENSRNOG00000062551 RatGTEx
  ENSRNOG00000063224 RatGTEx
  ENSRNOG00000086793 RatGTEx
Superfamily-SCOP SSF50814 UniProtKB/Swiss-Prot
UniProt A0A0G2K124 ENTREZGENE, UniProtKB/TrEMBL
  A6IPT5 ENTREZGENE, UniProtKB/TrEMBL
  A6IPT6 ENTREZGENE
  OBP_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9QYU9 ENTREZGENE, UniProtKB/TrEMBL
1 to 31 of 31 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Obp1f  odorant binding protein I f  LOC103690319  odorant-binding protein  Data merged from RGD:9122946 737654 PROVISIONAL
2014-08-25 LOC103690319  odorant-binding protein      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-02-11 Obp1f  odorant binding protein I f  Obp-1f  odorant-binding protein 1F  Symbol and Name updated to reflect Human and Mouse nomenclature 625702 APPROVED
2002-08-07 Obp-1f  odorant-binding protein 1F      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_expression expressed in nasal epithelium 633371
gene_protein 18,091-dalton protein 633371