Advanced Search (OLGA)

Gene: Itga8 (integrin subunit alpha 8) Rattus norvegicus

Analyze

Symbol:

Itga8

Name:

integrin subunit alpha 8

RGD ID:

621634

Description:

Predicted to enable signaling receptor activity. Predicted to be involved in several processes, including integrin-mediated signaling pathway; positive regulation of transcription by RNA polymerase II; and substrate adhesion-dependent cell spreading. Predicted to act upstream of or within several processes, including inner ear morphogenesis; memory; and positive regulation of transforming growth factor beta receptor signaling pathway. Located in dendritic spine membrane; focal adhesion; and perikaryon. Is active in glutamatergic synapse and postsynaptic density membrane. Biomarker of mesangial proliferative glomerulonephritis. Human ortholog(s) of this gene implicated in end stage renal disease; ovarian cancer; renal agenesis; and schizophrenia. Orthologous to human ITGA8 (integrin subunit alpha 8); PARTICIPATES IN glomerulonephritis pathway; altered integrin mediated signaling pathway; integrin mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

integrin alpha 8; integrin alpha-8; integrin, alpha 8; LOC364786; RGD1564327; similar to integrin alpha 8

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ITGA8 (integrin subunit alpha 8)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Itga8 (integrin alpha 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Itga8 (integrin subunit alpha 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ITGA8 (integrin subunit alpha 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ITGA8 (integrin subunit alpha 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Itga8 (integrin subunit alpha 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ITGA8 (integrin subunit alpha 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ITGA8 (integrin subunit alpha 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Itga8 (integrin subunit alpha 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	ITGA8 (integrin subunit alpha 8)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Itga8 (integrin alpha 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	itga8 (integrin, alpha 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	pat-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	pat-2	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	if	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	if	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	itga8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	80,213,139 - 80,410,633 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	80,213,143 - 80,410,633 (-)	Ensembl				GRCr8
mRatBN7.2	17	75,304,004 - 75,501,510 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	75,304,008 - 75,501,510 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	78,764,688 - 78,961,155 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	82,600,048 - 82,796,494 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	76,647,995 - 76,844,433 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	79,321,893 - 79,676,927 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	79,321,900 - 79,676,499 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	81,190,818 - 81,304,978 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Rnor_5.0	17	80,956,109 - 81,030,622 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	86,427,191 - 86,649,268 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	74,681,231 - 74,877,691 (-)	NCBI		Celera
Cytogenetic Map	17	q12.3	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant polycystic kidney disease (ISO)

end stage renal disease (ISO)

genetic disease (ISO)

mesangial proliferative glomerulonephritis (IEP)

ovarian cancer (ISO)

Ovarian Neoplasms (ISO)

renal agenesis (ISO)

Renal Hypodysplasia/Aplasia 1 (ISO)

schizophrenia (ISO)

Stomach Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,1-dichloroethene (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-nitrotoluene (EXP)

3,3',4,4',5-pentachlorobiphenyl (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetaldehyde (ISO)

acetamide (EXP)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

astemizole (EXP)

atrazine (EXP)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

beta-naphthoflavone (EXP)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bromochloroacetic acid (EXP)

cadmium dichloride (EXP)

carbon nanotube (ISO)

chloroprene (EXP)

chlorpyrifos (ISO)

choline (ISO)

corticosterone (EXP)

Cuprizon (EXP)

cyanocob(III)alamin (ISO)

cyproconazole (ISO)

decabromodiphenyl ether (EXP)

dimethylarsinic acid (ISO)

dioxygen (ISO)

diquat (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

ethanol (ISO)

flusilazole (ISO)

folic acid (ISO)

furan (EXP)

glycine betaine (ISO)

inulin (ISO)

L-methionine (ISO)

Lasiocarpine (ISO)

manganese(II) chloride (EXP)

mercury dibromide (ISO)

methylarsonic acid (ISO)

N-methyl-4-phenylpyridinium (EXP)

N-nitrosodiethylamine (EXP)

nickel atom (ISO)

nitrofen (EXP)

O-methyleugenol (ISO)

okadaic acid (ISO)

ozone (ISO)

panobinostat (ISO)

paracetamol (ISO)

paraquat (EXP)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP)

phenobarbital (EXP)

phenylmercury acetate (ISO)

phenytoin (ISO)

pioglitazone (ISO)

pirinixic acid (ISO)

progesterone (EXP,ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

testosterone (EXP)

tetrachloromethane (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

trimellitic anhydride (ISO)

triptonide (ISO)

valproic acid (ISO)

vorinostat (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell adhesion (IEA)

cell differentiation (IEA)

cell projection organization (ISO)

cell-cell adhesion (IBA)

cell-matrix adhesion (IEA,ISO)

embryonic morphogenesis (IEA)

establishment of protein localization (IEA,ISO)

extracellular matrix organization (ISO)

inner ear morphogenesis (ISO)

integrin-mediated signaling pathway (IBA,IEA)

kidney development (IEA,ISO)

memory (ISO)

mesodermal cell differentiation (IEA,ISO)

metanephros development (ISO)

nervous system development (IEA)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

positive regulation of transforming growth factor beta receptor signaling pathway (ISO)

smooth muscle cell differentiation (IEA,ISO)

smooth muscle tissue development (IEA,ISO)

substrate adhesion-dependent cell spreading (IEA,ISO)

tissue development (IEA)

Cellular Component

apical part of cell (IEA,ISO)

cell surface (IBA,IEA,ISO)

dendritic spine membrane (IDA)

endoplasmic reticulum (IEA,ISO)

focal adhesion (IDA)

glutamatergic synapse (IDA)

integrin complex (IBA,IEA)

membrane (IEA)

perikaryon (IDA)

plasma membrane (IEA)

postsynaptic density membrane (IDA)

Molecular Function

metal ion binding (IEA)

signaling receptor activity (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

altered integrin mediated signaling pathway (ISO)

glomerulonephritis pathway (IEP)

integrin mediated signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Identification of PRTFDC1 silencing and aberrant promoter methylation of GPR150, ITGA8 and HOXD11 in ovarian cancers.	Cai LY, etal., Life Sci. 2007 Mar 27;80(16):1458-65. Epub 2007 Jan 20.
2.	Regional and ultrastructural distribution of the alpha 8 integrin subunit in developing and adult rat brain suggests a role in synaptic function.	Einheber S, etal., J Comp Neurol. 1996 Jun 17;370(1):105-34.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	Alpha8 integrin in glomerular mesangial cells and in experimental glomerulonephritis.	Hartner A, etal., Kidney Int 1999 Oct;56(4):1468-80.
6.	Fibrillin-1 and alpha8 integrin are co-expressed in the glomerulus and interact to convey adhesion of mesangial cells.	Marek I, etal., Cell Adh Migr. 2014;8(4):389-95. doi: 10.4161/cam.28988.
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	Integrin alpha8beta1 is critically important for epithelial-mesenchymal interactions during kidney morphogenesis.	Müller U, etal., Cell. 1997 Mar 7;88(5):603-13. doi: 10.1016/s0092-8674(00)81903-0.
9.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
10.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
11.	GOA pipeline	RGD automated data pipeline
12.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
14.	Comprehensive gene review and curation	RGD comprehensive gene curation
15.	A missense mutation in the ITGA8 gene, a cell adhesion molecule gene, is associated with schizophrenia in Japanese female patients.	Supriyanto I, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jan 10;40:347-52. doi: 10.1016/j.pnpbp.2012.11.002. Epub 2012 Nov 12.
16.	The integrins.	Takada Y, etal., Genome Biol. 2007;8(5):215.
17.	A promoter polymorphism of the alpha 8 integrin gene and the progression of autosomal-dominant polycystic kidney disease.	Zeltner R, etal., Nephron Clin Pract. 2008;108(3):c169-75. doi: 10.1159/000116887. Epub 2008 Feb 14.

Additional References at PubMed

PMID:10742111	PMID:12477932	PMID:12904471	PMID:17275006	PMID:17300786	PMID:17537792	PMID:21335239	PMID:21423176	PMID:23154389	PMID:24439109	PMID:28701000

Genomics

Comparative Map Data

Itga8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	80,213,139 - 80,410,633 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	80,213,143 - 80,410,633 (-)	Ensembl				GRCr8
mRatBN7.2	17	75,304,004 - 75,501,510 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	75,304,008 - 75,501,510 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	78,764,688 - 78,961,155 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	82,600,048 - 82,796,494 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	76,647,995 - 76,844,433 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	79,321,893 - 79,676,927 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	79,321,900 - 79,676,499 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	81,190,818 - 81,304,978 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Rnor_5.0	17	80,956,109 - 81,030,622 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	86,427,191 - 86,649,268 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	74,681,231 - 74,877,691 (-)	NCBI		Celera
Cytogenetic Map	17	q12.3	NCBI

ITGA8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	15,513,954 - 15,719,922 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	15,513,954 - 15,719,936 (-)	Ensembl			hg38	GRCh38
GRCh37	10	15,555,953 - 15,761,921 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	15,599,094 - 15,801,776 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	10	15,599,093 - 15,801,776	NCBI
Celera	10	15,492,319 - 15,695,021 (-)	NCBI		Celera
Cytogenetic Map	10	p13	NCBI
HuRef	10	15,471,650 - 15,674,184 (-)	NCBI		HuRef
CHM1_1	10	15,559,210 - 15,761,820 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	10	15,531,985 - 15,737,921 (-)	NCBI		T2T-CHM13v2.0

Itga8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	12,111,443 - 12,306,755 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	12,111,443 - 12,306,733 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	2	12,106,632 - 12,301,985 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	12,106,632 - 12,301,922 (-)	Ensembl			mm10	GRCm38
MGSCv37	2	12,028,287 - 12,223,547 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	2	12,024,513 - 12,219,773 (-)	NCBI		MGSCv36	mm8
Celera	2	12,022,433 - 12,215,417 (-)	NCBI		Celera
Cytogenetic Map	2	A1	NCBI
cM Map	2	9.12	NCBI

Itga8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955429	11,932,570 - 12,120,821 (+)	Ensembl
ChiLan1.0	NW_004955429	11,932,764 - 12,120,757 (+)	NCBI	ChiLan1.0	ChiLan1.0

ITGA8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	28,363,781 - 28,573,171 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	28,369,106 - 28,578,498 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	15,838,320 - 16,045,206 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	16,114,999 - 16,321,277 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	16,114,999 - 16,321,360 (-)	Ensembl			panPan2	panpan1.1

ITGA8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	21,034,630 - 21,244,304 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	21,075,653 - 21,241,951 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	18,185,585 - 18,354,528 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	21,368,356 - 21,544,465 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	21,368,171 - 21,542,328 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	18,574,970 - 18,744,463 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	19,409,413 - 19,578,983 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	20,034,706 - 20,203,972 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Itga8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	16,485,714 - 16,655,428 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936574	5,984,939 - 6,155,164 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936574	5,985,181 - 6,155,067 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ITGA8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	46,132,913 - 46,303,343 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	10	46,132,887 - 46,303,659 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	50,827,993 - 51,000,242 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ITGA8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	15,482,746 - 15,684,161 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	15,482,750 - 15,683,481 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666051	21,068,023 - 21,273,578 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Itga8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624796	11,908,964 - 12,101,139 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624796	11,908,927 - 12,103,806 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in Itga8
1121 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	864
Count of miRNA genes:	313
Interacting mature miRNAs:	422
Transcripts:	ENSRNOT00000022711
Prediction methods:	Microtar, Miranda, Pita, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
152023626	Bp403	Blood pressure QTL 403	3.86		arterial blood pressure trait (VT:2000000)		17	24136127	84432719	Rat
631502	Cm26	Cardiac mass QTL 26	3.71		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	17	70613502	86062352	Rat
2301412	Kidm40	Kidney mass QTL 40		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	42388164	87388164	Rat
1354588	Bvd4	Brain ventricular dilatation QTL 4	5.31	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	58194064	87388164	Rat
1354654	Spl7	Serum phospholipid level QTL 7	5.5		blood phospholipid amount (VT:0006084)	blood phospholipid level (CMO:0001169)	17	38031354	83031354	Rat
2317038	Ginf3	Gastrointestinal inflammation QTL 3	2.89	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	17	54829503	93515804	Rat
1598871	Memor5	Memory QTL 5	5.3		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	17	40968017	89341781	Rat
1581512	Cm55	Cardiac mass QTL 55	2.8	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	27233445	83975845	Rat
1354629	Scl31	Serum cholesterol level QTL 31	4.1		blood cholesterol amount (VT:0000180)	blood total cholesterol level (CMO:0000051)	17	38031354	83031354	Rat
152025238	Slep14	Serum leptin concentration QTL 14	4.62		blood leptin amount (VT:0005667)		17	24390595	84432719	Rat
61466	Niddm12	Non-insulin dependent diabetes mellitus QTL 12	3.2	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	17	65154872	93515804	Rat
1354638	Insul1	Insulin level QTL 1	4.8		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	38031354	83031354	Rat
1354635	Bp245	Blood pressure QTL 245	6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	38031354	83031354	Rat
12904736	Cm121	Cardiac mass QTL 121		0.043	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	17	42388164	87388164	Rat
1300148	Bp192	Blood pressure QTL 192	3.47		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	17	46050126	91050126	Rat
4889894	Eae33	Experimental allergic encephalomyelitis QTL 33	5.2	0.0001	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	17	55604597	93006569	Rat
2324621	Coatc5	Coat color QTL 5			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	17	42654895	87654895	Rat
1354619	Bp242	Blood pressure QTL 242	6.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	37687877	82687877	Rat
1300131	Bp193	Blood pressure QTL 193	3.3		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	68550040	93515804	Rat
7488963	Bp369	Blood pressure QTL 369		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	63697147	82818564	Rat
1300129	Rf25	Renal function QTL 25	3.03		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	17	41062352	86062352	Rat
1354663	Bvd5	Brain ventricular dilatation QTL 5	3.51	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	32199534	86201342	Rat
152023740	Bp406	Blood pressure QTL 406	6.06		arterial blood pressure trait (VT:2000000)		17	24136127	84432719	Rat
152023737	Bp405	Blood pressure QTL 405	5.06		arterial blood pressure trait (VT:2000000)			24136127	84432719	Rat
152023736	Bp404	Blood pressure QTL 404	3.78		arterial blood pressure trait (VT:2000000)		17	24136127	84432719	Rat
724528	Uae4	Urinary albumin excretion QTL 4	4.9	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	17	36045537	81045537	Rat
2302365	Gluco40	Glucose level QTL 40	4.79		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	64569820	86954580	Rat

Markers in Region

RH131175

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	75,304,110 - 75,304,312 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	79,322,003 - 79,322,204	NCBI	Rnor6.0
Rnor_5.0	17	80,956,216 - 80,956,417	UniSTS	Rnor5.0
RGSC_v3.4	17	86,427,302 - 86,427,503	UniSTS	RGSC3.4
Celera	17	74,681,338 - 74,681,539	UniSTS
RH 3.4 Map	17	763.4	UniSTS
Cytogenetic Map	17	q12.3	UniSTS

BE120177

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	75,463,133 - 75,463,301 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	79,637,105 - 79,637,272	NCBI	Rnor6.0
Rnor_5.0	17	81,266,161 - 81,266,328	UniSTS	Rnor5.0
RGSC_v3.4	17	86,610,426 - 86,610,593	UniSTS	RGSC3.4
Celera	17	74,840,425 - 74,840,592	UniSTS
RH 3.4 Map	17	765.5	UniSTS
Cytogenetic Map	17	q12.3	UniSTS

MARC_50801-50802:1130354928:1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	75,500,497 - 75,500,715 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	79,675,487 - 79,675,704	NCBI	Rnor6.0
Rnor_5.0	17	81,303,966 - 81,304,183	UniSTS	Rnor5.0
RGSC_v3.4	17	86,648,262 - 86,648,479	UniSTS	RGSC3.4
Celera	17	74,876,679 - 74,876,896	UniSTS
Cytogenetic Map	17	q12.3	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	148	91	90	59	56	59	6	311	156	11	127	72	92	31	10	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001173972	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017600639	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF148797	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC168655	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473990	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000022711 ⟹ ENSRNOP00000022713

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	80,213,143 - 80,410,633 (-)	Ensembl
mRatBN7.2 Ensembl	17	75,304,008 - 75,501,510 (-)	Ensembl
Rnor_6.0 Ensembl	17	79,321,900 - 79,676,499 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000097386 ⟹ ENSRNOP00000076706

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	80,213,143 - 80,410,633 (-)	Ensembl
mRatBN7.2 Ensembl	17	75,304,008 - 75,501,510 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000119561 ⟹ ENSRNOP00000090641

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	80,213,143 - 80,410,633 (-)	Ensembl
mRatBN7.2 Ensembl	17	75,304,008 - 75,501,510 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000121450 ⟹ ENSRNOP00000101231

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	80,213,143 - 80,410,633 (-)	Ensembl

RefSeq Acc Id:

NM_001173972 ⟹ NP_001167443

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	80,213,139 - 80,410,633 (-)	NCBI
mRatBN7.2	17	75,304,004 - 75,501,510 (-)	NCBI
Rnor_6.0	17	79,321,896 - 79,676,499 (-)	NCBI
Rnor_5.0	17	80,956,109 - 81,030,622 (-)	NCBI
Rnor_5.0	17	81,190,818 - 81,304,978 (-)	NCBI
Celera	17	74,681,231 - 74,877,691 (-)	NCBI

Sequence:

show sequence

GTTGGCGGGCCGCACAGGAGAGGACTGTCACTGTGGACTCACCGAGCTCACTGACCCGGGACAC
CGGCCTCTGGGGAACATCAGGGCTCCTCCTCCTCTGGCTCCACGGCTCCCGATCCTGGGTGAGC
AGCGTTTGGGGCAGAGGACGATGTCTGCGAGAACCCACCGGGGTCCCCCGGAGAACTGGGCACC
TCCGTTCGCTTGTCTCTGTTGCGTCTCGGCCGTGCTGGGGATGCTGTGGTCCCCCGTGTCTCTG
GCGTTCAACTTGGACGTAGACAAGCTCACGGTGTACAGTGGCCCCGAGGGCAGCTACTTCGGCT
ACTCGCTGGACTTCTACATACCTGATGCGCGCACAGCCAGTGTCTTGGTGGGGGCGCCCAAAGC
CAACACTAGCCAGCCGGATATCGTAGAAGGGGGAGCTGTCTACTACTGTCCCTGGCCTGCAGAG
AGGTCTGCACAGTGCAAGCAGATACCCTTTGACACCACCAACAACAGGAAAATCAGAGTTAATG
GAACCAAAGAGCCTATAGAATTTAAATCAAACCAATGGTTTGGAGCCACAGTGAGAGCTCACAA
AGGAAAAGTTGTGGCTTGTGCCCCTTTATATCACTGGAGAACTCTGAAGCCTAATCCAGCAAAG
GACCCGGTTGGCACATGCTATGTAGCAATTCAGAACTTCAGTGCTTACGCTGAGCACTCACCCT
GTCGGAACAGCAACGTTGATCCTGAAGGCCAAGGTTACTGCCAAGCCGGCTTCAGTCTAGACTT
CTATAAGAATGGAGACCTTATAGTGGGAGGACCTGGAAGCTTTTACTGGCAAGGTCAGGTGATC
ACGGTCAGTGTAGCAGACATCATTGCAAATTACTCATTCAAAGACATTCTTCGAAAACTGGCAG
CAGAAAAGCAGACAGATGTGGCTCCAGCTTCCTATGATGACAGCTACCTTGGATATTCAGTTGC
TGCTGGAGAATTCACTGGGGACTCTCTGCAAGAATTGGTTGCTGGAATTCCAAGAGGAGCACAG
AACTTTGGATATGTCTCCATCATTAACTCCACAGATATGACCTTCATTCAGAATTTTACTGGTG
AGCAGATGGCATCTTATTTCGGATATACTGTTGTGGTATCAGATGTTAACAATGATGGCATGGA
TGACATATTGGTCGGGGCACCTCTCTTTATGGAGCGAGAATTTGAAAGTAACCCTAGAGAAGTG
GGTCAGGTCTACCTGTACCTACAAGTGAGCGCCCTCCTCTTCCAAGACCCACAGGTCCTTACGG
GCACAGAGACTTTTGGGAGATTCGGTAGTTCTGTGGCCCACTTGGGGGACCTGAACCAAGATGG
ATACAATGATATTGCCATCGGTGTGCCCTTTGCAGGCAAGGATCAAAGAGGTAAAGTCCTCATT
TACAACGGAAACGCCAGAGGCTTGCACAGCAAGCCTTCCCAAGTTCTGCAAGGAATATGGGGGT
CACAGACCATCCCTTCTGGATTCGGCTTTTCTCTAAGAGGAGACGCAGACATAGACAAGAATGA
TTACCCAGATTTACTTGTCGGGGCATTTGGAGAAGGGAAAGTGGCCGTGTACAGAGCAAGGCCA
GTTGTAACAGTGGATGCCCAGCTTCTGCTGCACCCAATGATTATCAACCTTGAAAATAAAACTT
GCCAGATTCCAGAATTCCCGACTCCTGTGGCCTGCTTTTCTTTAAGAGTCTGTGCATCTATAGC
AGGCCAGAGCATTTCAAATACAGTAGCCCTGATGGCCGAGGTGCAGTTAGATTTCCTGAAGCAA
AAAGGAGCCATCAAACGGACCCTCTTCCTCCACAACCACCAGTCCCACCTCATCTTCCCCTTCG
TGATGAGGCAGCAAAAATCCCTCCACTGCCAGGATTTTATGGTTTACCTTCGAGATGAAACTGA
ATTCCGAGATAAACTGTCTCCAATCAACGTTAGCCTGAACTACAGTTTGGATGATTCCACCTTT
GAAGATGGCCTGGAAGTGAAGCCGATTTTGAACCACTACAGGGAGAATGTCGTTACTGAGCAGG
CTCACATCCTGGTGGACTGTGGAGAAGACAACCTCTGTGTTCCTGACTTGAGGCTGTCAGCTAG
ACCAGATAAGCAGGAGATAATTATTGGGGATGAAAATCACCTAATGCTCATAATCAATGCAAGG
AATGAAGGAGAAGGAGCTTACGAAGCTGAACTCTTCGTCATGATTCCCGAAGAAGCAGATTACG
TTGGGATCGAGCGCAACAACAAGGGACTGAGGCTCCTGAGTTGTGAGTACAAGATGGAAAACGT
AACCAGGATGGTGGTGTGTGACCTTGGGAACCCGATGGTGACTGGAACGAATTTTTCTCTGGGC
CTCCGATTTGCTGTTCCTCGTCTTGAGAAAACAAACATGAGTATTAACTTCGATCTCCAAATCA
GAAGCTCCAACAAGGACAATCCTGACAGCAATTTCGTGAGCGTGCAAATCAACGTCACTGCCGT
GGCTCAGGTGGAAATCAGAGGAGTGTCCCACCCTCCCCAAATTGTTCTGCCCATCCACAACTGG
GAGCCAGCAGAGGAGCCCCACAAAGAGGAGGAAGTCGGTCCCCTGGTTGAACATATTTATGAGC
TGCACAATATTGGACCCAGCACCATCAGTGACAGCATTCTCGAAGTGGGCTGGCCATTCTCTGC
ACGGGAGGAGTTCCTCCTCTATGTCTTTCATCTTCAAACTCTGGGACCTCTACAATGTCAAACA
AATCCTGAGATCAACCCGCAGGATATAAAGCCTGCTGCCTCCCCAGAGGATACCCCTGAGCTCA
GCGCCTTCTTAAGAAATGCTACAATTCCCCATCTTGTCAGGAAGAGGGATGTGCCAGTGGTCCA
GCCCCACAGACAGAGCCCGGCAAAAATACTGAACTGTACCAACATTGACTGCTTGCAAATCTCG
TGTGCAGTGGGTCGCCTGGGAGGAGGAGAAAGTGCAGTTCTGAAGGTCAGATCGAGATTGTGGG
CGCACACATTCCTCCAGAGAAAGAACGACCCTTATGCTCTTGCATCCCTGGTGTCCTTTGAAGT
CAAGAAGATACCTTATAAAGAGCAGCCAGCAAAACTGCCAGCCGGGAGCACAGCGATTAAGACA
TCGGTTATTTGGGCCACTCCAAATGTCTCCTTCTCAATTCCACTGTGGGTCATAATACTAGCGA
TCCTTCTTGGCTTGCTGGTTCTGGCCATCTTAACTTTAGCTTTATGGAAGTGTGGATTCTTTGA
TAGAGCAAGACCTCCTCAGGATGAAATGACAGACAGGGAACAACTGACCAGTGACAAGACCCCG
GAGGCTTGACTTGGAACCATGAACACCTAAAATTCAAGCACTGGTCCTGTTCAAAGAAAGAAAG
AAAGAACACAAGGGTTGAATGATCATAGCCTTCCACACCTGCCAATGACCCAGGGAATGGAAGA
GTCCCTAATCTGTGTAACGCATTGGCAGGGACTACAGAGAACCCCACCGGAAAAGAAACACAGC
CACCAACACTGTAGGAACAATCCACAGCCATGAAGATTTCCTTTGCTCTCACCCTTTCACATCT
GGCCAATATTCTGGAACAGCTGTAGGAACTCAAACAACTGTCCAGATCAGCCCAATGTGACTCA
CAAAAACACAGTTCCTACAGAGACGAGATGGACCAAGATCGAACACTACTGTAATCCGATGGCG
TCTCGGACACCCCCCTATGGAAGAGAACCCTTTCTAAGGATGTGATGGCTCAGGGAGAAAAGCA
GATACAACGTTGGGACTGTGAAAGTGCTTGCAGAACTACAAAGATGATTTCACTAAGGAAGGAC
CAAAAATGTATTTATTTATGTTTCGTTTCTCTAGGTAGAAAATTGGGCCATCTAGAGGATTTGG
AGAGGACGATTTGGTTAGCTAGATTTCATCAGCACTCAACTTACTCCCTCTTAAGATAACTGTT
CTGTGCAGATAGCGTGTTTAATTGGGCTTCTTCAGGTGTTAGATGATGTTACACATGGTTTGGC
ATTAGGGCTCTTTTGTGCTTAATTTCCTGCTGCCTGGAGTGACATTCCTTCATGTTCTCCGGGA
ACTCATGTCTGCATAATTCAACTTTACAAAATCTTATATTTATAGTTCATTTTATATGTGTGAA
AAATCTATTTCCACTGACTTCTTTAAAGCATTCATTTCAAGGTACTCACTACCCTGATGCTGTT
GAAAACTACTAGCACAATTTGTAGAGTCCATATAAAAAAACAATTTAACTATATGGGTGAATAT
TATCTTGATAGCTATTGTAAACACCAACATTTACCTTGAAATTTACACACTTGTTTTCATTGTA
ATACCTCACATTCATGTAAAAGAGAAAAGTGTGTTGAGCATAAATAAGATAGAAATATATAAAG
TCATACAAGTATGAGCCAGGCAGACACACACTCTTAAGGACCTAACAATGTTTATTACAGCTTT
ATTAGCCACTCTTTATGGTTAATCTGTCCTAGCAAGTAATCTTGGAGAATAATCTTTTATATTT
AAGCTATTTTACCATCATCTTTACTTAAACGTTGCTTAAAGCGCTTGTAAATAATTCATAGTAA
TTCGTAATGTTATGATTTTGAAGTACTATTGAACAGCCAAATTCATAAGATTACCTGCACACTT
TTATATCCTTTTTATAATAATGAAAAATGCTACGGAGAAATGCTGAACAAAATGTTATGTGCAA
TATTTTATAGAACTATGTATCTGAGGCATGTTTACACTGGCATTAGTTTCTTTTTTTTTAATTA
ATATCCTGAATACTAAGTCTGATATAACAAGCTGACCAAACGTTTACAAAGCAGTTGGGAAAAT
CTGTGTCTCAGTTTCACCAATGACACTCTTTTTGAAAGACGATCCAAACTCACAGACAGTAAAC
ATGATGTGGTGCCTTAACCTGGAAAGGAGCCATTTGGCTTCAGTTGCCTGGAAAGCAAATGAAA
TGCAGAGTCGAAGATCACTGCTGTTCACCTTGCCCTGCTTGTCAGTTAACCTGTCCTGATAGCT
GCTTTATGTCTATCAGGAAATCAAATATGGTTCCCCGTCGATATGGCTAGTGCCTAGGGAACAC
TACACTGGCCTCAGAGAGTCACACACCAGCCTCTGGGGTTGTCTTTACTGTTAGTCTTTTCTGT
AAGACATTTCATAAGCAGAACGCTATCTATATGCTATCATTTGAGGGATGACAAACAGCTCACT
CTACACTTTTAACGCTTGTGATTTCTGAGGTGAGACCAATACAAACTCTTCAGAAGTTTAGAAT
GCATCTCTGATCTTAAAAGAACTCAGAGAACTCTTAGGGCAAAGCACAGGAACTGTGGGAGACA
GCCATGTGGGAAAAACTAAAGATGTCAGGGACCAACACAGAAGGTATGGGGATATCAAATCCAA
CTATGGCTTCCCATGGTCTCAACTGTGGAAGCGCAGGGGGCCGCCATACACATGCACACAGAAA
ACCAAGGTCAGGTGACCTCTCCTGGGACATGTTCCTCACAGAGAACACTGAGAATACAGCAGTG
CTCATGGCGTCGCTGACTCTTGTGACCCATTCTGTATTGGTATTCACGGGGATTCTATCTATAT
TTCTCTTCAACAAGTTCTATCCTAATTCTCACAGCTGTTTTTATAAGACACAGGGAAATGAGCA
GATTTTATAATCTTGGAGATTTTTATACACTAAAGCGTTCTAGTTGTCACTGAAATACAAATCT
TAGAATTCTTGTCTCATTTAAATACTTGTATAGAGACAGCGTAGATTTTCATATACCTATTTAC
ATTGTCACCAATAAAATTAAAAATTAAAGATGGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001167443	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAD31539	(Get FASTA)	NCBI Sequence Viewer
	AAI68655	(Get FASTA)	NCBI Sequence Viewer
	EDL78706	(Get FASTA)	NCBI Sequence Viewer
	EDL78707	(Get FASTA)	NCBI Sequence Viewer
	EDL78708	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000022713
	ENSRNOP00000022713.5
	ENSRNOP00000076706.1
	ENSRNOP00000090641.1
	ENSRNOP00000101231.1

RefSeq Acc Id:

NP_001167443 ⟸ NM_001173972

- UniProtKB:

B5DEG1 (UniProtKB/TrEMBL), F7F1E3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSARTHRGPPENWAPPFACLCCVSAVLGMLWSPVSLAFNLDVDKLTVYSGPEGSYFGYSLDFYI
PDARTASVLVGAPKANTSQPDIVEGGAVYYCPWPAERSAQCKQIPFDTTNNRKIRVNGTKEPIE
FKSNQWFGATVRAHKGKVVACAPLYHWRTLKPNPAKDPVGTCYVAIQNFSAYAEHSPCRNSNVD
PEGQGYCQAGFSLDFYKNGDLIVGGPGSFYWQGQVITVSVADIIANYSFKDILRKLAAEKQTDV
APASYDDSYLGYSVAAGEFTGDSLQELVAGIPRGAQNFGYVSIINSTDMTFIQNFTGEQMASYF
GYTVVVSDVNNDGMDDILVGAPLFMEREFESNPREVGQVYLYLQVSALLFQDPQVLTGTETFGR
FGSSVAHLGDLNQDGYNDIAIGVPFAGKDQRGKVLIYNGNARGLHSKPSQVLQGIWGSQTIPSG
FGFSLRGDADIDKNDYPDLLVGAFGEGKVAVYRARPVVTVDAQLLLHPMIINLENKTCQIPEFP
TPVACFSLRVCASIAGQSISNTVALMAEVQLDFLKQKGAIKRTLFLHNHQSHLIFPFVMRQQKS
LHCQDFMVYLRDETEFRDKLSPINVSLNYSLDDSTFEDGLEVKPILNHYRENVVTEQAHILVDC
GEDNLCVPDLRLSARPDKQEIIIGDENHLMLIINARNEGEGAYEAELFVMIPEEADYVGIERNN
KGLRLLSCEYKMENVTRMVVCDLGNPMVTGTNFSLGLRFAVPRLEKTNMSINFDLQIRSSNKDN
PDSNFVSVQINVTAVAQVEIRGVSHPPQIVLPIHNWEPAEEPHKEEEVGPLVEHIYELHNIGPS
TISDSILEVGWPFSAREEFLLYVFHLQTLGPLQCQTNPEINPQDIKPAASPEDTPELSAFLRNA
TIPHLVRKRDVPVVQPHRQSPAKILNCTNIDCLQISCAVGRLGGGESAVLKVRSRLWAHTFLQR
KNDPYALASLVSFEVKKIPYKEQPAKLPAGSTAIKTSVIWATPNVSFSIPLWVIILAILLGLLV
LAILTLALWKCGFFDRARPPQDEMTDREQLTSDKTPEA

hide sequence

Ensembl Acc Id:

ENSRNOP00000022713 ⟸ ENSRNOT00000022711

Ensembl Acc Id:

ENSRNOP00000076706 ⟸ ENSRNOT00000097386

Ensembl Acc Id:

ENSRNOP00000090641 ⟸ ENSRNOT00000119561

Ensembl Acc Id:

ENSRNOP00000101231 ⟸ ENSRNOT00000121450

Protein Domains

Integrin alpha first immunoglubulin-like Integrin alpha second immunoglobulin-like Integrin alpha third immunoglobulin-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B5DEG1-F1-model_v2	AlphaFold	B5DEG1	1-1062	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700589

Promoter ID:

EPDNEW_R11113

Type:

initiation region

Name:

Itga8_1

Description:

integrin subunit alpha 8

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	17	79,676,510 - 79,676,570	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621634	AgrOrtholog
BioCyc Gene	G2FUF-8635	BioCyc
Ensembl Genes	ENSRNOG00000016538	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000022711	ENTREZGENE
	ENSRNOT00000022711.6	UniProtKB/TrEMBL
	ENSRNOT00000097386.2	UniProtKB/TrEMBL
	ENSRNOT00000119561.2	UniProtKB/TrEMBL
	ENSRNOT00000121450.1	UniProtKB/TrEMBL
Gene3D-CATH	2.130.10.130	UniProtKB/TrEMBL
	Bicelle-embedded integrin alpha(iib) transmembrane segment	UniProtKB/TrEMBL
	Integrin domains. Chain A, domain 2	UniProtKB/TrEMBL
	ntegrin, alpha v. Chain A, domain 3	UniProtKB/TrEMBL
	ntegrin, alpha v. Chain A, domain 4	UniProtKB/TrEMBL
InterPro	FG-GAP	UniProtKB/TrEMBL
	Int_alpha_beta-p	UniProtKB/TrEMBL
	Integrin_alpha	UniProtKB/TrEMBL
	Integrin_alpha-2	UniProtKB/TrEMBL
	Integrin_alpha_C_CS	UniProtKB/TrEMBL
	Integrin_alpha_Ig-like_2	UniProtKB/TrEMBL
	Integrin_alpha_Ig-like_3	UniProtKB/TrEMBL
	Integrin_alpha_N	UniProtKB/TrEMBL
	Integrin_dom	UniProtKB/TrEMBL
KEGG Report	rno:364786	UniProtKB/TrEMBL
NCBI Gene	Itga8	ENTREZGENE
PANTHER	INTEGRIN ALPHA	UniProtKB/TrEMBL
	INTEGRIN ALPHA-8	UniProtKB/TrEMBL
Pfam	FG-GAP	UniProtKB/TrEMBL
	Integrin_A_Ig_2	UniProtKB/TrEMBL
	Integrin_A_Ig_3	UniProtKB/TrEMBL
	Integrin_alpha	UniProtKB/TrEMBL
	Integrin_alpha2	UniProtKB/TrEMBL
PhenoGen	Itga8	PhenoGen
PRINTS	INTEGRINA	UniProtKB/TrEMBL
PROSITE	FG_GAP	UniProtKB/TrEMBL
	INTEGRIN_ALPHA	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000016538	RatGTEx
SMART	Int_alpha	UniProtKB/TrEMBL
Superfamily-SCOP	SSF69179	UniProtKB/TrEMBL
	SSF69318	UniProtKB/TrEMBL
UniProt	A0A8I5Y696_RAT	UniProtKB/TrEMBL
	A0A8I6GID8_RAT	UniProtKB/TrEMBL
	A0ABK0LAZ6_RAT	UniProtKB/TrEMBL
	B5DEG1	ENTREZGENE, UniProtKB/TrEMBL
	F7F1E3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-12-23	Itga8	integrin subunit alpha 8	Itga8	integrin, alpha 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-05-26	Itga8	integrin, alpha 8	RGD1564327	similar to integrin alpha 8	Data merged from RGD:1564327	737654	APPROVED
2010-02-09	Itga8	integrin, alpha 8	Itga8	integrin alpha 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1564327	similar to integrin alpha 8	RGD1564327_predicted	similar to integrin alpha 8 (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-07	RGD1564327_predicted	similar to integrin alpha 8 (predicted)	LOC364786	similar to integrin alpha 8	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC364786	similar to integrin alpha 8			Symbol and Name status set to provisional	70820	PROVISIONAL
2004-02-26	Itga8	integrin alpha 8			Symbol and Name status set to approved	625702	APPROVED
2002-08-07	Itga8	integrin alpha 8			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	strongly and solely expressed in mesangial cells in glomeruli and renal vasculature	633055

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations